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Hubungan Antara Indeks Massa Tubuh dan Paritas dengan Inkontinensia Urin Tipe Tekanan dan Desakan pada Lansia Farahdiba Aisyah Putri Ridwan; Sadakata Sinulingga; Amir Fauzi; Hadrians Kesuma Putra; Ridwan Abdullah Putra
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.524

Tujuan: Mengetahui hubungan antara IMT dan paritas dengan SUI dan UUI pada lansia. Metode: Penelitian observasional analitik dengan pendekatan desain cross sectional, penelitian ini menggunakan data primer yang diperoleh melalui wawancara menggunakan kuesioner untuk diagnosis inkontinensia urin (QUID).Hasil: Dari 64 responden lansia perempuan terdapat 26 yang mengalami SUI (40,6 %) dan 14 yang mengalami UUI (21,9%), terdapat hubungan yang signifikan antara IMT dengan SUI (p<0,05). Selain itu, paritas memiliki hubungan yang tidak signifikan dengan SUI (P>0,05, UUI memiliki hubungan yang tidak signifikan dengan IMT dan paritas (p>0,05). Kesimpulan: Terdapat hubungan yang signifikan antara IMT dan SUI.Kata kunci: IU, IMT, Paritas, Perempuan Lansia Association between Body Mass Indeks and Parity with Stress and Urgency Urinary Incontinence in the Elderly AbstractObjective: To find out the association between BMI and parity with SUI and UUI in the elderly. Method: This research was an analytic observational study with a cross sectional approach, This study used primary data obtained through interviews and uses the Questionnaire for Urinary Incontinence Diagnosis (QUID). Results: Data from 64 female elderly respondents showed that there was 26 female elderly with SUI (40,6%) and 14 with UUI (21,9%), there is a significant association between BMI for SUI (p<0,05). In addition, parity had no significant association with SUI (p>0,05). Meanwhile, UUI has no significant relationship with BMI and parity (p>0,05).Conclution: There was a significant association between BMI and SUI.Key words: UI, BMI, Parity, Elderly Women

Effect Of Corona Virus Disease 2019 (Covid-19) on the Incidence of Preterm Birth And Asphyxia at Banjar Regional General Hospital Kulfa Sholehah; Akhmad Yogi Pramatirta; Firman F. Wirakusumah
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.490

Objective: This study aims to determine and analyze the effect of Corona Virus Disease (Covid-19) on the incidence of preterm birth and asphyxia at Banjar Regional General Hospital. Method: This was an analytical observational study with a retrospective cohort approach. The type of data involved in this study was secondary data derived from medical record with a total sample of 59 women in labor diagnosed with Covid-19 and 513 women in labor who were not diagnosed with Covid-19.Results : The result of the study showed that there was a significant difference in the incidence of preterm birth between women in labor diagnosed with Covid-19 and those who were not diagnosed with Covid-19 (ρ value=0.000 or ρ<0.05). Regarding the incidence of asphyxia, the result showed that there was no difference in the incidence of asphyxia between infants born to women diagnosed with Covid-19 and those born to women who were not diagnosed with Covid-19, with a ρ value of 0.523 or ρ>0.05. Women diagnosed with Covid-19 were at risk of giving birth to premature infants 5.308 times compared to women not diagnosed with Covid-19. The OR of the incidence of preterm birth was 5.308 with a 95% CI of 3.035-9.281. Furthermore, based on the statistical test result, it was revealed that Covid-19 had a low effect on the incidence of asphyxia with the OR value of 0.839 and a 95% CI of 0.489-1.439.Conclusion: Based on the results of the study, it can be concluded that there was an effect of Covid-19 just on the incidence of preterm birth.Pengaruh Corona Virus Disease 2019 (Covid-19) terhadap Kejadian Prematur dan Asfiksia di RSUD Kota BanjarAbstrak Tujuan: Penelitian ini mengukur dan menganalisis pengaruh Corona Virus Disease (Covid-19) terhadap kejadian prematur dan asfiksia di RSUD Kota Banjar. Metode: Penelitian berupa analitik observasi dengan pendekatan kohor retrospektif. Jenis data dalam penelitian ini adalah data sekunder dari rekam medis dengan jumlah sampel menggunakan total sampel yaitu 59 ibu bersalin dengan Covid-19 dan 513 ibu bersalin tidak dengan Covid-19.Hasil: Hasil penelitian menunjukkan terdapat perbedaan yang bermakna kejadian prematur pada Ibu Covid-19 dengan ibu yang tidak terdiagnosis Covid-19 (nilai ρ0.000) yang artinya p0.05. Ibu dengan Covid-19 berisiko melahirkan bayi prematur 5.308 kali dibandingkan pada ibu yang tidak terdiagnosis Covid-19, nilai OR kejadian prematur 5.308 dengan IK 95% 3.035-9.281. Dan dari hasil uji statistik diperoleh hasil yaitu Covid-19 berpengaruh rendah terhadap kejadian asfiksia dengan hasil uji statistik nilai OR 0.839 dengan IK 95% 0.489-1.439. Kesimpulan: Dari hasil penelitian dapat disimpulkan bahwa terdapat pengaruh Covid-19 terhadap kejadian prematur.Kata kunci: Asfiksia, Covid-19, Prematur

