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PENGARUH PENGECILAN UKURAN PARTIKEL PADA KASUS PEMBUATAN PULVERES DARI TABLET IBUPROFEN TERHADAP KECEPATAN DAN PROFIL DISOLUSI SERTA STABILITASNYA bestari, angi nadya; Sulaiman, T.N Saifullah; Purnamasari, Dita Ayu
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Fakultas Farmasi Universitas Gadjah Mada

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Pelepasan zat aktif dari sediaan salah satunya bergantung pada sifat fisika kimia obat yaitu luas kontak muka. Semakin kecil ukuran partikel maka luas kontak muka akan semakin besar. Luas kontak muka akan mempengaruhi disolusi dan stabilitasnya. Penelitian ini bertujuan untuk mengetahui pengaruh perubahan bentuk sediaan tablet menjadi sediaan pulveres terhadap kecepatan disolusi, profil disolusi dan stabilitasnya.Tablet ibuprofen konvensional utuh digerus dan diblender menjadi sediaan pulveres dan dilakukan uji disolusi menggunakan alat disolusi USP tipe II yaitu metode paddle dengan medium dapar fosfat pH 7,2. Pengungkapan hasil uji disolusi meliputi nilai Q30, DE45, konstanta laju disolusi (k). Kemiripan profil disolusi setiap sediaan dapat diketahui melalui perhitungan similarity factor (f2). Pulveres hasil penggerusan mortir-stamper dan blender ditinjau stabilitasnya dari aspek sifat organoleptis, profil disolusi, kecepatan disolusi dan kadarnya setelah masa penyimpanan selama 1, 2, 3 dan 4 minggu.Hasil disolusi menunjukkan bahwa perubahan bentuk sediaan dari sediaan tablet menjadi sediaan pulveres meningkatkan kecepatan dan profil disolusi dari 0,0627 menit-1 menjadi 0,3466 menit-1 dan 0,2981 menit-1 (p=0,029) serta nilai DE45 dariÂ 66,52% menjadi 96,76% dan 96,17% (p=0). Pulveres gerus dan pulveres blender stabil selama 4 minggu penyimpanan karena tidak menunjukkan perubahan sifat organoleptis dan nilai DE45 (%), konstanta laju disolusi (k) serta kadar zat aktif yang tidak berbeda secara signifikan (p>0,05).

Optimization Formula Tablet Extract of Bengkuang (Pachyrrhizus erosus) Variation Avicel® Ph 101 and Crospovidone Rizki Kharisma; Ika Puspita Sari; Angi Nadya Bestari
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Bengkuang (Pachyrrhizus erosus) contains daidzein which is pro-estrogenic compound, suppressing bone restoration by directing mechanism in bone estrogen receptor. Bengkuang can be developed into a useful source of phytoestrogens as a supplement in menopausal women. This study aims to determine the stability and influence of Avicel® PH 101 and crospovidone on granular flow properties and physical properties of Bengkuang tuber extract. Bengkuang tuber extracts were made into tablet preparations by wet granulation method. Variation of crospovidone composition was between 2-5%, while Avicel® PH 101 was between 38.86 to 41.86%. The tablet formulation is optimized using the Simplex Lattice Design method. The results show that the addition of Avicel® PH 101 can improve the index of determination, water absorption, moisture content, hardness, time of disintegration, and friability of the tablet, as well as crospovidone addition. Avicel® PH 101 and crospovidone interactions increase water content, decrease hardness, and tablet friability. The optimum tablet formula consists of composition of 293 mg of Avicel® PH 101 and 14 mg of crospovidone per tablet. Testing of optimum formula results with SLD method did not differ significantly to the response of the compression index, hardness and friability of the tablet. The tablet was stable at room temperature (30ºC ± 2 ºC) for four weeks.

Evaluation of Students’ Skills in Compounding of Divided Powders M Rifqi Rokhman; Hardika Aditama; Angi Nadya Bestari
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 9, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Several types of medicines for pediatric patients are not commercially available in appropriate dosage forms. While divided powder resulted from compounding process is an alternative to address this problem, the dosage accuracy is still profoundly a major issue. This research was aimed at comparing student’s ability prior to and after taking compounding practical work and analyzing weight accuracy of divided powders compounded by students. This research was designed as a pre-post study. Students who were taking compounding practical work (for 12 weeks) in 2017 were asked to fill a prescription contained divided powders in the beginning and the end of the semester, given enriched learning material of compounding technique videos and feedback as evaluation of their pretest results. The data is presented in the form of a percentage, while differences between pretest and post-test are compared utilizing Wilcoxon test. This study suggests that there was a significant increase of students’ ability in calculating the amount of each ingredient required to fill the prescription, choice of label color, approximating the beyond-use date, folding the divided powders, and making a copy of the prescription. However, there was a small number of students (15.3%) whose divided powders they have dispensed were in the allowed weight range. This study documents the need for quality assessment of medications prepared by students quantitatively and this assessment serves as a parameter of student performance.

PENGGUNAAN SIKLODEKSTRIN DALAM BIDANG FARMASI Angi Nadya Bestari
Majalah Farmaseutik Vol 10, No 1 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Obat dengan rasa yang tidak enak dan kelarutan yang rendah menjadi permasalahan dalam bidang farmasi. Pembentukan kompleks obat dengan siklodekstrin, dikenal sebagai kompleks inklusi, diketahui dapat meningkatkan kelarutan, laju disolusi, bioavailabilitas, stabilitas, dan menutupi rasa tidak enak dari obat. Artikel ini membahas tentang siklodekstrin ditinjau dari penggolongannya serta cara pembentukan, metode pembuatan, karakterisasi, dan hasil studi terhadap kompleks inklusi yang terbentuk. Siklodekstrin telah digunakan secara luas dalam bidang farmasi dan mempunyai potensi besar pada masa mendatang

ORALLY DISINTEGRATING TABLET MELOXICAM FORMULATION WITH VARIATION CONCENTRATION OF AC-DI-SOL® AND KOLLIDON CL® AS SUPERDISINTEGRANT AGENT Angi Nadya Bestari; T.N. Saifullah Sulaiman; Abdul Rohman
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Meloxicam is one of the most commonly prescribed anti-inflammatory drugs which is widely consumed by elderly patients. Meanwhile, elderly patients often have difficulty in consuming conventional tablets. Orally disintegrating tablet (ODT) is a solid dosage form that quickly dissolves when placed on the tongue and is expected to be the solution for patients who have difficulty consuming conventional tablets. The research aimed to formulate ODT meloxicam with a variation of superdisintegrant agent, Ac-Di-Sol and Kollidon CL, and obtain the superdisintegrant agent composition of the optimum formula. ODT contained 7,5 mg meloxicam as the active ingredient and excipients were included of Ac-Di-Sol and Kollidon CL as superdisintegrant agent, Avicel PH 102 as a filler binder, and magnesium stearate and talcum as a lubricant. Design Expert 7.1.5 software helped to determine the formula and optimum formula based on the composition of superdisintegrant agent, Ac-Di-Sol and Kollidon CL. ODT was made by direct compression method and was evaluated its physical properties of granul and tablet. The data then compared with the literature and analyzed later to get the optimum formula. The results showed that Kollidon CL could accelerate the disintegration time, while Ac-Di-Sol prolonged the disintegration time of ODT. The formula which consists of 4,5 mg Ac-Di-Sol and 10,5 mg Kollidon CL had DE60 93,12%. The optimum formula consisted of 5,4 mg Ac-Di-Sol and 9,6 mg Kollidon CL which resulted in 4,1 kg hardness response, 0,47% friability, 23 seconds disintegration time, and 19 seconds wetting time.

OPTIMIZATION OF FAMOTIDINE FLOATING TABLET FORMULA WITH COMBINATION OF HYDROXY PROPYL METHYL CELLULOSE K100M AND ETHYL CELLULOSE POLYMER Veronica Vita Adyanti; Angi Nadya Bestari; T. N. Saifullah Sulaiman
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Famotidine is a gastric ulcer drug, which has a low bioavailability and a short half-life, therefore the dosage form that can maintain its existence in gastric is necessary to maximize its efficacy inhibiting H-2 receptor. Floating tablet can be an alternative because it can increase drug residence time in the gastric. This study aims to identify the combination effect of HPMC K100M and ethyl cellulose towards the physical characteristic of famotidine floating tablet and get an optimum ratio of both polymers. The formulas are made based on simplex lattice design method by using Design Expert® 10 software. Optimum formula is obtained by analyzing the parameters, which are significantly influenced by the difference of polymer concentration with numerical optimization and verified by IBM SPSS Statistics 19 software with one sample t-test method. Increased level of HPMC K100M gives a significant effect on increasing the medium absorption rate by granules and swelling index, decreasing dissolution rate, and accelerating floating lag time. Increased level of ethyl cellulose gives a significant effect on increasing flow rate of granules, tablet hardness, and drug release rate, decreased tap index of granules and tablet friability. The interaction of both polymers can improve swelling index and reduce the dissolution rate. The combination of HPMC K100M with 18,53% w/w concentration and ethyl cellulose with 16,47% w/w concentration can provide the optimum physical characteristic of famotidine floating tablet.

