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INDONESIA
Journal of Medical Biomedical and Applied Sciences
Published by Innovative Journal
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Arjuna Subject : -
Articles 112 Documents
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Functionality Improvement of Gemfibrozil Formulations by QbD Approach A, Mukharya
Journal of Medical Biomedical and Applied Sciences Vol 1 (2014)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15520/.v1i0.22

Abstract

Die fill problem is encountered in production batches if the flow of the blend is not optimum. The flow of the blend is related to the characteristics of granules. The aim of this study was to formulate solid dosage form of gemfibrozil. Gemfibrozil is a waxy, crystalline, hydrophobic material that results in prolongation of disintegration time during storage in stability studies. Because of the fluffy nature of API flow problem was also encountered. Product and process characteristics important to desired performance must be derived from combination of prior knowledge and experimental assessment during product development, which is re-quired to achieve objectives of Quality by Design (QbD). From prior knowledge and experimental data, a multivariate model link-ing product and process measurements and desired attributes was constructed. Flow of gemfibrozil blend was improved by addi-tion of colloidal silicone dioxide, selecting microcrystalline cellulose of higher particle size and by producing granules of suffi-cient strength. Since the major portion of the tablet was gemfibrozil, the role of particle characteristics was also investigated.
Colours and Dyes from Natural Origin: A Review R, Dr. Sannd
Journal of Medical Biomedical and Applied Sciences Vol 4 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15520/.v1i0.23

Abstract

A colour influences our moods and emotions and generally enhances the way in which we enjoy our surround-ings. Colour is introduced into these materials using substances known as dyes and pigments. Natural dyes are colours having several applications in textiles, inks, cosmetics, etc. Nature has gifted us more than 500 dye-yielding plant species. The natural dyes offered any imaginable shade of colour, in great brilliance and with ex-act reproducibility. Natural dyes are less toxic, less polluting, less health hazardous, non-carcinogenic and non-poisonous. This paper explains the information regarding the natural colours and dyes so that they are more uti-lized by the industries for the well being of society. 
Coumarin as a Prominent Lead Nucleus, by Virtue of its Diversity in Bioactivity and Therapeutic Potential in Present Scenario of Chemical and Pharmaceutical Research Barve, Ashutosh
Journal of Medical Biomedical and Applied Sciences Vol 4 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15520/.v1i0.24

Abstract

Coumarins are well-known natural products displaying a broad range of biological activities1. Many naturally occurring as well as synthetic derivatives of coumarin have been found to possess diverse biological activities namely anticoagulant2, spasmolytic3, anthelmintic4, diuretic5 and anti-inflammatory6 activities. 4-Pyridyl and 4-piperidyl coumarin have been found to exhibit CNS depressant and analgesic activities in animal models7-9. The halogenated furanyl coumarins show antimicrobial action10, whereas isoxazolinyl and oxadiazolyl coumarins 11 inhibit enzymes like glucouronidase and 1, 2-lipoxygenase. Further, 2-biheterocyclic benzofurans with furan12, chromone13 ring systems exhibit antibacterial, psychotropic and anti-inflammatory properties.
Nanoparticulate Drug Delivery System of Geriforte V, Maruthappan
Journal of Medical Biomedical and Applied Sciences Vol 4 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (60.022 KB) | DOI: 10.15520/.v1i0.25

Abstract

The aim of the study Geriforte loaded Eudragit nanoparticles were prepared and targeted to various organs to a satisfactory level. Re-cent research on idealizing drug delivery systems which is progressing at a prodigious rate, aims at the development of drug delivery systems with maximum therapeutic benefits of drug delivery thus resulting in safe and effective management of diseases. Nanoparti-culate drug delivery system for Geriforte was developed, that would overcome the therapeutic risks of conventional formulations and was evaluated with respect to particle size, drug content, in vitro release and in vivo targeting. Geriforte is used to proven antistress adaptogenic, comprehensive, systemic and metabolic corrective. The commercially available formulations of Geriforte are associated with acute hemodynamic changes that result in nephrotoxicity and also have low bioavailability. Geriforte (GER) loaded Eudragit RL 100 nanoparticles were prepared using solvent evaporation technique, with 2% PVA as stabilizer. Three batches of nanoparticles with varying drug concentrations (GER-1, GER-2 and GER-3) were prepared. Cumulative % drug release of formulations GER-1, GER-2 and GER-3 was 91.25%, 90.79% and 85.18% respectively. Formulation GER-2, which proved to be the best showed a mean particle size of 232 nm and entrapment efficiency of 55.17%. The in vivo result of formulation GER-2 revealed that the drug loaded nanoparticles showed preferential drug targeting to liver followed by spleen and kidneys. 
Correlation between poor palliative performance scale (pps) with or without brain lesion and overall survival in KFSH Dammam hospital during the year 2015 Amani Alsayes, Aria Musailm, Dr. Ahmed Salah Ali, Muna Alshehabi,
Journal of Medical Biomedical and Applied Sciences Vol 3 No 12 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (617.131 KB) | DOI: 10.15520/.v3i12.26

