Indonesian Journal of Chemistry
Vol 20, No 3 (2020)

Antibacterial and Antioxidant Activities of Polyeugenol with High Molecular Weight

Erwin Abdul Rahim (Department of Chemistry, Tadulako University, Jl. Sukarno-Hatta Km 9, Palu 94148, Central Sulawesi, Indonesia)
Nur Istiqomah (Department of Chemistry, Tadulako University, Jl. Sukarno-Hatta Km 9, Palu 94148, Central Sulawesi, Indonesia)
Gilang Almilda (Department of Chemistry, Tadulako University, Jl. Sukarno-Hatta Km 9, Palu 94148, Central Sulawesi, Indonesia)
Ahmad Ridhay (Department of Chemistry, Tadulako University, Jl. Sukarno-Hatta Km 9, Palu 94148, Central Sulawesi, Indonesia)
Ni Ketut Sumarni (Department of Chemistry, Tadulako University, Jl. Sukarno-Hatta Km 9, Palu 94148, Central Sulawesi, Indonesia)
Indriani Indriani (Department of Chemistry, Tadulako University, Jl. Sukarno-Hatta Km 9, Palu 94148, Central Sulawesi, Indonesia)



Article Info

Publish Date
09 May 2020

Abstract

This study was aimed to prepare polyeugenol with high molecular weight and to evaluate its antibacterial and antioxidant activities. First, polyeugenol was synthesized from eugenol in the presence of H2SO4-CH3COOH (4:1) as catalyst. The synthesized polyeugenol was weighed by using viscometer, revealing its high molecular weight of (7.76–21.9) × 105 g/mol. Furthermore, the antibacterial activity of the polyeugenol was conducted against Staphylococcus aureus and Escherichia coli bacteria. It was conducted by applying well diffusion method at 1, 2, 3, 4 and 5% concentrations to observe inhibition zones, in which the tests showed that the antibacterial activity of the polyeugenol against S. aureus were 17.42, 17.76, 18.79, 21.42 and 22.55 mm, while those against E. coli were 15.87, 17.23, 17.56, 18.24 and 19.21 mm, respectively. In short, these results indicated a strong antibacterial activity. Then, tests on antioxidant activity against free radical DPPH (2,2-diphenyl-1-pycrylhydrazyl) gave the IC50 value of 80.47 µg/mL, indicating a strong antioxidant activity. Therefore, the polymer synthesized in this work has a high potential to be applied in various biomedical applications.

Copyrights © 2020






Journal Info

Abbrev

ijc

Publisher

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry

Description

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology ...