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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Kedokteran Brawijaya Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kebidanan Dan Kesehatan Tradisional Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Universa Medicina AcTion: Aceh Nutrition Journal Jurnal Kesehatan Reproduksi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal of Medicine Journal of Maternal and Child Health JKM (Jurnal Kebidanan Malahayati) Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Jurnal Kebidanan Harapan Ibu Pekalongan Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Jurnal Abdidas Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Nusantara Science and Technology Proceedings Plexus Medical Journal Indonesian Basic and Experimental Health Sciences Folia Medica Indonesiana

Uki Retno Budihastuti

Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Sebelas Maret, Surakarta/ Dr. Moewardi Hospital, Surakarta

Author-ID : 692440

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Mucin-1 expression in endometrium is higher in polycystic ovary syndrome than in normal women Budihastuti, Uki Retno; Sulistyowati, Sri; Melinawati, Eriana; Marbun, Yohan Pamuji
Universa Medicina Vol 39, No 2 (2020)
Publisher : Faculty of Medicine, Trisakti University

BackgroundThe polycystic ovary syndrome (PCOS) is caused by endocrine system dysfunction in women. MUCIN-1 (MUC-1) expression is found in endometrial tissues, which leads to implantation process dysfunction because of imbalance of trophoblast adhesion process. This study was conducted to compare endometrial MUC-1 expression between PCOS and normal women considering all existing external variables.MethodsThis cross-sectional study was conducted in General Hospital Dr. Moewardi Surakarta. Endometrial samples were obtained from 30 infertile PCOS women based on Rotterdam criteria, and 30 normal women. Life style and reproductive data such as age, menstrual problems, menstrual cycle, age at menarche, and BMI were collected. Subjects underwent endometrial biopsy in luteinizing hormone (LH) secretion phase LH + 5 days to LH + 10 days for immunohistochemistry (IHC) of MUC-1 expression. An independent-t and multiple linear regression test were used to analyze the data at significance level of p<0.05. ResultsMean MUC-1 expression in the PCOS endometrium (49.66 Â± 47.79) was significantly higher than in normal women (7.66 Â± 14.55) (p=0.03). Multivariate linear regression model of life style and reproductive variables with MUC-1 showed that PCOS (b=29.54; 95% CI 9.57-49.49; p=0.004) and BMI (b= 29.99; 95% CI 5.91-54.07; p=0.001) significantly increase MUC-1 expression. PCOS (Beta=0.37) was more important than BMI (Beta=0.30) in increasing the MUC-1 expression. ConclusionExpression of MUC-1 levels in the PCOS endometrium was higher than in normal women. This suggests that MUC-1 contributes to the unexplained reproductive failure in PCOS.

The role of genital tract infection inpreterm delivery: aretrospective study Satria, Yohanes Aditya Adhi; Budihastuti, Uki Retno; Susilawati, Tri Nugraha
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Preterm delivery is associated with higher mortality and morbidity of neonates, also increasestheir risk of having growth and development impairment.This study aimed toidentify the role ofgenital tract infection in preterm delivery. A retrospective study was conducted on medical records of mothers who had preterm delivery in a tertiary hospital in Surakarta, Indonesia during 2017. The data collected were mothers’ age and their gestational age, the history of current pregnancy, the number of previous abortion(s), mothers’ body temperature, the extent of abnormal vaginal discharge, and laboratory findings (white blood cell count, platelet count, red blood cell count, hemoglobin count, hematocrit level, urinalysis and microbiology results). The statistical differences amongst categorical and numerical data were analyzed using the Chi-Square test and the Mann-Whitney test. Based on the patient’s history and the examination results, we suspected genital tract infections in22.52% (25/111)of subjects. All of them had abnormal vaginal discharge despite only one case had been confirmed as streptococcal infection. This study found that the majority of mothers with probable genital tract infection hadpreterm premature rupture of the membrane whilst preeclampsiawas more evident in those without genital tract infection. We conclude that genital tract infection during pregnancy is a significant contributor to the occurence of premature birth so that microbiological testing is needed to confirm the diagnosis.

