The nanoparticle formula optimization from Temulawak extract (Curcuma xanthorrhiza) as adjuvant therapy

Greesty Finotory Swandiny (Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta)
Safira Nafisa (Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta)
Rahmatul Qodriah (Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta)
Gumilar Adhi Nugroho (Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta)
Muhammad Taher Bakhtiar (Kuliyyah of Pharmacy, International Islamic University Malaysia, Kuantan Pahang)

Interdisciplinary Social Studies
Vol. 3 No. 2 (2024): January-March 2024 (Regular Issue)

Temulawak extract was synthesized using temulawak sodium alginate. The nanoparticle formula was obtained by combining the characteristics of temuwak extract and temusawak. The microbeads were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The size of Alg-Curcuma was measured at SEM. The particle size distribution of the sample was analyzed using FTIR spectra. The results showed that the size of the resulting beads is microparticle in size. It was found that the temurawak extract is a good candidate as an anticancer agent. Therefore, there are several recommendations that can be done to optimize the synthesis of the material. The study reported that the recommended parameter is 12.5 kV with a flow rate of 0.1 mL/h (first batch synthesis).