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INDONESIA
BIOTROPIC The Journal of Tropical Biology
Published by Universitas Islam Negeri Sunan Ampel
ISSN : -     EISSN : -     DOI : -
Core Subject : Agriculture,
Agriculture, Biological Sciences & Forestry
Arjuna Subject : -
Articles 94 Documents
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The Ability of Secondary Metabolites from Actinomadura sp. as COVID-19 Protease Inhibitor: In Silico Method Yuriza Eshananda; Sri Martina Wiraswati; Sri Lestari; Afifah Mariana; Tia Erfianti; Hermin Pancasakti Kusumaningrum
Biotropic : The Journal of Tropical Biology Vol. 7 No. 2 (2023): Biotropic, Volume 7 Nomor 2, 2023
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/biotropic.v7i2.1926

Abstract

The pandemic of COVID-19 disease in the late of 2019 resulted in the massive screening for drug discovery purpose. However, there is still no reports about the ability of natural products from bacterial group of class Actinobacteria as COVID-19 inhibitor. The aim of this research is to identify the potential ability of natural compounds from Actinomadura sp., the member of class Actinobacteria, against two receptors of COVID-19 protease with PDB ID 6LU7 and 5R7Y. The eleven natural compounds were docked using AutoDock Vina and the interaction between receptor and ligands were analysed using LIGPLOT. The most potential compound was simulated for its interaction stability using Yet Another Scientific Artificial Reality Application (YASARA) dynamics. The result of molecular docking by AutoDock Vina showed that Sagamilactam become the most potential inhibitor for viral protease as it had lower binding affinity (6LU7:-12 and 5R7Y:-10.4) compared to the both of  native ligand (6LU7:-11.4 and 5R7Y:-4.6). Furthermore, the interaction of the most potential ligand showed the low number of Root Mean Square Deviation (RMSD) deviation in molecular dynamic simulations. This result validated the docking method that used and indicated that secondary metabolites produced from rare actinobacteria of Actinomadura sp. have promising possibility to inhibit COVID-19 protease.
Karakteristik Bakteri Endofit Akar Tanaman Kedelai Penghasil Hormon Tumbuh IAA Afifah Mariana; Agus Irianto; Iman Budisantoso
Biotropic : The Journal of Tropical Biology Vol. 7 No. 2 (2023): Biotropic, Volume 7 Nomor 2, 2023
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/biotropic.v7i2.1930

Abstract

The increase in soybean production and productivity has become a significant focus in the effort to meet global food demands. The use of environmentally friendly agricultural technologies and practices is a vigorously pursued strategy. Endophytic bacteria are one of the potential bioagents that can stimulate plant growth. The ability of endophytic bacteria to synthesizing the plant hormone indole-3-acetic acid (IAA) can be an alternative in the effort to enhance soybean plant productivity and ensure long-term agricultural sustainability. The objective of this study is to analyze diversity and ability of endophytic bacteria isolated from soybean roots to produce IAA. This research was conducted through several stages, including the isolation of endophytic bacteria from soybean root, evaluating the isolates' ablity  for IAA production, and characterizing potential isolates based on macroscopic and microscopic characteristics. This research indicated that a total of 11 endophytic bacteria isolates were obtained from soybean plant roots. Among them, four isolates, namely EAK4, EAK5, EAK6, and EAK8, demonstrated the capability to synthesizing IAA ranging from 35.46 to 44.56 ppm. These isolates showed various macroscopic and microscopic characteristics and hold promise as biological agents that promote planth growth.
Produksi Biomassa, Analisis Nutrisi dan Senyawa Bioaktif Jamur Grigit (Schizophyllum commune) Rida Oktorida Khastini; Rani Rahmawati
Biotropic : The Journal of Tropical Biology Vol. 7 No. 2 (2023): Biotropic, Volume 7 Nomor 2, 2023
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/biotropic.v7i2.1932

Abstract

Schizophyllum commune, a wild edible mushroom, has gained significant attention due to its potential as a valuable source of biomass, nutrients, and bioactive compounds. This study aims to explore the production of mycelial biomass and analyze its nutrient and bioactive compound content to be applied as a raw material in food production. The Schizophyllum commune was cultivated in potato dextrose broth media with temperature (25, 30, 35, and 40oC) and pH treatments (3, 7, and 8) to determine the optimal conditions for biomass production. Mycelia biomass was harvested and extracted. Nutrient and bioactive compounds were analyzed. Results showed that 30oC and pH 7 give the highest biomass production. Proximate analysis revealed that the mushroom's mycelia biomass contained high protein, low fat, and fiber. The analysis also demonstrated a rich profile of bioactive compounds, including flavonoid and phenolic compounds, respectively1 2,32 ± 0,95 dan 415,72 ± 15,23 g/100 g mycelia dry weight. Schizophyllum commune exhibits promising prospects for mycelial biomass production.
Penentuan Tipe Inhibisi Senyawa Analog Kurkumin CA2 terhadap Enzim α-Glukosidase dari Beras Lapuk Atiqoh Zummah; Endang Astuti; Bambang Purwono
Biotropic : The Journal of Tropical Biology Vol. 7 No. 2 (2023): Biotropic, Volume 7 Nomor 2, 2023
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/biotropic.v7i2.1952

Abstract

Diabetes is a health problem that exists throughout the world, especially in Indonesia. Based on data compiled from the International Diabetes Federation (IDF) in 2017, people with diabetes in Indonesia reached 10.3 million people, and if not handled properly it is suspected that there will be an increase to 21.3 million people in 2030. Curcumin analog compounds can used for the treatment of diabetes by inhibiting the enzyme α-glucosidase. The curcumin analog compound used in this study was synthesized from 4 methoxybenzaldehyde with cyclopentanone which was then called the CA2 compound. The α-glucosidase enzyme used in this study was obtained through extraction of weathered rice with an optimum pH of 4.5 and the enzyme extract fraction used was fraction II which had the highest activity compared to fractions I and III. The results showed that the values of the kinetic parameters Km and Vmax of the extracted α-glucosidase enzyme were 1.53 mM and 0.03 U/mL, respectively. The Km kinetic parameter value changed to 1.66 Mm while the Vmax value did not change when the α-glucosidase enzyme was inhibited by CA2 compound, so that the type of inhibition shown by CA2 compound was competitive.

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