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All Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Medicine JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Muhammad Adrianes Bachnas
Department Of Obstetrics And Gynaecology, Faculty Of Medicine, Universitas Sebelas Maret/Dr. Moewardi General Hospital, Surakarta
Health Professions Medicine & Pharmacology Public Health

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The Effect of Mesenchymal Secretome Stem Cell Therapy toward Caspase-3 Expression in Pregnant Mice with Pristan-Induced Lupus Model Adiyana, Febrian Andhika; Bachnas, M Adrianes; Sulistyowati, Sri; Anggraini, Nutria Widya Purna; Respati, Supriyadi Hari
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (32.121 KB) | DOI: 10.26911/theijmed.2020.5.3.298

Abstract

Background: Systemic lupus erythematosus (SLE) is one of the pregnancy complications which cause an increase in fetal and maternal com­p­lications which are mainly caused by pla­cen­tal damage due to chronic inflammation and apoptosis. The rate of apoptosis can be assessed by the high expression of caspase-3 which is the ma­jo­rexecutioner caspases of apoptosis. The use of Mesenchymal Secretome Stem Cell for SLE the­rapy has an anti-inflammatory and anti-apo­p­to­tic role. This study aimed to examine the effect of mesenchymal secretome stem cell therapy to­ward caspase-3 expression in pregnant mice with pris­tan-induced lupus model.Subjects and Method: This study was a ran­do­mized controlled trial. This study was con­ducted at the Prodia ProStem Laboratory, La­bo­ra­tory of the Faculty of Veterinary Medicine of Airlangga University, and Anatomical Pathology Laboratory, Faculty of Medicine, Airlangga Uni­ver­sity. A total of 14 healthy BALB/C female mice strain aged 6-8 weeks, with a bodyweight of 20-30 grams, were divided into two groups, (1) 7 preg­nant mice who received pristan therapy only, and (2) 7 pregnant mice who received pristan the­rapy and mesenchymal secretome stem cell.The dependent variable was the caspase-3 exp­res­sion. The independent variable was the ad­mi­ni­s­tration of mesenchymal secretome stem cell the­rapy. The caspase-3 expression was measured by an immunoreactive score. The data were ana­ly­zed using independent t-test.Results: After giving mesenchymal secretome stem cell therapy, the mean of the caspase-3 exp­res­sion in the treatment group (Mean=1.86; SD­=­0.66) was lower than the control group (Me­an­=­3.­30; SD = 1.42), with p=0.031.Conclusion: Mesenchymal secretome stem cell the­rapy is effective for reducing caspase-3 exp­res­sion in the placenta of pregnant mice with pris­tan-induced lupus model.Keywords: Caspase-3 expression, lupus, placen­taCorrespondence: Febrian Andhika Adiyana. Department of Obs­tet­rics and Gynecology, Faculty of Medicine, Uni­vesitas Sebelas Maret/Moewardi Surakarta, Indo­nesia. Email: FebrianAndhika@gmail.com. Mobile: 081215897960.Indonesian Journal of Medicine (2020), 05(03): 224-229https://doi.org/10.26911/theijmed.2020.05.03.07
Kasus yang Langka: Sebuah Persalinan Normal dari Wanita Hamil Prematur dengan Janin Sacrococcygeal Teratoma Cut Sheira Elnita; M. Adrianess Bachnas; Eric Edwin
Indonesian Journal of Obstetrics & Gynecology Science Special Issue: Case Report
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (758.429 KB)

