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All Journal Majalah Obstetri dan Ginekologi Universa Medicina Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Medicine Journal of Maternal and Child Health Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Plexus Medical Journal Folia Medica Indonesiana

Nutria Widya Purna Anggraini

Department Of Obstetrics And Gynaecology, Faculty Of Medicine, Universitas Sebelas Maret/Dr. Moewardi General Hospital, Surakarta

Author-ID : 2674247

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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LOW NEUTROPHIL-TO-LMPHOCYTE RATIO DECREASES RISK OF CORONAVIRUS DISEASE IN PREGNANT WOMEN Anggraini, Nutria Widya Purna; Sulistyowati, Sri
Universa Medicina Vol 39, No 2 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (511.184 KB)

BACKGROUNDCoronavirus Infection 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an emergency condition for global public health. Early detection of COVID-19 in pregnant women is needed. The neutrophil-to-lymphocyte ratio (NLR), as a marker of viral inflammatory response, is used to determine the presence of a viral or bacterial infection, both acute and chronic. The objective of this study was to determine the relationship between NLR and the polymerase chain reaction (PCR) swab test results in pregnant women with suspected coronavirus disease 2019.METHODSA cross-sectional study was conducted on 9 pregnant women with suspected COVID-19. The subjects were inpatients at Moewardi Hospital Surakarta from 19 April-19 May 2020, who had rapid tests, complete blood examinations, and PCR swab tests. The NLR was categorized based on early warning scores according to research developed at Zhejiang University, with cut-off point 5.8. Diagnosis of COVID-19 was confirmed by PCR swab tests. Relation between NLR and PCR swab results was analyzed by the prevalence ratio.RESULTSTwo patients (22.2%) had NLR >5.8, with positive swab results in both (100%). Seven patients with NLR <5.8 had positive swabs in only one (33.3%). The relationship between NLR and PCR swab test results showed a prevalence ratio of 0.143 (95% CI 0.023-0.877).CONCLUSIONPregnant women with NLR < 5.8 had a decreased risk of COVID-19. Routine blood examination is more suitable for finding pregnant women with suspected COVID-19.

Effect of L- Arginin on Placental Hipoxia Inducible Factor -1-Alpha (HIF-1-A) Expression at Preeclampsia Mice Models Anggraini, Nutria Widya Purna; Sulistyowati, Sri; Pramono, Besari Adi; Kristanto, Herman
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Placental hypoxia is one of the theories that cause preeclampsia. In placental hypoxia of preeclampsia, there is an increase of Hipoxia Inducible Factor 1 Alpha (HIF-1-A) expression as a response to hypoxia. L-Arginine administration through the L-Arginine-Nitric Oxide pathway is expected to improve placental hypoxia. This study aimed to examine the effect of L- Arginin on placental HIF-1-A expression at preeclampsia mice models.Subjects and Method: Experimental study with parallel group post-test only design. The study was carried out at the Veterinary Medicine Faculty of Airlangga University. Thirty six preeclampsia mice models were made with intravenous injection 10ng anti-Qa-2 on day 1-4 of pregnancy. They were divided into 2 groups: (1)18 mice without treatment (control) and (2) 18 mice were given L-Arginin 200 mg/kgBW/day on day 7-15 of pregnancy. They were terminated on day 16 then immunohistochemistry examination of HIF-1-A expression was done on the placental samples. The dependent variable was placental Hipoxia Inducible Factor-1-Alpha (HIF-1-A) expression. The independent variables were L-Arginin administration. HIF-1-A expression was measured by H-Score method. The data were analyzed by t-test. Results: The mean of placental HIF-1-A expressions of treatment group was lower (Mean= 7.98; SD=9.35) than control group (Mean=41.95; SD= 32.20), and it was statistically significant (p <0.001).Conclusion: L-Arginin reduces the Placental Hypoxia Inducible Factor Alpha (HIF-1-A) expression on preeclampsia mice model.Keywords: L-Arginine, HIF-1-A, PreeclampsiaCorrespondence: Nutria Widya Purna Anggraini. Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Sebelas Maret/ Dr. Moewardi General Hospital Surakarta. Jl Kolonel Sutarto 132, Surakarta, Central Java, Indonesia. Email: nutria_dr@staff.uns.ac.id. Mobile: 08122651819.Indonesian Journal of Medicine (2020), 05(03): 191-199https://doi.org/10.26911/theijmed.2020.05.03.03

