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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Published by Perkumpulan Obstetri dan Ginekologi Indonesia
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 9 Documents
 1 
Search results for , issue " Volume. 35, No. 1, January 2011" : 9 Documents clear
Distribution of Age, Stage, and Histopathology of Cervical Cancer: A Retrospective Study on Patients at Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, 2006-2010 Anggraeni, Tricia D.
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To review the distribution of age, stage at presentation, and histology of cervical cancer at Dr. Cipto Mangunkusumo Hospital. Materials and methods: This cross sectional study involved 2297 subjects with cervical cancer at Dr. Cipto Mangunkusumo Hospital and registered at the Cancer Registration Information System during 5 years period from January 2006 to December 2010. Histotype was confirmed by histopathology examination. The International Federation of Gynecology and Obstetrics (FIGO) classification was used to stage the disease. Result: The mean age of cervical cancer patients was 51.42 years old (SD 9.694, range 21 - 85). The highest incidence was in 35 - 64 years (87.3%), with the peak incidence in 40 - 59 years (71.3%). There were 0.4 % patients identified at stage IA1, 0.1% at stage IA2, 7.3% at stage IB1, 4.9% at stage IB2, 10.5% at stage IIA, 17.3% at IIB, 1.7% at stage IIIA, 50.2% at stage IIIB, 4.3% at stage IVA, 3.2% at stage IVB. Of the 2297 patients, 70.2% had epidermoid carcinoma, 15.1% had adenocarcinoma, 10.2% had adenosquamous, 0.6% had clear cell, 3.9% had other types. Conclusion: A large proportion of cervical cancer (76.7%) presented in advanced stage (≥ stage IIB). The highest incidence (57.8%) was in the age range 45 - 59 years. Squamous cell carcinoma is the most frequent histopathology type (70.2%), followed by adenocarcinoma (15.1%) and adenosquamosa (10.2%). A lack of effective screening programs aimed at detecting and treating precancerous conditions is a key reason for the high incidence of cervical cancer at advanced stage. [Indones J Obstet Gynecol 2011; 35-1: 21-4] Keywords: cervical cancer, age, stage, histopathology
Monoplant® the Indonesian Implant: The Overview of Implant and Its Development Gunardi, Eka R.
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Norplant®, as a first-generation levonorgestrel implant and containing six capsules, has been shown to be effective as long-term contraception since more than 25 years ago. In the process, then the number of implants was reduced to two rods called Norplant-2®, which is then updated into Jadena® (in Indonesia) or Jadelle® (in America). As a country with the largest implant acceptors in the world, Indonesia has developed its own implant method consisting of two rods called Indoplant®. Currently being developed implant that consists of single rod called Monoplant®. Monoplant® is expected to be the best option because it only consists of a single rod implant that is easy to insertion and remove, effective and safe for at least three years. [Indones J Obstet Gynecol 2011; 35-1: 40-6]
The Comparison of Clinical and Surgical Staging of Cervical Cancer: A Retrospective Study on Patients at Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia Pradipta, Bram