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Latar belakang: Insiden kehamilan dengan janin Sacrococcygeal Teratoma (SCT) yaitu1 dari 35.000 kelahiran hidup. SCT dideteksi dengan skrining ultrasonografi (USG) prenatal trimester kedua.Tujuan; Mendemonstrasikan peran USG janin dalam diagnosis SCT.Laporan kasus: Wanita 20 tahun G2P1A0 kehamilan 28 minggu keluhan kontraksi, pecah selaput ketuban. Teraba janin tunggal, fundus teraba massa padat. Pemeriksaan genital pembukaan serviks 7 cm, USG intrauterin tunggal perkiraan usia kehamilan 28 minggu, tampak massa echogenic campuran dari daerah sacrococcygeal, terdapat daerah padat kistik di dalam massa ukuran 11,4 x 12,3 cm. Kemungkinan invasi ke panggul janin  disimpulkan SCT tipe II. Persalinan pervaginam, berat janin 1600 gram , apgar score 2-3-4, dengan massa padat kistik pada sacrum ukuran 13x13cm. Tampak perdarahan dari massa teratoma.Hasil: SCT adalah neoplasma lesi kistik jinak. Komplikasi berupa perdarahan intramural masif dan distosia. Klasifikasi Altman: massa terdapat di eksterior atau intrapelvik, tipe I(47%): terletak di luar janin. tipe II(35%): massa terdapat di eksternal memiliki ekstensi intrapelvic. tipe III(8%): eksternal terletak di dalam panggul dan perut. tipe IV(10%): presakral tanpa presentasi eksternal. Pada USG, SCT muncul sebagai massa echogenisitas campuran yang memanjang dari sacrum. USG pada SCT padat (20%), kistik(30%) dan campuran(50%). Kesimpulan: Ultrasonografi mempengaruhi keputusan dan manajemen klinis sehingga prognosis baik.Kata kunci: Sacrococcygeal Teratoma, Kehamilan PrematurAbstractBackground:  The incidence of pregnancy with fetal Sacrococcygeal Teratoma (SCT) occurs in 1 out of every 35.000 live births. SCT detected by second trimester prenatal ultrasonography (USG) screening.Objective: Demonstrating the role of fetal ultrasound in the diagnosis of SCT.Case report: a 20 year old G2P1A0 with 28 weeks pregnancy came with contractions and membranes ruptured. Examination found were single fetus, fundus palpable a mass. The cervical dilatation 7 cm, intrauterine ultrasound a 28 weeks of age fetus, appears an echogenic mass in the sacrococcygeal region containing a dense area 11.4x12.3 cm. We concluded an invasive to the fetal pelvis was type II SCT. Vaginal delivery performed, baby weight 1600 grams, apgar score 2-3-4, solid mass in sacrum 13x13cm. Bleeding from teratoma mass emerged.Result: SCT is a rare tumour. Complications consist of massive bleeding and dystocia. SCT classified according to Altman. Type I(47%): located outside fetus, type II(35%): mass available on external with intrapelvic extension, type III(8%): externally located inside pelvis and abdomen, type IV(10%): presacral without external presentation. On ultrasound, SCT appears as a mixed echogenicity mass extending sacrum. Ultrasound: solid SCT(20%), cystic(30%) and mixed(50%).Conclusion: Ultrasonography affects decisions and clinical management that make a good prognosis.Key words: Sacrococcygeal Teratoma, Premature Pregnancy
THE EFFECT OF ABO BLOOD GROUP ON COVID-19 IN PREGNANCY Sri Sulistyowati; Nutria Widya Purna Anggraini; Soetrisno Soetrisno; Eric Edwin Yuliantara; Supriyadi Hari Respati; Muhammad Adrianes Bachnas; Wisnu Prabowo; Hafi Nurinasari; Dympna Pramelita; Dewi Setiyawati; Metharisa Sujana; Aldi Firmansyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art6

Abstract

Background: The COVID-19 virus has spread throughout the world and has been declared as a global pandemic by WHO. Some population groups are more susceptible to COVID-19, and one of them is pregnant women. Pregnancy increases risks of the COVID-19, especially thrombotic complications. The SARS-CoV-2 infection may vary widely from asymptomatic to severe infection. Some studies have shown that ABO blood group can be a marker of susceptibility to some disease progression. Objective:This study aims to investigate relationships between the ABO blood group, the COVID-19 infection and its complications in pregnant women at Dr. Moewardi Hospital, Surakarta.Methods: This study was an observational analytic study with a cross-sectional study design involving 40 pregnant women infected with COVID-19 at Dr. Moewardi Hospital, Surakarta. COVID-19 PCR swabs on the women were administered on their oropharynx and nasopharynx, and laboratory examination of the ABO blood group in all samples was performed. Comparative data distribution of blood groups in the population and the global population distribution were calculated by Chi Square Goodness of Fit. Comparative data between ABO blood group distributions, blood parameters and complications (respiratory, thrombotic, other infections, and death) were calculated by Chi square test and then by One-Way ANOVA. Next, correlation tests for the complications of the blood group and the ages applied a multinomial regression.Results: There were significant differences of thrombotic complications on the blood group of pregnant women infected with COVID-19 (p=0.027). Blood type B significantly tended to experience thrombotic complications when compared to other blood groups (p=0.022).Conclusion: The ABO blood group could affect the complication levels in the pregnant women infected with the COVID 19.
Perbandingan Faktor Risiko antara Pertumbuhan Janin Terhambat Onset Dini dan Lambat di RSUD Dr. Moewardi Prilla Firsty Prasetyo Putri; Muhammad Adrianes Bachnas; Nutria Widya Purna Anggraini; Abdurahman Laqif
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 2 Juli 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6.n2.459

