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All Journal Nusantara Medical Science Journal INOMED
Dwi Widyawati
Universitas Sultan Ageng Tirtayasa
Materials Science & Nanotechnology Neuroscience

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Maternal Obesity, Metabolic Syndrome, and Long-Term Effects on Offspring: A Developmental Origins of Health and Disease (DOHaD) Perspective Nabila Aulia Tsaqifah; Rifdah Hanifah; Firda Asma'ul Husna; Mailani Dwi Hidayati; Dwi Widyawati; Ghea Farmaning Thias Putri; Ainina Al Shadrina
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.47907

Abstract

Introduction: The global prevalence of obesity among women of reproductive age has increased markedly over the past two decades, reaching 24% in high-income and 16% in low- and middle-income countries. This trend contributes to adverse maternal and neonatal outcomes, including a 2–4-fold higher risk of gestational diabetes, a threefold increase in preeclampsia, and up to a 50% higher caesarean delivery rate. Maternal metabolic disorders also have long-term consequences for offspring metabolic and cardiovascular health. Objective: To synthesize current biological and epidemiological evidence linking maternal metabolic status to offspring health within the Developmental Origins of Health and Disease (DOHaD) framework. Methods: A comprehensive search was conducted in PubMed, Scopus, and Web of Science from January 2015 to September 2025 using keywords related to maternal obesity, metabolic syndrome, DOHaD, offspring health, and epigenetics. Included studies comprised human and animal research with follow-up beyond two years, while case reports, editorials, and studies without long-term outcomes were excluded. Findings: From 22 eligible studies, consistent evidence indicates that maternal obesity and metabolic syndrome affect offspring through placental dysfunction, systemic inflammation, and epigenetic reprogramming. Offspring of obese mothers show a 1.5–2.8-fold increased risk of obesity and insulin resistance during adolescence and adulthood. Epigenome-wide analyses reveal altered methylation of genes regulating lipid metabolism (LEP, IGF2) and inflammatory pathways, supporting the DOHaD hypothesis. Conclusion: Maternal metabolic health critically shapes offspring developmental and metabolic outcomes. Preconception and antenatal interventions targeting metabolic optimization provide key opportunities to prevent intergenerational transmission of metabolic risk and promote healthier future generations.
Exosomes from Stem Cells as Emerging Therapeutics for Chronic Kidney Disease: A Systematic Review Ghea Farmaning Thias Putri; Dwi Widyawati; Zahara Nurfatihah Z
International Journal of Medicine and Public Health Vol 2, No 2 (2025): October
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/inomed.v2i2.35502

Abstract

Penyakit ginjal kronis (PGK) merupakan tantangan kesehatan global dengan pilihan terapi yang terbatas di luar pengobatan konvensional. Eksosom yang berasal dari sel punca mesenkimal (MSC) telah muncul sebagai kandidat yang menjanjikan karena sifat regeneratifnya dan kemampuannya untuk memodulasi inflamasi, fibrosis, dan apoptosis. Tinjauan sistematis ini bertujuan untuk mengevaluasi potensi terapeutik eksosom turunan MSC untuk PGK. Pencarian komprehensif dilakukan di PubMed, Scopus, dan ScienceDirect untuk studi yang diterbitkan antara tahun 2020 dan 2025 menggunakan kata kunci spesifik. Dua puluh empat studi praklinis in vivo memenuhi kriteria inklusi. Temuan ini secara konsisten menunjukkan bahwa eksosom turunan MSC meningkatkan luaran ginjal dengan mengurangi fibrosis, inflamasi, stres oksidatif, dan apoptosis sekaligus meningkatkan fungsi ginjal dan regenerasi jaringan. Aksi mekanistik dikaitkan dengan modulasi jalur TGF-β/Smad, Wnt/β-catenin, dan p38MAPK/ERK yang dimediasi ROS, serta aktivitas mikroRNA spesifik seperti miR-21a-5p, miR-186-5p, dan miR-381-3p. Strategi prekondisi meningkatkan efikasi terapeutik, termasuk hipoksia, stimulasi melatonin, dan modifikasi genetik. Hasil ini menyoroti eksosom turunan MSC sebagai strategi terapeutik yang menjanjikan untuk PGK. Namun, translasi klinis memerlukan protokol isolasi standar, dosis optimal, dan uji klinis skala besar untuk memastikan keamanan dan efikasi jangka panjang.Kata Kunci : Penyakit Ginjal Kronis, Sel Punca Mesenkimal, Eksosom, Terapi Regeneratif
Co-Authors Ainina Al Shadrina Firda Asma’ul Husna Ghea Farmaning Thias Putri Ghea Farmaning Thias Putri Mailani Dwi Hidayati Rifdah Hanifah Tsaqifah , Nabila Aulia Zahara Nurfatihah Z