The Effect of Mesenchymal Secretome Stem Cell Therapy toward Caspase-3 Expression in Pregnant Mice with Pristan-Induced Lupus Model Adiyana, Febrian Andhika; Bachnas, M Adrianes; Sulistyowati, Sri; Anggraini, Nutria Widya Purna; Respati, Supriyadi Hari
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Systemic lupus erythematosus (SLE) is one of the pregnancy complications which cause an increase in fetal and maternal complications which are mainly caused by placental damage due to chronic inflammation and apoptosis. The rate of apoptosis can be assessed by the high expression of caspase-3 which is the majorexecutioner caspases of apoptosis. The use of Mesenchymal Secretome Stem Cell for SLE therapy has an anti-inflammatory and anti-apoptotic role. This study aimed to examine the effect of mesenchymal secretome stem cell therapy toward caspase-3 expression in pregnant mice with pristan-induced lupus model.Subjects and Method: This study was a randomized controlled trial. This study was conducted at the Prodia ProStem Laboratory, Laboratory of the Faculty of Veterinary Medicine of Airlangga University, and Anatomical Pathology Laboratory, Faculty of Medicine, Airlangga University. A total of 14 healthy BALB/C female mice strain aged 6-8 weeks, with a bodyweight of 20-30 grams, were divided into two groups, (1) 7 pregnant mice who received pristan therapy only, and (2) 7 pregnant mice who received pristan therapy and mesenchymal secretome stem cell.The dependent variable was the caspase-3 expression. The independent variable was the administration of mesenchymal secretome stem cell therapy. The caspase-3 expression was measured by an immunoreactive score. The data were analyzed using independent t-test.Results: After giving mesenchymal secretome stem cell therapy, the mean of the caspase-3 expression in the treatment group (Mean=1.86; SD=0.66) was lower than the control group (Mean=3.30; SD = 1.42), with p=0.031.Conclusion: Mesenchymal secretome stem cell therapy is effective for reducing caspase-3 expression in the placenta of pregnant mice with pristan-induced lupus model.Keywords: Caspase-3 expression, lupus, placentaCorrespondence: Febrian Andhika Adiyana. Department of Obstetrics and Gynecology, Faculty of Medicine, Univesitas Sebelas Maret/Moewardi Surakarta, Indonesia. Email: FebrianAndhika@gmail.com. Mobile: 081215897960.Indonesian Journal of Medicine (2020), 05(03): 224-229https://doi.org/10.26911/theijmed.2020.05.03.07

The Effectiveness of Letrozole-Electroacupuncture Adjuvant Therapy in Reducing Resistance and Pulsatility Indices in Women with Polycystic Ovarian Syndrome Octavia, Dhamayanti Eka; Budihastuti, Uki Retno; Melinawati, Eriana; Anggraini, Nutria Widya Purna; Yuliantara, Eric Edwin; Nurwati, Ida; Hadi, Cahyono
Journal of Maternal and Child Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Polycystic Ovarian Syndrome (PC

Massive Adherent Placenta, Placenta Percreta Yuliantara, Eric Edwin; Anggraini, Nutria Widya Purna; Prisasanti, Dympna Prameilita
Journal of Maternal and Child Health Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Adherent placentas including placenta accreta, increta and percreta are conditions where there is abnormal implanta

Skin manifestations of COVID-19 in a pregnant woman with premature rupture of membranes: A case report Sri Sulistyowati; Nutria Widya Purna Anggraini
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 1, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss1.art14

The number of COVID-19 cases, especially with pregnancy, remains a problem in the world and in Indonesia. The main clinical symptoms include fever (temperature >38°C), cough, and shortness of breath. In addition, it can be accompanied by fatigue, myalgia, gastrointestinal symptoms such as diarrhea, and even recently found manifestations of skin disorders. Skin manifestations in COVID-19 pregnant patients are still a rare condition. Skin manifestations can be an early sign of such infection, which therefore requires clinicians’ notice to allow them to conduct early COVID-19 screening in pregnant women for better outcomes of the mother and the baby. We present a 26-year-old primigravida at 39 weeks of gestational age with premature rupture of membranes and COVID-19 infection. Her complaints included itchy maculopapular rash and urticaria, then the pregnancy was terminated by a caesarean section, and the baby was born with good conditions. The skin lesions were given a mixture of corticosteroid cream and fusidic acid. The mother and the baby were discharged in a good condition.

THE EFFECT OF ABO BLOOD GROUP ON COVID-19 IN PREGNANCY Sri Sulistyowati; Nutria Widya Purna Anggraini; Soetrisno Soetrisno; Eric Edwin Yuliantara; Supriyadi Hari Respati; Muhammad Adrianes Bachnas; Wisnu Prabowo; Hafi Nurinasari; Dympna Pramelita; Dewi Setiyawati; Metharisa Sujana; Aldi Firmansyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art6