Perbandingan Faktor Risiko antara Pertumbuhan Janin Terhambat Onset Dini dan Lambat di RSUD Dr. Moewardi Prilla Firsty Prasetyo Putri; Muhammad Adrianes Bachnas; Nutria Widya Purna Anggraini; Abdurahman Laqif
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.459

Tujuan: Mengetahui perbandingan faktor risiko antara pertumbuhan janin terhambat onset dini dan lambat di RSUD Dr. Moewardi.Metode: Penelitian observasional analitik dengan pendekatan cross sectional menggunakan data sekunder rekam medis ibu dengan pertumbuhan janin terhambat di RSUD Dr. Moewardi mulai 1 Januari 2020–31 Desember 2021. Pengambilan data menggunakan teknik total sampling, Data diolah menggunakan SPSS dan dianalisis menggunakan uji univariat, kemudia bivariat yaitu uji Chi Square.Hasil: Hasil analisis bivariat menunjukkan bahwa tidak terdapat perbedaan bermakna pada variabel usia, paritas, Indeks Massa Tubuh (IMT), pekerjaan ibu, hipertensi, preeklamsi, diabetes melitus, anemia, asma antara pertumbuhan janin terhambat onset dini dan onset lambat (p>0,05).Kesimpulan: Tidak terdapat perbedaan yang bermakna pada usia ibu, paritas, Indeks Massa Tubuh (IMT), pekerjaan ibu, preeklamsi, hipertensi, diabetes melitus, anemia, asma antara kejadian pertumbuhan janin terhambat onset dini dan lambat di RSUD Dr. Moewardi.Comparison of Risk Factor For Early and Late Onset Intrauterine Growth Restriction in RSUD Dr. MoewardiAbstract Objective: To find out the comparison of risk factors between early-onset and late onset intrauterine growth restriction at RSUD Dr. Moewardi.Method: This research is an analytical observational with a cross sectional approach was done by using medical records of pregnant woman with intrauterine growth restriction at RSUD Dr. Moewardi from January 1, 2020– December 31, 2021. Data was collected using a total sampling technique. And processed by SPSS then analyzed using univariate test, and Chi Square test.Results: The results of bivariate analysis showed that there was no significant differences of age, maternal employment, parity, Body Mass Index (BMI), maternal employment, hypertension, preeclampsia, diabetes mellitus, anemia, asthma between early-onset and late-onset with intrauterine growth restriction (p>0,05).Conclusion: There were no significant differences of maternal age, parity, Body Mass Index (BMI), preeclampsia, maternal employment, hypertension, diabetes mellitus, anemia, asthma between early and late onset intrauterine growth restriction at RSUD Dr. Moewardi.Key words: Risk Factor, Intrauterine Growth Restriction, Early Onset, Late Onset

Effect of Curcumin towards Metabolic Disturbance Parameters in Patient with PCOS: A Systematic Review and Meta-Analysis of Clinical and Preclinical Randomized Controlled Trials Angeline Ekafentie; Nicolas Daniel Widjanarko; Yuliana Yosephine; Mutiara Riani
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.484