Abstract

Tujuan: Mengetahui perbandingan faktor risiko antara pertumbuhan janin terhambat onset dini dan lambat di RSUD Dr. Moewardi.Metode: Penelitian observasional analitik dengan pendekatan cross sectional menggunakan data sekunder rekam medis ibu dengan pertumbuhan janin terhambat di RSUD Dr. Moewardi mulai 1 Januari 2020–31 Desember 2021. Pengambilan data menggunakan teknik total sampling, Data diolah menggunakan SPSS dan dianalisis menggunakan uji univariat, kemudia bivariat yaitu uji Chi Square.Hasil: Hasil analisis bivariat menunjukkan bahwa tidak terdapat perbedaan bermakna pada variabel usia, paritas, Indeks Massa Tubuh (IMT), pekerjaan ibu, hipertensi, preeklamsi, diabetes melitus, anemia, asma antara pertumbuhan janin terhambat onset dini dan onset lambat (p>0,05).Kesimpulan: Tidak terdapat perbedaan yang bermakna pada usia ibu, paritas, Indeks Massa Tubuh (IMT), pekerjaan ibu, preeklamsi, hipertensi, diabetes melitus, anemia, asma antara kejadian pertumbuhan janin terhambat onset dini dan lambat di RSUD Dr. Moewardi.Comparison of Risk Factor For Early and Late Onset Intrauterine Growth Restriction in RSUD Dr. MoewardiAbstract Objective: To find out the comparison of risk factors between early-onset and late onset intrauterine growth restriction at RSUD Dr. Moewardi.Method: This research is an analytical observational with a cross sectional approach was done by using medical records of pregnant woman with intrauterine growth restriction at RSUD Dr. Moewardi from January 1, 2020– December 31, 2021. Data was collected using a total sampling technique. And processed by SPSS then analyzed using univariate test, and Chi Square test.Results: The results of bivariate analysis showed that there was no significant differences of age, maternal employment, parity, Body Mass Index (BMI), maternal employment, hypertension, preeclampsia, diabetes mellitus, anemia, asthma between early-onset and late-onset with intrauterine growth restriction (p>0,05).Conclusion: There were no significant differences of maternal age, parity, Body Mass Index (BMI), preeclampsia, maternal employment, hypertension, diabetes mellitus, anemia, asthma between early and late onset intrauterine growth restriction at RSUD Dr. Moewardi.Key words: Risk Factor, Intrauterine Growth Restriction, Early Onset, Late Onset
Co-Authors Abdurahman Laqif Adiyana, Febrian Andhika Aldi Firmansyah Aldika Akbar, Muhammad Ilham Askandar Tjokroprawiro Cut Sheira Elnita Dewi Setiyawati Dympna Pramelita Ecccita Raheestyningtyas Eric Edwin Yuliantara Ernawati Ernawati Hafi Nurinasari Hermanto Tri Joewono Jimmy Yanuar Anas Khanisyah Erza Gumilar Laksana, Muhammad Ardian Cahya Metharisa Sujana Nutria Widya Purna Anggraini Prilla Firsty Prasetyo Putri PUNGKY MULAWARDHANA, PUNGKY Soetrisno Soetrisno Sri Sulistyowati Sri Sulistyowati Supriyadi Hari Respati Supriyadi Hari Respati Uki Retno Budihastuti Wardhana, Manggala Pasca Wisnu Prabowo