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PCJN Pharmaceutical and Clinical Journal of Nusantara

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Published by Nusantara Scientific Medical

ISSN : - EISSN : 29854040 DOI : 10.58549

Core Subject : Health, Science,

Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

Journal that publishes Focus & Scope research articles, which include: Pharmaceutical Biology Pharmaceutical Technology Pharmaceutical Chermistry Pharmacology Clinical Pharmacy Microbiology Pharmacy This journal is published by the Nusantara Scientific Journal , which is published March, July, and November.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 27 Documents

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Antibacterial Activity of Staphylococcus capitis, Bacillus cereus, Pantoea dispersa From Telang Flower (Clitoria ternatea L) Kombucha Bath Soap as a Pharmaceutical Biotechnology Product Yuliana Kolo; Firman Rezaldi; M. Fariz Fadillah; Aris Ma'ruf; Fernanda Desmak Pertiwi; Fajar Hidayanto
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Telang lower kombucha is a probiotic drink that has the potential to enhance the immune system, active cosmetic ingredients, and its waste has been proven to be used as an organic liquid fertilizer preparation. The purpose of this study was to make a formulation and preparation of liquid bath soap with an active ingredient in a solution of seagrass kombucha fermentation at a sugar concentration of 20%, 30%, and 40% in inhibiting the growth of S. capitis, B. cereus, and P. dispersa bacteria. via the disc diffusion method. The results of the study have proven that based on the post hoc test analysis, kombucha bath soap at a concentration of 40% is significantly different from the concentration of 20% and 30% but not significantly different from the positive control and the concentration of 40% is the best concentration in inhibiting the growth of the three test bacteria. compared with the treatment and the two comparisons.

TESTING THE EFFECTIVENESS OF BIDARA LEAF ETHANOL EXTRACT (Ziziphus mauritiana L.) IN GEL PREPARATIONS FOR BURN WOUNDS IN MALE RABBIT (Oryctolapus cuniculus) Sulasmi Sulasmi; Angga Nugraha Sanjaya; Sofia Elia Sari Bangun; Cucu Arum Dwi Cahaya
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Abstract Bidara plants have many benefits in the treatment of sore skin, ulcers, and burns. Burns are a form of tissue damage or loss caused by contact with a heat source such as fire, hot water, electricity, radiation, or corrosive substances. This study aims to determine the effectiveness of the ethanol extract of bidara leaf in healing burns in male rabbits compared to bioplacenta. This study used an experimental method of maceration extraction using 96% ethanol. To test the effect of burns, 15 test animals were grouped into five groups, each of which used three test animals. The treatment group was a gel-based negative control group, a positive bioplacenta control group, and a treatment group with bidara leaf ethanol extract at concentrations of 5%, 10%, and 15%. The results of the research on the effectiveness of healing burns in the three formulations, namely a concentration of 15%, showed faster healing of wound diameter in male rabbits compared to concentrations of 5% and 10% but were not more effective when compared to bioplacenta ointment. Keywords: Bidara leaf ethanol extract, burns, ointment and bioplacenton

Analysis of Embryo Development and Early Performance of Larvae of Barbonymus Schwanenfeldii: A Systematic Review Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Tengadak fish is a freshwater fish that can be found in rivers, lakes and canals and ditches. One of the important phases in fish development is the embryo. Embryo development (embryogenesis) is more in the process of formation and development of the embryo, not only the increase in the number and mass of embryonic blastomer cells but also the activity of blastomeric cells.The purpose of this study was to analyze the stages of embryonic development and early larval performance in Tengadak fish (Barbonymus schwanenfeldii). This study used systematic literature review using data from PubMed, NCBI, Google Scholar databases using keywords, namely, “embryo, performance, Tengadak fish (Barbonymus schwanenfeldii)”. Approximately, 350 articles were obtained for the keywords “embryo, performance, Tengadak fish (Barbonymus schwanenfeldii)”. All articles were selected based on inclusion criteria and exclusion and obtained as many as 27 articles that meet the inclusion criteria From the results of research conducted, it can be concluded that this research has sequentially described the embryonic development and early performance of the larvae of the barbonymus schwanenfeldii. Need research on the other animal for future research.

