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Majalah Farmaseutik

majalahfarmaseutik
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Published by Universitas Gadjah Mada

ISSN : 1410590x EISSN : 26140063 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Majalah Farmaseutic accepts submission concerning in particular fields such as pharmaceutics, pharmaceutical biology, pharmaceutical chemistry, pharmacology, and social pharmacy.

Arjuna Subject : -

Articles 6 Documents

Search results for , issue "Vol 12, No 2 (2016)" : 6 Documents clear

ORALLY DISINTEGRATING TABLET MELOXICAM FORMULATION WITH VARIATION CONCENTRATION OF AC-DI-SOL® AND KOLLIDON CL® AS SUPERDISINTEGRANT AGENT Angi Nadya Bestari; T.N. Saifullah Sulaiman; Abdul Rohman
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Meloxicam is one of the most commonly prescribed anti-inflammatory drugs which is widely consumed by elderly patients. Meanwhile, elderly patients often have difficulty in consuming conventional tablets. Orally disintegrating tablet (ODT) is a solid dosage form that quickly dissolves when placed on the tongue and is expected to be the solution for patients who have difficulty consuming conventional tablets. The research aimed to formulate ODT meloxicam with a variation of superdisintegrant agent, Ac-Di-Sol and Kollidon CL, and obtain the superdisintegrant agent composition of the optimum formula. ODT contained 7,5 mg meloxicam as the active ingredient and excipients were included of Ac-Di-Sol and Kollidon CL as superdisintegrant agent, Avicel PH 102 as a filler binder, and magnesium stearate and talcum as a lubricant. Design Expert 7.1.5 software helped to determine the formula and optimum formula based on the composition of superdisintegrant agent, Ac-Di-Sol and Kollidon CL. ODT was made by direct compression method and was evaluated its physical properties of granul and tablet. The data then compared with the literature and analyzed later to get the optimum formula. The results showed that Kollidon CL could accelerate the disintegration time, while Ac-Di-Sol prolonged the disintegration time of ODT. The formula which consists of 4,5 mg Ac-Di-Sol and 10,5 mg Kollidon CL had DE60 93,12%. The optimum formula consisted of 5,4 mg Ac-Di-Sol and 9,6 mg Kollidon CL which resulted in 4,1 kg hardness response, 0,47% friability, 23 seconds disintegration time, and 19 seconds wetting time.

SITOTOXICITY OF COMPOUND ISOLATED FROM THE LEAVES OF TITHONIA DIVERSIFOLIA (HEMSLEY) A.GRAY) AGAINST T47D, MCF-7 AND EVSA-T CELLS Arfian Bela Mahardika; Subagus Wahyuono; Mae Sri Hartanti Wahyuningsih
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Tithonia diversifolia (Hemsley) A. Gray) is one of the plants that are traditionally used to treat various diseases. The previous studies using Bioassay Guided Isolation methods has obtained the active compound (MTT, HeLa cells; IC50 9.776 g / mL). The cytotoxic effects of active compounds against breast cancer cells is unknown. This study aims to determine the cytotoxicity of theactive compound isolated from the leaves of T. diversifolia on breast cancer cells (T47D; MCF-7 and EVSA-T). The isolated compounds from T. diversifolia tested their cytotoxicity against breast cancer cells (T47D, MCF-7 and EVSA-T), using MTT method with a series of concentration of 0.39 to 50 ug/mL. Each concentration of the group performed triplicate and calculated the percentage of cell growth inhibition with probit analysis to calculate the IC50 value. The test results showed that the active compound have a cytotoxic effect on T47D, MCF-7 and EVSA-T cells with IC50 values are respectively (2.44; 4.697; 3.522) ug/mL, so this compound potential to be developed as an anticancer agent, especially breastcancer

OPTIMIZATION OF FAMOTIDINE FLOATING TABLET FORMULA WITH COMBINATION OF HYDROXY PROPYL METHYL CELLULOSE K100M AND ETHYL CELLULOSE POLYMER Veronica Vita Adyanti; Angi Nadya Bestari; T. N. Saifullah Sulaiman
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Famotidine is a gastric ulcer drug, which has a low bioavailability and a short half-life, therefore the dosage form that can maintain its existence in gastric is necessary to maximize its efficacy inhibiting H-2 receptor. Floating tablet can be an alternative because it can increase drug residence time in the gastric. This study aims to identify the combination effect of HPMC K100M and ethyl cellulose towards the physical characteristic of famotidine floating tablet and get an optimum ratio of both polymers. The formulas are made based on simplex lattice design method by using Design Expert® 10 software. Optimum formula is obtained by analyzing the parameters, which are significantly influenced by the difference of polymer concentration with numerical optimization and verified by IBM SPSS Statistics 19 software with one sample t-test method. Increased level of HPMC K100M gives a significant effect on increasing the medium absorption rate by granules and swelling index, decreasing dissolution rate, and accelerating floating lag time. Increased level of ethyl cellulose gives a significant effect on increasing flow rate of granules, tablet hardness, and drug release rate, decreased tap index of granules and tablet friability. The interaction of both polymers can improve swelling index and reduce the dissolution rate. The combination of HPMC K100M with 18,53% w/w concentration and ethyl cellulose with 16,47% w/w concentration can provide the optimum physical characteristic of famotidine floating tablet.

