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<![CDATA[Distribusi Polimorfisme Gen Transforming Growth Factor Beta-1 (T869C) Pada Pasien Psoriasis Di Kota Medan, Sumatera Utara ]]>
<![CDATA[Rahmiwita, Rahmiwita]]>;
<![CDATA[Siregar, Yahwardiah]]>;
<![CDATA[Ichwan, Muhammad]]>
<![CDATA[ Buletin Farmatera Vol 6, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Sumatera Utara ]]>
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DOI: 10.30596/bf.v6i1.3981
<![CDATA[Psoriasis is a chronic inflammatory skin disease with a prevalence in the world around 2-3%. TGF-?1 is a growth factor that has a polymorphism in its genes. The TGF-?1 gene polymorphism plays a role in the pathogenesis of psoriasis. This is a descriptive study with a simple random sampling technique. This study was conducted on the strored of DNA specimens collected from 62 psoriasis patients comprising 33 women and 29 men. This study aims to determine the frequency distribution of the TGF-?1 gene polymorphism (T869C) in patients with psoriasis. The TGF-?1 gene polymorphism (T869C) was determined using PCR-based restricted fragment length polymorphism (PCR-RFLP). TC genotype was the most prevalent (50%) of TGF-?1 (T869C) gene polymorphism in psoriasis patients, followed by TT genotype (6.5%) and CC (43.5%). TC variant is the most variant of TGF-?1 (T869C) gene polymorphism in psoriasis sufferers in Medan]]>
<![CDATA[Deselularisasi Hati sebagai Scaffold Rekonstruksi Organoid Hati ]]>
<![CDATA[Sibuea, Christine Verawaty]]>
<![CDATA[ Buletin Farmatera Vol 6, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Sumatera Utara ]]>
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DOI: 10.30596/bf.v6i1.4560
<![CDATA[The latest approach in tissue engineering techniques is the use of deselularized native organ as scaffolds for organ reconstruction. Scaffolds made from natural or synthetic matrix have many shortcomings in providing ideal extracellular matrix microstructure for cell proliferation and differentiation. Deselularized native scaffold can maintain the extracellular matrix of native organs, as an ideal microstructure scaffold for cell proliferation and differentiation. This technique answers the challenge of high need for liver transplants due to the limitations of liver donors and the need as liver models for drug testing.for drug testing. Liver is a complex organ, so ideal microstructure is needed in liver organoid reconstruction techniques to produce good synthetic and metabolic functions of the liver]]>
<![CDATA[TREATMENT OF ADULT INTUSSUSCEPTION WITH NON-OPERATIVE MANAGEMENT: A CASE REPORT ]]>
<![CDATA[Rahman, Shahrul]]>;
<![CDATA[Anas, Muhammad Al]]>
<![CDATA[ Buletin Farmatera Vol 6, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Sumatera Utara ]]>
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DOI: 10.30596/bf.v6i1.5551
<![CDATA[Intussusceptions, defined as insertion of proximal part of intestine into distal one, it is the second most common acute abdomen pathology after appendicitis. Acute intussusception is one of the common causes of acute intestinal obstruction in children, but on seldom occasions associated with leading points to the intussusceptions. The symptoms are the result of intussusception, like intestinal obstruction, volvulus due to subserosa lipoma and hemorrhage due to ulcerations of the overlying mucosa caused by direct pressure from the lipoma or the intussusception itself. Intussusception in adults is very rare. Most intussusception cases must be treated surgically. In patients who present with a vague history and constellation of abdominal symptoms pointing towards obstruction and are found to have a short segment intussusception, it is a valid option to apply a conservative approach with caution. Based on the available literature, CT scan evaluation seems to have both diagnostic and prognostic value, as it provides enough evidence with regards to signs indicating the need for surgery. Herewith, we describe a rare case of intussusception in Indonesian adult which was successfully treated non-surgically]]>
<![CDATA[Case Report: Preoperative Hormone Replacement Therapy in Hypocortisol and Hypothyroid Patients with Residual Pituitary Adenoma Tumors ]]>
<![CDATA[Nasution, Huwainan Nisa]]>
<![CDATA[ Buletin Farmatera Vol 6, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Sumatera Utara ]]>
