<![CDATA[Background: Free radical exposure poses significant threats to public health by damaging cells and causing degenerative diseases like cancer and premature aging. Antioxidants are vital in neutralizing these radicals. Jatropha curcas L. leaves contain bioactive compounds with promising antioxidant and wound healing properties, warranting evaluation in a practical gel form. Methods: This study used a true experimental design with a posttest-only control group; quercetin was the control, while the treatment groups received different gel formulations of Jatropha curcas L. leaf extract. Results: The pure extract had very strong antioxidant activity (IC50 0.32 ppm). Gel formulations (Formula 2 and Formula 3) also exhibited strong antioxidant activity, with IC50 values of 30.90 ppm and 35.85 ppm, respectively; Formula 2 performed better. Quercetin showed strong activity at 1.22 ppm. One-way ANOVA (p < 0.01) confirmed significant differences between groups. Conclusions: The Jatropha curcas L. leaf extract gel has significant antioxidant potential and is effective in preventing oxidative damage, supporting its use in safe, gel-based herbal skin products.]]>
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