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Journal of Medical Biomedical and Applied Sciences

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Published by Innovative Journal

ISSN : - EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Articles 112 Documents

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Study of Telmisartan Versus Carvedilol for Prevention of Atrial Fibrillation Recurrence in Hypertensive Patients K. China Venkanna, Dr. CH. Ananda Kumar, G. Rama Krishna,
Journal of Medical Biomedical and Applied Sciences Vol 3 No 12 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Atrial remodeling, leading to atrial fibrillation (AF), is mediated by the reninâangiotensinâaldosterone system. Mild hypertensive outpatients (systolic/diastolic blood pressure 140â159/90â99 mmHg) in sinus rhythm who had experienced â¥ 1 electrocardiogram (ECG)-documented AF episode in the previous six months received randomly Telmisartan 80 mg/day or carvedilol 25 mg/day. Blood pressure and 24-hour ECG were monitored monthly for one year; patients were asked to report symptomatic AF episodes and to undergo an ECG as early as possible. One hundred and thirty-two patients completed the study (Telmisartan, n=70; carvedilol, n=62). Significantly fewer AF episodes were reported with Telmisartan versus carvedilol (14.3% vs. 37.1%; p<0.003). Left atrial diameter, assessed by echocardiography, was similar with Telmisartan and carvedilol (3.4Â±2.3 cm vs. 3.6Â±2.4 cm). At study end, both regimes significantly reduced mean left ventricular mass index, but the reduction obtained with Telmisartan was significantly greater than with carvedilol (117.8Â±10.7 vs. 124.7Â±14.5; p<0.0001). Mean blood pressure values were not significantly different between the groups (Telmisartan 154/97 to 123/75 mmHg; p<0.001; carvedilol 153/94 to 125/78 mmHg; p<0.001). Telmisartan was significantly more effective than carvedilol in preventing recurrent AF episodes in hypertensive AF patients, despite a similar lowering of blood pressure

Investigating the mechanical properties of Thiel-embalmed metatarsals Gatt, Alfred
Journal of Medical Biomedical and Applied Sciences Vol 3 No 12 (2016)
Publisher : Journal of Medical Biomedical and Applied Sciences

Introduction: Fresh-frozen cadaveric samples are often utilized for research and the study of anatomy. Thiel embalming offers the possibility of preserving human tissue and bone without requiring special freezing equipment. Thus mechanically testing Thiel embalmed bone to compare with fresh frozen samples becomes increasingly important.Method: The 1st and 5th metatarsals were harvested from 3 cadavers which had one foot fresh frozen and the other Thiel embalmed. These metatarsals underwent 3-point testing until fracture.Results: 5th metatarsal average fracture force for Thiel embalmed and fresh frozen samples was equal to 305N (SD241N) and 539N (SD232N) respectively. Similarly average fracture force for Thiel embalmed and fresh frozen 1st metatarsals was equal to 614N (SD192N) and 694 (SD273N) respectively.Conclusion: Thiel embalmed metatarsals yield at a lower force than fresh-frozen metatarsals obtained from the same cadaver. Thus one should be cautious about utilizing these preserved bones in situations where bone strength is required.

In Vivo Antidiabetic Activity of Aqueous Extract of Psidium Quajava in Alloxanised Diabetic Mice IK, Njangiru
Journal of Medical Biomedical and Applied Sciences Vol 5 No 1 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Psidium quajava has for long been employed in the management of many diseases in Kenya, including diabetes mellitus. However, the use of this plant extract lacks scientific validation in regard to its efficacy. This study aimed at investigating in vivo antidiabetic activity of aqueous extract of Psidium quajava in alloxanized diabetic mice. Antidiabetic property was assessed through oral and intraperitoneal administration of aqueous plants extract at doses of 50, 100, 200 and 300mg/kg body weight and profiling the levels of blood glucose after 0, 1, 2, 3, 4, 6 and 24 hours using a glucometer. The mineral composition of the aqueous plant extract was assayed using Total Reflection X-ray Fluorescence system (TRXF), while the different types of secondary metabolites were assessed using standard procedures. The aqueous plant extract exhibited a dose dependent hypoglycemic activity in alloxanized diabetic mice. The studied plant extract contained alkaloids, flavonoids, saponins, tannins, and total phenols at varying concentration. The mineral profile demonstrated the presence of detectable levels of K, Ca, Ti, V, Mn, Fe, Ni, Cu, Zn and As. The plantâs aqueous extract was effective in lowering blood glucose levels.

Seroprevalence of hepatitis E Virus among pregnant women attending Wad Madani Teaching Hospital, Sudan Dawoud, Abakar Adam
Journal of Medical Biomedical and Applied Sciences Vol 5 No 2 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Background: HEV is considered as one of liver diseases and other complications. The mortality rate may reach up to 20% in pregnant women with each passing trimester, making HEV infection the most severe hepatitis in pregnancy of all recognized hepatitis. Pregnancy appears to be a potential risk factor for viral replication and leads extreme low immune status of pregnant women. Hepatitis E in pregnancy is also associated with high rates of spontaneous abortion, intrauterine death, and preterm labour. Objectives: the objectives of this research are to estimate the Seroprevalence of HEV infection among pregnant women and detect IgG and IgM antibodies of HEV in pregnant women. Furthermore, association between HEV infection and disease determinants like age and different trimesters in pregnant women were investigated. Finally correlation between infection and (age, parity number, history of abortion, consumption of raw meat, and drinking of infiltrated water) and positive cases were also studied. Materials and methods: This was a descriptive cross-sectional hospital based study. Ninety serum samples randomly collected from pregnant women attended to Wad Madani hospital of obstetrics and gynecology were enrolled in the study. The age groups of the study population were 22 (24.4 %) aged less than 20 years, 41 (45.6 %) aged between 21-30 years and 27 (30.0 %) aged more than 40 years. also 30(33.3 %) had no history of abortion and 60 (66.7 %) had history of abortion.Results: 51 (56.7%) of participants diagnosed positive for anti-HEV IgG, while 39 (43.3%) gave negative results for anti-HEV IgG. On the other hand, 6 (6.7%) showed circulating anti-HEV IgM in sera of examined women, while 84 (93.3%) were negative for anti-HEV IgM. Liver function tests analysis revealed that only ALP and AST were affected by HEV infection (P value 0.020 and 0.026 respectively). According to age groups, there was significant relationship between Seroprevalence of anti-HEV IgG and anti-HEV IgM (P value 0.027). The highest prevalence noted among age group 21 â 30 years (45.6%) for IgG and less than 20 years (24.4%) for IgM. There is little relation between the positive results with biochemical findings. This study concluded that HEV was more prevalence in second (24%) and third trimester (59%) than first trimester (17%). The study recommended carrying out more studies and in large number of samples.

