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All Journal Nusantara Medical Science Journal Media Gizi Kesmas Jurnal Pengabdian Masyarakat As-salam International Journal of Cell and Biomedical Science
Tsaqifah , Nabila Aulia
Medical Study Program, Faculty Of Medicine And Health Science, Universitas Sultan Ageng Tirtayasa, Serang, 42121
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Engineered Stem Cell-Derived Exosomes for Precision Regenerative Medicine: Molecular Targeting, Cargo Optimization, and Therapeutic Applications Ghea Farmaning Thias Putri; Dwi Widyawati; Firda Asma'ul Husna; Rifdah Hanifah; Nabila Aulia Tsaqifah
International Journal of Cell and Biomedical Science Vol 5 No 13 (2026)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v5i13.85

Abstract

Regenerative medicine has increasingly transitioned from cell-based therapies to cell-free approaches due to the constraints of stem cell transplantation, such as limited engraftment efficiency, immunogenicity, tumorigenic potential, and difficulties in clinical standards. Among novel cell-free methodologies, stem cell-derived exosomes have garnered considerable interest as nanoscale extracellular vesicles that facilitate tissue repair via paracrine signaling. Recent advancements in molecular biology and bioengineering have facilitated the creation of modified exosomes, permitting precise alterations of surface molecules and bioactive cargo to improve therapeutic specificity and efficacy. This narrative review encapsulates current advancements in synthetic stem cell-derived exosomes for precision regenerative medicine, emphasizing molecular targeting techniques, therapeutic cargo optimization, and applicability across various disease types. Literature pertinent to the years 2020 to 2025 was sourced from PubMed, Scopus, and ScienceDirect and subjected to qualitative analysis. The results demonstrate that modified exosomes can efficiently regulate critical biological pathways associated with apoptosis, inflammation, angiogenesis, and tissue regeneration. Improved targeting specificity increases tissue accumulation and therapeutic efficacy, while tailored cargo allows for precise modulation of molecular signaling in damaged microenvironments. Despite encouraging preclinical results, challenges related to production standardization, cargo uniformity, dosage optimization, and long-term safety hinder clinical translation. However, ongoing advancements in bioengineering, nanotechnology, and regulatory structures position modified exosomes as strong contenders for the development of next-generation regenerative therapeutics. Engineered stem cell-derived exosomes are a versatile and unique platform with considerable promise to connect molecular mechanisms and clinical applications in precision regenerative medicine.
From Oxidative Stress to Fibrogenesis: A Comprehensive Review of a Composite Oxidative-Fibrotic Index in Hypoxia-Associated MAFLD Dwi Widyawati; Ghea Farmaning Thias Putri; Ayu Tiara Fitri; Rifdah Hanifah; Nabila Aulia Tsaqifah; Yani Dwi Lestari; Rossa Amelia
International Journal of Cell and Biomedical Science Vol 5 No 13 (2026)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v5i13.91

Abstract

Metabolically associated fatty liver disease (MAFLD) is a leading cause of chronic liver disease, with fibrosis representing the strongest predictor of adverse clinical outcomes. Emerging evidence suggests that intermittent hypoxia, commonly associated with obstructive sleep apnea, contributes to fibrosis progression through oxidative stress-mediated mechanisms. This review aims to synthesize current evidence on the role of intermittent hypoxia in driving oxidative stress and hepatic fibrogenesis in MAFLD, and to propose a Composite Oxidative-Fibrotic Index as an integrative biomarker framework. A narrative review was conducted using major biomedical databases to identify experimental and clinical studies evaluating hypoxia-induced oxidative stress, redox-sensitive signaling pathways, and fibrogenic responses in MAFLD. Intermittent hypoxia induces repetitive hypoxia-reoxygenation cycles that promote reactive oxygen species generation, impair antioxidant defenses, and activate redox-sensitive pathways, including HIF-1α, NF-κB, and Nrf2 dysregulation. These mechanisms contribute to hepatic stellate cell activation, extracellular matrix remodeling, and increased liver stiffness. Evidence indicates that individual oxidative and fibrogenic biomarkers are insufficient to capture the dynamic progression of fibrosis. The proposed Composite Oxidative-Fibrotic Index integrates oxidative stress markers, signaling mediators, fibrogenic indicators, and liver stiffness measurement into a unified framework. This approach may improve early detection, risk stratification, and monitoring of fibrosis progression in hypoxia-associated MAFLD, with potential implications for biomarker-guided clinical management and targeted therapeutic strategies.
English English Rifdah Hanifah; Nabila Aulia Tsaqifah; Deannisa Fajriaty
Media Gizi Kesmas Vol 15 No 1 (2026): MEDIA GIZI KESMAS (JUNE 2026)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgk.v15i1.2026.145-157

