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Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
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Articles 11 Documents
Search results for , issue "Volume 10 No. 1 January 2022" : 11 Documents clear
Long-term Outcome of Severe Preeclampsia Cases: Cross – Sectional Study: Keluaran Jangka Panjang Kasus Preeklamsia Berat: Studi Potong Lintang Yuditiya Purwosunu; Nurida M. Siagian
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 1 January 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i1.637

Abstract

Objectives: To investigate the long term outcome of severe preeclampsia mother by clinically and laboratory, and the long term outcome of the baby that she delivered. Method: This is a cross sectional study was conducted at Obstetrics Outpatient Clinic Dr. Cipto Mangunkusumo General Hospital (Cipto Mangunkusumo NCGH) on January–June 2017, of patients with previous severe preeclampsia that gave birth in Cipto Mangunkusumo NCGHon January 2014 – December 2016, and was descriptively analyze using SPSS Statistics 24. Results: One hundred and twenty seven patients were studied, divided into 3 groups of post – delivery time which were 6 months, 12 months, and 24 months. The 6 months’ group, mean of blood pressure were 147/92 mmHg (SD 38/SD 39), BMI 29 kg/m2 (SD 6), CRP level 16.6 mg/l (0.3 – 42.60) and urine protein dipstick 1 (0 – 3). The 12 months’ group, mean of blood pressure were 112/88 mmHg (SD 12/SD 24), BMI 21s kg/m2 (SD 7), CRP level 12.7 mg/l (3.4 – 15.2) and urine protein dipstick 0 (0 – 3). The 24 months’ group, mean blood pressure 154/95 mmHg (SD 45/SD 62), BMI 28.83 kg/m2, CRP level 14,2 mg/l (SD 8.54) and urine protein dipstick 0 (0 – 3). Meanwhile, the long – term outcome of babies that 68% baby were born with preterm condition and mean birth weight were 1943 grams (SD 1245), the 5th minute Apgar score >7 were 63.78%, and only 44.88% baby had normal growth development. Conclusion: The long – term outcome patients with previous severe preeclampsia are blood pressure, BMI, and CRP level still high, and negative urine protein level until 2 years of post – delivery. The long – term outcome of the babies that delivered were on preterm condition and low birth weight, with less than 50% had normal growth and development. Keywords: c–reactive protein, growth and development, proteinuria, post–delivery, severe preeclampsia. Abstrak Tujuan: Untuk mengetahui keluaran jangka panjang pada pasien ibu PEB dari sudut klinis dan laboratoris, serta keluaran jangka panjang bayi yang dilahirkan. Metode: Penelitian ini menggunakan desain potong lintang terhadap pasien riwayat PEB yang pernah melahirkan di RSUPN Dr. Cipto Mangunkusumo pada bulan Januari 2014–Desember 2016. Subjek diminta datang ke Poli Obstetri RSUPN Dr. Cipto Mangunkusumo pada Januari–Juni 2017 untuk dilakukan pemeriksaan klinis dan laboratoris (CRP dan protein urin), serta dilakukan analisa deskriptif menggunakan SPSS Statistik 24. Hasil: Sebanyak 127 pasien yang diteliti terbagi dalam 3 kelompok yaitu pasien riwayat PEB pasca persalinan 6 bulan (kelompok I), 12 bulan (kelompok II), dan 24 bulan (kelompok III). Kelompok I didapatkan rerata tekanan darah (TD) 147/92 mmHg (SD 38/SD 39), IMT 29 kg/m2 (SD 6), kadar CRP 16,6 mg/l (0,3 – 42,60) dan protein urin 1 (0 – 3). Kelompok II didapatkan rerata tekanan darah (TD) 112/88 mmHg (SD 12/SD 24), IMT 21 kg/m2 (SD 7), kadar CRP 12,7 mg/l (3,4 – 15,2) dan protein urin 0 (0 – 3). Kelompok III rerata TD 154/95 mmHg (SD 45/SD 62), IMT 28,83 kg/m2, dengan rerata kadar CRP 14,2 mg/l (SD 8,54) dan protein urin 0 (0 – 3). Sedangkan keluaran jangka panjang bayi yang dilahirkan bahwa 68% lahir dengan kondisi preterm dengan rerata berat lahir 1.943 gram (SD 1.245), nilai Apgar menit ke-5 >7 63,78%, dan hanya 44,88% tumbuh – kembang bayi normal. Kesimpulan: Gambaran keluaran jangka panjang pasien riwayat PEB didapatkan tekanan darah, IMT dan kadar CRP masih tinggi, serta protein urin urin negatif setelah 2 tahun pascapersalinan. Keluaran jangka panjang bayi yang dilahirkan mayoritas kondisi preterm dan berat lahir rendah, dengan kurang dari 50% bayi tumbuh – kembang normal. Kata kunci: c– reactive protein, preeklamsia berat, proteinuria, pascapersalinan, tumbuh kembang bayi.
Multiple Congenital Anomalies: Meningoencephalocele, Labiopalatoschisis and Clubfoot with Normal Chromosomal Analysis : Multipel Kongenital Anomali : Meningoensefalokel, Labiopalatoskhizis, dan Kaki Pengkor dengan Hasil Analisis Kromosom Normal Sefty M. Samosir; Angghea Rachmiawaty; Ita Fatati; Alamsyah Aziz
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 1 January 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i1.1366