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DOI: 10.30596/bf.v6i1.5636
<![CDATA[Pituitary tumors are benign tumors that occur in the pituitary gland with a presentation of 10% of all intracranial tumors. If the size of the tumor is 1 cm, the pituitary tumor is called a macroadenoma, the large size will have a mass effect so that there is an emphasis on the tumor area and its surroundings. This emphasis will manifest in hyposecretion of the hormones produced in the pituitary. We report a case of 57-year-old male with complaints of decreased vision since 3.5 months. The patient had previously been diagnosed with a pituitary tumor 6 years ago and had surgery. After diagnostic steps, the patient is diagnosed with a residual pituitary adenoma tumor with hypocortisol and hypothyroidism. Hormone replacement therapy was performed by administering methilprednisolone tablets 16 mg-0-8 mg and levothyroxine tablets 1 x 50 g. The patient was planned to undergo an Endoscopic Endonasal Excision Tumor surgery with 125 mg/12 hour preoperative injection of methilprednisolon. The provision of preoperative hormone replacement therapy aims to correct hormonal imbalances that can be an intraoperative complication]]>
<![CDATA[Cholesterol Levels After Maximum Physical Activity in White Rats (Rattus Norvegicus) ]]>
<![CDATA[Togatorop, Wilson H. S.]]>;
<![CDATA[Harahap, Novita Sari]]>
<![CDATA[ Buletin Farmatera Vol 6, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Sumatera Utara ]]>
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DOI: 10.30596/bf.v6i1.4630
<![CDATA[The effect of physical activity on biological functions can be either positive or negative influences. Severe physical activity can increase oxygen consumption by 100-200 times compared to resting conditions. Increased use of oxygen, especially by muscle contracting, causes an increase in the number of free radicals. This study aims to determine the effect of maximum physical activity on cholesterol levels in white rats. The research design was used an experimental study with a post-test and control group design. Subjects were male white rats (Rattus Norvegicus), 20 of them were 3-4 months old, body weight was 180-200 grams. Subjects were divided into 2 groups randomly, each group consisted of 10 white rats, namely the control group: not given maximum physical activity; group treated: given maximum physical activity in the form of swimming until almost submerged. The results showed a significant increase in cholesterol levels (p=0.035; p0.05) in the treatment group, namely the group that was given maximum physical activity in the form of swimming to almost drowning, compared to the control group, namely the group that did not swim. The study concluded that there was an effect of maximum physical activity on blood cholesterol levels in white rats (Rattus Norvegicus).]]>
<![CDATA[The Relationship between Changes in Nutrition Status and Length of Hospitalization in Patients in Department of Internal Medicine at University of Sumatera Utara Hospital ]]>
<![CDATA[Lubis, Nenni Dwi Aprianti]]>;
<![CDATA[Sianturi, Chaca Theresia]]>;
<![CDATA[Balatif, Ridwan]]>
<![CDATA[ Buletin Farmatera Vol 6, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Sumatera Utara ]]>
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DOI: 10.30596/bf.v6i1.4446
<![CDATA[The nutritional status of patients is one factor that influences the length of stay. This study is an analytic study with a cross-sectional design aiming to observe nutritional status, length of treatment, and the relationship between the two variables. The population in this study were patients aged 19-64 years who were treated in the Internal Medicine KSM at USU Hospital in the period August to October 2019. 52 patients were the study samples, with consecutive sampling as the sample selection technique used. We collected research data as nutritional status and length of stay through anthropometric measurements and structured interviews. We distinguish nutritional status based on Body Mass Index (BMI) and Subjective Global Assessment (SGA). The results showed 34 patients (65.4%) based on BMI values decreased nutritional status from 21.473.79 to 21.183.83 Kg /m2. Based on SGA, 32 patients (61.5%) experienced a decrease in score. The mean treatment period was 5.021.36 days. From the chi-square test results, it is known that changes in nutritional status based on BMI have a significant relationship to the length of stay with a p-value 0.05.]]>