Abstract

Background: Through metabolic, immunological, and neurodevelopmental pathways, maternal microbiome is critical for fetal growth and perinatal health through metabolic, immunological, and neurodevelopmental pathways. Pregnancy-related nutritional therapies have emerged as potential strategies for improving maternal and newborn health by influencing the mother's microbiota. The goal of this review is to compile the available data on nutritional therapies that target the microbiota during pregnancy and their effects on postnatal outcomes. Objectives: To synthesize the current evidence on microbiome-targeted nutritional interventions during pregnancy and their effects on perinatal outcomes. Methods: A systematic literature search was conducted using PubMed to identify relevant studies published between 2020 and 2026. The search employed keywords related to pregnancy, maternal nutrition, the microbiome, and perinatal outcomes. Original studies investigating dietary or nutritional interventions during pregnancy and their effects on maternal microbiota and microbiome-related or perinatal outcomes were included in this review. Eligible studies underwent title and abstract screenings, followed by full-text assessments. Due to methodological variability across studies, the findings were synthesized using a narrative approach. Results: The results indicate that the composition and function of the maternal microbiota can be changed by interventions such as probiotics, prebiotics, specific dietary patterns (such as the Mediterranean diet), and balanced energy and protein supplements. These interventions may affect the colonization of the newborn microbiota, immunological development, metabolic programming, and infection risk through mechanisms involving microbial metabolites, including short-chain fatty acids and breast milk-mediated pathways. However, due to differences in study design, microbiome assessment methods, intervention categories, and outcome measurements, the evidence remains inconsistent. Conclusion: Nutritional interventions targeting the microbiome during pregnancy have the potential to improve perinatal outcomes. However, substantial methodological heterogeneity among studies and limited longitudinal evidence restrict their translation into standardized clinical recommendations. Further rigorously designed studies with standardized methodologies and long-term follow-ups are needed to clarify their efficacy, mechanisms, and clinical relevance.
PENCEGAHAN STUNTING BERBASIS EDUKASI KESEHATAN DAN LINGKUNGAN PADA REMAJA, IBU HAMIL, DAN KELUARGA DI DESA SUKACAI Ghea Farmaning Thias Putri; Dwi Widyawati; Rifdah Hanifah; Nabila Aulia Tsaqifah; Ainina Al Shadrina Shadrina
JPMA - Jurnal Pengabdian Masyarakat As-Salam Vol. 6 No. 1 (2026): Jurnal Pengabdian Masyarakat As-Salam (JPMA)
Publisher : Asosiasi Dosen Perguruan Tinggi Islam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37249/jpma.v6i1.1618

