The Influence of Guided Inquiry Learning Model toward The Interest of Learning Study of Biology Student Cross-Interest. This quasy Experiment research aims to determine the influence of guided inquiry learning model toward the interest of biology students learning cross-interest involving 66 high school students in Tenggarong Seberang. The research design used non-equivalent pretest-posttest control group design. The data analysis of the increase ofstudents’ learning interest in the application of this learning model was obtained from the mean of N-Gain, while the influence of inquiry learning model was guided against the interest of learning done through t-test for normal distributed data and U Mann-Whitney U test for abnormally distributed data. Based on data analysis, it was found that biology learning interest score after learning process in experiment and control class was significantly different (sig. (2- tailed) <0.05). In addition, there was an increase in student interest in the low category but significantly different (U test = 257.0 
                        
                        
                        
                        
                            
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