Abstract

Objective : To perform chromosomal microarray when similar case was found.Methods: Case reportCase : G1P0A0, 20 years-old, 23-24 weeks gestation, normal BMI, was diagnosed by ultrasonography with multiple congenital anomaly consisted by meningoencephalocele, labiopalatoschisis, and clubfoot. Amniocentesis was performed to manage karyotyping analysis and a result of 46 XY was obtained. Neonate was delivered with exact condition according to prenatal diagnosis and was demised 6 hours postnatal. Patient had no history of smoking or DM, and no familial congenital deformity. Patient was a worker in textile manufactory and inadequacy folic acid intake during pregnancy was known.Early suspicion of aneuploidy as cause of multiple congenital anomalies in this case was not proven otherwise. Serology test also found no congenital infection. Literature research indicated tendency of MTHFR polymorphisms. Genetic analysis such as chromosomal microarray to establish involvement of MTHFR polymorphism is needed.Conclusion : This case should behold as clinicians’ consideration to perform additional examination and patients counseling when similar anomaly was found during prenatal ultrasonography examination.Keyword : chromosomal microarray,karyotyping; MTHFR polymorphism, mutiple congenital anomaly. Abstrak Tujuan : Untuk melakukan pemeriksaan chromosomal microarray pada kasus yang sama.Metode: Laporan kasus.Kasus : G1P0A0, usia 20 tahun, hamil 23-24 minggu, didiagnosis secara ultrasonografi dengan kelainan kongenital multipel berupa meningoensefalokel, celah bibir-palatum, dan club foot. Amniosentesis dilakukan pada pasien untuk analisis kromosom dan didapatkan hasil 46 XY. Bayi lahir dengan kondisi yang sama dengan diagnosis prenatal tersebut dan meninggal 6 jam pasca salin. Dari hasil anamnesis dan pemeriksaan kami dapatkan pasien bukan perokok, tidak ada keluarga dengan cacat bawaan, indeks masa tubuh pasien normal. Pasien merupakan karyawan pabrik tekstil dan pasien tidak mengkonsumsi asam folat adekuat selama kehamilan. Dua data terakhir yang kemungkinan berkontribusi terjadinya kelainan kongenital multipel pada kasus ini, yaitu kontak dengan teratogen dan defisiensi asam folat. Dugaan awal kelainan kromosom sebagai penyebab kelainan kongenital multipel pada kasus ini tidak terbukti. Sayangnya, investigasi-investigasi lebih lanjut berupa analisis genetik, seperti pemeriksaan apakah terdapat polimorfisme MTHFR yang berhubungan dengan defisiensi asam folat pada kasus ini tidak dilakukan karena keluarga pasien menolak. Kesimpulan : Kasus ini sebaiknya menjadi bahan pertimbangan klinisi untuk melakukan pemeriksaan tambahan dan edukasi ke pasien pada saat menemukan kelainan yang sama pada pemeriksaan ultrasonografi prenatal.Keyword: chromosomal microarray; karyotyping; multipel kongenital anomali; polimorfisme MTHFR
Increased Knowledge and Attitudes of Preconception Care using the Dedi Torri Application: Peningkatan Pengetahuan dan Sikap Perawatan Prakonsepsi melalui Aplikasi Dedi Torri Ni nyoman Y. Abriyani; Tri Sunarsih; Luluk Rosida
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 1 January 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i1.1453