Abstract

Stunting masih menjadi tantangan kesehatan masyarakat yang berdampak pada kualitas pembangunan sumber daya manusia, khususnya di wilayah pedesaan. Program pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman dan kesadaran mengenai pencegahan stunting pada remaja, ibu hamil, keluarga, serta kader kesehatan desa di Desa Sukacai melalui pendekatan edukasi terpadu berbasis kesehatan dan lingkungan. Kegiatan ini melibatkan 40 peserta yang terdiri dari 19 remaja, 8 ibu hamil, 10 ibu dengan balita, dan 3 kader kesehatan desa, dengan metode pembelajaran partisipatif dan dialogis. Evaluasi dilakukan menggunakan observasi terstruktur, checklist partisipasi, dan sesi refleksi akhir. Hasil menunjukkan bahwa 70% peserta terlibat aktif dalam diskusi, dan 78% peserta berada pada kategori pemahaman tinggi berdasarkan kemampuan menjelaskan kembali faktor risiko dan langkah pencegahan stunting. Kegiatan ini juga berhasil mengklarifikasi miskonsepsi terkait imunisasi, gizi ibu hamil, dan praktik sanitasi. Keunikan program ini terletak pada pendekatan terpadu multi-target yang melibatkan remaja, ibu hamil, dan keluarga secara simultan sebagai satu sistem pencegahan stunting berbasis komunitas. Model ini menekankan sinergi lintas fase kehidupan sebagai strategi promotif yang lebih berkelanjutan dibandingkan pendekatan parsial dan berpotensi direplikasi pada wilayah pedesaan dengan karakteristik serupa.
Maternal Obesity, Metabolic Syndrome, and Long-Term Effects on Offspring: A Developmental Origins of Health and Disease (DOHaD) Perspective Nabila Aulia Tsaqifah; Rifdah Hanifah; Firda Asma'ul Husna; Mailani Dwi Hidayati; Dwi Widyawati; Ghea Farmaning Thias Putri; Ainina Al Shadrina
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.47907

Abstract

Introduction: The global prevalence of obesity among women of reproductive age has increased markedly over the past two decades, reaching 24% in high-income and 16% in low- and middle-income countries. This trend contributes to adverse maternal and neonatal outcomes, including a 2–4-fold higher risk of gestational diabetes, a threefold increase in preeclampsia, and up to a 50% higher caesarean delivery rate. Maternal metabolic disorders also have long-term consequences for offspring metabolic and cardiovascular health. Objective: To synthesize current biological and epidemiological evidence linking maternal metabolic status to offspring health within the Developmental Origins of Health and Disease (DOHaD) framework. Methods: A comprehensive search was conducted in PubMed, Scopus, and Web of Science from January 2015 to September 2025 using keywords related to maternal obesity, metabolic syndrome, DOHaD, offspring health, and epigenetics. Included studies comprised human and animal research with follow-up beyond two years, while case reports, editorials, and studies without long-term outcomes were excluded. Findings: From 22 eligible studies, consistent evidence indicates that maternal obesity and metabolic syndrome affect offspring through placental dysfunction, systemic inflammation, and epigenetic reprogramming. Offspring of obese mothers show a 1.5–2.8-fold increased risk of obesity and insulin resistance during adolescence and adulthood. Epigenome-wide analyses reveal altered methylation of genes regulating lipid metabolism (LEP, IGF2) and inflammatory pathways, supporting the DOHaD hypothesis. Conclusion: Maternal metabolic health critically shapes offspring developmental and metabolic outcomes. Preconception and antenatal interventions targeting metabolic optimization provide key opportunities to prevent intergenerational transmission of metabolic risk and promote healthier future generations.
Co-Authors Ainina Al Shadrina Ainina Al Shadrina Shadrina Ayu Tiara Fitri Deannisa Fajriaty Dwi Widyawati Dwi Widyawati Dwi Widyawati Dwi Widyawati Firda Asma'ul Husna Firda Asma'ul Husna Ghea Farmaning Thias Putri Ghea Farmaning Thias Putri Ghea Farmaning Thias Putri Mailani Dwi Hidayati Rifdah Hanifah Rifdah Hanifah Rifdah Hanifah Rifdah Hanifah Rifdah Hanifah Rossa Amelia Yani Dwi Lestari