Background: The COVID-19 virus has spread throughout the world and has been declared as a global pandemic by WHO. Some population groups are more susceptible to COVID-19, and one of them is pregnant women. Pregnancy increases risks of the COVID-19, especially thrombotic complications. The SARS-CoV-2 infection may vary widely from asymptomatic to severe infection. Some studies have shown that ABO blood group can be a marker of susceptibility to some disease progression. Objective:This study aims to investigate relationships between the ABO blood group, the COVID-19 infection and its complications in pregnant women at Dr. Moewardi Hospital, Surakarta.Methods: This study was an observational analytic study with a cross-sectional study design involving 40 pregnant women infected with COVID-19 at Dr. Moewardi Hospital, Surakarta. COVID-19 PCR swabs on the women were administered on their oropharynx and nasopharynx, and laboratory examination of the ABO blood group in all samples was performed. Comparative data distribution of blood groups in the population and the global population distribution were calculated by Chi Square Goodness of Fit. Comparative data between ABO blood group distributions, blood parameters and complications (respiratory, thrombotic, other infections, and death) were calculated by Chi square test and then by One-Way ANOVA. Next, correlation tests for the complications of the blood group and the ages applied a multinomial regression.Results: There were significant differences of thrombotic complications on the blood group of pregnant women infected with COVID-19 (p=0.027). Blood type B significantly tended to experience thrombotic complications when compared to other blood groups (p=0.022).Conclusion: The ABO blood group could affect the complication levels in the pregnant women infected with the COVID 19.

Prenatal Diagnosis and Management of Advanced Abdominal Pregnancy in Dr. Moewardi Hospital Surakarta: A Case Series Akbar, Uchti; Anggraini, Nutria Widya Purna; Yuliantara, Eric Edwin; Bachnas, Muhammad Adrianes; Ridwan, Robert; Sulistyowati, Sri
Journal of Maternal and Child Health Vol. 6 No. 5 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Background: The abdominal pregnancy is a pregnancy anywhere in the abdominal cavity other than the tube, ovary, and broad ligament. Abdominal pregnancy has 7.7 times greater risk than tubal pregnancy and 90 times greater than intrauterine pregnancy. This study aims to reveal the diagnosis and treatment of abdominal pregnancy in Dr. Moewardi Hospital Surakarta. Subjects and Method: This was a case series study conducted at Dr. Moewardi Hospital Surakarta. This study report three cases of advanced abdominal pregnancy at Dr Moewardi Hospital (2019 – 2020), that consisted of two cases of advanced abdominal pregnancy to term, and one advanced abdominal pregnancy with acute abdomen. Case presentation: Case 1 (it was found abdominal pregnancy at 30 weeks), the condition of the mother and the fetus was good, the pregnancy was continued until the gestational age was term. The patient was given corticosteroids for lung maturation and magnesium sulfate for neuroprotection. Case 2 (an abdominal pregnancy was found at term), it was decided to immediately terminate it with good preoperative preparation. Both patients in case 1 and case 2 had good result in both the mother and the fetus. The placenta was left in situ in both cases to prevent massive bleeding and injury to the gastrointestinal organs. Case 3 (advanced abdominal pregnancy with acute abdominal symptoms) decided to undergo an emergency laparotomy and removal of the placenta. Conclusion: Abdominal pregnancy must be diagnosed and managed properly to reduce maternal mortality and morbidity. In advanced abdominal pregnancy, it could be considered to continue the pregnancy until the term. The placenta management of in situ without methotrexate might be considered in cases of abdominal pregnancy.

Enhancing Nutrients Knowledge during Pregnancy through Webinars to Prevent Stunting Bachnas, Muhammad Adrianes; Sulistyowati, Sri; Yuliantara, Eric Edwin; Anggraini, Nutria Widya Purna; Prabowo, Wisnu; Respati, Supriyadi Hari; Nurinasari, Hafi; Ridwan, Robert; Astetri, Lini; Yuliani, Saffana Oka; Carissa, Dinda; Alamsyah, Meuthia
Journal of Maternal and Child Health Vol. 7 No. 5 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Background: Indonesia still has a high stunting rate, 1.2 million out of 5 million births each year result in stunted baby growth. linear growth in utero, the process can be caused by maternal malnutrition, which can result in intrauterine growth inhibition and low birth weight, and result in stunting. This study aims to analyze the effectiveness of the webinar in improving nutrition knowledge during pregnancy to prevent stunting growth. Subjects and Method: This is a cross sectional study conducted in July, 15th 2022 using the Zoom Meeting webinar platform. Target population are all young POGI and POGI Members who took part in webinars and online conversations using the Zoom Meeting program. This study used random sampling, and sample size are 161. The independent variables of this study was learning via webinars while the dependent variable was nutrient knowledge. Data were analyzed by paired t-test statistical test. Results: There was a significant difference score of knowledge in pregnant women after (Mean= 8.60) compared to before webinars (Mean= 6.52). Conclusion: The result of this study indicates that learning method via webinars increased maternal understanding about optimal nutrient during pregnancy. Keywords: stunting, nutrients, webinar, pregnant women Correspondence: Nutria Widya Purna Anggraini. Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret/Dr. Moewardi General Hospital, Surakarta, Central Java, Indonesia. Jl. Kolonel Sutarto No. 132 Jebres, Surakarta. Email: nutria_dr@staff.uns.ac.id. Mobile: 08122651819.