Abstract

Objetive: To determine the increase in knowledge and attitude of preconception care through the application of DeDitorRi.Methods: Uses pre-experiment using a one group pre-test and post-test design.Result: Based on the paired t test in the first health education using the DeDi torRi application to the difference in knowledge obtained with a p value of 0.000 in attitudes with a p value of 0.000. Based on paired t test in the second health education using the DeDitorRi application to the difference of knowledge obtained with a p value of 0.000 and an attitude with a p value of 0.000.Conclusion: Preconception care health education through DeDi torRi (application-based module) and education that is given repeatedly to reproductive age mothers can influence the increase in knowledge and attitude of preconception care.Keywords: health education applications, preconception care, women of reproductive. Abstrak Tujuan : Untuk mengetahui peningkatan pengetahuan dan sikap perawatan prakonsepsi melalui aplikasi DeDi torRi. Metode : Pre-eksperimen dengan menggunakan rancangan one group pre-test dan post-test.Hasil: Berdasarkan uji paired t test pada pendidikan kesehatan pertama menggunakan aplikasi DeDi torRi terhadap beda pengetahuan yang didapatkan dengan p value sebesar 0,000 pada sikap dengan p value 0,000. Berdasarkan uji paired t test pada pendidikan kesehatan kedua menggunakan aplikasi DeDi torRi terhadap beda pengetahuan yang didapatkan dengan p value sebesar 0,000 dan pada sikap dengan p value 0,000.Kesimpulan: Pendidikan kesehatan menggunakan aplikasi DeDi torRi (aplikasi berbasis modul) efektif dalam meningkatkan pengetahuan dan sikap pada perempuan usia reproduktif terhadap perawatan prakonsepsi. Kata kunci: aplikasi pendidikan kesehatan, perawatan prakonsepsi, perempuan usia reproduktif.
The Pruritic Urticarial Papules and Plaques of Pregnancy (PUPPP): Papula Urtikaria Pruritik dan Plak pada Kehamilan (PUPPP) Riyan H. Kurniawan; Ugi U. Dimas; Afria Arista
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 1 January 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i1.1521

Abstract

Objective: To report a rare case of pruritic urticarial papules and plaques of pregnancy (PUPPP) in multiparous woman and its literature review.Methods: A case report with literature review.Discussion: This article reports a multigravida woman, presented with aterm pregnancy with sign and symptoms of pruritic urticarial papules and plaques since the first trimester of pregnancy. This case supports the morphological variation of skin lesions in PUPPP, as the patient had lesions other than the characteristic urticarial papules and plaques, with hyperpigmentation skin changes. The management of this case include oral and topical corticosteroids, oral antihistamines and moisturizer is used to relieve pruritus and skin lesions.Conclusion: PUPPP should be included in the differential diagnosis to differentiate this entity from other dermatoses associated with pregnancy, in order to provide appropriate treatment and reassurance.Keywords: papules, plaques, pregnancy, pruritic, urticarial. Abstrak Tujuan: Untuk melaporkan kasus langka mengenai papula urtikaria pruritik dan plak pada kehamilan (PUPPP) perempuan multipara, membahas literatur terkait pada PUPPP.Metode: Laporan kasus dengan telaah literatur.Diskusi : melaporkan kasus perempuan multigravida, datang dalam usia kehamilan cukup bulan dengan tanda dan gejala papula, plak, urtikaria dan pruritus sejak trimester pertama kehamilan. Kasus ini mendukung variasi morfologi lesi kulit pada PUPPP, karena pasien memiliki lesi selain papula dan plak urtikaria yang khas, dengan perubahan kulit hiperpigmentasi. Penatalaksanaan kasus ini meliputi kortikosteroid oral dan topikal, antihistamin oral dan pelembab yang digunakan untuk meredakan pruritus dan lesi kulit.Kesimpulan: PUPPP perlu dimasukkan dalam diagnosis banding untuk membedakan entitas ini dari penyakit kulit lain yang terkait dengan kehamilan, untuk memberikan pengobatan dan pelayanan yang tepat.Kata kunci: kehamilan, , papula, plak, pruritus, urtikaria
Influence of Total Hysterectomy to Sexual Function: Pengaruh Histerektomi Total dengan Fungsi Seksual Andini Z. Dini; Ferry Yusrizal; Firmansyah Basir; Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 1 January 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i1.1524