The Differences of Folliculogenesis between Treated with Letrozole and Letrozole-Electroacupuncture in Women with Polycystic Ovary Syndrome Yulyanti, Yulyanti; Budihastuti, Uki Retno; Melinawati, Eriana; Sulistyowati, Sri; Nurwati, Ida
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder that most often causes infertility. It occurs due to the failure of folliculogenesis, thus causing non-ovulation. Letrozole is a 3rd generation drug of non-steroidal aromatase inhibitors, which can increase ovulation rates. Electroacupuncture is the insertion and manipulation of needles into acupuncture points (acupoints) that are selected specifically based on the meridian system and connected to the electrode stimulator. This study aimed to determine the differences of the effects of letrozole and letrozoleelectroacupuncture (letrozole-EA) on the improvement of folliculogenesis in women with PCOS.Subjects and Method: This was an analytic observational study with a case-control design. This study was conducted at the Gynecology Polyclinic and Sekar Clinic, Dr. Moewardi Hospital, Surakarta. A sample of 30 infertile women aged 20-45 years was selected by fixed disease sampling. The criteria of the PCOS were determined based on Rotterdam criteria. The dependent variable was the diameter of the follicle. The independent variables were the administration of letrozole and letrozole-EA. Transvaginal ultrasound of Voluson P6 was used to measure the folliculogenesis. The data were analyzed by independent t-test.Results: On the second day after treatment, the diameter of the follicles in the letrozole-EA group (mean= 6.92; SD= 1.60) was bigger than the letrozole group (mean=5.66; SD=1.11), and it was statistically significant (p=0.004).Conclusion: Combination of letrozole and letrozole-EA therapy is more effective in increasing follicular diameter development than letrozole therapy only.Keywords: polycystic ovary syndrome, folliculogenesis, Letrozole, electro-acupunctureCorrespondence: Yulyanti. Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Central Java, Indonesia. Email: dr.yulyanti@gmail.com. Seluler: +6285264806570.Indonesian Journal of Medicine (2020), 05(03): 214-223https://doi.org/10.26911/theijmed.2020.05.03.06

The Difference of Endometrial Vascular Endothelial Growth Factor (VEGF) Expression between Polycystic Ovarian Syndrome (PCOS) and Normal Women Saputra, Ricky Bernadi; Budihastuti, Uki Retno; Sulistyowati, Sri; Melinawati, Eriana; Respati, Supriyadi Hari
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder in women characterized by increased levels of androgens, ovulatory dysfunction, and Polycystic Ovarian Morphology (PCOM), as well as a combination of classic clinical features. Women with PCOS experience changes in the endometrium and endometrial receptivity markers such as VEGF (Vascular Endothelial Growth Factor). VEGF increases the permeability and dilation of endometrial blood vessels which play an important role in implantation. This study aimed to analyze the difference of VEGF expression between women with PCOS and normal women.Subjects and Method: This study was a case-control study design conducted at the polyclinic of the Department of Obstetrics and Gynecology, Dr. Moewardi Hospital, Surakarta, Central Java, in July 2020. There were 30 infertile women with PCOS (diagnosis based on Rotterdam criteria, consensus 2003) and 30 women without PCOS as the sample of this study. The dependent variable was VEGF expression. The independent variables were age, BMI, family history with PCOS, menarche, occupation, and education. VEGF expression was obtained from an endometrial biopsy on days 19-24 of periods. The differences in VEGF expression (in %) were analyzed by the Mann-Whitney test. VEGF determinants were analyzed by a multiple linear regression.Results: The mean of VEGF expression in women with PCOS (Mean=64.33; SD=44.43) was higher than in women without PCOS (Mean= 7.90; SD=8.73) and the result was statistically significant (p<0.001). PCOS (b=42.09; 95%CI=64.26 to -19.93; p<0.001) and obese (b=38.63; 95%CI=-63.44 to -13.82; p=0.003) increased VEGF expression.Conclusion: VEGF expression in the endometrium of women with PCOS is higher than normal women.Keywords: VEGF, endometrium, Polycystic Ovarian SyndromeCorrespondence: Ricky Bernadi Saputra. Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Indonesia. Telp: 081221161933 Email: rickysaputradr@gmail.comIndonesian Journal of Medicine (2020), 05(03): 230-239https://doi.org/10.26911/theijmed.2020.05.03.08