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To evaluate the accuracy of clinical examination in determining the stage of operable cervical cancer and the extent of the disease. Method: The study involved 58 subjects from outpatient, emergency unit, and ward of Department of Obstetrics and Gynecology Dr. Cipto Mangunkusumo Hospital, from January 2008 to December 2010 with a diagnosis of cervical cancer. Patients who were diagnosed with cervical cancer up to stage IIA were included and patients lost to follow-up, receiving preoperative neo-adjuvant chemotherapy, and died before getting treatment were excluded. The outcomes evaluation were postoperative clinical staging, including the presence of enlarged lymph nodes, parametrial involvement, and tumor size. Lymph nodes, parametrial, and the tumor size were assessed from the surgery and pathological anatomy results. Result: The age distribution of 58 subjects ranged from 25 to 70 years (mean 48.39 years, SD 8.82). Squamous cell carcinoma was the most frequent type (44.9%), followed by adenocarcinoma (24.1%). Errors in preoperative clinical staging compared with postoperative was 40% in stage IA1, 9.52% in stage IB1, 17.65% in stage IB2, and 7.14% in stage IIA. Sensitivity, specificity, positive predictive value, and negative predictive value for preoperative clinical examination of lymph nodes were 11.1%, 100%, 100%, and 85.96%. Sensitivity, specificity, positive predictive value, and negative predictive value for preoperative clinical examination of parametrial involvement were 37.5%, 100%, 100%, and 90.90%. Sensitivity, specificity, positive predictive value, and negative predictive value for preoperative clinical examination of the tumor size were 91.84%, 88.89%, 97.83% and 66.67%. Conclusion: Clinical examination has limitation, especially in determining lymph nodes and parametrial involvement. Other diagnostic modalities in determining the extent of the disease is necessary. Enforcement of the right diagnosis in patients with cervical cancer is needed to determine the appropriate treatment. [Indones J Obstet Gynecol 2011; 35-1: 25-9] Keywords: staging, cervical cancer, preoperative, postoperative
Relation between CYP17 Polymorphism and Hyperandrogenemia in Polycystic Ovarian Syndrome Wiweko, Budi
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objectives: To find 5-untranslated region polymorphism of CYP17 gene and its connection with hyperandrogenemia in polycystic ovarian syndrome. Methods: A cross sectional descriptive study with consecutive random sampling method. Body mass index, ovarian morphology by ultrasonography, fasting insulin level, fasting blood glucose level, 17-hydroxyprogesterone level, total testosterone level, serum hormone binding globulin level, and CYP17 gene polymorphism in 45 subject with PCOs and 45 control subject who attend Yasmin clinic of Cipto Mangunkusumo General Hospital with menstruation problems were measured. CYP17 gene polymorphism was evaluated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method with MspA1 restriction enzyme. Results: In PCOs group, the genotype distribution were; 11.1% subject with genotype CC, 71.1% subject with genotype TC and 17.8% subject was wild type TT. In non PCOs group, the genotype distribution for CC, TC and TT respectively were 13.3%, 46.7% and 40%. There was significant difference between both group in distribution of TC and TT genotype, with p value 0.013. Frequencies of allele c and allele t in PCOs group were 47% and 53%. In non PCOs group, frequency of allele c and t were 37% and 63%. There were tendency for higher frequency of allele c in the PCOs group but the difference was not statistically significant. Median FAI value for genotype CC homozygote, TC heterozygote and TT homozygote in PCOs group respectively were; 6.82 (6.07 - 8.23); 5.59 (0.25 -21.45) and 4.74 (3.48 - 8.88). There was tendency for increase FAI value in PCOs group corresponds to variant allele, but the result was not statistically different. Conclusion: There were higher proportion of CC homozygote and TC heterozygote genotype in PCOs patient with tendency of increasing FAI value. [Indones J Obstet Gynecol 2011; 35-1: 3-7] Keyword: polycystic ovarian syndrome, free androgen index, CYP17 polymorphism
Profile of Policystic Ovarian Syndrome Patients in Dr. Cipto Mangunkusumo General Hospital Jakarta March 2009 - March 2010 Pangastuti, Niken P.