Analysis Of Medicinal Plants On Embryo Development Of Mice (Mus Musculus L.) And White Rats (Rattus Novergicus): A Systematic Review Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

White rats are often used to assess protein quality, toxicity, carcinogenic, and pesticide content of an agricultural food product. M. Musculus mice are rodents that are very easy to breed, and easy to maintain. Embryogenesis is the process of growth and development of the embryo. The purpose of this study was to analyze medicinal plants on the embryonic development of Mice (Mus musculus L) and White Rats (Rattus Novergicus). This method uses a Systematic Review approach which is based on the Preferred Guide to Reporting Items for Systematic Review and Meta-analysis (PRISMA). Total of 700 articles were obtained which then entered the elimination stage resulting in 50 articles on medicinal plants (Mus musculus L) and White Rats (Rattus Novergicus). Based on the results of the study, it can be concluded that the identification of medicinal plants that are toxic to the embryonic development of Mice (Mus musculus L.) White Rats (Rattus Novergicus).

Apis Mellifera Propolis Extract As A Stimulator Of Brain Cell Development (Study On Experimental Animals) Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Apis mellifera could have potential as cell growth stimulator ability of the propolis. It also expected to increase the growth and proliferation of brain cells. This study aimed to analyze Apis mellifera Propolis Extract as a Stimulator of Brain Cell Development in Experimental Animals. This research is an experimental study using a completely randomized design (CRD) with 6 treatments and 4 replications. The research consisted of making Propolis Extract, Making Media (DMEM Stock Media, Washing Media, Culture and Treatment Media), Brain Cell Isolation and Culture, Observation of Culture Results (Cell Viability, Population Doubling Time, The results found that all treatments with propolis extract showed higher average viability than the control, which had average viability of 86.3%. Based on PDT (Population Doubling Time value), propolis extract has a good effect on brain cell growth, hence increasing cell proliferation. In addition, the confluent brain cells of rats given propolis extract had higher average confluency than those not given propolis extract. Propolis extract can protect neurons from damage by increasing the brain-derivatedneurotrophic factor (BDNF) gene expression in cell line neuron cultures.

Testing Honey on Chicken Embryos as Candidates for Herbal Medicine in Indonesia Maslichah Mafruchati; Jonathan Makuwira
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

The nutrients in honey had function as antioxidants. The aim of this study was to testing honey on chicken embryos as candidates for herbal medicine in Indonesia. This study used treatment method, consisting of 6 (six) doses of honey products. The solution volume of each treatment dose was fixed at 10 l/egg via the route to the air bag. At the age of 13 days, embryo morphology and possible abnormalities were observed in all treatments. Each two eggs are cracked. The remainder was continued by incubation in the incubator until day 21. During this time the eggs were observed and the number was recorded to find out which eggs would die and which eggs would hatch at the end of the incubation period. Newborn chicks (DOC) were weighed and observed for possible morphological abnormalities. From the results of the research conducted, it was found that the percentage of viable chicken eggs sprouted after being injected with honey (days 13-21 after inoculation) and the morphology of chicken embryos after being injected with honey. Chicken Embryo Weight and Body Length Measurements were carried out in chicken embryos. The conclusion of the study is that propolis from honey products can be used as herbal medicine.

Familiar Edible Flowers in Indonesia I Nyoman Bagus Aji Kresnapati; Muhammad Eka Putra Ramandha; Nurul Indriani
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Flowers besides being used as ornamental plants, they can also be consumed. Flowers that can be consumed are called Edible Flowers. Edible flowers in general can be consumed directly, usually in tea or can be served in the form of processed food. Edible flowers contain phytochemical compounds such as anthocyanins, flavonoids, phenolics, carotenoids which are useful as antioxidants. Indonesia is rich in biodiversity with a variety of plant species that can grow, including edible flowers. There is diversity, but only a few edibles that can grow and are familiar to Indonesian people will be reviewed in this article.

Potential Bark Cinnamomum burmanii in Regenerating Damaged Liver Cells of Mice (Mus musculus) Diabetes Mellitus Model Abdul M Ukratalo; Martha Kaihena; Dion P O Sirait; Nadira Pattimura; Dodikrisno Ekaputra Manery
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 2 No. 01 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Diabetes mellitus is a chronic disease that can quickly increase the prevalence of complications in sufferers, such as liver damage. This study aims to examine the effect of methanol extract cinnamon bark (Cinnamomum burmanii Bl) in regenerating liver cell damage mice (Mus musculus) Diabetes Mellitus through the histological picture. 20 mice were divided into 5 groups which consisted of a negative control group, Positive control and a group of mice that were given methanol extract bark Cinnamomum burmannii dose of 125 mg/head/day, 250 mg/head/Day and 500 mg/head/day. In the positive control group and the group of mice that will be given extract streptozotocin injected dose of 0.2 ml and observed blood sugar levels if sugar levels have increased then given methanol extract bark Cinnamomum burmannii with a dose that has been determined and blood sugar levels were measured. On the last day, surgery is performed to remove the liver, after which histological preparations are made. The results showed that the administration of bark extract Cinnamomum burmanii can regenerate damaged liver cells of mice due to diabetes mellitus. This is due to the content of secondary metabolite compounds contained in the bark of Cinnamomum burmannii.