ENDO PERIO LESION- A CASE REPORT George, Priyanka Mariam
Journal of Medical Biomedical and Applied Sciences Vol 5 No 2 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Endo Perio lesions are a common finding in the dental practice. Progression of an endodontic lesion, if allowed leads to periodontal involvement or vice versa. This is a case report on an endodontic lesion with periodontal involvement that has been treated by performing Root Canal Treatment (RCT) followed by flap surgery.

WHY PAIN ??? Patel, Shahil
Journal of Medical Biomedical and Applied Sciences Vol 5 No 3 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Most of us are having trouble like pain either at the starting of our day while wake-up from bed either due to lack of sleep/ inadequate diet and water etc. or at the end of our work while moving from office and/ or at the home after having terrible work at home as compare to office work.

Periodontal approach to improve Aesthetics : A Case Report Vellayappan, Radha
Journal of Medical Biomedical and Applied Sciences Vol 5 No 3 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

A variety of factors including teeth form/position and gingival tissue levels may influence the overall smile aesthetics [1, 2]. In the last decade a great interest was focused on plastic periodontal surgery as a reliable tool to enhance esthetics

More insight into the mode of action of lipophilic antitumor drugs containing a platinum (II) fragment Vanchanagiri, Kranthi
Journal of Medical Biomedical and Applied Sciences Vol 5 No 3 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)) (Carboplatin 2) is a second generation platinum anticancer drug following Cis-diamminedichloroplatinum(II) (Cisplatin 1). In the present study Cisplatin and Carboplatin analogs are attached to the acid group of the bile acid via an ester link called as ChAPt(n)Cis and ChAPt(n)Carbo. The in vitro antitumor activity of Cisplatin 1 along with the corresponding ChAPt derivatives evaluated against a panel of five tumor cell lines of different histogenic origin. A series of biological methods starting from Sulforhodamine B (SRB) assay to determine IC50, Cell cycle analysis, Annexin-V assay and Caspase assays were performed with the aim to scrutinize the anticancer mode of action on HepG2 (hepatocellular car cinoma) cell line. The compounds exerted a dose dependent antiproliferative action at micro molar concentrations and the effect of these structural variations on anticancer activity was elaborated and discussed more in detail. To summarize, several compounds revealed significant antitumor activity and surprisingly the ChAPt(11)Cis and ChAPt(11)Carbo induce programmed cell death with molecular features different from each other, suggesting that both drugs induce apoptosis through different initial pathways.

The Ultimate Solution of any JOINT âPAIN (Coservative) JOINT-CURE Harbal for Osteoarthitis, Rheumatoid Arthritis, Backache due to Facet Arthritis, Spondilytis and Other Joint Pain Patel, Shahil
Journal of Medical Biomedical and Applied Sciences Vol 5 No 04 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Abstract: Aim:Why we get PAIN???Do we exercise every day?Do we have proper diet, water, air?How many of us are using PAIN KILLER MEDICINE daily?Without knowing the fact of PAIN Killer safety.....To find the effectiveness, Randomise Clinical trials with the Use of the JOINT -CURE herble"Churna" as an alternative treatment to any invasion in joints for the Pain relief ofOsteoarthritis, Rheumatoid arthritis, Facet Arthritis and / or any kind of Joint Pain.

Suberoylanilide Hydroxamic Acid (SAHA) with Antioxidant vitamin E: Induces ER Stress Pathway in Human Cervical Cancer Cell Line Sharma, Monal
Journal of Medical Biomedical and Applied Sciences Vol 5 No 04 (2017)
Publisher : Journal of Medical Biomedical and Applied Sciences

Suberoylanilide hydroxamic acid (SAHA) is a targeted inhibitor of histone deacetylase, which has been reported to inhibit cell growth, induce apoptosis in a variety of tumor cells and shown to be an anti-cancer agent. This study describes the anti-tumor effect of SAHA alone and in combination with antioxidant vitamin E in human epithelial cervical cancer (HeLa) cells. Cell cycle analysis of drug HeLa cells showed slight decrease in cell population at the G1 phase, and increase at the G2/M Phase with concomitant decrease in S phase. We also observed SAHA induce anti-proliferative effect in a dose dependent manner and caused DNA fragmentation. Expression of CHOP and Bax/Bcl-2 Ratio were found to be augmented after post treatment. Level of Reactive oxygen species (ROS) was increased and antioxidant enzyme catalase activity was decreased after treatment, suggesting that SAHA induced apoptosis is an endoplasmic reticulum stress pathway. This study provides a better understanding of molecular mechanism of anti- tumor effect of SAHA and gives insight of the development of better undersigned combinatorial chemotherapy strategies.

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