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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 14 Documents
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Search results for , issue "Vol. 44 No. 1 (2025)" : 14 Documents clear
Rapid isolation and characterization of Wharton's jelly-derived mesenchymal stem cells maintained in fresh-prepared human AB-serum Tjahjono, Yudy; Dewi, Sianty; Novita, Bernadette Dian; Wijaya, Hendy; Putra, Brilliant Dwi; Kuncorojakti, Suryo; Hendriati, Lucia; Jong, FX Himawan Haryanto; Widodo, Teguh; Malonda, Franklin Vincentius
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.65-72

Abstract

Background Mesenchymal stem cells (MSCs) are valued in regenerative medicine for their multipotency, proliferative capacity, and immunomodulatory properties. Wharton’s jelly-derived MSCs (WJ-MSCs) from the umbilical cord offer a non-invasive, promising source for clinical applications, because easy isolation, lack of ethical concerns, and the presence of both embryonic and adult stem cells have made them a valuable source for use in therapeutic applications and regenerative medicine. This study aimed to optimize WJ-MSC isolation and characterization methods. Methods Human umbilical cords from three healthy donors were collected post-cesarean under strict inclusion criteria. WJ-MSCs were isolated using the explant culture method, with cells adhering to T75 flasks pre-coated with 2% gelatin. Cultures were maintained in Dulbecco’s Modified Eagle Medium (DMEM) supplemented with 10% freshly prepared Human AB serum and monitored for 21 days. Flow cytometry (BD FACSAria) was performed at passages 1 and 5 to assess MSC markers CD105, CD73, CD90, and CD44, alongside the exclusion marker CD45. Results WJ-MSCs exhibited fibroblast-like morphology by passage 1 and showed robust proliferation. Flow cytometry revealed high CD44 expression (~60%) at passage 1, while CD105, CD73, and CD90 became prominent by passage 5. CD45 remained low, suggesting minimal hematopoietic contamination. Conclusion This study confirms the feasibility of isolating and expanding WJ-MSCs using DMEM with 10% human AB serum. While consistent cell growth was achieved, the 21-day culture period may require optimization for scalability, including serum concentration, substrate coatings, and oxygen levels. CPJ-MSCs may be preferable for applications demanding rapid expansion and early marker expression.
Mineral levels in lactating Lagos women: blood-breast milk correlation and environmental-nutritional influences Oyelowo, Oluwakemi; Makwe, Christian; Adejare, Abdullahi; Ajulo, Oyinkansola; Dieobi, Cynthia
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.73-83

Abstract

Background Lifestyle choices and environmental exposure to certain materials have been reported to alter the distribution of key electrolytes in the blood and breastmilk of pregnant women and, in some cases, worsen micronutrient deficiencies. This study aimed to determine the association of sodium, iron, potassium, and calcium ions in maternal blood with those in breast milk and how maternal lifestyle routines could affect the level of these micronutrients.   Methods A cross-sectional study was conducted involving 30 breastfeeding mothers with newborns. They were administered a pre-tested questionnaire following informed consent. Blood and breastmilk specimens were obtained thereafter to determine the serum and breastmilk levels of iron, potassium, sodium, and calcium. Data were analyzed using unpaired t-tests with the significance level of p<0.05.   Results A significant reduction in serum and breastmilk potassium ion levels (p<0.001 for both) was found in lactating women taking vitamin D, vitamin B, calcium, and folic acid supplements, particularly with increased serum iron levels. Conversely, exposure to paints (p<0.001), radiation (p<0.001), borehole water (p<0.05) and tap water (p<0.05) increased potassium ion levels in both blood and breastmilk. Notably, significant correlations existed between blood and breastmilk levels of sodium and potassium ions.   Conclusions While breastmilk sodium and potassium ion levels are directly related to the level in the serum, supplemental intake of some vitamins as well as exposure to paints and radiation could significantly reduce blood and breastmilk potassium, thus further worsening the micronutrient deficiency (aka hidden hunger) in pregnant women.
Galectin-3 and galectin-1 interactions in breast cancer therapy Rani, Vanitha Innocent; Manohari, Aleti Lakshmi; Murali, Uthamalingam; Imran, Mohd; Correya, Mary Anelia; Chakraborty, Tamalika; Bagchi, Preenon; Das, Gunamoni
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.101-112