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To study phenotype profile and correlation between fasting blood glucose-fasting insulin ratio and luteinizing hormonefollicle stimulating hormone ratio with free androgen index in polycycstic ovarian syndrome in Dr. Cipto Mangunkusumo Hospital Jakarta. Method: A descriptive cross-sectional study was carried out at Dr. Cipto Mangunkusumo General Hospital Jakarta in March 2009 - March 2010, using secondary data, were involved 105 reproductive age women who has been diagnosed as PCOs with Rotterdam criteria. History of the subjects was taken from medical record that consist of interview result about menstrual history and clinical manifestations of hyperandrogenemia and clinical, biochemical, and ovarian ultrasound assessment. Result: From 105 women were identified, 100 women with oligo/amenorrhea (94.2%) and 34 women with hirsutism (32.4%). Further evaluation of the 105 cases, it was identified 80% subjects with polycystic ovaries morphology, 34.3% with hyperandrogenemia, 71.4% with insulin resistant, and 66.7% with increasing LH and FSH ratio. While, the most symptom and sign combination is oligo/amenorrhea and polycystic ovaries morphology, that is 44.8%. With Spearman non parametric correlation test, there were a significant correlation between fasting blood glucose-fasting insulin ratio and free androgen index (FAI) with coefficient of correlation -0.342 and and between LH/FSH and FAI with coefficient of correlation 0.386. Conclusion: The most common symptom and sign of PCOs patients in this study were oligo/amenorrhea and polycystic ovaries and insulin resistant. There were significant correlations between fasting blood glucose-fasting insulin ratio and LH/FSH with FAI. [Indones J Obstet Gynecol 2011; 35-1: 8-13] Keywords: polycystic ovarian syndrome, insulin resistance, luteinizing hormone hypersecretion, hyperandrogenemia
The effect of 17β Estradiol Exposure on Mutant p53 Expression in Hydatidiform Mole Trophoblast Cell Culture Nurseta, Tatit
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objectives: To compare the mutant p53 expression in normal trophoblast (N) cell culture with hydatidiform mole trophoblast (HM) cell culture which was exposed to 17β estradiol. Methods: An experimental study conducted at the Laboratory of Physiology Faculty of Medicine, Brawijaya University Malang using N cell culture and HM cell culture with 17β estradiol exposure. Trophoblast cell culture of normal and hydatidiform mole was divided in 6 groups, such as: 1. Without added 17β estradiol; 2. Added 5 nm 17β estradiol; 3. Added 10 nm 17β estradiol; 4. Added 20 nm 17β estradiol; 5. Added 40 nm 17β estradiol; 6. Added 80 nm 17β estradiol. Then performed immunocytochemistry staining using p53 mutant primary antibody and observed the expression of p53 mutant. Data from observations analized with the ANOVA test and correlation test. Results: Mutant p53 expression in N cell culture showed no significant differences in each treatment dose of 17β estradiol (p = 0086 > 0.05). The dose at 80nm 17β estradiol showed an average of highest mutant p53 expression on N cell culture rather than giving the dose of 17β estradiol on 40 nm, 20 nm, 10nm and 5 nm. While the control group showed a lowest average of mutant p53 expression in N cell culture when compared to the treatment group which was exposed to 17β estradiol. Mutant p53 expression in HM cell culture showed a significant difference at each treatment dose of 17β estradiol (p = 0.000 < 0.05). The existence of the effect of 17β estradiol begins when the expression of mutant p53 in HM cell culture becomes higher after being given treatment in the form of 17β estradiol on the dose of 5 nm compared with the expression of 17β estradiol in the control group. Then the expression of mutant p53 in HM cell culture is increasing when given doses of 17β estradiol at 20 nm and 40 nm. At a dose of 40 nm it shows the highest expression of mutant p53. Expression of mutant p53 in HM cell culture decreased when given at doses 80 nm. Conclusion: Mutant p53 expression in N cell culture exposed to 17β estradiol showed no significant difference. Expression of mutant p53 in HM cell culture which was exposed to 17β estradiol showed a significant difference. Mutant p53 expression in N and HM cell culture which was exposed to 17β estradiol showed significantly different, in which mutant p53 expression in N cell culture is lower than the expression of mutant p53 in HM tissue culture. [Indones J Obstet Gynecol 2011; 35-1: 30-5] Keyword: p53 mutant, 17β-estradiol, hydatidiform mole
The Effect of Analog GnRH before Laparoscopic Cystectomy to Ovarian Reserve which was Measured with anti Müllerian Hormone at Bilateral Endometriosis Cyst Sumapraja, Kanadi
