<![CDATA[Coenzyme Q10 (CoQ10) possesses potent antioxidant activity; however, its therapeutic efficacy is limited by poor solubility, large particle size, and low bioavailability, which lead to poor bodily absorption and high susceptibility to environmental degradation. To address these limitations, Nanostructured Lipid Carriers (NLC) are utilized due to their ability to enhance solubility, stability, and bioavailability. Within this system, the concentration of solid lipids, such as stearic acid, plays a pivotal role; its long carbon chain forms an imperfect crystalline matrix that multiplies drug entrapment capacity, prevents drug expulsion during storage, and enhances topical penetration via a skin-occlusive effect. This study aims to investigate the effect of varying stearic acid concentrations on the particle size and physicochemical characteristics of CoQ10-loaded NLCs. The NLCs were prepared using the emulsification and high-shear homogenization method, followed by characterization encompassing organoleptic properties, homogeneity, pH, spreadability, particle size, and polydispersity index. The results demonstrated that increasing the stearic acid concentration significantly influenced both the physicochemical profile and particle size. The formula with the optimal stearic acid concentration yielded nanometer-scale particle sizes with a homogenous polydispersity index. In conclusion, variations in stearic acid concentration exert a significant effect on the physical characteristics of CoQ10 NLCs, and an appropriate concentration can produce a stable nano-delivery system for topical application.]]>
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