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Maternal and Fetal Outcome on Pregnancy in Advanced Maternal Age Dewi, Sianty; Ferry, Ferry; Toynbee, Eddy; Prayudhana, Sandhy
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: Pregnancy in advanced maternal age (AMA) was classified as high risk. The study aims to provide a better description of pregnancy outcome in AMA. Method: The cross sectional study was to review the demography, medical and obstetrics problems, mode of delivery, maternal and fetal outcome in Tangerang General Hospital as a referral center in Banten. The data were taken from medical records of 35-year-old and above women age who delivered on the period of January to December 2014. Result: The total number of delivery and live birth was 6,107 and 5,926 respectively, including 1,548 (25.36%) pregnancies in AMA. The prevalence of grandmultiparities was 11.4%. The average education level was mostly elementary. The prevalence of hypertension in pregnancy was 34.6%. There was increasing trend of miscarriages from 10.8% in 35-40-year-old group to 25% in above 45- year-old group. Pregnancy complications were higher consisting of 3.2% multifetal, 16.6% malpresentation, and 7.1% placenta previa. Cesarean section rate was 33.6%. Maternal near-missed cases were 56 of 1000 and the maternal mortality rate (MMR) was 932 of 100,000 live births. The prevalence of stillbirth and perinatal mortality were 5.3% and 12.9%; respectively. Conclusion: Adverse maternal and fetal outcome were higher in AMA as it takes special attention and multidiscipline-approached care started from preconception, antenatal, preparation of delivery, and also postpartum care. Keywords: advanced maternal age (AMA), fetal outcome, maternal outcome, pregnancy

Maternal and Fetal Outcome on Pregnancy in Advanced Maternal Age Dewi, Sianty; Ferry, Ferry; Toynbee, Eddy; Prayudhana, Sandhy
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No.3, July 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: Pregnancy in advanced maternal age (AMA) was classified as high risk. The study aims to provide a better description of pregnancy outcome in AMA. Method: The cross sectional study was to review the demography, medical and obstetrics problems, mode of delivery, maternal and fetal outcome in Tangerang General Hospital as a referral center in Banten. The data were taken from medical records of 35-year-old and above women age who delivered on the period of January to December 2014. Result: The total number of delivery and live birth was 6,107 and 5,926 respectively, including 1,548 (25.36%) pregnancies in AMA. The prevalence of grandmultiparities was 11.4%. The average education level was mostly elementary. The prevalence of hypertension in pregnancy was 34.6%. There was increasing trend of miscarriages from 10.8% in 35-40-year-old group to 25% in above 45- year-old group. Pregnancy complications were higher consisting of 3.2% multifetal, 16.6% malpresentation, and 7.1% placenta previa. Cesarean section rate was 33.6%. Maternal near-missed cases were 56 of 1000 and the maternal mortality rate (MMR) was 932 of 100,000 live births. The prevalence of stillbirth and perinatal mortality were 5.3% and 12.9%; respectively. Conclusion: Adverse maternal and fetal outcome were higher in AMA as it takes special attention and multidiscipline-approached care started from preconception, antenatal, preparation of delivery, and also postpartum care. Keywords: advanced maternal age (AMA), fetal outcome, maternal outcome, pregnancy

Uric Acid Concentration With Risk Factors For Hypertensionwith Coronary Heart Disease Patients Who Do Moderaty Intensity Physical Exercise Amalia, Nindya; Dewi, Sianty; Sarvasti, Dyana
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 2, No 3 (2020): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v2i3.2664

Introduction: Complication of hypertension causes 45% of deaths from heart disease. Programs for improving quality of life in heart disease patients such as Cardiovascular Prevention and Rehabilitation program, usually includes one component, which is to do moderate-intensity physical exercise. previous study suggested that moderate-to-high intensity physical exercise could increase uric acid. Aim: To examine the correlation between uric acid concentration and risk factors for hypertension in patients with coronary heart disease who do moderate intensity physical exercise. Method: This was a retrospective study using data from medical records with cross-sectional design. The sampling method used purposive sampling based on subjective consideration and the availability of certain criteria. Analysis used chi-square analysis Results: The data were taken from medical records from 2012 until July 2019. Sampling, which appropriates for inclusion and exclusion criteria in Husada Utama Hospital, was 30 samples, 25 male, and 5 female. The majority of subjects in this research was 56-65 years old. The youngest was 40 years old while the oldest was 77 years old. Data analysis results showed that patients who had hypertension risk factors and increased uric acid were 17 patients (85%) and who did not have hypertension risk factors1. They did not experience an increase were seven people (70%) from the chi-square test. significant with p = 0.003 (p