Abstract

Objective: To determine whether there are differences the impact of total hysterectomy on sexual function between each woman. Women who perform total hysterectomy often experience fear of the negative effects of hysterectomy on their sexual function.Methods: Randomized clinical trials have been conducted in outpatient clinic Obstetrics and Gynecological wards of Dr. Muhammad Hoesin General Hospital, Palembang from February to October 2020. There were 40 samples of women undergoing a total hysterectomy met the inclusion criteria. Sexual function before and after hysterectomy was analyzed with the Wilcoxon test. Data analysis using SPSS version 22.0.Results: This study showed decreased of desire, decreased stimuli, decreased orgasm, increased lubrication, increased sexual satisfaction, and increased dyspareunia samples after a total hysterectomy. However, with statistical analysis obtained results there were no meaningful changes in sexual function of desire (p = 0.849), stimuli (p = 0.716), lubrication (p = 0.261), orgasm (p = 0.839), sexual satisfaction (p = 0.613) and dyspareunia (p = 0.510) after total hysterectomy .Conclusion: It can be concluded that there is no significantly total hysterectomy effect on sexual function, based on FSFI (sexual desire, sexual arousal, lubrication, orgasm, sexual satisfaction, and pain.Keywords: clinical trial, FSFI, hysterectomy, sexual function. Abstrak Tujuan: Mengetahui adakah perbedaan dampak histerektomi total pada fungsi seksual antara setiap perempuan. Perempuan yang melakukan histerektomi total sering mengalami ketakutan akan efek negatif histerektomi pada fungsi seksualnya. Metode: Telah dilakukan uji klinis secara acak di poliklinik rawat jalan bangsal Obstetri dan Ginekologi RSUP Dr. Muhammad Hoesin Palembang dari bulan Februari sampai Oktober 2020. Sebanyak 40 sampel perempuan yang menjalani histerektomi total memenuhi kriteria inklusi. Fungsi seksual sebelum dan sesudah histerektomi dianalisis dengan uji Wilcoxon. Analisi data menggunakan SPSS versi 22.0.Hasil: Penelitian ini menunjukkan penurunan hasrat, penurunan rangsangan, penurunan orgasme, peningkatan lubrikasi, peningkatan kepuasan seksual, dan peningkatan dispareunia setelah histerektomi total. Namun dengan analistik statistik didapatkan hasil tidak ada perubahan yang bermakna pada fungsi seksual yaitu hasrat (p=0,849), rangsangan (p=0,716), lubrikasi (p= 0,716), lubrikasi (p=0,261), orgasme (p=0,839), kepuasan seksual (p= 0,613), dan dispareunia (p= 0,510) setelah histerektomi total.Kesimpulan: Dapat disimpulkan bahwa tidak ada pengaruh histerektomi total yang signifikan terhadap fungsi seksual berdasarkan FSFI (hasrat, seksual, gairah seksual, lubrikasi, orgasme, kepuasan seksual, dan nyeri.Kata kunci: fungsi seksual, FSFI, histerektomi, uji klinis.
Fetomaternal Outcome of Aterm Labor with Pregnant Thrombocytopenia: Luaran Fetomaternal pada Ibu Hamil Aterm dengan Trombositopenia Rajuddin Rajuddin; Muhammad Iqbal; Cut M. Yeni
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 1 January 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i1.1526

