IgG and IgM Serological Profile in Primary and Secondary Dengue Infection: Profil Serologis IgG dan IgM sebagai Indikator Infeksi Primer dan Sekunder Dengue

Tri Ade Saputro (Program Studi Sarjana Terapan Teknologi Laboratorium Medis, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Surabaya, Jawa Timur, Indonesia)
Nur Vita Purwaningsih (Program Studi Sarjana Terapan Teknologi Laboratorium Medis, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Surabaya, Jawa Timur, Indonesia)
Waras Budiman (Program Studi Sarjana Terapan Teknologi Laboratorium Medis, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Surabaya, Jawa Timur, Indonesia)
Mulya Fitrah Juniawan (Program Studi Pendidikan Biologi, Fakultas Pendidikan Komunikasi dan Sains, Universitas Muhammadiyah Surabaya, Jawa Timur, Indonesia)

Medicra (Journal of Medical Laboratory Science/Technology)
Vol. 9 No. 1 (2026): July

Dengue Hemorrhagic Fever (DHF) remains a major health problem in endemic regions, requiring accurate laboratory examinations to support diagnosis. Serological testing of immunoglobulin G (IgG) and immunoglobulin M (IgM) is widely used to differentiate between primary and secondary dengue infections. This study aimed to analyze the serological profile of IgG and IgM as indicators of primary and secondary dengue infection in patients with DHF. A descriptive cross-sectional design was employed using secondary data from 170 patients who underwent IgG and IgM testing at RSUD Haji Surabaya. Data were analyzed descriptively by calculating frequency distributions and percentages. The results showed that the distribution was dominated by IgG positive and IgM negative findings (62%), followed by both IgG and IgM positive (17%), IgM positive only (10%), and both negative results (11%). These findings indicate that most patients experienced secondary dengue infection. Therefore, IgG and IgM serological testing plays an important role in determining the phase of dengue infection; however, it should be combined with other diagnostic methods to improve diagnostic accuracy.