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The Difference of Anxiety between Primigravide Normal Pregnancy and Severe Preeclamsia at Dr. Moewardi Hospital Sani, Azizah Amalia Novia; Anggraini, Nutria Widya Purna; Wicaksono, Bagus
Nexus Kedokteran Klinik Vol 4, No 3 (2015): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Women with first ongoing pregnancy (primigravide) came through physical and physicological adaptation which can lead into physicological problem. High-risk pregnancy like preeclamsia have some complication thatÂ increased women worries which causing anxiety in their pregnancy. Mental burden in high-risk pregnancy causing some problem toward both motherâs and fetusâs health quality and also complication in labor. This study aimed to know difference of anxiety between primigravide normal pregnancy and severe preeclamsia. Methods: This study was an analitycal observasional study with cross sectional approach taken at Obstetri and Gynecologi Policlinic ofÂ Dr. Moewardi Hospital, in Desember 2014 until January 2015. The sampling method was using purposive sampling. There were 40 respoden in total which devided into 20 responden of normal pregnancy and 20 responden of severe preeclamsia. Anxiety level was measured using HARS (Hamilton Anxiety Rating Scale) questionnaire. Data was analyzed using Chi square test to compare anxiety differences between the two group. Results: It was found 8 participant (40%) show no anxiety and 12 participant (60%) having mild anxiety in normal pregnancy. While in severe preeclamsia was found 5 participants (25%) having mild anxiety, 13 participants (65%) having moderate anxiety, and 2 participant (10%) having severe anxiety. The result of analysis by Fischer exact test showed p=0,002 (p<0,05). Conclusions: There was an anxiety difference between primigravide normal pregnancy and severe preeclamsia Keywords: anxiety, pregnancy, preeclamsiaÂ

The Correlation between Women with Gestastional Hypertension and Preterm Birth Rates at Dr. Moewardi Hospital Amalia, Farrah Putri; Anggraini, Nutria Widya Purna; Randita, Amandha Boy Timor
Nexus Kedokteran Klinik Vol 5, No 3 (2016): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Hypertensive disorders of pregnancy is a medical problem that often arises in pregnant women. Hypertensive disorders of pregnancy contributes to various of perinatal outcomes, particularly preterm birth which is the most common cause of perinatal deaths. Gestational hypertension is one form of hypertensive disorders of pregnancy with the highest incidence rates. This study aims to determine the association between women with gestational hypertension and preterm birth rate at Dr. Moewardi Hospital. Methods: This research was an observational analytic study with cross sectional approach. The samples were pregnant women with gestational hypertension who gave birth at Dr. Moewardi Hospital in July 2014 - July 2015 (n = 87). The samples were selected by consecutive sampling method. Data of maternal blood pressure was obtained from medical records and grouped by the degree of hypertension (mild, moderate, severe). Data of gestational age of delivery was also obtained from medical records and divided into preterm (<37 weeks) and aterm (37 - 42 weeks) birth. Spearman test was used to measure correlation between variables with level of significance 5%. Results: There were a total of 35 preterm births of 87 mothers with gestational hypertension, with details as follows: 8 preterm births from mothers with mild hypertension (25.8%), 15 preterm births from mothers with moderate hypertension (60%), and 12 preterm births from mothers with severe hypertension (38.7%). Spearman correlation test showed a correlation coefficient (r) = -0.111 and p = 0.306. Conclusion: This research shows a statistically insignificant correlation (p=0.306) between women with gestational hypertension and preterm birth rate at Dr. Moewardi Hospital. Keywords: Gestational hypertension, preterm birth.Â

LOW NEUTROPHIL-TO-LMPHOCYTE RATIO DECREASES RISK OF CORONAVIRUS DISEASE IN PREGNANT WOMEN Anggraini, Nutria Widya Purna; Sulistyowati, Sri
Universa Medicina Vol 39, No 2 (2020)
Publisher : Faculty of Medicine, Trisakti University