Objective: Polycystic Ovarian Syndrome (PCOS) is a gynecologic and endocrine disorder with metabolic disturbances and infertility as the most common long-term consequences. Curcumin comes up as one of the alternative herbal remedies in PCOS treatment options. This study aimed to investigate the therapeutic effect of curcumin on metabolic disturbance parameters in PCOS patients and PCOS-modeled rats. Method: A systematic search of eligible studies was done using PubMed, Google Scholar, EBSCO-Host, and ProQuest according to the PRISMA 2009 guideline. We further assessed for risk of bias using SYRCLE’s risk of bias tool for preclinical studies and The Cochrane risk of bias assessment tool for the clinical studies. We used Review Manager (version 5.4) with random effect model to obtain a pooled mean difference with 95% CIs. Results: Five preclinical studies and three clinical studies were selected and pooled. The significant decrease in the level of Fasting Plasma Glucose (FPG), Fasting Insulin (FI), lipid profile, and Homeostatic Model of Insulin Resistance (HOMA-IR) value, and a significant increase in Quantitative Insulin-Sensitivity Check Index (QUICKI) value found in preclinical studies. The result for clinical studies showed a significantly decreased HOMA-IR values (SMD=-0.36, p=0.001), FPG level (SMD=-3.32, p=0.0001), Serum Insulin level (SMD=-1.47, p=0.002), and increased QUICKI value (SMD=0.01, p=0.006). Conclusion: Curcumin offers a substantial effect on metabolic disturbance parameters in PCOS patients and could be an alternative promising treatment for PCOS patients in the future.Pengaruh Kurkuma terhadap Parameter Gangguan Metabolik pada Pasien SOPK: Tinjauan Sistematis dan Meta-Analisis Uji Acak Preklinis dan Klinis TerkontrolAbstrakTujuan: Sindrom Ovarian Polikistik (PCOS) merupakan suatu kelainan ginekologi dan endokrin dengan gangguan metabolisme dan infertilitas sebagai konsekuensi jangka panjang yang paling umum ditemukan. Kurkumin muncul sebagai salah satu pengobatan herbal alternatif dalam pilihan terapi PCOS. Penelitian ini bertujuan untuk menyelidiki efek terapeutik kurkumin terhadap parameter gangguan metabolik pada pasien PCOS dan model tikus yang mengalami PCOS.Metode: Penelitian ini dilakukan dengan mencari studi penelitian yang memenuhi syarat menggunakan PubMed, Google Scholar, EBSCO-Host, dan ProQuest mengikuti PRISMA 2009. Penilaian risiko bias studi menggunakan SYRCLE’s Risk of Bias Tool untuk penelitian preklinis dan The Cochrane Risk of Bias Assessment Tool untuk penelitian klinis. Sintesis kuantitatifmenggunakan Review Manager (versi 5.4) dengan random effect model untuk mendapatkan pooled mean difference dengan interval kepercayaan 95%.Hasil: Sebanyak lima studi penelitian preklinis dan tiga studi penelitian klinis memenuhi kriteria. Terdapat penurunan signifikan kadar gula darah puasa, insulin puasa, profil lipid, dan nilai HOMA-IR, serta peningkatan nilai QUICKI pada studi preklinis. Pada studi klinis menunjukkan penurunan nilai HOMA-IR (SMD=-0,36, p=0,001), gula darah puasa (SMD=-3,32, p=0,0001), insulin serum (SMD=-1,47, p=0,002), dan peningkatan nilai QUICKI (SMD=0,01, p=0,006).Kesimpulan: Curcumin dapat memberikan efek terapeutik terhadap parameter gangguan metabolik pasien PCOS dan menjadi salah satu tatalaksana alternatif pasien PCOS di masa depan.Kata kunci: kurkuma; gula darah puasa; sindrom ovarium polikistik.

