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All Journal Paediatrica Indonesiana PREPOTIF : Jurnal Kesehatan Masyarakat
Theresia Santi
Faculty of Medicine, President University, Cikarang, West Java
Health Professions Medicine & Pharmacology Public Health

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Evaluation of anti-diphtheria toxoid antibody persistence in school-age children in Jakarta, Indonesia Santi, Theresia; Prayitno, Ari; Munasir, Zakiudin; Hadinegoro, Sri Rezeki S.; Harahap, Alida Roswita; Werdhani, Retno Asti; Sah Bandar, Ivo Novita; Jo, Juandy; Hegar, Badriul
Paediatrica Indonesiana Vol. 64 No. 5 (2024): September 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.5.2024.447-53

Abstract

Background Diphtheria can be effectively prevented by adequate immunization. A combined vaccine against diphtheria toxoid, pertussis, and tetanus toxoid (DPT) is currently used in routine pediatric immunizations. Outbreaks of diphtheria could emerge in Indonesia as a consequence of declining routine vaccination during the COVID-19 pandemic. Objective To analyze the impact of the first (administered at 18-24 months of age ) and second diphtheria boosters (administered at 5-7 years of age ) in retaining protective levels of anti-diphtheria toxoid antibodies. We also investigated for relevant factors associated with anti-diphtheria toxoid antibody titers. Methods This cross-sectional study was conducted in the Senen District of Jakarta, Indonesia. The inclusion criteria were healthy children aged 6 to 7 years with documented history of DPT vaccination. Primary vaccination defined as 3 doses of DPT at age less than 1 year , first booster was DPT vaccination at 18-24 years of age, and second booster was diphtheria-tetanus (DT) vaccination received at 5 to 7 years of age. Peripheral blood specimens were obtained from participating children, after informed consent was provided by their parents. Antibodies against diphtheria in sera specimens were assessed by commercial anti-diphtheria toxoid immunoglobulin G (IgG) enzyme-linked immunosorbent assay. Results There were 154 children included in the study, with a female majority (61%). Overall, specific humoral immunity against diphtheria was observed in 113 children (73.4%). There was no statistical difference in immunity level between genders. Importantly, children who received the first and second diphtheria booster had significantly higher anti-diphtheria antibody level than those who did not receive both diphtheria booster (P<0.001). Conclusion Booster vaccinations are crucial among school-age children in Indonesia to improve their anti-diphtheria immunity and to minimize a risk of diphtheria outbreaks.
OFFICE SYNDROME LITERATURE REVIEW : LATEST RESEARCH INSIGHTS AND FUTURE DIRECTIONS Nusasenjaya, Radite; Santi, Theresia; Purwoko, Reza Yuridian; Melati, Rima; Anugrah, Andreas Surya
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.38142

Abstract

Sindroma Perkantoran atau Office syndrome merupakan kumpulan gejala yang terutama terjadi akibat kebiasaan bekerja dengan posisi statis dalam jangka waktu lama, yang sering timbul pada pekerja kantor. Sindrom ini mencakup berbagai gangguan muskuloskeletal dan masalah kesehatan lainnya yang disebabkan oleh duduk yang berkepanjangan, postur tubuh yang buruk, gerakan berulang, dan pengaturan ergonomis yang tidak memadai. Tinjauan literatur ini bertujuan untuk mengisi kesenjangan pengetahuan, menyediakan gambaran holistik tentang Sindroma Perkantoran, dan memberikan dasar untuk penelitian lebih lanjut serta pengembangan rekomendasi berbasis bukti. Metodologi penelitian menggunakan narrative literature review dengan pencarian sistematis melalui database PubMed, Scopus, Web of Science, CINAHL, dan PsycINFO menggunakan kata kunci spesifik. Temuan penelitian menunjukkan prevalensi Sindroma Perkantoran mencakup gangguan muskuloskeletal berkisar 33,8-95,3%, dengan tingkat keparahan lebih tinggi di negara berkembang dibanding negara maju. Sindroma Perkantoran mencakup dua masalah utama: gangguan muskuloskeletal (work related musculoskeletal disorder/WMSD) dan Sindrom Penglihatan Komputer (Computer Vision Syndrome/CVS). Faktor risiko meliputi penggunaan komputer dalam waktu lama, usia lanjut, gerakan berulang, stres, posisi yang sama dalam waktu lama, beban kerja berat, merokok, pengalaman kerja berkepanjangan, kurang latihan fisik, dan status pendidikan. Responden perempuan dilaporkan lebih mungkin mengalami gangguan muskuloskeletal dibandingkan laki-laki. Penanganan mencakup pendekatan non-farmakologis seperti edukasi ergonomi dan perbaikan postur kerja, serta pendekatan farmakologis menggunakan analgesik, relaksan otot, dan obat adjuvan. Inovasi terkini termasuk terapi seluler seperti Mesenchymal Stem Cells (MSC), Platelet-Rich Plasma (PRP), eksosom, dan potensi modulasi vitamin D.
Vitamin D deficiency in newborns: a tropical paradox Naomi Esthernita F. Dewanto; Theresia Santi; Zaneth Sugiri; Nancy Napitupulu; Juandy Jo
Paediatrica Indonesiana Vol. 66 No. 1 (2026): January 2026
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background  Previous studies have shown a 'tropical paradox' in Indonesia, where despite being a tropical country with abundant sunlight, a widespread vitamin D inadequacy is observed in various populations. This paradox extends to Indonesian children, who predominantly exhibit low vitamin D levels, yet research specifically investigating vitamin D status in the newborn remains notably limited. Objective To determine the prevalence of low level of vitamin D and elucidate its correlation with the conditions of newborns in Jakarta, Indonesia. Methods This retrospective study analyzed data from newborns undergoing assessment at Siloam Hospital Kebon Jeruk, Jakarta, from June 2022 to May 2024. We collected the following data: newborn’s vitamin D level, demographic and clinical characteristics, as well as available maternal data. Serum 25-hydroxyvitamin D [25(OH)D] levels between < 20, 20–29.9 and ≥ 30 ng/mL were classified as deficient, insufficient, and sufficient, respectively. Statistical analyses were used to compare baseline characteristics and outcomes based on vitamin D status. Results Of the 243 newborns studied, 70.4% were classified as vitamin D deficient, 22.2% as insufficient, and 7.4% as sufficient. Subjects’ median vitamin D level was 15.7 (range 1.2 – 57.1)  ng/mL. No significant difference in vitamin D levels was observed between male and female newborns (p=0.190) and between newborns with birthweight < 2,500 and the ones with birth weight ≥2,500 grams (p=0.794). Vitamin D levels were not significantly different between healthy and sick newborns (p=0.537). Maternal vitamin D status was available for only a small proportion (15.6%) of mothers, highlighting the need for further investigation into maternal-newborn vitamin D status. Conclusion Although a high prevalence of newborn with vitamin D deficiency was observed in our study participants, no significant difference in vitamin D levels was observed between healthy and sick newborns. No correlation was observed between sex or birth weight, and vitamin D levels as well. Future inquiries should explore maternal vitamin D status in greater detail and assess the prolonged health consequences of hypovitaminosis D in newborns.  
Co-Authors Anugrah, Andreas Surya Ari Prayitno, Ari Badriul Hegar Harahap, Alida Roswita Ivo Novita Sah Bandar Juandy Jo Juandy Jo Munasir, Zakiudin Nancy Napitupulu Naomi Esthernita F. Dewanto Nusasenjaya, Radite Purwoko, Reza Yuridian Retno Asti Werdhani Rima Melati Sri Rezeki S. Hadinegoro, Sri Rezeki S. Zaneth Sugiri