Abstract

Objective : To determine the relationship between term pregnant women and the incidence of post-partum haemorrhage, duration of healing of incision/perineorhaphy wounds, fetal thrombocytopenia, APGAR value and birth weight of infants in dr. Zainal Abidin Hospital Banda Aceh.Methods: Design of research is observational analytic with a cross sectional approach. The research sample was taken by the total sampling method. The population in this study were all pregnant patients at term who came to the dr. Zainoel Abidin Hospital Banda Aceh and experienced thrombocytopenia at a predetermined time, met the inclusion and exclusion criteria. Analysis data with the Pearson correlation test formula to assess the strength of the relationship between two variables.Results: The prevalence of aterm pregnant women with thrombocytopenia who visited and gave birth at Dr. Zainoel Abidin General Hospital during the study period was 1.62% from 1850 visited pregnant women. A total of 30 samples in this study, obtained a maternal outcome were postpartum haemorrhage as much as 60% (p-value 0.000). The duration of wound healing was 26.70%, (p-value 0.008). While the fetal outcomes were the incidence of neonatal thrombocytopenia 50% (p-value 0,000), nenonatal asphyxia with an APGAR value of 4-6 as much as 43.30% (p-value 0.003) and low birth weight of the baby at 36.70% (p-value 0.033). The five variables obtained a positive correlation with varying strengths of the relationship.Conclusion: There is a close relationship between the incidence of thrombocytopenia at term pregnant women at delivery and fetomaternal outcomes in dr. Zainoel Abidin Hospital Banda AcehKeywords: fetal outcome, maternal outcome, Score APGAR, thrombocytopenia. Abstrak Tujuan : Untuk mengetahui hubungan ibu hamil aterm dengan kejadian perdarahan post-partum, lamanya penyembuhan luka insisi/perineorafi, trombositopenia janin, nilai APGAR dan berat badan lahir bayi di Rumah Sakit Umum dr. Zainal Abidin Banda Aceh. Metode: Jenis penelitian ini adalah analitik observasional dengan pendekatan cross sectional. Sampel penelitian diambil dengan metode total Sampling. Populasi pada penelitian ini adalah semua pasien hamil aterm yang datang ke RSUD dr. Zainoel Abidin Banda Aceh dan mengalami trombositopenia pada rentang waktu yang telah ditentukan, memenuhi kriteria inklusi dan eksklusi. Analisa data dengan melakukan uji korelasi Pearson untuk menilai kekuatan hubungan dua variabel.Hasil: Prevalensi ibu hamil aterm dengan trombositopenia pada penelitian adalah 1,62% dari 1850 ibu hamil yang berkunjung. Sebanyak 30 sampel pada penelitian didapatkan luaran maternal yaitu perdarahan postpartum sebanyak 60% (p-value 0,000). Lama penyembuhan luka didapatkan26,70%, (p-value 0,008). Sedangkan luaran fetal yaitu kejadian trombositopenia neonatus 50% (p-value 0,000), asifiksia nenonatus dengan nilai APGAR 4-6 sebanyak 43,30% (p-value 0,003) dan berat badan bayi lahir rendah 36,70% (p-value 0,033). Kelima variabel didapatkan korelasi positif dengan kekuatan hubungan yang bervariasi.Kesimpulan: Terdapat hubungan erat antara kejadian trombositopenia ibu hamil aterm saat persalinan terhadap luaran fetomaternal di RSUD dr. Zainoel Abidin Banda Aceh.Kata kunci : luaran fetal, luaran maternal, nilai APGAR, trombositopenia.
Return of Fertility After Discontinuation of Contraception According Type of Contraception, Duration of Use, Age and BMI: Kembalinya Kesuburan Pasca Penghentian Alat Kontrasepsi Berdasarkan Jenis Kontrasepsi, Lama Pemakaian, Usia dan IMT Quinita M. J. Noronha; Hafi Nurinasari; Uki R. Budihastuti; Darto
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 1 January 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i1.1527