CORRELATION OF BODY MASS INDEX WITH MENARCHE AGE IN ELEMENTARY SCHOOL STUDENTS IN KRIAN Icha, Icha; Dewi, Sianty; Sudewi, Ni Putu
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 6, No 1 (2024): January
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v6i1.5368

Introduction: Early menarche is increasing throughout the world, including in Indonesia. The average age of early menarche in Indonesia is less than 10 years based on the results of Riset Kesehatan Dasar or Basic Health Research 2013. Early menarche can cause stress, cardiovascular disease, and the risk of breast cancer. Early menarche can be influenced by various factors, one of which is nutritional status which can be assessed by body mass index.Objective: To determine the relationship between Body Mass Index and Menarche Age in elementary school “X” in Krian.Method: This study used a cross-sectional research design, conducted on a population of elementary school children in grades IV-VI aged 9-12 years at primary school “X” in Krian with the inclusion criteria being School Health Unit (Unit Kesehatan Sekolah or UKS) data and the exclusion criteria being having chronic diseases. Data analysis was carried out using the Spearman Correlation test.Results: 49 samples were obtained consisting of 7 people in class IV, 14 people in class V, and 28 people in class VI. From the sample, 8 children had a low BMI (16.3%), 30 children had a normal BMI (61.3%), and 11 children had a high BMI (22.5%). Meanwhile, for early menarche 6 people (12.2%), normal menarche 43 people (87.8%), and no late menarche (0%) obtained a p-value = 0.616 (p>0.05). The percentage of early menarche in obese BMIs is higher than in other BMIs with a percentage of 6.1%.Conclusion: There is no significant correlation between body mass index and age at menarche due to the small number of samples.

CORRELATION OF ACADEMIC STRESS WITH OLIGOMENORRHEA IN FEMALE MEDICAL STUDENTS Soewangsa, Queency Amelia; Dewi, Sianty; Dian Putri, Maria Patricia
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 6, No 1 (2024): January
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v6i1.5369

Introduction: Oligomenorrhea is defined as an irregular menstrual cycle of more than 35 days or only experiencing 4 to 9 menstrual cycles in a year. According to research involving 12,964 women of childbearing age in China, it was found that 1,579 women (12.2%) experienced oligomenorrhea. Risk factors for oligomenorrhea are poor nutritional status, namely BMI < 18.5 or ≥ 25, excessive physical activity, high levels of stress (around 20%), and late age at menarche. Various studies have found a relationship between stress and abnormal menstrual cycles.Objective: To determine the relationship between academic stress and oligomenorrhea infemale students at the Faculty of Medicine, Widya Mandala Catholic University, Surabaya, Class of 2019.Method: Analytical observational research with a cross-sectional approach. The population for this research is all 7th-semester female students at the Faculty of Medicine, Widya Mandala Catholic University, Surabaya, class of 2019, with a total sample of 32 female students taken using simple random sampling. The independent variable is academic stress while the dependent variable is oligomenorrhea. The research instrument used a questionnaire. Data analysis used the Spearman Rank correlation test.Result: A total of 20 respondents (62.5%) experienced moderate levels of academic stress, 3 respondents (9.4%) experienced low levels of academic stress, and 9 respondents (28.1%) experienced high levels of academic stress. For the menstrual cycle from August to October 2022, 23 female students (71.9%) experienced normal menstrual cycles, and 9 female students (28.1%) experienced oligomenorrhea. The results of the Spearman Rank correlation test obtained a significance value of 0.023.Conclusion: There is a relationship between academic stress and oligomenorrhea in students at the Faculty of Medicine, Widya Mandala Catholic University, Surabaya, Class of 2019.

