Low critical thinking skills and student learning outcomes are still widely found, especially in chemistry learning. This study aims to analyze the application of STEM integrated problem-based learning (PBL) on chemistry materials, and to analyze STEM-based learning integrated with PBL to improve students' critical thinking skills and learning outcomes on chemistry materials. The method used in this research is a systematic literature review based on articles traced through Google Schoolar, Garuda, and ERIC databases. The data obtained was then analysed descriptively. The results showed that: (1) From a number of STEM-PBL implementations that have been carried out in various fields, the implementation of STEM-PBL in chemistry learning obtained a percentage of 32%; (2) STEM-PBL implementation can improve students' critical thinking skills and learning outcomes ranging from moderate to high categories. STEM-PBL learning is effectively used to improve critical thinking skills and learning outcomes, so it can be used as an alternative in chemistry learning.
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