Abstract

Objective : To determine the relationship between the type of contraception, duration of use, BMI, and age on the return of fertility.Methods : This was an analytic observational study with a cross-sectional design. The subjects in this study was 123 multigravida mothers who had met the inclusion criteria, namely with a history of regular intercourse and the exclusion criteria in this study were multigravida mothers with a history of abortion and failure of the family planning method. Data were collected by direct interviews and medical record data. Data were analyzed using Chi-square test and Logistic Regression test.Results: The results of the Chi-square analysis showed a relationship between the type of contraception (p=0.001;OR=1.29) and age (p=0.031;OR=4.69) with the return of fertility. However, there was no correlation between the duration of use (p=0.964;OR=0.97) and BMI (p=0.246;OR=0.50) with the return of fertility. In the logistic regression test, there was no partial effect of the type of contraception (p=0.997;OR=0.22) and age (p=0.058;OR=0.01).Conclusion : Based on the results of the analysis, it can be concluded that there is a relationship between the type of contraception and age with the return of fertility after family planning, where non-hormonal contraceptives and <30 years of age return to fertility faster, namely <1 year, but there is no relationship between duration of use and BMI with the return of fertility after family planning.Keywords: contraception, family planning, fertility. Abstrak Tujuan: Mengetahui hubungan jenis kontrasepsi, lama pemakaian, IMT, dan usia terhadap kembalinya kesuburan.Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain potong lintang. Subjek penelitian ini adalah ibu multigravida yang telah memenuhi kriteria inklusi yaitu dengan riwayat senggama teratur dan bersedia menjadi responden serta kriteria ekslusi dalam penelitian ini adalah ibu multigravida dengan riwayat abortus dan kegagalan metode KB. Besar subjek dalam penelitian ini sebanyak 123 orang. Pengambilan data dilakukan dengan wawancara langsung dan melihat data rekam medis. Analisis data dilakukan uji statistik Chi-square dan uji Regresi Logistik.Hasil : Hasil analisis dengan Chi-square, menunjukan adanya hubungan jenis kontrasepsi (p = 0,001; OR = 1,29) dan usia (p=0,031; OR = 4,69) dengan kembalinya kesuburan. Namun, tidak terdapat hubungan lama pemakaian (p= 0,964; OR =0,97) dan IMT (p= 0,246; OR =0,50) dengan kembalinya kesuburan. Pada uji regresi logistik tidak terdapat pengaruh parsial dari jenis kontrasepsi (p=0,997; OR =0,22) dan usia (p=0,058; OR=0,01).Kesimpulan : Berdasarkan hasil analisis yang dilakukan dapat disimpulkan terdapat hubungan jenis kontrasepsi dan usia dengan kembalinya kesuburan pasca KB, dimana pada jenis kontrasepsi non hormonal dan usia < 30 tahun lebih cepat kembali subur yaitu < 1 tahun, namun tidak terdapat hubungan lama pemakaian dan dengan kembalinya kesuburan pasca KB.Kata kunci: keluarga berencana, kesuburan kontrasepsi.
Nifedipine, Calcium Channel Blocker (Antihypertensive), as a Tocolytic to inhibit Premature Birth in Reducing the Risk of Neonatal Death in Childbirth: Meta-Analysis and Systematic Review of Large Clinical Trial: Nifedipine, Penghambat Kanal Kalsium (Antihipertensi), sebagai Tokolitik dalam Menghambat Kelahiran Prematur dalam Menurunkan Risiko Kematian Neonatus Pada Persalinan: Meta-Analisis dan Telaah Sistematis dari Studi Besar Uji Klinis Axel J. Olda; Joue Abraham Trixie; Glenn Bolang; Yoga Rahmat Witular; Saerang Langi
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 1 January 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i1.1549

Abstract

Objective: To evaluate the role of nifedipine as a tocolytic agent.Methods: Literature searches use medical search engines for example Pubmed, Google Scholar and Medical scientific journals, as like the American kind of Journal that is Learning Obstetrics and also learn about Gynecology. The literature used were published from 1986 to 2020. The main data extraction was in the form of an extended gestation period, divided into 48 hours, 7 days, and 37 weeks with data analysis using the RevMan 5.4 application. Result: Twenty-four clinical trials were analyzed with total amount shown of 2,889 study subjects. The purpose of using kind of nifedipine to be such a tocolytic indicates no significant difference, within 48 hours or (RR 1.06; 95% CI, 0.99 - 1.13; p shown = 0.12), 7 days (RR 1.02; 95% CI, 0.95 - 1.09; p = 0.57), and up to 37 weeks (RR 1.22; 95% then CI, 0.96 - 1.54; p = 0.10) at the time it is compared with the group of control.Conclusion: Administration of nifedipine as a tocolytic did not have a statistically significant difference, both in prolonging pregnancy and side effects for pregnant women and neonates compared to the control group.Keyword: meta-analysis, nifedipine, preterm delivery, prolongation pregnancy, tocolytic. Abstrak Tujuan: Untuk mengevaluasi peran nifedipin sebagai tokolitik.Metode: Pencarian literatur menggunakan mesin pencari medis seperti Pubmed, Google Scholar dan jurnal ilmiah medis, seperti American Journal of Obstetrics and Gynecology. Literatur yang digunakan dalam rentang tahun 1986 - 2020. Kata kunci adalah ("pregnant woman" OR pregnancy) AND ("preterm birth" OR "preterm labor") AND nifedipine. Ekstraksi data utama berupa perpanjangan masa kehamilan, dibagi menjadi 48 jam, 7 hari, dan 37 minggu dengan analisis data menggunakan aplikasi RevMan 5.4Hasil: Dua puluh empat uji klinis yang dianalisa dengan total 2,889 subjek penelitian. Penggunaan nifedipine sebagai tokolitik menunjukkan tidak ada sesuatu yang berbeda secara signifikan, dalam 48 jam (RR 1.06; 95% then CI, 0.99 - 1.13; p results = 0.12), 7 hari (RR shown 1.02; 95% then CI, 0.95 - 1.09; p = 0.57), dan sampai 37 minggu (RR 1.22; 95% CI, 0.96 - 1.54; p shown = 0.10) apabila dibandingkan dengan kelompok kontrol. Begitu pun dengan efek samping pada ibu hamil (RR 0.99; 95% CI, 0.74 - 1.31; p = 0.92) dan neonatus (RR 0.93; 95% of CI, 0.83 - 1.04; p shown = 0.21), ditemukan adanya kesamaan yang serupa pada grup atau golongan dalam kendali.Kesimpulan: Pemberian nifedipine sebagai tokolitik tidak memiliki perbedaan yang signifikan secara statistik, baik dalam memperpanjang masa kehamilan maupun efek samping kepada ibu hamil dan neonatus dibandingkan dengan kelompok kontrol.Kata kunci: kelahiran prematur, meta-analysis, nifedipin, prolongation pregnancy, tokolitik
Risk of Malignancy Index 3 (RMI3) Performance as a Predictor Advanced Stage Epithelial Ovarian Carcinoma used for NACT: Perfoma Risk of Malignancy Index 3 (RMI3) sebagai Prediktor Karsinoma Ovarium Epithelial Stadium Lanjut untuk Pertimbangan Pemberian NACT Tatit Nurseta; Putu A. Herliawati; Dhian E. P. Harnandari; Kusworini Handono; Yahya Irwanto; Sutrisno Sutrisno
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 1 January 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i1.1599