Perbandingan Faktor Risiko antara Pertumbuhan Janin Terhambat Onset Dini dan Lambat di RSUD Dr. Moewardi Prilla Firsty Prasetyo Putri; Muhammad Adrianes Bachnas; Nutria Widya Purna Anggraini; Abdurahman Laqif
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.459

Tujuan: Mengetahui perbandingan faktor risiko antara pertumbuhan janin terhambat onset dini dan lambat di RSUD Dr. Moewardi.Metode: Penelitian observasional analitik dengan pendekatan cross sectional menggunakan data sekunder rekam medis ibu dengan pertumbuhan janin terhambat di RSUD Dr. Moewardi mulai 1 Januari 2020–31 Desember 2021. Pengambilan data menggunakan teknik total sampling, Data diolah menggunakan SPSS dan dianalisis menggunakan uji univariat, kemudia bivariat yaitu uji Chi Square.Hasil: Hasil analisis bivariat menunjukkan bahwa tidak terdapat perbedaan bermakna pada variabel usia, paritas, Indeks Massa Tubuh (IMT), pekerjaan ibu, hipertensi, preeklamsi, diabetes melitus, anemia, asma antara pertumbuhan janin terhambat onset dini dan onset lambat (p>0,05).Kesimpulan: Tidak terdapat perbedaan yang bermakna pada usia ibu, paritas, Indeks Massa Tubuh (IMT), pekerjaan ibu, preeklamsi, hipertensi, diabetes melitus, anemia, asma antara kejadian pertumbuhan janin terhambat onset dini dan lambat di RSUD Dr. Moewardi.Comparison of Risk Factor For Early and Late Onset Intrauterine Growth Restriction in RSUD Dr. MoewardiAbstract Objective: To find out the comparison of risk factors between early-onset and late onset intrauterine growth restriction at RSUD Dr. Moewardi.Method: This research is an analytical observational with a cross sectional approach was done by using medical records of pregnant woman with intrauterine growth restriction at RSUD Dr. Moewardi from January 1, 2020– December 31, 2021. Data was collected using a total sampling technique. And processed by SPSS then analyzed using univariate test, and Chi Square test.Results: The results of bivariate analysis showed that there was no significant differences of age, maternal employment, parity, Body Mass Index (BMI), maternal employment, hypertension, preeclampsia, diabetes mellitus, anemia, asthma between early-onset and late-onset with intrauterine growth restriction (p>0,05).Conclusion: There were no significant differences of maternal age, parity, Body Mass Index (BMI), preeclampsia, maternal employment, hypertension, diabetes mellitus, anemia, asthma between early and late onset intrauterine growth restriction at RSUD Dr. Moewardi.Key words: Risk Factor, Intrauterine Growth Restriction, Early Onset, Late Onset

Co-Authors Abdurahman Laqif Adiyana, Febrian Andhika Akbar, Uchti Alamsyah, Meuthia Aldi Firmansyah Alim, Fadel Muhammad S. Amalia, Farrah Putri Amandha Boy Timor Randita Anggraeni, Asih Arib Farras Wahdan Astetri, Lini Azizah Amalia Novia Sani Bachnas, Muhammad Adrianes BAGUS WICAKSONO Besari Adi Pramono Carissa, Dinda Chasanah, Meriska Dewi Dewi Setiyawati Dympna Pramelita Eriana Melinawati Eric Edwin Yuliantara Farrah Putri Amalia Firmansyah, Aldi Hadi, Cahyono Hafi Nurinasari Hafi Nurinasari Herman Kristanto Ida Nurwati Khoeronisa, Siti Lini Astetri Merina, Hikmah F. Metharisa Sujana Muhammad Adrianes Bachnas Muhammad Adrianes Bachnas Nugraha, Gagah B Adi Nugraha, Gagah Baskara Adi Nurinasari, Hafi Nuur, Aliffudin Octavia, Dhamayanti Eka Prabowo, Helena Adelia Pradana, Muhammad Denny Gagah Prameilita, Dympna Prilla Firsty Prasetyo Putri Prisasanti, Dympna Prameilita Putri, Hanifa Fauzia Widya Rahmawati, Oktantia Dyah Randita, Amandha Boy Timor Ridwan, Robert Robert Ridwan Sani, Azizah Amalia Novia Sigit Setyawan Soetrisno Soetrisno Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Uki Retno Budihastuti Vidya Ismiaulia Wasyanto, Trisulo Wicaksono, Bagus WISNU PRABOWO Wisnu Prabowo Wisnu Prabowo Yonathan Siswo Pratomo Yuliani, Saffana Oka

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