MENINGKATKAN PERAN AKTIF REMAJA SMA DALAM PROMOSI PENCEGAHAN INFEKSI MENULAR SEKSUAL Novita, Bernadette Dian; Dewi, Sianty; Hertanto, Maria Patricia Dian; Young, Andre; Khudrati, Wilson Christianto; Meredith, Jennifer
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 4 No. 6 (2023): Volume 4 Nomor 6 Tahun 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v4i6.21338

Infeksi Menular Seksual (IMS) adalah salah satu penyakit menular yang sering ditemui pada kelompok remaja. Pengaruh internal dan lingkungan tidak didukung oleh pemahaman mengenai kesehatan reproduksi dan penyakit menular seksual, pengawasan dari orang tua serta budaya masyarakat yang menganggap informasi ini sebagai hal yang tabu sehingga remaja mencari informasi dari sumber yang tidak tepat. Fakultas Kedokteran Universitas Katolik Widya Mandala Surabaya bersama Komisi Remaja Keuskupan Surabaya merasa perlu diadakan penyuluhan untuk menghasilkan agen edukatif dari kelompok usia remaja yang dapat memberikan edukasi serta konseling terkait pencegahan serta bahaya dari IMS. Pelatihan ini bertujuan untuk meningkatkan kemampuan remaja melakukan promosi kesehatan terkait IMS, pentingnya vaksinasi Human Papilloma Virus (HPV) untuk mencegah IMS serta etika dalam menggunakan media sosial. Metode pelaksanaan kegiatan melalui tahap pengembangan modul pelatihan, tahap implementasi dan pelatihan, serta tahap monitoring dan evaluasi. Tahap implementasi dilaksanakan dengan melakukan pelatihan kepada remaja dalam bentuk seminar awam melalui Zoom sedangkan tahap monitoring dan evaluasi melalui lomba poster dengan menggunakan media sosial Instagram. Evaluasi menggunakan pre-test dan post-test, serta penilaian karya poster digital di media sosial Instagram oleh ahli dengan menggunakan rubrik penilaian. Melalui kegiatan abdimas ini, mitra dapat turut berperan aktif melalui pengetahuan yang telah diperoleh kepada masyarakat, khusunya remaja melalui media sosial dengan bahasa yang mudah dipahami. Saran untuk kegiatan berikutnya adalah dengan memperluas materi terkait IMS dan agar kegiatan ini dapat dilakukan secara rutin.

Rapid isolation and characterization of Wharton's jelly-derived mesenchymal stem cells maintained in fresh-prepared human AB-serum Tjahjono, Yudy; Dewi, Sianty; Novita, Bernadette Dian; Wijaya, Hendy; Putra, Brilliant Dwi; Kuncorojakti, Suryo; Hendriati, Lucia; Jong, FX Himawan Haryanto; Widodo, Teguh; Malonda, Franklin Vincentius
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.65-72

Background Mesenchymal stem cells (MSCs) are valued in regenerative medicine for their multipotency, proliferative capacity, and immunomodulatory properties. Wharton’s jelly-derived MSCs (WJ-MSCs) from the umbilical cord offer a non-invasive, promising source for clinical applications, because easy isolation, lack of ethical concerns, and the presence of both embryonic and adult stem cells have made them a valuable source for use in therapeutic applications and regenerative medicine. This study aimed to optimize WJ-MSC isolation and characterization methods. Methods Human umbilical cords from three healthy donors were collected post-cesarean under strict inclusion criteria. WJ-MSCs were isolated using the explant culture method, with cells adhering to T75 flasks pre-coated with 2% gelatin. Cultures were maintained in Dulbecco’s Modified Eagle Medium (DMEM) supplemented with 10% freshly prepared Human AB serum and monitored for 21 days. Flow cytometry (BD FACSAria) was performed at passages 1 and 5 to assess MSC markers CD105, CD73, CD90, and CD44, alongside the exclusion marker CD45. Results WJ-MSCs exhibited fibroblast-like morphology by passage 1 and showed robust proliferation. Flow cytometry revealed high CD44 expression (~60%) at passage 1, while CD105, CD73, and CD90 became prominent by passage 5. CD45 remained low, suggesting minimal hematopoietic contamination. Conclusion This study confirms the feasibility of isolating and expanding WJ-MSCs using DMEM with 10% human AB serum. While consistent cell growth was achieved, the 21-day culture period may require optimization for scalability, including serum concentration, substrate coatings, and oxygen levels. CPJ-MSCs may be preferable for applications demanding rapid expansion and early marker expression.