INPATIENT SATISFACTION ANALYSIS OF THE NATIONAL HEALTH INSURANCE USERS IN QUALITY SERVICES IN WARD OBSTETRICS AND GYNECOLOGY HOSPITAL YOGYAKARTA SLEMAN Shanendra Ulfa F; Abdul Karim Zulkarnain
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Along with the expanding world of health, the hospital’s role has grown into a service industry that is strongly influenced by the market. Consumers have become one factor in determining the existence of the service industry. Customer satisfaction becomes an important thing that needs to be considered in order to sustain the industry from fierce competition. The purpose of this study was to measure the level of satisfaction of the patients on the National Health Insurance in obstetrics and gynecology hospital ward Yogyakarta Sleman, especially in terms of quality of service. Samples are selected patients with accidental sampling method with a number of 100 respondents. Research instrument used was a questionnaire with closed questions. Data were processed descriptively and analyzed to determine the level of compatibility between performance and expectations along with paired t test, gap test, chi square test and contingency coefficient. Based on Cartesian diagram the service performance of assurance, empathy, and tangibles dimensions have been implemented well and its performance should be maintained. While the dimensions of reliability and responsiveness is considered less important for the patient. Patients are not satisfied on the dimensions of reliability, responsiveness, assurance, and empathy. While the patients had been satisfied in tangibles dimension, characteristics of age and education did not significantly influence patient satisfaction. Whereas, the employment and income characteristics significantly influence patient satisfaction.

PIPER BETLE EXTRACT PATCH (Piper betle L): THE INFLUENCE IN ADDING REALESE ENHANCER SUBSTANCES TOWARDS PHYSIOCHEMICAL AND ANTIBACTERIAL ACTIVITY Mufrod Mufrod; Suwaldi Suwaldi; Subagus Wahyuono
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Piper betle extract has an antibactery activity with eugenol as a major active substance its sparingly soluble in water. Piper betle extract mucoadhesive patch was a suitable form used in oral cavity for inhibiting Streptococcus mutans a bactery that caused plaque. Physicochemical properties and the release of active substance affect the acceptability of patch as well as antibacterial activity. Glycerin, propilen glycol and tween 80 are the substances(release enhancer substances/RES) that affect the flexibilty and release the active substance from patc. The aim of the research was to investigate the influance of the concentration of extract and addition of RES to the physicochemical and antibacterial activity of the patchs. Extract obtained by infusion method. Extract piper betle made based on variation concentration of extract 0,5%, 1%,2%,3% ,4% and adding release enhancer subtances glycerin, propilen glycol and tween 80. Patches produced tested for physicochemical properties including uniformity of weight, surface pH, folding endurance, swelling index and antibactery activity. Data obtained were descriptiv and statisticaly analize. The result showed that release enhancer substances affect the physicochemical properties and antibactery activity of the patches. The adding release enhancer substances increasing the value of folding endurance and swelling index and antibactery activity of patch.

OPTIMIZING FORMULA OF FAST DISINTEGRATING TABLET NATRIUM DICLOFENAC β-CYCLODEXTRIN INCLUSION COMPLEX WITH CROSPOVIDONE AS THE SUPERDISINTEGRANT AND MICROCRYSTALLINE CELLULOSE PH 102 AS THE FILLER BINDER Wahyu Irawan; T.N. Saifullah Sulaiman
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Natrium diclofenac (Na-DCF) is one of non-steroidal anti-inflammatory drug (NSAID) that have a bitter taste. The inclusion complex of NaDCF with β-cyclodextrin (BSD) can be made to mask the unpleasant taste. The inclusion complex of natrium diclofenac-β-cyclodextrin (NaDCFBSD) was prepared by spray drying method in 1:1 molar ratio. NaDCF, BSD, and NaDCF-BSD inclution complex was characterized by Fourier Transform Infrared Spectroscopy (FTIR). NaDCF-BSD complex was formulated into Fast Disintegrating Tablet (FDT) by optimizing crospovidone as superdisintegrant and microcrystalline cellulose (MCC) PH 102 as filler binder. FDTs were made by direct compression method. A respond test of taste was conducted on the FDT of optimum formula. The optimum physical properties of FDTs were produced by formulating 5,79% crospovidone and 39,21% MCC PH 102. The respond test of taste results showed that FDT with NaDCF in inclution complex have a better taste than FDT with NaDCF without inclusion complex.

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