<![CDATA[Hyperlipidemia is a condition of increased fat levels in the blood that can cause cardiovascular disease. Treatment generally uses HMG-CoA reductase inhibitors such as simvastatin. However, if used continuously it can result in unwanted effects. The flavonoids in rambutan to leaves are suspected to had antihyperlipidemia activity, making them an alternative to therapy. The purpose of this study is to formulate a preparation of ethanol extract capsules of rambutan leaves and evaluate the antihyperlipidemia activity in vivo. Experimental research was conducted on 25 mice divided into 5 groups, consisting of K (+), K (-), as well as FI, FII, and FIII preparations with varying doses of the 75, 150, and 300 mg/kg BB. The evaluation results of the capsule's physical properties indicate that all formulations meet the established requirements. Statistical analysis showed significant difference between at K (-) and all treatment groups, namely (p < 0.05). In contrast, no significant difference between K (+) and all test formulas, namely (p > 0.05). Giving 300 mg/kg BB produced the best activity, with a 25.7% reduction in total cholesterol. The capsules can be used as an alternative to natural remedies to help lower total cholesterol levels.]]>
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