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All Journal Buletin Farmatera Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Indonesian Journal of Health Sciences Research and Development (IJHSRD) Jurnal Kesehatan Tambusai Eduvest - Journal of Universal Studies Journal of General Procedural Dermatology and Venereology Indonesia Jurnal Multidisiplin Indonesia
Oentari, Widyaningsih
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Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Noninvasive diagnostic modality for skin cancer Siregar, Remenda; Nurhayati, Raja; Oentari, Widyaningsih; Sari, Ari Karmila
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 2
Publisher : UI Scholars Hub

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Abstract

Histopathological examination is the gold standard for the diagnosis of nonmelanoma and melanoma skin cancer, but it is an invasive procedure that consumes time and requires large costs. The average cure rate for skin cancer is high with early detection and appropriate treatment. This is an article review that was made through findings from several scientific articles. There are several noninvasive imaging modality choices that can be used for screening at low cost, high quality, and faster result, which includes dermoscopy, optical coherence tomography, reflectance confocal microscopy, electrical impedance spectroscopy, multispectral imaging, and SIAscopy®. These imaging modalities can assist in the detection of skin cancer using a combination of high-quality computer science, mathematics, and optics. This can improve the efficiency of diagnosis and management, reduce treatment costs, and increase patient satisfaction while utilizing teledermatology.
Intense pulsed light (IPL) as adjuvant therapy for acne vulgaris: A case series Oentari, Widyaningsih; Sutrisno, Angie Regina; Jusuf, Nelva Karmila; Nasution, Khairina
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 3
Publisher : UI Scholars Hub

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Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicle with polymorphic clinical manifestation typically found on facial, neck and/or back area. The pathogenesis is complex and multifactorial. Management of acne vulgaris is determined based on its severity. Adjuvant therapies, such as intense pulsed light (IPL), have been described in accelerating the healing process during treatment. Case Illustration: We report two cases regarding the usage of IPL as adjuvant therapy in acne vulgaris. Both patients were diagnosed with moderate acne vulgaris. The first patient was given topical adapalene 0.1% gel every night and sunscreen in the morning, and the other patient was given clindamycin gel applied twice a day, benzoyl peroxide 2.5% cream applied once a day at night, and sunscreen in the morning. Both patients were treated using IPL as their adjuvant therapy every three weeks, with a total of 2 IPL sessions in 2 months. Evaluation using clinical and ultraviolet-induced red fluorescence (UVRF) examination showed gradual improvement. Discussion: IPL as an adjuvant therapy of acne vulgaris has been thought to interfere with the function of the sebaceous glands by its direct phototoxic effects and thermal damage. It also has bactericidal effects on C. acnes through the formation of free radicals. The combination of topical treatment and IPL yielded clinical improvements in both patients.Conclusion: IPL may be beneficial as adjuvant therapy in acne vulgaris in this case series.
Management of basal cell carcinoma with excision followed by rotation advancement flap Siregar, Remenda; Puspita, Fitri; Oentari, Widyaningsih; Sari, Ari Karmila
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 3
Publisher : UI Scholars Hub

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Background: Basal cell carcinoma (BCC) is the most common malignant skin tumor and is derived from pluripotent cells in the basal layer of the epidermis. One of the BCC management options is surgery followed by a skin flap to close the wound defect. Case Illustration: We present a 43-year-old woman with a major complaint of non-healing sores on the left zygomatic region, close to the medial canthus, with frequent episodes of bleeding and itching since one year before admission. The lesion was excised and followed by histopathological examination, which revealed the BCC diagnosis with tumor-free edges. Closure of the defect with a rotation advancement flap was performed with good results. Discussion: The diagnosis of BCC in this patient was based on history taking, dermatological and histopathological examination. According to the dermatological examination, the patient presented with superficial ulcers with hyperpigmented bases, irregular margins and raised edges, partly covered by crust in the left zygomatic region, consistent with typical clinical manifestation of BCC. Histopathological findings of BCC may vary according to the subtype. However, most cases of BCCs usually have similar histological characteristics. Conclusion: The functional and cosmetic result of BCC following excision and defect closure with rotation advancement flap yielded good results with a shorter healing time.
ApaI Vitamin D Receptor Gene Polymorphisms in Psoriasis Oentari, Widyaningsih; Roesyanto-Mahadi, Irma D; Siregar, Yahwardiah
Buletin Farmatera Vol 6, No 1 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i1.6528