Successful Repair Management for Urinary Bladder Perforation During Myomectomy on Cervical Myoma on Patients with Previous Cesarean Section: A Challenging Case Report Indra Adi Susianto; Ferry Santoso; Iwan Prasetyo; Diana Novitasari; Dimas Sindhu Wibisono; Jerry Ferdinand Haposan Saragih
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.497

The 20-25% incidence of uterine myoma often experienced by women in childbearing age and 2% of these uterine myomas attach and grow in the uterine cervical area. The chief complain of cervical myom are lumps in the lower abdomen that are getting bigger and pressing on the urinary bladder cause difficulty in urinating and are accompanied by bloody urine, although the amount of menstrual blood is still within reasonable limits. Like uterine myomas, cervical myomas are not fused with the myometrial lining but are covered by thin connective tissue on the surface.The procedure of cervical myoma based on ACOG (American College of Obstetrics and Gynecology) is hysterectomy if the patient no longer wants to get pregnant, or myomectomy if the patient still wants to have children. Both of these actions have a very high risk in which vascularization in the pelvic area will be very complex, pressure on cervical myoma will have a high risk of injuring the urinary bladder mucosa and when setting aside the lower segment of the uterus there is a risk of injury. We present a 38-year-old woman with 30x 26 x 22 cm giant cervical myoma and secondary infertility that was treated with challenging laparotomi myomectomy in colaboration with urologist to preserve fertility. There was a tear in the upper part of the urinary bladder which was elongated with irregular edges measuring 12 x 5 cm after enucleation cervical myoma. The tear was repaired immediately and there are no complications in the form of vesico-vaginal fistulas or vesico-cervical postoperatively. Penanganan Komplikasi Perforasi Vesika Urinaria saat tindakan Miomektomi pada Mioma Servikal pada Pasien Bekas Seksio Sesaria: Sebuah Laporan KasusAbstrak20-25% insiden neoplasma jinak ini sering dialami oleh wanita terjadi pada wanita usia subur dan 2% nya melekat dan tumbuh pada area servik uteri. Meskipun jumlah darah menstruasi masih dalam batas wajar, tapi keluhan dari mioma uteri yang melekat pada servik adalah benjolan pada perut bawah yang semakin membesar dan menekan pada vesika urinaria sehingga menyebabkan kesulitan berkemih. Menurut American Collage of Obstetric and Gynecology tindakan miomektomi apabila pasien masih ingin mempunyai keturunan. Meskipun resiko yang sangat tinggi karena vaskularisasi area pelvis sangat kompleks, tindakan inijuga beresiko mencederai mukosa vesika urinaria dan resiko cedera pada ureter tunnel. Tulisan ini merupakan kasus seorang wanita berusia 38 tahun dengan mioma serviks permagna berukuran 30 x 26 x 22 cm dengan infertilitas sekunder yang dilakukan miomektomi secara laparotomi bersama ahli urologi. Terdapat perforasi pada vesica urinaria bagian atas memanjang dengan tepi tidak beraturan berukuran 12 x 5 cm setelah tindakan enukleasi mioma serviks. Robekan tersebut dapat diperbaiki dan tidak ada komplikasi berupa fistula vesiko- vagina atau vesiko-serviks pasca operasi.Kata kunci: Perforasi Kandung Kemih, Miomektomi, Mioma Serviks, Infertilitas Sekunder

Front Cover, Editorial Team, Table of Contents, and Back Cover Obgynia Jurnal
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Prevalensi dan Luaran Pasien dengan Spekrtum Plasenta Akreta Adiguna Gurnita; Setyorini Irianti
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.293