The Effect of Particle Size Reduction from Ibuprofen Tablet to Ibuprofen Pulveres on Its Dissolution Rate, Dissolution Profile, and Drug Stability Angi Nadya Bestari; T.N. Saifullah Sulaiman; Dita Ayu Purnamasari
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

A factor that influences the release of active ingredient from its dosage form is total particle surface area of drugs that contact with medium. The smaller size of particle can increase the particle surface area which can influence its dissolution and stability. This study aimed to determine the effect of tablet particle size reduction to its organoleptic properties, dissolution rate, dissolution profile, and stability after storage periods of 1, 2, 3, and 4 weeks. Ibuprofen tablet was changed its form by crushing into pulveres dosage form. The pulveres dissolution was conducted by USP type II dissolution tester (paddle method) with phosphate buffer pH 7,2 as the medium. The results of dissolution testing included the value of Q30, DE45, and dissolution rate constant (k). The similarity of dissolution profiles for each preparation could be known by the calculation of similarity factor (f2). Dissolution results showed that changed in particle sizes from the tablet to pulveres could increase dissolution rate constant from 0,063/minute to 0,347/minute and 0,298/minute (p = 0,029) and the DE45 value from 66,52% to 96,76% and 96,17% (p = 0). Pulveres were stable for 4 weeks of storage which were shown by there were not any changes in organoleptic properties. Furthermore, the value of DE45 (%), dissolution rate constants (k) and levels of active substances were not significantly different (p> 0,05) after 4 weeks of storage. The f2 value of ibuprofen tablet and ibuprofen pulveres was under 50 that meant the dissolution profil among them was not similar.

Optimasi Formula Tablet Floating Famotidin Menggunakan Kombinasi Matriks Gum Xanthan dan Hidroksi Propil Metil Selulosa K100M Shelinia Prima Sari; Angi Nadya Bestari; T. N. Saifullah Sulaiman
Majalah Farmaseutik Vol 15, No 2 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Famotidin adalah obat antihistamin H2 yang digunakan dalam pengobatan penyakit tukak lambung (peptic ulcer), tukak duodenal, ataupun keadaan hipersekresi yang patologis. Tablet floating famotidin dapat meningkatkan bioavailabilitas dengan mempertahankan waktu tinggal tablet dalam lambung dan mendekatkan famotidin pada tempat absorpsinya pada lambung bagian atas. Penelitian ini bertujuan untuk mengetahui komposisi optimum HPMC K100M serta gum xanthan dan pengaruh variasi keduanya terhadap sifat fisik granul dan tablet floating famotidin. Pembuatan delapan formula tablet floating famotidin menggunakan metode granulasi basah. Respon formula optimum didapat dengan evaluasi granul dan sifat fisik tablet. Evaluasi granul meliputi uji sifat alir dengan metode kecepatan alir dan uji daya serap granul. Evaluasi tablet meliputi keragaman bobot, kekerasan, kerapuhan, swelling index, floating lag time, total waktu floating, disolusi obat, dan penetapan kadar. Penentuan formula optimum menggunakan Design Expert versi 10.0.1. Peningkatan HPMC K100M meningkatkan daya serap granul, kekerasan tablet, dan swelling index secara signifikan. Peningkatan gum xanthan meningkatkan kecepatan alir granul, kerapuhan tablet, dan floating lag time secara signifikan. Kombinasi keduanya menurunkan persentase obat terdisolusi secara signifikan. Formula optimum tablet floating famotidin merupakan formula dengan kombinasi HPMC K100M sebesar 30% b/b dan gum xanthan sebesar 5% b/b.

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