Abstract

Galectins, a family of β-galactoside-binding proteins, play critical roles in tumor progression, angiogenesis, and immune evasion, making them significant therapeutic targets in cancer treatment. By binding β-galactoside containing glycoconjugates, galectins modulate immune responses, apoptosis, and tumor development. The increasing recognition of their oncogenic roles has led to the development of carbohydrate- and peptide-based inhibitors that competitively bind to the carbohydrate recognition domain (CRD), disrupting galectin-mediated immune evasion, T-cell apoptosis, and angiogenesis. Given their intricate functions in the tumor microenvironment, a comprehensive evaluation of galectin inhibitors is warranted. This review synthesizes recent advancements in galectin-targeted therapies, including their mechanisms of action, efficacy in preclinical models, and potential synergy with chemotherapeutic agents and monoclonal antibodies. Despite promising developments, challenges remain in optimizing treatment regimens, overcoming resistance mechanisms, and identifying predictive biomarkers for patient stratification. Patient stratification, based on molecular or genetic profiles, is essential for enhancing therapeutic efficacy and ensuring personalized treatment approaches. A systematic literature search (2014–2024) was conducted using Google Scholar, ProQuest, Science Direct, and Scopus databases, with key terms including galectin inhibitors, cancer therapy, tumor microenvironment, immune evasion, and targeted therapy. This review highlights the role of galectin-1 and galectin-3 in breast cancer therapy, emphasizing their impact on tumor progression, immune modulation, and resistance to conventional treatments. Further translational research is necessary to refine clinical applications, optimize combination strategies, and establish biomarkers that enhance the integration of galectin inhibitors into existing treatment paradigms.
Optimizing prehospital care: a comprehensive review of evidence-based protocols for tension pneumothorax management Alsamhari, Abdullah; Gilkaramenthi, Rafiulla; Alamer, Bader Hussain; Jebreel, Albaraa; Abdulbari, Hamdi Hasan; Mushawwah, Saad M.; Altaezi, Lara
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.113-128

Abstract

It is of the utmost importance to diagnose and treat tension pneumothorax (TPX) as soon as possible, because if not recognized and treated, it may swiftly cause collapse of the respiratory and circulatory systems.  An estimated 5% of people with serious thoracic injuries may die from this avoidable cause, making it a leading cause of death in trauma and prehospital situations.  Methods for diagnosis, procedures for intervention, and strategies for training are the primary foci of this study, which aims to provide a synthesis of evidence-based protocols for the prehospital treatment of TPX. A literature search was done on Pubmed and Google Scholars databases to identify the relevant literature from 2015 to 2025. This review focuses on the use of point-of-care ultrasonography to improve diagnosis accuracy and assesses the effectiveness of needle decompression and finger thoracostomy as first-line therapies.  We will go over the main research that back these methods, how they differ between regions, and the difficulties of implementing them in prehospital care.  Standardized training methods and further studies on appropriate intervention strategies are two of the significant gaps in the literature that are pointed out in this review.  These results provide suggestions for improving prehospital care, increasing survival rates, and enhancing clinical practice. This review highlights current evidence-based strategies for diagnosing and managing tension pneumothorax (TPX) in prehospital settings. It emphasizes advancements such as point-of-care ultrasound (POCUS) and interventions such as needle decompression and finger thoracostomy. The review also addresses challenges in protocol implementation, especially in developing EMS systems such as in Saudi Arabia, citing issues such as training disparities, limited resources, and system readiness.

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