A randomized controlled trial on the effectiveness and safety of tranexamic acid in decreasing blood loss in cesarean section Sianty Dewi
JURNAL WIDYA MEDIKA Vol. 2 No. 1 (2014)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v2i1.1647

Background: WHO reported more than 100,000 maternal death due to obstetric hemorrhage annually, in other hand Cesarean Section (CS) is a common surgery done to save mother and child with one of the complications is hemorrhage. tranexamic acid (TXA) as antifibrinolytic might improve maternal outcome by decreasing blood loss in CS. Objectives:Determine effectiveness and safety of tranexamic acid in decreasing blood loss in cesarean section. Method:A prospective, double blinded, randomized controled study in Obstetrics and Gynecology Department of Southern Philippines Medical Center. The participants are 124 women underwent CS, 62 women given tranexamic acid after cord cut compared to 62 given placebo. Estimated blood loss, cardiac rate, systolic blood pressure before and after CS, events during CS and additional medicines. Hemoglobin and hematocrit was taken before and after CS, course in the ward, blood transfusion, adverse events, mortality and length of hospital stay were compared. Results: Socio demographic, clinical profile, events after interventions, need of additional medicines and complications are similar for both group (p-value>0.05). The cardiac rate after CS is significantly higher in TXA group (tranexamic:85.1±11.5 placebo:80.1±15. 6, p-value=0.0441), but still in normal range. Conclusion: Tranexamic acid is not recommended to be given routinely to reduce blood loss in CS, instead its more beneficence to abort severe bleeding hence its should be available during CS. There was no adverse events recorded in both treatment and placebo group showed safety of tranexamic acid.

EPIDEMIOLOGIC STUDY OF ENDOMETRIAL LESION CHARACTERISTICS BY AGE IN PATHOLOGY DIAGNOSTIC CENTER IN SURABAYA 2015-2017 Sianty Dewi; Imelda Theodora; Bernadette Dian Novita; Yulia Widyasari; Ricardo Gunadi; Maria Amelia Suhardi; Vincentius Diamantino Supit
JURNAL WIDYA MEDIKA Vol. 7 No. 1 (2021): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v7i1.3167

Background: The etiology of endometrial lesions varies from benign to malignant. Early detection and management of malignancy give the best prognosis for the patient. While studies in America and Europe report a 3-5% risk of malignancy in women below 50 years and a significant increase up to 75-80% in postmenopausal, the availability of national epidemiologic data is limited, therefore the study is held.Method: A descriptive- retrospective study. Total sampling obtained from endometrial specimens in Pathology Diagnostic Center-Prof JH Lunardhi, Sp.PA(K) from 2015 to 2017, while gestation-related, inadequate sample, and incomplete report are excluded. Data analyzed by IBM SPSS 23.0 version. Result: Data of 560 samples, 90% from curettage, 8% hysterectomy, and 2% hysteroscopy. The majority belonged to the 40-49 age group (44.3%). Secretory phase endometrium is the most common finding in the age group of 20-29 years (26.9%). Proliferative phase endometrium is the most common finding. The highest incidence of endometrial hyperplasia occurred in the age group of 40-49 years, for both typical and non-atypical. Endometrial malignancy was found mostly in the 50-59 years (37.03%). Conclusion: The prevalence of endometrial lesions differed according to age groups, with physiological changes, endometritis, polyps, and hyperplasia were most common under 50 years old and the risk of malignancy increased 4.39 times (p.00) beyond 50 years old.

TELEMEDICINE AS AN OPTION FOR HEALTH SERVICE LIMITATIONS IN COVID-19 PANDEMIC ERA Bernadette Dian Novita; Sianty Dewi; Evelyn Ongkodjojo; Agatha Christi Palupi; Immanuel Michael; Paul L. Tahalele
JURNAL WIDYA MEDIKA Vol. 7 No. 2 (2021): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v7i2.3430

Coronavirus disease 2019 (COVID-19) pandemic era provides a new habit in form of self-quarantine or physical distancing. The recommendation is to delay visits to health facilities if it is not in the emergency condition to slow down the spread of COVID-19 transmission. This study aims to develop a telemedicine system that integrates three main components, namely doctors, patients, and hospital management in Gotong Royong Hospital Surabaya to minimize the transmission of COVID-19 while still provides comprehensive health services. The development of telemedicine service is divided into 3 stages. In the first stage, emergency screening was carried out by developing Frequently Asked Questions (FAQs). The second stage was continued with prototype testing and the last part was improving the system to create a better referral system. Gotong Royong Hospital telemedicine has been active since June 2021, within 2 months, 45 patients are willing to use telemedicine services. The results showed that telemedicine was easily accepted by patients in internal medicine clinic services (p

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