Abstract

Psoriasis is a chronic autoimmune skin disorder that is an autoimmune disease and still considers a global problem. This condition is suspected to be contributed by genetic and environmental factors. Several studies have shown an association between vitamin D gene receptor polymorphisms and the risk of psoriasis. This study was an observational study, which involved 64 research subjects, who were psoriasis patients. Each subject was interviewed and went through physical examination, also Polymerase Chain Reaction - Restriction Fragment Length Polymorphism (PCR-RFLP) examination to determine ApaI (rs7975232) vitamin D receptor gene polymorphism. After the tabulation of the data, we found that the age of psoriasis onset in this study was 21 to 40 years old with an average of 34.40 14.98 years old. The majority of our subjects ApaI VDR gene polymorphism genotype was aa (53.1%). This is consistent with the results of several studies conducted in Asia.
UJI EFEKTIVITAS EKSTRAK KULIT PISANG BARANGAN ( MUSA ACUMINATA LINN ) SEBAGAI ANTIBAKTERI TERHADAP STAPYLOCOCCUS AUREUS SECARA IN VITRO Filzah, Cut Echi Razita Sabrina; Chandra, Rudi; Oentari, Widyaningsih
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.38983

Abstract

Penyakit kulit sering terjadi di Indonesia, karena Indonesia merupakan negara beriklim tropis yang mendukung perkembangan parasit, bakteri, jamur, dan virus. Kondisi ini bisa menyerang siapa saja dan dapat muncul diberbagai bagian tubuh. Infeksi bakteri seringkali menjadi penyebab utama penyakit kulit, dengan Staphylococcus aureus menjadi salah satu penyebab yang paling umum.Staphylococcus aureus merupakan salah satu bakteri patogen utama yang ada pada manusia yang umumnya flora normal tetapi, dapat juga menyebabkaninfeksi dengan berbagai manifestasi klinis. Infeksi terjadi karena kemampuan bakteri ini untuk berkembang biak, menyebar kedalam jaringan serta melalui produksi berbagai bahan ekstraseluler diantaranya : enzim, toksin, dan lain-lain. Ada 3 metabolit yang dihasilkan oleh bakteri Staphylococcus yaitu : nontoksin, eksotoksin, dan enterotoksin.Jenis penelitian yang digunakan adalah penelitian eksperimental dengan metode kuantitatif dengan rancangan penelitian true experimental dengan Posttest Only Control Group Design.Pada penelitian ini digunakan rumus federer. Variabel bebas penelitian ini adalah ekstrak kulit pisang barangan (Musa Acuminata linn) dengan kosentrasi 25%, 50%, 75%, 100%. Variabel terikat penelitian ini adalah zona hambat bakteri Staphylococcus aureus. Adapun kesimpulan yang didapat oleh peneliti untuk hasil penelitian tersebut antara lain Analisis statistik menggunakan ANOVA menunjukkan perbedaan yang signifikan antara kelompok perlakuan (F = 12,026, p = 0,001). Uji post-hoc Tukey HSD mengungkapkan bahwa perbedaan signifikan terdapat antara konsentrasi 25% dengan 75% dan 100% (masing-masing p = 0,002 dan p < 0,001), serta antara konsentrasi 50% dengan 100% (p = 0,017). Tidak terdapat perbedaan signifikan antara konsentrasi 75% dan 100% (p = 0,575), yang menunjukkan bahwa efek antibakteri mulai mendekati saturasi pada konsentrasi tertinggi.
The Relationship Between Personal Hygiene And Skin Complaints In Orphanage Children In The Medan Area District Lubis, Adhayani; Raja Siambaton, Michael Bahal; Oentari, Widyaningsih
Jurnal Multidisiplin Indonesia Vol. 2 No. 12 (2023): Jurnal Multidisiplin Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jmi.v2i12.864