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BACKGROUNDCoronavirus Infection 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an emergency condition for global public health. Early detection of COVID-19 in pregnant women is needed. The neutrophil-to-lymphocyte ratio (NLR), as a marker of viral inflammatory response, is used to determine the presence of a viral or bacterial infection, both acute and chronic. The objective of this study was to determine the relationship between NLR and the polymerase chain reaction (PCR) swab test results in pregnant women with suspected coronavirus disease 2019.METHODSA cross-sectional study was conducted on 9 pregnant women with suspected COVID-19. The subjects were inpatients at Moewardi Hospital Surakarta from 19 April-19 May 2020, who had rapid tests, complete blood examinations, and PCR swab tests. The NLR was categorized based on early warning scores according to research developed at Zhejiang University, with cut-off point 5.8. Diagnosis of COVID-19 was confirmed by PCR swab tests. Relation between NLR and PCR swab results was analyzed by the prevalence ratio.RESULTSTwo patients (22.2%) had NLR >5.8, with positive swab results in both (100%). Seven patients with NLR <5.8 had positive swabs in only one (33.3%). The relationship between NLR and PCR swab test results showed a prevalence ratio of 0.143 (95% CI 0.023-0.877).CONCLUSIONPregnant women with NLR < 5.8 had a decreased risk of COVID-19. Routine blood examination is more suitable for finding pregnant women with suspected COVID-19.

Effect of L- Arginin on Placental Hipoxia Inducible Factor -1-Alpha (HIF-1-A) Expression at Preeclampsia Mice Models Anggraini, Nutria Widya Purna; Sulistyowati, Sri; Pramono, Besari Adi; Kristanto, Herman
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Placental hypoxia is one of the theories that cause preeclampsia. In placental hypoxia of preeclampsia, there is an increase of Hipoxia Inducible Factor 1 Alpha (HIF-1-A) expression as a response to hypoxia. L-Arginine administration through the L-Arginine-Nitric Oxide pathway is expected to improve placental hypoxia. This study aimed to examine the effect of L- Arginin on placental HIF-1-A expression at preeclampsia mice models.Subjects and Method: Experimental study with parallel group post-test only design. The study was carried out at the Veterinary Medicine Faculty of Airlangga University. Thirty six preeclampsia mice models were made with intravenous injection 10ng anti-Qa-2 on day 1-4 of pregnancy. They were divided into 2 groups: (1)18 mice without treatment (control) and (2) 18 mice were given L-Arginin 200 mg/kgBW/day on day 7-15 of pregnancy. They were terminated on day 16 then immunohistochemistry examination of HIF-1-A expression was done on the placental samples. The dependent variable was placental Hipoxia Inducible Factor-1-Alpha (HIF-1-A) expression. The independent variables were L-Arginin administration. HIF-1-A expression was measured by H-Score method. The data were analyzed by t-test. Results: The mean of placental HIF-1-A expressions of treatment group was lower (Mean= 7.98; SD=9.35) than control group (Mean=41.95; SD= 32.20), and it was statistically significant (p <0.001).Conclusion: L-Arginin reduces the Placental Hypoxia Inducible Factor Alpha (HIF-1-A) expression on preeclampsia mice model.Keywords: L-Arginine, HIF-1-A, PreeclampsiaCorrespondence: Nutria Widya Purna Anggraini. Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Sebelas Maret/ Dr. Moewardi General Hospital Surakarta. Jl Kolonel Sutarto 132, Surakarta, Central Java, Indonesia. Email: nutria_dr@staff.uns.ac.id. Mobile: 08122651819.Indonesian Journal of Medicine (2020), 05(03): 191-199https://doi.org/10.26911/theijmed.2020.05.03.03