The Effectiveness of Letrozole Adjuvant Therapy - Electro Acupuncture in Reducing the Number of Follicles and Body Weight and Increasing Endometrial Thickness in Women with Polycystic Ovary Syndrome Wesliaprilius, Todung Antony; Budihastuti, Uki Retno; Melinawati, Eriana; Sulistyowati, Sri; Nurwati, Ida; Hadi, Cahyono
Journal of Maternal and Child Health Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Acupuncture can improve menstrual cycle recovery and decrease body mass index (BMI) in women with PCOS. The effect of acupuncture can be enhanced by giving letrozol. Researchers are interested in knowing the comparison between letrozol therapy with letrozol + electroacupuncture on body weight, follicle count, and endometrial thickness in women with polycystic ovary syn

The Effectiveness of Edutainment toward Pregnancy Care on Knowledge, Attitude, and Action in Pregnant Women Firdausia, Shalsabilla Tiara; Budihastuti, Uki Retno; Dewi, Yulia Lanti Retno
Journal of Maternal and Child Health Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Playing or studying in a plea

Partial molar pregnancy with live fetus in first trimester: what should we do next Eric Edwin; Uki Retno Budihastuti; Cut Sheira Elnita
Jurnal Kedokteran Syiah Kuala Vol 20, No 2 (2020): Volume 20 Nomor 2 Agustus 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i2.18505

Abstract. The incidence of a normal live fetus with a partial mole is extremely rare, and it varies between 5 per 100000 and 1 per 10000 of the pregnancies. A partial molar pregnancy is a variation of a molar pregnancy in which an embryo either develops incompletely or with multiple structural anomalies.A 27-year-old Primigravide at 13 weeks of gestation got admitted with spotting per vaginam, excessive nausea and vomiting, and her ultrasound revealed a hydropic placenta with multiple cysts with a live fetus. Regarding these findings, the patient continued her pregnancy under close observation, and advanced sonographic evaluations were done to rule out other differentials. Ultrasonography found mosaicism in the partial mole (mostly diploid, a small part is triploid). In this condition, the prognosis condition for the fetus to be born safely is still probable. Ethics committee meetings are held with the consideration of the fetus's condition, whether monitoring is carried out regularly, and terminating the pregnancy in case of fetal emergency.The optimal management of hydatidiform mole with the coexistent live fetus is currently uncertain. Antenatal consultation should include a detailed discussion of maternal and fetal risks. It is also necessary to have close follow-up and evaluation of the patient's condition during the antenatal and postnatal period. Keywords: first trimester, live fetus , management, partial molar pregnancy

Hypnobreastfeeding Dapat Menurunkan Kecemasan Pada Ibu Post Partum Lutfiana Puspita Sari; Harsono Salimo; Uki Retno Budihastuti
Jurnal Kebidanan dan Kesehatan Tradisional Vol 4 No 1 (2019): Jurnal Kebidanan dan Kesehatan Tradisional
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jkkt.v4i1.95