The Level of Public Knowledge About the Treatment of Gastritis at The Kyan Sehat Pharmacy Dian Sarirotul Karimah; Jamaludin Al Jamaludin Efendi
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 2 No. 01 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Gastritis is an inflammatory condition of the gastric mucosa, which can be acute or chronic, with a very high number of sufferers in Indonesia. Public knowledge and awareness about gastritis is still lacking, one of which is the adoption of an unhealthy lifestyle. If left continuously, it will damage the function of the stomach and will increase the risk of getting gastric cancer which can lead to death. This research was able to find out “Level of Public Knowledge About Gastritis Treatment at the Kyan Sehat Pharmacy”. This type of research is observational by making descriptive observations, The data taken is done quantitatively. The data collected is in the form of quantitative data. This study describes how the level of public knowledge about the treatment of gastritis, explore the relationship between the level of knowledge and self-medication behavior using a survey method with a questionnaire as the main instrument. The results show that the level of knowledge of the respondents regarding the treatment of gastritis is 55% which is a good category, the sufficient category is 40% and the less category is 5%. And gastritis treatment behavior obtained data as much as 17% have gastritis (ulcer) treatment behavior which is in the good category, for the sufficient category, namely 70%, and the less category, namely 13%. So knowledge about gastritis (ulcer) treatment has good knowledge, namely as much as 55% and gastritis (ulcer) treatment behavior has sufficient behavior as much as 70%

Antioxidant Activity of Fresh Decinte, Fresh Sari, and Fresh Ethanol Extract of Soursop (Annona muricata L.) Leaves Using DPPH Method Eva Fransiska; Anny Sartika Daulay; Ridwanto Ridwanto; Rafita Yuniarti
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 2 No. 01 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Antioxidants are compounds that are able to ward off or reduce free radicals in the body so that they can prevent several diseases. Soursop leaves (Annona muricata L.) are used as a traditional herbal medicine to prevent or treat cancer, as well as a natural antioxidant, which is usually used by people by boiling it. The purpose of this study was to look at the phytochemical screening by comparing fresh boiled water, fresh juice, and a fresh extract of soursop leaves, as well as test the antioxidant activity with the addition of DPPH (1,1-diphenyl-2-picrylhydrazyl) and measured using a UV-Vis spectrophotometer at 516 nm. The results of the soursop leaf phytochemical screening showed that there were groups of chemical compounds such as flavonoids, glycosides, tannins, and saponins. The results of testing the antioxidant activity by looking at the maximum wavelength of DPPH, using a UV-Vis spectrophotometer, obtained IC50 values for fresh juice of 770.067 µg/mL, fresh decoction of 1,022.8422 µg/mL, and ethanol extract of 299.733 µg/mL. Based on the results of the study, it was shown that the ethanol extract had stronger antioxidant activity than a fresh decoction and the fresh juice of soursop leaves.

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nusantarascientific.journal@gmail.com

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nusantarascientific.journal@gmail.com

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Jalan Jamin Ginting No. 55 Mangga, Kec. Medan Tuntungan, Kota Medan, Sumatera Utara 20142

Location
Kota medan,

Sumatera utara

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Nasri

Contact Email nusantarascientific.journal@gmail.com

Phone +6285943109283

Journal Mail Official nusantarascientific.journal@gmail.com

Editorial Address Jalan Jamin Ginting No. 55 Mangga, Kec. Medan Tuntungan, Kota Medan, Sumatera Utara 20142

Location Kota medan, Sumatera utara INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Nasri

Contact Email
nusantarascientific.journal@gmail.com

Phone
+6285943109283

Journal Mail Official
nusantarascientific.journal@gmail.com

Editorial Address
Jalan Jamin Ginting No. 55 Mangga, Kec. Medan Tuntungan, Kota Medan, Sumatera Utara 20142

Location
Kota medan,

Sumatera utara

INDONESIA