Abstract

Effect of Early versus Delayed Cord Clamping on Hematological Parameters of Term Neonates: Pengaruh Penjepitan Tali Pusat Dini Dibandingkan dengan Tertunda pada Parameter Hematologi Neonatus Aterm Chaithra Ravishankar; Ratan Kumar Das; Chandra Bhanu Dalal; Tapan Pattanaik
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 1 January 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i1.1618

Abstract

Objectives : To compare the serum bilirubin, hemoglobin, and hematocrit in term infants undergoing delayed cord clamping with early cord clamping after normal and caesarean delivery.Methods : This is a prospective observational study. The neonates in which cord clamping was done within 15 seconds were considered in early cord clamping (ECC) group and where cord clamping was done after 1 minute was considered in delayed cord clamping (DCC) group. The PCV, Hb, serum bilirubin were observed after 48 hours in both the groups and compared.Results : There was statistically significant difference in means of Hb level (p = 0.001) and PCV level (p = 0.001) between DCC and ECC group whereas no statistically significant difference was present in total serum bilirubin level (p = 0.359).Conclusion: There was no significant increase in risk of polycythaemia and hyperbilirubinemia between delayed cord clamping and early cord clamping group rather has beneficial effects in increasing the haemoglobin and haematocrit in the infants.Keywords : delayed cord clamping, early cord clamping, hematocrit, hemoglobin, serum bilirubin, hyperbilirubinemia. Abstrak Tujuan: Untuk membandingkan bilirubin serum, hemoglobin, dan hematoklit pada bayi aterm yang dilakukan delayed cord clamping dan early cord clamping setelah persalinan normal dan seksio sesarea.Metode: Studi ini merupakan studi prospektif. Neonatus yang dilakukan cord clamping dalam 15 detik dikelompokkan pada delayed cord clamping (DCC). PCV, Hb, bilirubin serum diobservasi dalam 48 jam pada kedua kelompok, kemudian dibandingkan.Hasil: Terdapat perbedaan signifikan antara kadar Hb (p = 0,001) dan PCV (p = 0,0010 antara kelompok DCC dan ECC, sedangkan tidak terdapat perbedaan signifikan pada kadar bilirubin serum total (p = 0,3590Kesimpulan: Tidak terdapat peningkatan signifikan polisitemia dan hyperbilirubinemia antara DCC dan ECC.Kata kunci: delayed cord clamping, early cord clapming, hematokrit, hemoglobin, serum bilirubin, hyperbilirubinemia

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