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Sumatera utara
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Buletin Farmatera
Published by Universitas Muhammadiyah Sumatera Utara
ISSN : 2528410X     EISSN : 2528410X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 244 Documents
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Effect of Vitamin E Use on Hot Flash Reduction in Menopausal Women Fadlullah Asykari Sibagariang; Rahmanita Sinaga
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract

Abstract : Hot flash is a sudden hot sensation that usually appears in the chest, neck, and face, accompanied by sweating, heart palpitations, and can be triggered by a warm environment, hot drinks, or emotional stress. These symptoms are often the main reason women seek medical care during perimenopause because it can interfere with quality of life. Vitamin E, with its antioxidant properties, has been shown to be able to reduce the intensity and frequency of hot flashes through improved adrenal function. This study aims to assess the effect of Vitamin E administration on the reduction of hot flashes in menopausal women. The method used was an experiment with administering Vitamin E daily for four weeks to the study subjects. Data was obtained from a questionnaire of hot flash patients in 2022 at Bhayangkara Hospital Medan based on a doctor's examination and the HFRS scale. The results of the statistical test showed a P-Value of 0.000, lower than alpha 0.05, so the null hypothesis was rejected. In conclusion, Vitamin E is significantly effective in reducing hot flashes in menopausal women.
The Effect Of Smart Phone Use Intensity On Academic Procrastination And Learning Motivation Of Students At Muhammadiyah University Of North Sumatera Rif'at Zulkarnain; Ratih Yulistika Utami
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract

Abstract: Indonesia is a country with more than 190 million smartphone users. This makes Indonesia the fourth largest smartphone user in the world after China, India, and the United States. Students tend to use smartphones with high intensity. High smartphone use can lead to smartphone addiction. Objective: to analyze the effect of smartphone usage intensity on academic procrastination behavior and learning motivation in students at the University of Muhammadiyah North Sumatra. Method: This research is an analytical study using a cross-sectional method, with a sample of 63 people divided into 7 people each from 9 faculties at the University of Muhammadiyah North Sumatra. The sampling technique uses the Probability Sampling procedure, namely Consecutive Sampling. All samples filled out three questionnaires to measure the intensity of smartphone use, learning motivation, and academic procrastination. The data obtained will be analyzed using univariate and bivariate analysis techniques, then to test the hypothesis using the Spearman test to assess whether there is an influence between the independent and dependent variables. Results: The Spearman correlation test showed that smartphone usage intensity influenced academic procrastination among students at the University of Muhammadiyah North Sumatra, with a correlation coefficient of 0.790 (p-value of 0.001). The correlation coefficient of smartphone usage on learning motivation among students at the University of Muhammadiyah North Sumatra was -0.531 (p-value of 0.001), indicating a strong and negative relationship between the two variables. Conclusion: High smartphone usage intensity will increase academic procrastination, while high smartphone usage intensity will decrease student learning motivation.
Pengaruh Pemberian Ekstrak Rumput Bambu (Lophatherum gracile) sebagai Hepatoprotektor pada Mencit Jantan (Mus musculus) Zidan Imana Putra Fauzi; Des Suryani
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract

Abstract: The use of paracetamol in toxic doses can cause impaired liver function. Bamboo grass is a plant that contains antioxidants, so it can be a hepatoprotector in protecting the liver from damage caused by paracetamol. The dose of Lopatherum gracile as a hepatoprotector has been studied in the dose range of 200 mg/kg body weight and 800 mg/kg body weight, with an effective dose result of 800 mg/kg body weight. The purpose of this study was to determine the effective dose of the hepatoprotector of bamboo grass extract against paracetamol-induced liver function in mice. This study is a true experiment with a post-test-only control group design. 5 groups were given treatment for 7 days, namely the negative control group (C-), positive control (C+), treatment 1 (T I): 400 mg/kg body weight, treatment 2 (T II): 600 mg/kg body weight, and treatment 3 (T III): 800 mg/kg body weight.  The SGOT and SGPT levels between groups were analysed by one-way ANOVA and post hoc Bonferroni. The results of the ANOVA test showed a significant difference in the level of SGOT and SGPT, namely p=0.001. The post hoc test showed no significant difference in SGOT and SGPT levels between T(II) and T(III), with negative controls of p:0.242, and p:0.100, and there was no significant difference in average SGOT between T2 and T3. The effective dose of hepatoprotector of bamboo grass extract in a group of paracetamol-induced mice was 600 mg/kg body weight.
The Effect of Mangrove Leaf Extract (Rhizophora apiculata) on Blood Cholesterol Levels of White Mice (Mus musculus) Induced by Egg Yolk Putri Ridha Yuliansyah; Nurfadly Nurfadly; Emni Purwiningsih; Humairah Medina Liza Lubis
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract

Abstract: Cholesterol is the primary sterol in the human body, produced by the liver. While essential, excessive cholesterol can accumulate as plaques in blood vessels. Rhizophora apiculata contains secondary metabolites such as flavonoids, tannins, alkaloids, saponins, and terpenoids, which are believed to influence HDL and LDL levels. This study aims to investigate the effect of Rhizophora apiculata leaf extract on HDL and LDL levels in male white mice (Mus musculus) induced with egg yolk. This true experimental study applied a post-test with a control group design. A total of 36 white mice were divided into six groups, consisting of negative, positive, and treatment groups. Mice were acclimatised for one week, induced with quail egg yolk, and administered Rhizophora apiculata leaf extract for 30 days. Blood HDL and LDL levels were then measured and analysed using One-way ANOVA. The Shapiro-Wilk and Levene’s tests showed p-values 0.05. The One-way ANOVA indicated significant differences in HDL and LDL levels between groups (p0.05). LSD post hoc tests showed treatment groups P1, P2, and P3 differed significantly from the negative control. Rhizophora apiculata leaf extract affects HDL and LDL levels in male white mice induced by egg yolk.

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