Abstract

Presence of brain lesions ,either primary or metastatic lesions ,may be the cause of cognitive function deterioration among cancer patients. This leads to further deterioration in his physical ability and tolerance for oral feeding. All these deteriorations are translated in low palliative performance status scores and subsequently poor outcome and less hope for more days for the patients to live as stated by the studies that correlate the survival with the palliative performance scale.
Benign leiomyoma metastasizing to multiple organs and literature review Gagliardi c, Polonsky A, wright A,
Journal of Medical Biomedical and Applied Sciences Vol 3 No 12 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (690.395 KB) | DOI: 10.15520/.v3i12.27

Abstract

Uterine leiomyomas are highly common. Their incidence is generally cited as 20-25%, but has been  shown to be as high as 70-80% in studies using histologic or sonographic examination. Distant metastasis is extremely rare and is of unknown etiology. It primarily affects women of reproductive age and  might appear years after gynecological procedures such as myomectomy or hysterectomy.
Computational Thinking Guiding Change in Online Education Quinn, Brigette J.
Journal of Medical Biomedical and Applied Sciences Vol 3 No 12 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (593.268 KB) | DOI: 10.15520/.v3i12.28

Abstract

As a result of instant access to data, information and knowledge anywhere, anytime, today’s students have rapidly acquired educational opportunities. Online education continues to grow at a pace much faster than face to face enrollments. There is a need for faculty development and training who can teach with technology, design and develop online courses in order to meet the increasing student demand. Faculty barriers to online education include loss of interpersonal student relationships, technology challenges, pedagogical concerns, institutional policy problems and unidentified support or compensation for all associated processes. At the crossroads of problem identification, strategy, and adoption of innovation, Computation Thinking (CT) offers a logical, exploratory, expandable and collaborative way of solving a complex problem in a state of change. This paper aims to summarize and synthesize the literature on both CT and faculty barriers to adoption of online education. A further aim is to offer suggestions for collaborative faculty design and development opportunities in exploring their own experience with online education using CT as a framework for problem-solving.
Incidence of inpatient mortality in the palliative medicine unit at tertiary care hospital in Saudi Arabia Dr. Muna Alshehabi, Dr. Ahmed Salah Ali, Amani Alzayer,
Journal of Medical Biomedical and Applied Sciences Vol 3 No 12 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (642.29 KB) | DOI: 10.15520/.v3i12.32

Abstract

After one year of the official opening of the hospital as a tertiary care facility mainly managing cancer patients in the Eastern province in Saudi Arabia IN 2006, a palliative care service has been established as a section under medical oncology department to serve patients at King Fahad Specialist Hospital in Dammam, Saudi Arabia.
Four FATCO syndrome cases: clinical, autopsy and placental features with literature review update Francisco Valente, Purificação Tavares, Rosete Nogueira, Joaquim Sá, Catarina Varela, GraÃ
Journal of Medical Biomedical and Applied Sciences Vol 3 No 12 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1166.66 KB) | DOI: 10.15520/.v3i12.33

Abstract

Fibular Aplasia-Tibial Campomelia-Oligosyndactyly, or FATCO, is a rare syndromic condition reported in 18 cases so far, from which only 3 were diagnosed at prenatal stages. In this study we report comprehensive clinical, placental and autopsy findings of four additional prenatal cases of FATCO, with the aim of further delineating this syndromic condition. Understanding this disorder at prenatal stages will allow for an earlier diagnosis through the identification of key features, thus permitting an adequate parental counselling about the pregnancy development.
Supernumerary buccal cusp in left maxillary 1st deciduous molar- An unusual case Ayesha Sameera, Jess Dass Govada, E. Sridhar Reddy,
Journal of Medical Biomedical and Applied Sciences Vol 3 No 12 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (579.727 KB) | DOI: 10.15520/.v3i12.34

Abstract

Presence of accessory cusp on the buccal surface of a tooth may occasionally pose problems to dentists. Although its presence may not be a cause for alarm in most instances, nevertheless it can lead to serious consequences if it is damaged. This report describes a rare finding of accessory cusp seen on the buccal surface of the 1st maxillary deciduous Molar and the need for continuous dental surveillance and preventive measures have been highlighted.

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