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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
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Articles 2 Documents
 1 
Search results for , issue "Vol. 7 No. 1 (2019)" : 2 Documents clear
A review of wound healing activity on different wound models Verma, Renuka; Gupta, Pushpa Prasad; Satapathy, Trilochan; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 7 No. 1 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.187 KB) | DOI: 10.18231/2348-0335.2018.0013

Abstract

Wound is an injury of living tissue or break in the epithelial integrity of the upper layer of skin. This may lead to disturbance of skin anatomical structure and their function. The normal wounds start to heal immediately after an injury. Normal healing process involved: inflammatory phase, proliferation phase and maturation phase. Now a day wound healing is a challenging clinical problem. So, necessity of effective wound management is required. The various screening models play important role to understand the basic process of tissue repair and treatment of wounds. Wide varieties of in-vitro, ex-vivo and in-vivo models have been developed for evaluation of wound healing activity. The in-vitro models includes Chick chorioallantoic membrane assay, Fibroblast assay, Collagen assay, Scratch assay, Endothelial cell in vitro tube formation assay, Keratinocytes assay. Ex-vivo models includes organotypic culture, human ex vivo skin culture, porcine model, Human organotypic skin explanted culture and the in-vivo models includes Excision wound model, Incision wound Model, Burn wound model, Dead space wound model.The aim of this review article is detailed study of different types of in-vitro, ex-vivo and in-vivo models for evaluation of wound healing activity.
Water-in-Oil-in-Water multiple emulsions of ibuprofen for paediatrics using african walnut seed oil Ogundipe, O. D.; Oladimeji , F. A.
Journal of Applied Pharmaceutical Research Vol. 7 No. 1 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (582.139 KB) | DOI: 10.18231/2348-0335.2018.0014

Abstract

Many prolonged-release dosage forms have employed multiple emulsions (MEs) systems. Hence, this study formulated water-in-oil-in-water (w/o/w) MEs of ibuprofen using African walnut seed oil (AWSO) for paediatrics use. The MEs were prepared by a two-step emulsification method, using Span 80® and Tween 80® as primary and secondary emulsifiers, respectively. The MEs were evaluated by their physical properties, drug entrapment efficiency, stability and drug release profile. From the study, stable MEs of ibuprofen (100 mg / 5 ml) can be prepared with 25 % w/v Span 80® as the primary emulsifier, and 8, 10 or 12 % w/v Tween 80® as the secondary emulsifier. The optimum ratios of oil to water in the primary emulsion were 1:1 and 3:2, while that of primary emulsion to external aqueous phase were 1:1 and 1:2. The amount of the ibuprofen released from the MEs was ≤ 35.6 % at 5 hours. The study offers ibuprofen emulsions which may require once daily dosing compared to other available paediatric dosage forms of the drug which require three to four times dosing daily. It also provides information on AWSO as a possible drug carrier in the formulation of w/o/w MEs of ibuprofen for paediatrics.

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