Tujuan: Plasenta akreta mengakibatkan risiko perdarahan ibu dan morbiditas anak akibat prematuritas. Prevalensi dan luaran pasien dengan spekrum plasenta akreta di Indonesia masih rendah. Penelitian ini bertujuan mencari tingkat prevalensi serta membandingkan luaran pada ibu dengan plasenta akreta.Metode: Desain penelitian merupakan penelitian deskriptif observasional yang diperoleh dari rekam medis tahun 2015–2019 di RSUP Dr. Hasan Sadikin Bandung periode Februari-April 2020.Hasil: Pada 39 pasien dengan plasenta akreta didapatkan wanita berusia >35 tahun sebanyak 22 orang (56,4%). Kondisi yang banyak ditemui pada pasien plasenta akreta meliputi multipara sebanyak 26 orang (66,7%) dan riwayat seksio sesarea >1x sebanyak 20 orang (51.3%). Sebanyak 30 pasien (76,9%) membutuhkan 3 unit 200 mL Packed Red Cell (PRC). Sebanyak 31 bayi (83,7%) yang lahir dari ibu dengan plasenta akreta lahir kurang bulan atau prematur dan 26 bayi (70,2%) mengalami berat badan lahir rendah (BBLR), serta dari 17 bayi prematur, 8 (52,9%) bayi mengalami stunting.Kesimpulan: Pasien dengan plasenta akreta di RSUP Dr. Hasan Sadikin Bandung mayoritas berusia tua, merupakan multipara dan memiliki riwayat seksio sesarea >1x. Pasien dengan plasenta akreta cenderung mengalami pendarahan yang banyak serta terdapat banyak bayi BBLR dan stunting. Prevalence and Outcome of Placenta Spectrum Accreta AbstractObjective: Placenta accreta carries a risk of maternal bleeding and child morbidity due to prematurity. The prevalence and outcomes of patients with spectrum placenta accreta in Indonesia are still limited. This study aims to evaluate the prevalence and outcomes in mothers with placenta accreta.Method: This is an observational descriptive study obtained from medical records for 2015–2019 at Dr. Hasan Sadikin Bandung from February–April 2020.Results: In 39 patients with placenta accreta, there were 22 women aged >35 years (56.4%). Conditions that were often found in patients with placenta accreta included multiparas in 26 people (66.7%) and history of cesarean section > 1x in 20 people (51.3%). A total of 30 patients (76.9%) required 3 units of 200 mL Packed Red Cell (PRC). A total of 31 babies (83.7%) born to mothers with placenta accreta were born preterm or premature and 26 babies (70.2%) had low birth weight (LBW), and of 17 premature babies, 8 (52.9%) babies are stunted.Conclusion: Patients with placenta accreta at Dr. Hasan Sadikin Bandung are mostly old, multiparous, and have history of more than 1 cesarean section. Patients with placenta accreta tend to experience heavy bleeding and there are many LBW and stunted babies.Key words: placenta accreta, placenta accreta spectrum, LBW, stunting

Efektifitas Penerapan Bundles IDO Sectio Caesarea: Scoping review Siti Jubaedah; Yanti Hermayanti; Erniati Erniati
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.476

Tujuan: Tinjauan ini bertujuan untuk mengidentifikasi literatur tentang bundles IDO yang telah terbukti berhasil menurunkan angka kejadian IDO, dapat dijadikan panduan dalam penerapan bundles IDO pada pasien SC Metode: Pencarian dilakukan di beberapa database yaitu PubMed, Scopus dan CINAHL dengan kata kunci yang digunakan yaitu P=Pasien Post-operasi SC OR Cesarean Delivery, Concept=Surgical Site Infections OR SSI, Context=Bundles OR Procedure.Hasil: Delapan belas studi yang melibatkan total 24450. Tiga studi RCT, tujuh Cohort Studi retrospektif, lima Cross Sectional Studi, satu experiment dan dua Case Control studi. Kesimpulan: Bundles IDO terdiri dari Preoperasi: Mandi preoperasi,tidak dilakukan pencukuran rambut,bila mengganggu pakai clipper electrik, pertahankan kadar gula darah ≤200 mg/dl. Intraoperasi: Pemberian Antibiotik, skin dan vaginal preparasi, pertahankan normothermia, kebersihan tangan, penggantian sarung tangan dan set instrument, gunakan jahitan khusus untuk penutupan subkutan dan penutupan kulit. Post operasi: Pertahankan kadar gula darah ≤200 mg/dl, segera lepas kateter urine maksimal 24 jam kecuali ada indikasi, penggantian wound dressing Postoperative day 2, Edukasi Pasien tentang perawatan luka post operasi. Bundles ini dapat menurunkan angka kejadian infeksi IDO pada pasien yang dilakukan operasi SC.The Effectiveness of Implementing IDO Sectio Caesarea Bundles: Scoping reviewAbstractObjective: This review aims to identify the literature on SSI bundles which have been proven successful in reducing the incidence of SSI, which can be used as a guide in implementing SSI bundles in SC patients.Method: The search was carried out in several databases, namely PubMed, Scopus and CINAHL with the keywords used, namely P=Postoperative SC OR Cesarean Delivery Patient, Concept=Surgical Site Infections OR SSI, Context=Bundles OR Procedure.Results: Eighteen studies involving a total of 24450. Three RCT studies, seven Cohort Retrospective Studies, five Cross Sectional Studies, one experimental and two Case Control studies.Conclusion: SSI Bundles consist of Pre-surgery: Pre-surgery shower, no hair cutting, use an electric clipper if it bothers you, maintain blood sugar levels ≤200 mg/dl. Intraoperative: Administration of antibiotics, skin and vaginal preparation, maintain normothermia, hand hygiene, change of gloves and instrument sets, use special sutures for subcutaneous closure and skin closure. Post surgery: Maintain blood sugar level ≤200 mg/dl, immediately remove the urinary catheter for a maximum of 24 hours unless there is an indication, replace the wound dressing Postoperative day 2, educate patients about postoperative wound care. These bundles can reduce the incidence of SSI infections in patients undergoing SC surgery.Key words: Bundles, SSI, Post-Sesection Caesarean Patients

