This study aims to determine the effect of entrepreneurship learning, entrepreneurship knowledge, industrial work practice experience and family environment on entrepreneurial interest either directly or indirectly through self-efficacy as an intervening variable. The population in this study were 3530 students of class XII SMK Negeri Makassar City and a sample of 845 students slovin formula with a standard error of 3% by Cluster Random Sampling method. The data collection method used a questionnaire. Data analysis using descriptive analysis, path analysis, and sobel test using SPSS and Smart PLS software. The results showed that 1) directly, there is a positive and significant effect of entrepreneurship learning, entrepreneurial knowledge and family environment on self-efficacy 2) directly, there is a positive and significant effect of entrepreneurship learning, entrepreneurial knowledge, self-efficacy and on entrepreneurial interest, 3) indirectly, there is a positive and significant effect of entrepreneurship learning, entrepreneurial knowledge and family environment on entrepreneurial interest through self-efficacy. However, industrial work practice experience is not significant on self-efficacy and entrepreneurial interest of vocational students
                        
                        
                        
                        
                            
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