Study examines the effects of professionalism and organizational commitment on nurses’ performance, with competence as a mediating variable, at the Regional General Hospital (RSUD) of South Konawe Regency. A quantitative survey was conducted involving all 46 nurses in the study population. Data were collected using a five-point Likert-scale questionnaire and analyzed with Partial Least Squares Structural Equation Modeling (PLS-SEM) using SmartPLS 4.0. The results show that professionalism and organizational commitment each have positive and significant effects on competence and nurses’ performance, while competence also has a positive and significant effect on nurses’ performance. Competence partially mediates the effects of professionalism and organizational commitment on nurses’ performance. These findings indicate that strengthening nurses’ performance requires an integrated approach that reinforces professional values and organizational commitment while continuously developing clinical and professional competence.
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