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To know the effect of preoperative GnRH-a treatment to preserve the ovary after laparoscopic excision of endometriomas by measuring antimüllerian hormonal before and after operation and analize the correlation with age and size of the endometrioma. Methods: Double blind randomized control trial, which is done to patients with bilateral endometriomas in Raden Saleh Clinic. Subject devided into groups GnRH-a and placebo. Patient was undergoing laparoscopic excision after four weeks of medication (GnRHa or placebo). AMH Serum levels was measured before preoperative medication and four weeks after operation. Result: There were eight bilateral endometriomas (25% patients requirement), 4 patient GnRH-a and four patients placebo, all with primary infertility. The average changes of AMH serum level before and after laparoscopy ovarian cystectomy in GnRH-a groups was 0.011 ng/ml and placebo groups was 1.502. The average changes of AMH serum level, in age strativication on both groups show the same result, GnRH-a 0.035 and placebo 1.681. In diameter cyst strativication, GnRH-a 0.011 and placebo 1.090. Conclusions: With the restrictiveness of the patient, this study find GnRH-a therapy initiated before laparoscopic cystectomy has better outcomes in ovarian reserve compared with placebo, and also the same result in age and size of cyst strativication analize. [Indones J Obstet Gynecol 2011; 35-1: 14-7] Keywords: laparoscopic cystectomy, GnRH-a, ovarian reserve
Correlation of Inhibin A Serum Level with Preeclampsia Pratama, Dian
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: The purpose of this research is to analyze the difference of Inhibin A serum level between preeclampsia patients with normal pregnant patients and to analyze the relation between Inhibin A serum level with preeclampsia. Method: Comparison of average Inhibin A serum level of the preeclampsia group with normal pregnancy was analyzed by using Mann-Whitney test, and the correlation between Inhibin A serum level and preeclampsia was using biserial point correlation test. Samples were obtained from blood of patient suffered preeclampsia and also normal pregnancy, each containing 17 samples according inclusion and exclusion criterias. Patients came to Hasan Sadikin Hospital and two satellite hospitals in August to November 2010. Result: Characteristic test in two groups of study showed that both groups were homogeny and could compared. Mean level of Inhibin A serum was higher in preeclampsia (1268.08 pg/ml) than normal pregnancy (911.12 pg/ml) (p = 0.042) there was a strong positive correlation between Inhibin A serum level with preeclampsia (r pbi = 0.354; p = 0.027). Conclusion: From this research, we can conclude that Inhibin A serum level in preeclampsia is higher than normal. There is a positive correlation of Inhibin A serum level with preeclampsia. [Indones J Obstet Gynecol 2011; 35-1: 36-9] Keywords: inhibin A serum, normal pregnancy, preeclampsia
Effects of Peritoneal Fluid on Sperm Motility and Viability in Endometriosis Tasya, Marissa
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 1, January 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

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Abstract

Objective: To know the effects of peritoneal fluid on sperm motility and viability in patients with endometriosis. Design/data identification: This was a laboratory experimental study to peritoneal fluid from endometriosis and non-endometriosis patients who underwent surgery in Dr. Hasan Sadikin Hospital and around with endoscopy facility which fulfill inclusion and exclusion criterias. Experiments was performed in ASTER Fertility Clinic, Dr. Hasan Sadikin Hospital. Method: Semen samples were normozoospermic of which has been prepared using swim up method with sperm count 3 x 106/ml. The sperm were exposed to peritoneal fluid from endometriosis and non-endometriosis patients and analyzed at h 0, 1, 3, 6, and 24 to see the difference of sperm motility and viability postincubation with endometriosis peritoneal fluid. The sperm viability was detected using trypan blue 0.4%. Result: Exposure of sperm to peritoneal fluid reduced sperm motility significantly from the h 6 observation (Zw = 2.17; p = 0.03) and the h 24 (Zw = 2.35; p = 0.01). The sperm viability which incubated with endometriosis peritoneal fluid reduced significantly from h 6 observation (Zw = 1.99; p = 0.04) and the h 24 (Zw = 2.55; p = 0.01). Conclusion: The endometriosis peritoneal fluid reduced the motility and viability of the sperm began from the h 6 postincubation. This indicate the possibility of involvement of endometriosis peritoneal fluid to infertility. [Indones J Obstet Gynecol 2011; 35-1: 18-20] Keywords: sperm motility, sperm viability, endometriosis

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