Journal of Pharmaceutical Sciences and Community
Vol. 23 No. 1 (2026)

Stability of Orally Dissolving Film of Zingiber officinale Roscoe Extract With HPMC And Maltodextrin as Polymer

Srie Rezeki Nur Endah (Department of Pharmacy, Faculty of Health Science, Perjuangan University, Tasikmalaya, Indonesia)
Iis Nur Asiah (Department of Pharmacy, Faculty of Health Science, Perjuangan University, Tasikmalaya, Indonesia)
Susanti Susanti (Department of Pharmacy, Faculty of Health Science, Perjuangan University, Tasikmalaya, Indonesia)
Nitya Nurul Fadilah (Department of Pharmacy, Faculty of Health Science, Perjuangan University, Tasikmalaya, Indonesia)
Ali Nofriyaldi (Department of Pharmacy, Faculty of Health Science, Perjuangan University, Tasikmalaya, Indonesia)



Article Info

Publish Date
24 Jun 2026

Abstract

The pharmaceutical industry is developing pharmaceutical technology with better bioavailability because the drugs are absorbed pre-gastric, namely orally dissolving film (ODF). The ODFs containing HPMC as a film-forming agent exhibit brittleness, stickiness, and a rough surface. In contrast, maltodextrin polymer-based films have a smooth transparent surface, tensile strength, and mouthfeel. Testing the effect of varying concentrations of maltodextrin as a film-forming agent on the characterization of ODF. Three formulas with different ratio of HPMC and maltodextrin polymer (2:1; 2:2; 2:3) were tested for organoleptic, film thickness, pH, folding endurance, disintegration, and stability of the ODF. The test results were then analyzed statistically using the one-way analysis method. Formulas 1, 2, and 3 reduce the characteristics of ODF red ginger extract in the form of a thin yellow-brown layer with a distinctive odor and spicy taste, a film thickness of 0,06-0,10 mm, a ph of 6,82-6,92, a folding endurance of 368-418x fold, and a disintegration of 48,59-61,39 seconds. Variations in the concentration of maltodextrin as a polymer show that there is an influence on the characteristics of the ODF red ginger extract, which is indicated by a sig value of <0,05 in testing a film thickness, pH, folding endurance, and disintegration.

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Journal Info

Abbrev

jfsk

Publisher

Subject

Description

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) or J. Pharm. Sci. Community firstly published in 2003, is a peer-reviewed, open access journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, ...