PCJN Pharmaceutical and Clinical Journal of Nusantara
Vol. 2 No. 01 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara

Potential Bark Cinnamomum burmanii in Regenerating Damaged Liver Cells of Mice (Mus musculus) Diabetes Mellitus Model

Abdul M Ukratalo (Department of Biology, Faculty of Mathematics and Natural Sciences, Pattimura University, Ambon)
Martha Kaihena (Department of Biology, Faculty of Mathematics and Natural Sciences, Pattimura University, Ambon)
Dion P O Sirait (Department of Biology, Faculty of Mathematics and Natural Sciences, Pattimura University, Ambon)
Nadira Pattimura (STIKES Maluku Husada, Ambon)
Dodikrisno Ekaputra Manery (Faculty of Medicine, Pattimura University, Ambon)



Article Info

Publish Date
28 Mar 2023

Abstract

Diabetes mellitus is a chronic disease that can quickly increase the prevalence of complications in sufferers, such as liver damage. This study aims to examine the effect of methanol extract cinnamon bark (Cinnamomum burmanii Bl) in regenerating liver cell damage mice (Mus musculus) Diabetes Mellitus through the histological picture. 20 mice were divided into 5 groups which consisted of a negative control group, Positive control and a group of mice that were given methanol extract bark Cinnamomum burmannii dose of 125 mg/head/day, 250 mg/head/Day and 500 mg/head/day. In the positive control group and the group of mice that will be given extract streptozotocin injected dose of 0.2 ml and observed blood sugar levels if sugar levels have increased then given methanol extract bark Cinnamomum burmannii with a dose that has been determined and blood sugar levels were measured. On the last day, surgery is performed to remove the liver, after which histological preparations are made. The results showed that the administration of bark extract Cinnamomum burmanii can regenerate damaged liver cells of mice due to diabetes mellitus. This is due to the content of secondary metabolite compounds contained in the bark of Cinnamomum burmannii.

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Journal Info

Abbrev

pcjn

Publisher

Subject

Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

Description

Journal that publishes Focus & Scope research articles, which include: Pharmaceutical Biology Pharmaceutical Technology Pharmaceutical Chermistry Pharmacology Clinical Pharmacy Microbiology Pharmacy This journal is published by the Nusantara Scientific Journal , which is published March, July, and ...