Background: Post partum period is condition of a time that very influential on the psychological and social conditions for women after giving birth. The incidence of post partum blues increased in this period of time with a prevalence of 30% to 75%. Post partum blues give effect to the early cessation of breastfeeding process which is contribute to child mortality under 5 years of 11.6%. This is associated with the practice of exclusive breastfeeding that are not optimal as a result of post partum blues experienced by woman after giving birth. The purpose is to analyze the anxiety in the group given the Hypnobreastfeeding intervention treatment and which is not given the intervention treatment, held at RSUP Dr. Suradji Tirtonegoro, Klaten. Method: Research is experimental design with randomized control trial. The population is all pregnant women in Puskesmas Jogonalan I area of Klaten. A total of 60 post partum object was selected for this study by simple random sampling. This was a randomized controlled trial, conducted at RSUP Dr. Suradji Tirtonegoro, Klaten. Results: The difference of dependent variables between the two groups were tested by Mann-Whitney. Conclusion: There is a differences and significance level of result of degree of anxiety between both treatment result with p=0.002. Hypnobreastfeeding intervention treatment can relief anxiety level for post- partum mother

Changes in LIF expression on PCOS as biomarker implantation Uki Retno Budihastuti; Eriana Melinawati; Sri Sulistyowati; Tanti Arianti
Majalah Obstetri dan Ginekologi Vol. 29 No. 1 (2021): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V29I12021.23-27

Objectives: This study aimed to compare the endometrial expression of LIF PCOS compared to normal and determine the effect of PCOS and external variables that affect LIF expression.Materials and Methods: This retrospective case control study with a correlational approach was conducted at Sekar Clinic, General Hospital Dr. Moewardi Surakarta. Subject were taken by consecutive sampling starting from September 2018 –. Februari 2019. External variable: age, occupation, family history PCOS, menarche, and BMI were recorded. The research samples were 60 subjects consisting of 30 PCOS patients based on Rotterdam criteria and 30 fertile women. In the luteinizing hormone (LH) secretion phase at LH + 5 days - LH + 10 days, an endometrial biopsy is performed with pipelle curettage, then it is examined by immunohistochemistry. Statistical analysis was performed using the Mann-Whitney, linier regression test.Results: Mean of LIF expression was found significantly lower in PCOS group (1.53±3.65) compared to control group (35.33±21.04, with p=<0.001). Multivariate analysis linear regression in the effect of PCOS and external variables to endometrial LIF expression models showed PCOS (b=-1.14; 95% CI=-1.56 – -0.72; p=<0.001) and occupation (b = 0.32; 95% CI=0.14 – 0.52; p=0.001) significantly decreases LIF expression. PCOS (B=-1.14) is more important than Occupation (B=0.33) in decreasing LIF expression.Conclusion:LIF expression decreased in the endometrium of PCOS patients and occupations compared to normal group, with considering all existing variables.

Apakah Endometriosis Mempengaruhi Kualitas Embryo pada Pasien Invitro Fertilization? Dewanto Suryoningrat; Abdurahman Laqif; Soetrisno Soetrisno; Uki Retno Budihastuti; Sri Sulistyowati
JURNAL KESEHATAN REPRODUKSI Vol 8, No 1 (2021)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.63039

Latar Belakang Invitro Fertilization merupakan salah satu manajemen infertilitas yang baik, namun masih didapatkan adanya kesamaan peluang kegagalan perkembangan embrio sebanyak 50% dibandingkan dengan pasien yang tidak mengalami endometriosis.Tujuan: untuk mengetahui hubungan endometriosis dan kualitas embrio pada pasien yang menjalani program invitro fertilization.Metode: Data yang dikumpulkan merupakan data pada rekam medis pasien Klinik Fertilitas Sekar yang menjalani invitro fertilization di Klinik Fertilitas Sekar RSUD Dr. Moewardi Surakarta pada Januari 2010 – Desember 2019. Analisis menggunakan uji deskriptif dan Uji T tidak berpasangan. Hasil dianggap signifikan jika p ≤ 0,05.Hasil dan Pembahasan: Dalam penelitian ini, rerata kualitas embrio baik memiliki perbedaan yang signifikan (p<0.05) antara pasien dengan endometriosis dan pasien tanpa endometriosi, sedangkan kualitas embrio buruk tidak memiliki perbedaan yang signifikan (p>0.05).Kesimpulan: Endometriosis memiliki hubungan yang signifikan dengan kualitas embrio pada wanita yang menjalani program IVF.

