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Profile of Hypertension Patient Characteristics Based on Measurements Using the Hypertension Knowledge Level Scale (HKLS) Questionnaire: Profil Karakteristik Pasien Hipertensi Berdasarkan Pengukuran Menggunakan Kuisioner Hypertension Knowledge Level Scale (HKLS) Ninik Mas Ulfa; Latifah Agnes Susanti; Tri Doso Sapto Agus Priyono
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 10 No. 1 (2025): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v10i1.502

Abstract

Hypertension is an abnormal blood pressure that can be measured in at least three different situations. Generally, if blood pressure is more than 140/90 mmHg, then a person is considered to have high blood pressure. Patient characteristics greatly influence the knowledge of hypertensive patients. Knowledge about hypertension influences the patient's own blood pressure control. This study aims to determine the level of patient knowledge about hypertension in controlling blood pressure at one of the Community Health Centers in Lamongan district. This research uses a prospective research method with a nonprobability sampling technique using Accidental Sampling. Prospective data was obtained from the results of the validated Indonesian version of the HKLS questionnaire, distributed to patients starting January-February 2024 with a total of 50 patients. The research  results were analyzed descriptively, and that the number of patients with a high level of knowledge was 28 patients (56%) and 22 with low knowledge. patients (44%). The number of patients whose blood pressure was controlled was 28 (56%) and the number of patients whose blood pressure was not controlled was 22 (44%). Based on the results of research by classifying HKLS questionnaire statements, it was found that the majority of patients had a poor level of knowledge regarding lifestyle and its complications. The conclusion of this study is that the profile of patient characteristics regarding hypertension knowledge using the HKLS questionnaire in blood pressure control.
Overview of Asthma Control Levels in Asthma Patients at the Pulmonary Polyclinic of Kediri District Hospital: Gambaran Tingkat Kontrol Asma pada Pasien Asma di Poliklinik Paru RSUD Kabupaten Kediri Arifani; Tri Doso Sapto Agus Priyono; Elly Megasari; Ninik Mas Ulfa
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 11 No. 2 (2026): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v11i2.592

Abstract

Asthma is a chronic inflammation that causes the respiratory tract to become hyperresponsive, causing periodic symptoms such as shortness of breath, wheezing, chest tightness, and repeated coughing. This study aims to determine the level of asthma control in asthma patients at the Lung Polyclinic of Kediri District Hospital. This type of research is descriptive quantitative with a purposive sampling technique. This study was conducted at the Lung Polyclinic of Kediri District Hospital with a total of 35 respondents. Descriptive data analysis used the percentage of each question in the asthma control test questionnaire. The results of the study with the most gender were female 22 (62.86%), age 35-44 years 14 (40%), high school education 16 (45.71%), housewife occupation 13 (37.14%), and a history of asthma > 10 years 13 (37.14%). The drugs given were a mixture of salbutamol, codeine, theophylline, and methylprednisolone as many as 25 (71.4%); salbutamol, codeine, theophylline, methylprednisolone, and seretide inhalation 5 (14.3%); and salbutamol, codeine, theophylline, methylprednisolone, and berotec inhalation 5 (14.3%). The results of the asthma control test questionnaire, obtained respondents who were well controlled 16 (45.71%), partially controlled 17 (48.57%), and uncontrolled 2 (5.72%). Conclusion: The results of this study indicate that the level of asthma control in asthma patients at the Lung Polyclinic of Kediri District Hospital is partially controlled.  
The Effect of Stearic Acid Variation on the Physicochemical Profile of Coenzyme Q10 Nanostructured Lipid Carriers: Pengaruh Variasi Asam Stearat terhadap Profil Fisikokimia Nanostructured Lipid Carriers Koenzim Q10 Tri Doso Sapto Agus Priyono; Lintang Bismantara; Ninik Mas Ulfa; Dian Nurmawati
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 11 No. 2 (2026): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v11i2.603

Abstract

Coenzyme Q10 (CoQ10) possesses potent antioxidant activity; however, its therapeutic efficacy is limited by poor solubility, large particle size, and low bioavailability, which lead to poor bodily absorption and high susceptibility to environmental degradation. To address these limitations, Nanostructured Lipid Carriers (NLC) are utilized due to their ability to enhance solubility, stability, and bioavailability. Within this system, the concentration of solid lipids, such as stearic acid, plays a pivotal role; its long carbon chain forms an imperfect crystalline matrix that multiplies drug entrapment capacity, prevents drug expulsion during storage, and enhances topical penetration via a skin-occlusive effect. This study aims to investigate the effect of varying stearic acid concentrations on the particle size and physicochemical characteristics of CoQ10-loaded NLCs. The NLCs were prepared using the emulsification and high-shear homogenization method, followed by characterization encompassing organoleptic properties, homogeneity, pH, spreadability, particle size, and polydispersity index. The results demonstrated that increasing the stearic acid concentration significantly influenced both the physicochemical profile and particle size. The formula with the optimal stearic acid concentration yielded nanometer-scale particle sizes with a homogenous polydispersity index. In conclusion, variations in stearic acid concentration exert a significant effect on the physical characteristics of CoQ10 NLCs, and an appropriate concentration can produce a stable nano-delivery system for topical application.