Peran Phosphatase Regenerating Liver-3 dan Vascular Endothelial Growth Factor dalam Progresivitas Kanker Ovarium Epitelial Sharvianty Arifuddin
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.526

Tujuan: Mengetahui peran phosphatase regenerating liver-3 (PRL-3) dan vascular endothelial growth factor (VEGF) dalam progresivitas kanker ovarium.Metode: Penelitian dilakukan pada penderita kanker ovarium di beberapa rumah sakit jejaring Fakultas Kedokteran Universitas Hasanuddin Makassar. Pengambilan sampel dilaksanakan secara consecutive sampling. Pengambilan cairan ascites dan jaringan tumor pada saat operasi dilakukan untuk pemeriksaan hematoksilin eosin dan immunohistokimia, dan pemeriksaan mRNA dengan RT-PCR. Pemeriksaan hematoksilin eosin untuk mengukur histopatologi. Pemeriksaan imunohistokimia dilakukan untuk mengetahui ekskpresi PRL-3 dan VEGF. RT-PCR digunakan untuk melakukan pemeriksaaan mRNA PRL-3. Data dianalisis dengan uji chi-square dan analisis korelasi Spearman pada taraf signifikansi 5%.Hasil: Hasil diperoleh 38 subyek penelitian yang terdiri dari 26,3% stadium awal dan 73,7% stadium lanjut. Ekspresi PRL-3 tidak berbeda secara bermakna berdasarkan stadium, derajat diferensiasi, dan lokasi tumor dengan p > 0,05. Ekspresi PRL-3 pada kanker ovarium primer yang disertai metastasis lebih tinggi secara bermakna dibandingkan dengan kanker ovarium primer tanpa metastasis (p<0,05). Ekspresi VEGF tidak berbeda secara bermakna berdasarkan stadium, derajat diferensiasi, kanker ovarium primer, dan lokasi tumor dengan p > 0,05. Ada korelasi positif yang bermakna antara ekspresi PRL-3 dengan VEGF pada kanker ovarium epitelial (p<0,05).Kesimpulan: Tingginya ekspresi PRL-3 meningkatkan ekspresi VEGF dan progresivitas kanker ovarium epitelial. The Role of Phosphatase Regenerating Liver-3 and Vascular Endothelial Growth Factors in The Progressivity of Ovarium Epithelial CancerAbstractObjective: To determine the role of liver regenerating phosphatase-3 (PRL-3) and vascular endothelial growth factor (VEGF) in the progression of ovarian cancer.Method: This study was conducted on ovarian cancer patients in several teaching hospitals in the Department of Obgyn, Faculty of Medicine, Hasanuddin University, Makassar. Sampling was carried out by consecutive sampling. Sampling of ascites fluid and tumor tissue at the time of surgery was carried out for hematoxylin eosin and immunohistochemical examination, and for mRNA examination by RT-PCR. Eosin hematoxylin examination to measure histopathology. Immunohistochemical examination was carried out to determine the expression of PRL-3 and VEGF. RT-PCR was used to examine PRL-3 mRNA. Data were analyzed by chi-square test and Spearman correlation analysis at 5% significance level. Results: The results obtained were 38 research subjects consisting of 26.3% early stage and 73.7% advanced stage. PRL-3 expression did not differ significantly based on the stage, degree of differentiation, and tumor location with p > 0.05. PRL-3 expression in primary ovarian cancer with metastases was significantly higher than in primary ovarian cancer without metastases (p<0.05). VEGF expression did not differ significantly based on stage, degree of differentiation, primary ovarian cancer and tumor location with p > 0.05. There was a significant positive correlation between PRL-3 expression and VEGF in epithelial ovarian cancer (p<0.05). Conclusion: The high expression of PRL-3 increases the expression of VEGF and the progression of epithelial ovarian cancer. Key words: ovarian cancer, phosphatase regenerating liver-3, vascular endothelial growth factor

