Physicochemical and Pharmacokinetic Property Prediction of Substances in Centella asiatica using pkCSM: Prospects for the Creation of Therapeutic Formulations from Plant Isolates

Faisal Akhmal Muslikh (Departement of Pharmacy, Faculty of Pharmacy, Bhakti Wiyata Institute of Health Sciences, Kediri)
Fendy Prasetyawan (Departement of Pharmacist Professional, Faculty of Health, Kadiri University, Kediri)
Rosa Juwita Hesturini (Departement of Pharmacy, Faculty of Pharmacy, Bhakti Wiyata Institute of Health Sciences, Kediri)
Fita Sari (Departement of Pharmacy, Faculty of Pharmacy, Bhakti Wiyata Institute of Health Sciences, Kediri)
Anis Akhwan Dhafin (Departement of Pharmacy, Faculty of Health, Kadiri University, Kediri)
Muhammad Alviyan Shutiawan (Departement of Pharmacy, Faculty of Health, Kadiri University, Kediri)
Elsa Mahardika Putri (Departement of Pharmacy, Faculty of Health, Kadiri University, Kediri)
Okky Intan Mawarni (Departement of Pharmacy, Faculty of Health, Kadiri University, Kediri)

International Journal of Global Sustainable Research
Vol. 1 No. 3 (2023): November 2023

Indonesia is a megabiodiversity country with the second-largest abundance of biodiversity in the world. Centella asiatica (CA) is an important medicinal herb used in various countries in the world. It is known to have good pharmacological activity, but more scientific data is still needed to justify its increasing use, especially regarding its pharmacokinetics and safety. The aim of the research was to predict the physicochemical and pharmacokinetic properties of the compounds contained in CA. The compound content was obtained from journal references that collected information from Dr. Duke's Phytochemical and Ethnobotanical Database, then each compound was subjected to physicochemical and pharmacokinetic analysis using a web tool. The results show that the compounds quercetin and kaempferol are compounds that have good physicochemical and pharmacokinetic properties compared to other compounds contained in CA.