This study aims to test the administration of ethanol extract of cat's whisker leaves (Orthosiphon stamineus) to reduce cholesterol levels in female Sprague Dawley rats. This type of research is a quasi-experiment design using a one group pre-test and post-test design. The population in this study was 30 female Sprague Dawley rats aged ± 3 months with a body weight of around 150-250 grams. Data were analyzed using the t test statistic at = 5%. The results of the research showed that the highest decrease in cholesterol levels was in female Sprague Dawley rats at a test dose of 1000 mg/kgBW and there was an effect of ethanol extract of cat's whisker leaves (Orthosiphon stamineus) on reducing cholesterol levels in female Sprague Dawley rats
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