Chemistry Indonesian Journal of Chemical Research
Vol 12 No 2 (2024): Edition for September 2024

Radioisotope 32P for Keloid Therapy: A Review

Rahman, Wira Y (Unknown)
Budiawan, Budiawan (Unknown)
Suseno, Heny (Unknown)



Article Info

Publish Date
25 Sep 2024

Abstract

Keloids are skin disorders resulting from an abnormal wound healing response, often leading to excessive scar tissue growth. Keloids can be itchy, painful, and aesthetically disturbing. Keloid therapy varies, but until now, there is no standard method that is effective due to different patient responses. Racial, environmental, and genetic variables influence keloids. Various therapeutic techniques, such as surgery, cryotherapy, corticosteroid injections, laser light, and radiotherapy, have been used to treat keloids, but each has advantages and disadvantages. However, these treatments have limitations, such as high recurrence rates and patient discomfort. The application of radioisotope therapy, specifically using 32P, has emerged as a promising alternative. Radioisotope 32P emits β-particles, effectively inhibiting keloid cell growth by causing DNA damage and reducing collagen production. Studies show that 32P therapy significantly reduces keloid size and recurrence rates while causing minimal patient discomfort. Although there are potential risks, such as damage to surrounding healthy tissue, 32P therapy provides a practical and non-invasive option for keloid management. However, more research is required to fully understand this method’s effectiveness, safety, and long-term impact on keloid therapy, optimize treatment protocols, and minimize side effects.

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Journal Info

Abbrev

Indonesian Journal of Chemical Research (Indones.

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Engineering Environmental Science

Description

Indo. J. Chem. Res. is a journal that regularly publishes primary articles covering all branches of chemistry and its sub-disciplines. Published articles consist of complete research, short communication, and review articles. The scope of published articles is not limited to inorganic chemistry, ...