The Effect of Mesenchymal Secretome Stem Cell Therapy toward Caspase-3 Expression in Pregnant Mice with Pristan-Induced Lupus Model Adiyana, Febrian Andhika; Bachnas, M Adrianes; Sulistyowati, Sri; Anggraini, Nutria Widya Purna; Respati, Supriyadi Hari
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Systemic lupus erythematosus (SLE) is one of the pregnancy complications which cause an increase in fetal and maternal complications which are mainly caused by placental damage due to chronic inflammation and apoptosis. The rate of apoptosis can be assessed by the high expression of caspase-3 which is the majorexecutioner caspases of apoptosis. The use of Mesenchymal Secretome Stem Cell for SLE therapy has an anti-inflammatory and anti-apoptotic role. This study aimed to examine the effect of mesenchymal secretome stem cell therapy toward caspase-3 expression in pregnant mice with pristan-induced lupus model.Subjects and Method: This study was a randomized controlled trial. This study was conducted at the Prodia ProStem Laboratory, Laboratory of the Faculty of Veterinary Medicine of Airlangga University, and Anatomical Pathology Laboratory, Faculty of Medicine, Airlangga University. A total of 14 healthy BALB/C female mice strain aged 6-8 weeks, with a bodyweight of 20-30 grams, were divided into two groups, (1) 7 pregnant mice who received pristan therapy only, and (2) 7 pregnant mice who received pristan therapy and mesenchymal secretome stem cell.The dependent variable was the caspase-3 expression. The independent variable was the administration of mesenchymal secretome stem cell therapy. The caspase-3 expression was measured by an immunoreactive score. The data were analyzed using independent t-test.Results: After giving mesenchymal secretome stem cell therapy, the mean of the caspase-3 expression in the treatment group (Mean=1.86; SD=0.66) was lower than the control group (Mean=3.30; SD = 1.42), with p=0.031.Conclusion: Mesenchymal secretome stem cell therapy is effective for reducing caspase-3 expression in the placenta of pregnant mice with pristan-induced lupus model.Keywords: Caspase-3 expression, lupus, placentaCorrespondence: Febrian Andhika Adiyana. Department of Obstetrics and Gynecology, Faculty of Medicine, Univesitas Sebelas Maret/Moewardi Surakarta, Indonesia. Email: FebrianAndhika@gmail.com. Mobile: 081215897960.Indonesian Journal of Medicine (2020), 05(03): 224-229https://doi.org/10.26911/theijmed.2020.05.03.07

The Effectiveness of Letrozole-Electroacupuncture Adjuvant Therapy in Reducing Resistance and Pulsatility Indices in Women with Polycystic Ovarian Syndrome Octavia, Dhamayanti Eka; Budihastuti, Uki Retno; Melinawati, Eriana; Anggraini, Nutria Widya Purna; Yuliantara, Eric Edwin; Nurwati, Ida; Hadi, Cahyono
Journal of Maternal and Child Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Polycystic Ovarian Syndrome (PC

Massive Adherent Placenta, Placenta Percreta Yuliantara, Eric Edwin; Anggraini, Nutria Widya Purna; Prisasanti, Dympna Prameilita
Journal of Maternal and Child Health Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Adherent placentas including placenta accreta, increta and percreta are conditions where there is abnormal implanta

The Correlation between Women with Gestastional Hypertension and Preterm Birth Rates at Dr. Moewardi Hospital Farrah Putri Amalia; Nutria Widya Purna Anggraini; Amandha Boy Timor Randita
Nexus Kedokteran Klinik Vol 5, No 3 (2016): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.048 KB)

Background: Hypertensive disorders of pregnancy is a medical problem that often arises in pregnant women. Hypertensive disorders of pregnancy contributes to various of perinatal outcomes, particularly preterm birth which is the most common cause of perinatal deaths. Gestational hypertension is one form of hypertensive disorders of pregnancy with the highest incidence rates. This study aims to determine the association between women with gestational hypertension and preterm birth rate at Dr. Moewardi Hospital. Methods: This research was an observational analytic study with cross sectional approach. The samples were pregnant women with gestational hypertension who gave birth at Dr. Moewardi Hospital in July 2014 - July 2015 (n = 87). The samples were selected by consecutive sampling method. Data of maternal blood pressure was obtained from medical records and grouped by the degree of hypertension (mild, moderate, severe). Data of gestational age of delivery was also obtained from medical records and divided into preterm (<37 weeks) and aterm (37 - 42 weeks) birth. Spearman test was used to measure correlation between variables with level of significance 5%. Results: There were a total of 35 preterm births of 87 mothers with gestational hypertension, with details as follows: 8 preterm births from mothers with mild hypertension (25.8%), 15 preterm births from mothers with moderate hypertension (60%), and 12 preterm births from mothers with severe hypertension (38.7%). Spearman correlation test showed a correlation coefficient (r) = -0.111 and p = 0.306. Conclusion: This research shows a statistically insignificant correlation (p=0.306) between women with gestational hypertension and preterm birth rate at Dr. Moewardi Hospital. Keywords: Gestational hypertension, preterm birth.

