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INDONESIA
Jurnal Fitofarmaka Indonesia
Published by Universitas Muslim Indonesia
ISSN : 23560398     EISSN : 25412329     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA" : 5 Documents clear
Studi Komparasi Aktivitas Antiradikal Bebas Ekstrak Metanol Kulit Buah Pisang Ambon (Musa acuminata Colla) Muda dan Matang dengan Metode DPPH Abd. Malik; Reni Fauziah; Ahmad Najib
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.1062

Abstract

Ambonese banana fruit peel has antioxidant, antimicrobial, and anti-inflammatory activities. This search aims to investigate the potential of free radical scavengers based on the binding of DPPH free radicals (1,1-Diphenyl-2-picryl Hidrazil). Ambonese banana fruit peel was extracted by maceration using methanol. Free radical activity assay on sample measured by inhibition of DPPH using spectrophotometer UV-Vis at a wavelength at 516 nm. Identification by the TLC method showed that the peel extract of Ambonese banana was active as free radical scavengers where the DPPH solution changed in color from purple to yellow after being sprayed. The calculation results in IC50 values of each sample methanol extract of unripe Ambonese banana fruit peel is 11.78 µg/mL, while the methanol extract of the ripe Ambonese banana fruit peel is 151.56 µg/mL. The standard quercetin has IC50 values of 4.44 µg/mL. The result showed that the methanol extract from the Ambonese banana fruit peel (Musa acuminata Colla) has antioxidantactivity.
Uji Aktivitas Antiinflamasi Teh Cang Salak Secara In Vitro Dengan Metode Stabilisasi Membran Human Red Blood Cell Burhannuddin Burhannuddin; I Wayan Karta
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.903

Abstract

The use of natural ingredients can be an alternative as an anti-inflammatory agent with lower side effects. This study aims to determine the anti-inflammatory activity of cang salak tea in vitro using the human red blood cell membrane stabilization method. Cang salak tea is made into a drink in four formulations, namely P1, P2, P3, and P4 with a volume of 200 ml each. The four formulations were tested for phytochemicals and anti-inflammatory with red blood cell membrane stabilization method using diclofenac sodium as a positive control. The percentage value of red blood cell membrane stability for each formulation was then analyzed statistically with One-Way Anova and LSD tests to see the level of difference between formulations and their effect on cell membrane stability. The formulation of cang salak tea contains phytochemical compounds such as folinol (379,094 - 430,299 mg/100g GAE), flavonoids (5,299 - 7,959 mg/100g QE), alkaloids (24,312 - 28,472 mg/100g) and has antioxidant activity with a value of 3,996 - 6,222 ppm. The highest levels of active polyphenolic compounds were found in the P2 formulation, flavonoids in the P2 formulation, and alkaloids in the P3 formulation. The highest antioxidant activity was found in cang salak tea formulation P1 which had the lowest PPM value in the IC50 test. The percentage of red blood cell membrane stability in various formulations of cang salak tea had a significant difference with the highest value in formulation P1 (112.6 %), followed by formulation P2 (102 %), P3 (100, 2 %), and P4 (99, 7%) (P≤0.05). Based on the LSD test results of cang salak tea formulations P1, P2, and P3 were significantly different from the positive control (P≤0.05). While the P4 formulation was not significantly different from the positive control (P≥0.05). Cang salak tea formulations P1, P2, P3, and P4 were able to stabilize red blood cell membranes which showed strong anti-inflammatory activity
Aktivitas Larvasida Ekstrak Daun Bintaro (Cerbera odollam Gaertn.) Terhadap Larva Nyamuk Aedes aegypti Virsa Handayani; Rezki Amriati Syarif; Aktsar Roskiana Ahmad; Andi Afifah Amdar
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.940

Abstract

Bintaro Leaf (Cerbera odollam Gaertn) contains alkaloids, flavonoids, saponins and tannins that have the potential as larvicides. The study aimed to determine the mortality rate of Aedes aegypti mosquito larvae after administration of Bintaro leaf extract as indicated by the LC50 value. The extract was obtained by maceration method. The yield of Bintaro Leaf (Cerbera odollam Gaertn)extract was 6.03%. This study used 180 mosquito larvae (Aedes aegypti) instar III, divided into test solutions made with 4 concentrations (10,000 ppm, 1000 ppm, 100 ppm and 50 ppm), positive control using Abate and negative control using Aquadest. Observations were made after 24 hours of treatment. The results of the larvacide test showed that the Bintaro leaf extract was effective as a larvicidal as indicated by the LC50 value of 21.170 g/mL 1000 g/mL.  
Karakterisasi Senyawa Penghambat Polimerisasi Heme Dari Ekstrak Etanol Buah Pare (Momordica charantia L.) Purwaning Nugroho Widiyati; Syamsudin Syamsudin; Partomuan Simanjuntak
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.937

Abstract

Malaria, which is caused by a parasitic infection of the genus Plasmodium, is still reported as a disease that contributes a high mortality rate in the world. However, there is another problem currently being faced, namely the incidence of patient resistance to antimalarial drugs on the market, causing an urgent need to develop new antimalarial drugs that are safe and inexpensive. Research on the ethanol extract of bitter melon (Momordica charantia L.) was carried out with the aim of providing information as an alternative antimalarial drug based on the mechanism of heme polymerization inhibition according to the method of Huy et. al and to identify the compound isolate fraction which is predicted to have the antimalarial activity. The ethanol extract of bitter melon (Momordica charantia L.) was prepared by maceration method using 96% pharmaceutical grade ethanol, partitioned using ethyl acetate and distilled water. Part of the partition which was soluble in ethyl acetate was fractionated using column chromatography (SiO2; i. n-hexane-ethyl acetate = 10 : 1 ~ 1 : 1; CH2Cl2-MeOH = 10 : 1 ~ 1 : 1 The results of heme polymerization inhibition test obtained isolate fraction 8.5 which had the highest activity, namely IC50 302.78 ppm and IC50 (chloroquine diphosphate as a positive control IC50 218.71 ppm).The results of identification by LCMS/MS spectroscopy showed that isolate fraction 8.5 contained several chemical compounds such as momordicoside L; momordicoside I and momordicoside F2 and quercetin The chemical compound that is predicted to play a role in inhibiting Heme polymerization is quercetin
Studi Penambatan Molekuler Senyawa Tectoquinone Terhadap Enzim α-Glukosidase Ahmad Najib; Rais Razak; Izzatul Fikril Mujtahid
Jurnal Fitofarmaka Indonesia Vol 10, No 2 (2023): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i2.1059

Abstract

The investigation focused on conducting an in silico screening of chemical compounds isolated from Syzygium oblanceolatum (C.B.Rob) to identify potential bioactive compounds that could act as inhibitors of α-Glucosidase. This screening involved tectoquinone as the potential inhibitor for α-Glucosidase and employed the Autodock Vina Docking process. The target enzyme, α-Glucosidase, was used as the receptor with 20 binding sites on the enzyme receptor 1LWJ and the Autodock Vina program was utilized for this purpose. The values of ∆Gbind and the lowest RMSD were determined for each of the 20 targeted binding sites on 1LWJ, representing the free energy change (∆G) resulting from the docking. The docking results demonstrated that the free energy change (∆G) for the 20 targeted binding sites ranged from -6.346 kcal/mol to -9.720 kcal/mol. The most favorable free energy change (∆G) was observed at the 16th binding site with a value of -9.720 kcal/mol, while the highest was recorded at the 18th binding site with a value of -6.346 kcal/mol.

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