<![CDATA[ApaI Vitamin D Receptor Gene Polymorphisms in Psoriasis ]]>
<![CDATA[Oentari, Widyaningsih]]>;
<![CDATA[Roesyanto-Mahadi, Irma D]]>;
<![CDATA[Siregar, Yahwardiah]]>
<![CDATA[ Buletin Farmatera Vol 6, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Sumatera Utara ]]>
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DOI: 10.30596/bf.v6i1.6528
<![CDATA[Psoriasis is a chronic autoimmune skin disorder that is an autoimmune disease and still considers a global problem. This condition is suspected to be contributed by genetic and environmental factors. Several studies have shown an association between vitamin D gene receptor polymorphisms and the risk of psoriasis. This study was an observational study, which involved 64 research subjects, who were psoriasis patients. Each subject was interviewed and went through physical examination, also Polymerase Chain Reaction - Restriction Fragment Length Polymorphism (PCR-RFLP) examination to determine ApaI (rs7975232) vitamin D receptor gene polymorphism. After the tabulation of the data, we found that the age of psoriasis onset in this study was 21 to 40 years old with an average of 34.40 14.98 years old. The majority of our subjects ApaI VDR gene polymorphism genotype was aa (53.1%). This is consistent with the results of several studies conducted in Asia.]]>
<![CDATA[The Association Between the Physical Fitness Index and the Grade Point Average in Faculty of Medicine UMSU Students ]]>
<![CDATA[Lubis, Debby Mirani]]>;
<![CDATA[Asfur, Robitah]]>
<![CDATA[ Buletin Farmatera Vol 6, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Sumatera Utara ]]>
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DOI: 10.30596/bf.v6i1.3333
<![CDATA[The GPA (Grade Point Average) is the passing score for each course a student gets every semester which is currently often used as a requirement for further study students (Masters or Specialists) or applying for jobs so that the GPA is considered important to describe student intelligence during taking the educational process. Many things affect student intelligence, one of which will be discussed and proven in this study is the value of the Physical Fitness Index. This study aims to determine the relationship between the Physical Fitness Index and the GPA score of FK UMSU students. This research is an analytical study using a cross-sectional approach. The research site was conducted at the Faculty of Medicine UMSU from April to June 2020. A total of 94 subjects with male gender totaled 25 people (26.6%), women totaled 69 people (73.4%). Based on the measurement of the Physical Fitness Index which was carried out using the Harvard Step Test method, the mean value of all 2018 students was 49.57. The average GPA of all 2018 students was 3.00. Based on the results of the statistical test, the relationship between the Faculty of Medicine UMSU student body fitness index and the cumulative grade point average is p = 0.87. Therefore, it can be concluded that there is no significant association between the Faculty of Medicine UMSU student body fitness index and the grade point average.]]>
<![CDATA[Comparison of the Incidence of Nausea and Vomiting in the Administration of Tramadol 100 mg Suppositories with Intravenous Post-Spinal Anesthesia for Lower Extremity Surgery ]]>
<![CDATA[Putra, Adhi Setia]]>
<![CDATA[ Buletin Farmatera Vol 6, No 1 (2021) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Sumatera Utara ]]>
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DOI: 10.30596/bf.v6i1.6516
<![CDATA[Pendahuluan :Post operative nausea vomiting (PONV) pasca pemberian tramadolPostoperative nausea vomiting (PONV) after intravenous administration of tramadol has a high incidence rate, so it needs alternative drug administration to overcome this problem. This study aims to compare the incidence of postoperative nausea and vomiting in the intravenous administration of tramadol suppositories. A double-blind analytical experimental study, involving 36 subjects divided into tramadol suppositories and intravenous tramadol post-extremity surgery with spinal anesthesia at Haji Adam Malik Hospital and Network Hospital in 2013. The incidence of PONV in tramadol suppository subjects was much lower than in intravenous tramadol subjects.]]>
