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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 7 Documents
Search results for , issue "Vol. 2 No. 2 (2014)" : 7 Documents clear
Phytosome: a novel dosage form for herbal drug delivery Choudhury, Ananta; Verma, Swati; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

Phytosome is a complex of a natural active ingredient and phospholipids. The term ‘Phyto’ means plant while ‘some’ means cell like structure. It is claimed that phytosome increases absorption of "conventional herbal extracts" or isolated active principles both orally as well as topically. In this era phytosome gain popularity as a potential drug delivery device due to excessive demand and utility of herbs or herb based medicines. This advance technology offers amenities like improved absorption, enhanced delivery & increased bioavailability of herbal extracts. These drug-phospholipid complexes can be fabricated in the form of solution, suspension, emulsion, syrup, lotion, gel, cream, aqueous micro dispersions. Standardized plant extracts, mainly polar phytoconstituents like flavonoids, terpenoids, tannins, xanthones shall be introduced in form of phytosome.
Simultaneous estimation of pyrantel pamoate, praziquantel & febantel by high performance liquid chromatography using dual wavelength Sajjanwar, Rupali; Bhaskaran, Shyamala; Kakati, Kulesh; Kumar Jha, Shailendra
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

A sensitive, fast, and stability-indicating gradient reverse-phase liquid chromatography method was developed for quantitative simultaneous estimation of Pyrantel pamoate, Praziquantel and Febantel using reverse phase high performance liquid chromatography by gradient elusion with dual wavelength at a specified time interval. All three ingredients were well separated with Phenominax Hypersil C18 (ODS) (4.6 X100mm) 3µm column. The various factors affecting different parameters during method development by HPLC was analyzed and standardized.
Preparation and evaluation of herbal cream Dubey, Aditi; Prasad, Pushpa; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

A herbal fairness cream was formulated using herbal extracts which have potential antioxidant activity. Creams were basically formulated using the hydro alcoholic extracts of Glycyrrhiza glabra (root and Stolons),Camellia sinensis (leaf), Pleurotus osttreatus (mushroom plant). The prepared formulation were subjected to different evaluation like spreadability, pH, appearance, viscosity, drug content, irritability and antioxidant properties. The prepared formulation was found stable and effective. Among the several combination Liquorice & Green Tea based preparation shows better results. From the results it was concluded that it is possible to develop creams containing herbal extracts having potent antioxidant and fairness property and can be used as the provision of a barrier to protect skin.
Comparative study of hexane extract for volatile and non volatile components of leaves and rhizomes of Acorus calamus linn. using high performance thin layer chromatography (HPTLC) Bisht, AS; Chauhan, Monika; Joshi, A; Joshi, Y; Dimri, A; Singh, V; Juyal, D
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

The present communication attempts to evaluate the comparative study of leaves and rhizomes of Acorus calamus Linn. (Family; Araceae) using High Performance Thin Layer Chromatography (HPTLC). Since the plant contains various volatile and non-volatile components so paper advocates the quantitative study using hexane extract. Acorus calamus Linn. is a well known medicinal plant in traditional medical systems having various ethno-pharmacological uses. As the official source of the plant is roots and rhizomes, but here study had been done comparatively with leaves. Previously leaves of Acorus calamus were not regarded as useful part of plant, but recently there is growing interest in leaves of the said plant. The leaves are considered to possess various activities such as an insect repellent, when cut up and kept with grain storage; anti-hyperlipidemic; anti-diabetic; antipsychotic; anti-inflammatory and analgesic. As there is no detailed work reported in leaf constituents of the plant, therefore the study revealed specific quantitative HPTLC data for the plant for future standardization work. HPTLC analysis of both leaves and rhizomes showed the presence of Asarone, β- sitosterol, lupeol and Ursolic acid when matched with marker compounds.
Development and characterization of topical phyto-formulation for antifungal activity Choudhury, Ananta; Verma, Reema; Sinha, Devnarayan; Sahu, Saurabh; Roy, Am
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

The present study was aimed to develop a potent antifungal topical gel using Curcumin and fluconazole in suitable combination. In these studies we have prepared different gel formulations using polymer like carbapol, Hydroxy propylmethyl cellulose, as well as excepients like tri-ethanolamine, methanol, glycerin and purified water. The formulated gel were evaluated in context of different parameters like drug content, pH, spreadability viscosity , in-vitro drug release , anti-microbial effect etc. Candida albicans was used as a model fungus to evaluate the antifungal activity of the prepared formulations.
In-situ gel: a study of dental diseases Bisht, Neha; Goswami, Laxmi; Kothiyal, Preeti
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

In-situ forming polymeric gelling systems has become prominent among novel drug delivery system (NDDS) in recent years due to advantages such as sustained and prolonged drug action, improved patient compliance and reduced frequency of administration of the drug in comparison to conventional drug delivery system (DDS). This is a type of mucoadhesive DDS where the polymeric formulation is in sol form before administration and once comes in contact with body fluids; it undergoes gelation to form a gel. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultraviolet irradiation from which drug gets released in sustained and controlled manner. Conventional formulation for the treatment of dental diseases has certain drawbacks. A new concept of in situ gel was develop to overcome the shortcoming of conventional formulation which deals with dental diseases. Conventional oral formulations like solution, suspension, and ointments have many disadvantages which result into poor bioavailability of drug in the buccal cavity. In-situ forming polymeric formulation drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in-situ to form a gel.
Various approaches for targeting colon: a review Raghuvanshi, Neha Singh; Goswami, Laxmi; Kothiyal, Preeti
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

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Abstract

The colonic region of GIT has become an increasingly important site for drug delivery and absorption. This site specific delivery of drug to lower parts of the GIT is advantage for localized treatment of several colonic disease like colon cancer, crohn’s disease, ulceratice colitis, IBD, diarrhea etc. colon targeted drug delivery system (CTDDS) ensure direct treatment at the disease site and avoiding the systemic side effects. It is suitable for absorption site for protein and peptide drugs. Cytochrome P450 3A class of drug metabolizing enzyme, have lower activity in colon. This review, mainly compares the primary approaches for (CTDDS) Colon targeted Drug Delivery system namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process

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