Abstract

Personal hygiene is a person's self-care to maintain cleanliness and health for physical and psychological well-being. Hygiene maintenance is necessary for individual comfort, safety, and health. One of a person's hygiene efforts is to care for skin hygiene. Low hygiene can be one of the precipitating factors for developing skin diseases. Orphanages are social institutions that accommodate, educate, and care for abandoned children, orphans, orphans, and orphans. Environmental conditions in the orphanage can cause many children to experience skin diseases, such as itching, heat or burning, bumps, and white patches, usually caused by the lack of clean water, alternating use of towels, and rarely changing bed linen and pillowcases. This study aimed to determine the relationship between personal hygiene and skin complaints in orphanages in Medan Area District. This research is analytical and uses a quantitative approach with a cross-sectional research design. This study used a sample of 77. Data in this study were collected through questionnaires and then analyzed using univariate and bivariate tests using Chi-Square. It was continued with validity and reality tests. Based on univariate tests, the majority of respondents have good personal hygiene. Based on bivariate tests using Chi-Square, it is known that the p-value is <0.05, so it can be concluded that there is a relationship between personal hygiene and skin complaints.
Pengaruh Ekstrak Daun Buncis (Phaseolus vulgaris L.) Terhadap Uji Antioksidan Dan Anti Aging Tikus Galur Wistar Yang Terpapar Sinar UVB Pratama, Oky; Trishna, Trishna; Oentari, Widyaningsih
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 2 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i2.621

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak daun buncis (Phaseolus vulgaris L.) terhadap aktivitas antioksidan dan anti-aging pada tikus galur Wistar yang terpapar sinar UVB. Paparan sinar UVB dapat menyebabkan stres oksidatif dan penuaan dini dengan meningkatkan produksi radikal bebas pada kulit. Dalam penelitian ini, tikus diberi perlakuan dengan dosis ekstrak daun buncis yang berbeda, kemudian dilakukan pengukuran aktivitas antioksidan melalui uji biokimia. Efek terhadap tanda-tanda penuaan juga dianalisis melalui pemeriksaan histologi kulit dan kadar kolagen. Hasil penelitian menunjukkan bahwa ekstrak daun buncis secara signifikan meningkatkan aktivitas antioksidan dan mengurangi tanda-tanda penuaan pada kulit tikus yang terpapar sinar UVB. Temuan ini menunjukkan bahwa ekstrak daun buncis berpotensi sebagai agen alami untuk mencegah stres oksidatif dan penuaan kulit yang disebabkan oleh paparan sinar UVB.
Test of The Effectiveness of Kepok Banana Peel Extract Serum on Hair Growth in Guinea Pigs Sihombing, Fenny Theresia; Chandra, Rudi; Oentari, Widyaningsih
Eduvest - Journal of Universal Studies Vol. 5 No. 2 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i2.50896

Abstract

Hair plays an important role in supporting appearance and confidence, while hair loss is a common problem. In Indonesia, the prevalence of hair loss reaches 20% in adults and increases with age. Natural approaches such as Kepok banana peel extract, which is rich in antioxidants, flavonoids, and vitamins, are increasingly in demand as an alternative to hair care. This study aims to evaluate the effectiveness of Kepok banana peel extract serum on hair growth in guinea pigs. The method used was a laboratory experimental study with five treatment groups, namely Kepok banana peel extract serum with concentrations of 20%, 30%, 40%, negative Control, and positive Control (minoxidil® 5%). Each group consisted of five guinea pigs (n = 5), and observations were made over four weeks. The results showed that the 30% concentration of Kepok banana peel extract serum had the best effectiveness, with an average hair growth of 0.17814 ± 0.084711 g, close to the effectiveness of 5% minoxidil® (0.19124 ± 0.050439 g). Statistical analysis showed a significant difference between the negative Control and the 30% treatment (p = 0.003 in the third week). In conclusion, Kepok banana peel extract serum with a concentration of 30% has the potential to be an effective alternative to hair care
Laporan Awal: Survei Berbasis Situs Daring Mengenai Kekambuhan Psoriaris Pascavaksinasi Coronavirus Disease (COVID)-19 di Sumatera Utara, Indonesia Chandra, Rudi; Oentari, Widyaningsih; Djohan, Djohan; Natali, Oliviti
Majalah Kedokteran Indonesia Vol 73 No 3 (2023): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.73.3-2023-972