The Difference of Anxiety between Primigravide Normal Pregnancy and Severe Preeclamsia at Dr. Moewardi Hospital Azizah Amalia Novia Sani; Nutria Widya Purna Anggraini; Bagus Wicaksono
Nexus Kedokteran Klinik Vol 4, No 3 (2015): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Background: Women with first ongoing pregnancy (primigravide) came through physical and physicological adaptation which can lead into physicological problem. High-risk pregnancy like preeclamsia have some complication that increased women worries which causing anxiety in their pregnancy. Mental burden in high-risk pregnancy causing some problem toward both mothers and fetuss health quality and also complication in labor. This study aimed to know difference of anxiety between primigravide normal pregnancy and severe preeclamsia. Methods: This study was an analitycal observasional study with cross sectional approach taken at Obstetri and Gynecologi Policlinic of Dr. Moewardi Hospital, in Desember 2014 until January 2015. The sampling method was using purposive sampling. There were 40 respoden in total which devided into 20 responden of normal pregnancy and 20 responden of severe preeclamsia. Anxiety level was measured using HARS (Hamilton Anxiety Rating Scale) questionnaire. Data was analyzed using Chi square test to compare anxiety differences between the two group. Results: It was found 8 participant (40%) show no anxiety and 12 participant (60%) having mild anxiety in normal pregnancy. While in severe preeclamsia was found 5 participants (25%) having mild anxiety, 13 participants (65%) having moderate anxiety, and 2 participant (10%) having severe anxiety. The result of analysis by Fischer exact test showed p=0,002 (p<0,05). Conclusions: There was an anxiety difference between primigravide normal pregnancy and severe preeclamsia Keywords: anxiety, pregnancy, preeclamsia

Hypoxia Inducible Factor-1-Alpha Expression on Preeclampsia Mice Model With L-Arginine Administration Nutria Widya Purna Anggraini; Sri Sulistyowati; Muhammad Adrianes Bachnas; Eric Edwin Yuliantara; Wisnu Prabowo; Uki Retno Budihastuti
Folia Medica Indonesiana Vol. 57 No. 3 (2021): September
Publisher : Universitas Airlangga

Preeclampsia is hypertension in pregnancy that aﬀects 2% to 8% of pregnancies worldwide and causes significant maternal and perinatal morbidity and mortality. In the pathogenesis of preeclampsia, placental hypoxia plays an important role, associated with excessive trophoblast apoptosis resulting in decreased trophoblast and spiral arteries invasion. This placental hypoxic condition will induce increased expression of Hypoxia Inducible Factor -1-Alpha (HIF-1-A). L-Arginine is a potent vasodilator presumably to improve preeclampsia placental hypoxic conditions and reduce HIF-1-A expression. This study was an experimental study with a parallel-group post-test only design. Thirty-six preeclamptic mice models were divided into 2 groups. The control group (K1) 18 preeclamptic mice model without treatment and the treatment group (K2) 18 preeclamptic mice given L-Arginine. The independent variable was the administration of L-Arginine and the dependent variable is the placental HIF-1-A expression. Statistical analysis used unpaired t-test on normal data distribution, and Mann Whitney test on abnormal data distribution. The mean of placental HIF-1-A expression K1 was 2.47 ± 1.65 with a minimum value of 0.4 and a maximum value of 6.6. At K2 0.93 ± 0.55 with a minimum value of 0.0 and a maximum value of 2.0. Statistical tests showed that the placental HIF-1-A expression in the treatment group was significantly lower than that in the control group (p <0.001). In conclusion, the expression of HIF-1-A in preeclamptic mice model placenta decreased with L-Arginine administration.

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