The Relationship between Ferritin Levels and Uterine Inertia in Labor Women Astri Ayu Agus; Andi Mardiah Tahir; Nurbani Bangsawan; Maisuri T Chalid; Efendi Lukas; Lenny M. Lisal
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.494

Objective: To determine the relationship between ferritin levels and the incidence of uterine inertia in pregnant women. Method: This study uses a prospective cohort design. The study was conducted on all pregnant women aged 20-40 years who had antenatal care and be in labor at the Teaching Hospital in the Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University. Data were analyzed with the chi-square test and the Mann-Whitney test. Results: Obtained 76 pregnant women where 44.7% of them had uterine inertia. The average ferritin level in the uterine inertia group was significantly lower (3.80 ± 2.84 ng/mL) than without the uterine inertia group (12.99 ± 11.40 ng/mL) with a value p<0.001. The average ferritin level in the mild anemia group was significantly higher (9.83 ± 10.35 ng/mL) than in the moderate anemia group (3.82 ± 2.51 ng/mL) with a p-value <0.05. Pregnant women with moderate anemia were found to be 4.68 more susceptible uterine inertia than pregnant women with mild anemia.Conclusion: There was a relationship between ferritin levels in pregnant women and the incidence of uterine inertia where low ferritin levels was risk factor of uterine inertia.Hubungan Kadar Feritin dengan Kejadian Inersia Uteri pada Ibu BersalinAbstrak Tujuan: Untuk mengetahui hubungan antara kadar feritin dan kejadian inersia uteri pada ibu bersalin. Metode: Penelitian ini menggunakan rancangan kohort prospektif. Penelitian dilakukan pada semua wanita hamil usia 20-40 tahun yang melakukan antebatal care dan persalinan di Rumah Sakit Pendidikan di bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Hasanuddin. Data dianalsiis dengan uji chi square dan uji Mann Whitney. Hasil: Diperoleh 76 ibu hamil, sebanyak 44,7% di antaranya mengalami inersia uteri. Rata-rata kadar feritin pada kelompok inersia uteri secara signifikan lebih rendah (3,80±2,84 ng/mL) dibandingkan rata-rata kadar feritin pada kelompok tidak inersia uteri (12,99±11,40 ng/mL) dengan nilai p<0,001. Rata-rata kadar feritin pada kelompok anemia ringan secara signifikan lebih tinggi (9,83±10,35 ng/mL) dibandingkan rata-rata kadar feritin pada kelompok anemia moderat (3,82±2,51 ng/mL) dengan nilai p<0,05. Ibu hamil dengan anemia moderat mempunyai risiko mengalami inersia uteri sebanyak 4,68 kali lebih besar dibandingkan ibu hamil dengan anemia ringan. Kesimpulan: Ada hubungan antara kadar feritin ibu hamil dan kejadian inersia uteri. Rendahnya kadar feritin menjadi salah satu penyebab kejadian inersia uteri.Kata kunci: Feritin, Ibu Bersalin, Inersia Uteri

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Wiryawan Permadi

Contact Email obgyniajurnal@gmail.com

Phone -

Journal Mail Official obgyniajurnal@gmail.com

Editorial Address -

Location Kota bandung, Jawa barat INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Wiryawan Permadi

Contact Email
obgyniajurnal@gmail.com

Phone
-

Journal Mail Official
obgyniajurnal@gmail.com

Editorial Address
-

Location
Kota bandung,

Jawa barat

INDONESIA