Abstract

Introduction: Psoriasis is a chronic inflammatory skin disorder that is often associated with autoimmune conditions. Vaccination has been considered one of the external factors that can trigger psoriasis flare. Recently, there have been reports linking the COVID-19 vaccine to the occurrence of psoriasis flare. The objective of this study was to examine the impact of COVID-19 vaccination on the incidence of psoriasis flares in Indonesia. Methods: This web-based cross-sectional study utilized Google forms and was conducted from September 2020 to February 2021 in North Sumatera, Indonesia. The study included psoriasis patients aged less than 18 years who had received COVID-19 vaccines. Data were collected and analyzed descriptively. Result: Out of 130 respondents, most were women (60.8%) aged 26-35 years (33.1%) with a disease duration of 1-10 years (48.5%). The most common type of psoriasis before vaccination was plaque and scalp (20.4%). Approximately 80% had no history of COVID-19 infection prior to vaccination, and 71.5% received the Sinovac vaccine. Among them, 49 respondents (37.7%) experienced flares after vaccination, mainly following the first dose (57.1%) and predominantly with Sinovac (77.6%). Flares were more common in women (67.3%) aged 26-35 years (28.6%) with disease duration of 1-10 years (59.2%). Most flares occurred greater than 2 weeks after vaccination (51%), and the post-vaccination type of psoriasis was frequently plaque and scalp (24.5%). Conclusion: The incidence of psoriasis flares after COVID-19 vaccinations was 37.7%. The administration of COVID-19 vaccinations may play role as a potential trigger for flares in psoriasis patients.
THE RELATIONSHIP BETWEEN DIET AND ACNE VULGARIS IN STUDENTS OF FACULTY OF MEDICINE 2022-2023 PRIMA INDONESIA UNIVERSITY : DIET AND ACNE VULGARIS Valensia, Valensia; Oentari, Widyaningsih; Chandra, Rudi
INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD) Vol. 6 No. 2 (2024): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
Publisher : STIKes Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36566/ijhsrd/Vol6.Iss2/277

Abstract

Background: The skin is the outermost part of the body that functions as a barrier between humans and the environment. The structure of the skin is affected by various factors such as climate, age, gender, race, and location in the body. The skin consists of 3 main layers, namely the epidermis, dermis, and subcutaneous. In addition, the skin has sebaceous glands or oil glands located on the skin, hair, and nails. These glands function to maintain skin moisture, especially when they are active and developing during puberty. However, activity can also cause skin problems, such as warts, dermatitis, and acne vulgaris. Methods: The type of research conducted is observational analytical research on the Kendall's Tau design approach. The sampling technique is stratified random sampling. As many as 98 respondents were obtained who met the inclusion criteria of the research object. Results: Shows that the most commonly found sex is female. This study shows that there is no relationship between milk consumption and acne vulgaris. Conclusion: Based on the results of the study, there was no significant relationship between the frequency of milk consumption and acne vulgaris, the amount of milk consumption per day and per week, because milk contains zinc and vitamin A. Zinc functions as an anti-inflammatory agent in acne by inhibiting the growth of C. acnes bacteria, and milk contains vitamin D, so it has a pleiotropic effect that can prevent lesions in acne vulgaris.
Co-Authors Djohan Djohan Filzah, Cut Echi Razita Sabrina Fitri Puspita Fransisca, Silvia Harmila, Riva Nita Jusuf, Nelva Karmila Lubis, Adhayani Nasution, Khairina Natali, Oliviti Nurhayati, Raja Pratama, Oky Raja Siambaton, Michael Bahal Remenda Siregar, Remenda Roesyanto-Mahadi, Irma D Rudi Chandra Sari, Ari Karmila Sihombing, Fenny Theresia Sutrisno, Angie Regina Trishna, Trishna Valensia, Valensia Yahwardiah Siregar