Co-Authors ., Darto Abdurahman Laqif Abdurahman Laqif Abdurahman Laqif Abida Zuhra Jatiningtyas Adhimukti, Fahmi Affi Angelia Ratnasari Agustina, Devita Alfi Marita Tristiarti Alfi Marita Tristiarti Alfi Marita Tristiarti Ali Djamhuri Alifa, Rosita Ambar Mudigdo Amir, Nikmah Ayu Ramadhani Angelia Ratnasari, Affi Anggraeni, Asih Anik Lestari Anik Lestari Annang Giri Moelyo Argyo Demartoto, Argyo Arianty, Meike Arifin, Ayu Kusuma Puspasari Aris Sudiyanto Armadhani, Riska Asih Anggraeni Asih Anggraeni Astuti, Susiana Yuni Bachnas, Muhammad Adrianes Bachtiar, Harrys Bambang Purwanto Besar, Dwi Sakti Berlian Bhisma Murti Brahmana, Ivanna Beru Brian Wasita Cahyono Hadi Chintya, Shally Ayu Cut Sheira Elnita Damalita, Annisa Fitriana Damayanti, Siti Darto Darto Darto Darto - Darto Darto Darto Darto Debree Septiawan Dewanto Suryoningrat Dewi, Rizqa Kartika Dewi, Yulia Lanti Ratna Dewi, Yulia Lanti Ratna Dian Asih Ning Utami Dian Kusumawardani Dian Rahmawati Didik Gunawan Tamtomo Didik Tamtomo, Didik Dwi Apriyanti Eka Tri Wulandari, Eka Tri Endang Sutisna Eriana Melinawati Eric Edwin Yuliantara Ermawati, Dwi Hesti Ertiana, Dwi Eti Poncorini Pamungkasari Fahsan, Fatmiyanti Farras Wahdan, Arib Fatmawati, Zeny Fauzia, Raina Lola Fazrina, Gina Firdausia, Shalsabilla Tiara Fitria Wulandari Frafitasari, Dika Yanuar Habibatullah, Afifa Intifadha Hadi, Cahyono Hadianti, Ayunita Dwi Hafi Nurinasari Hafiizha, Attahira Amalia Handriani, Winei Haniah, Alfi Zamilul Hanifah, Rofi'atul Hanifah, Rofi’atul Harsono Salimo Harsono Salimo Hastuti, Tri Ari Hermawan Udiyanto Hermawan Udiyanto Heru Priyanto Heru Priyanto Heru Priyanto Hidayah, Fristyaningrum Ida Nurwati Immanuela Maria Regita Indradewa, Rhian Insan Ksyatria, Yudhista Ngudi Jannah, Ahadyah Miftahul Jannah, Ahadyah Miftahul Jatiningtyas, Abida Zuhra Jayanti, Saktryana Endang Ragil Juhrotun Nisa, Juhrotun Ksatriya, Yudhistya Ngudi Insan Kunaryanti, Kunaryanti Kusnandar Kusnandar Laqif, Abdurahman Laqif, Abdurrahman Lunardhi Susanto Lutfiana Puspita Sari Maghfiroh, Ainul Mahendra Wijaya Mahendra Wijaya Marbun, Yohan Pamuji Marliana, Wiwit Martaningrum, Herlina Ika Metanolia Sukmawati Mufidah, Amatullah Muhammad Adrianes Bachnas Mulyoto Pangestu MULYOTO PANGESTU Murdikawati, Dayang Fitri Murdikawati, Dayang Fitri Mushthafa, Mufti Mutiara, Bunga Ngudi Insan Ksyatria, Yudhistira Ningrum, Sintia Ayu Ningsih, Hepti Widia Nurul Qomariah Nutria Widya Purna Anggraini Nuur, Aliffudin Ode, Diana Pertiwi, Mumpuni Intan Poncorini, Eti Prasetya, Hanung Prastyoningsih, Aris Putriarsih, Ryanawati Putrinadia, Aninditya Verinda Qomariah, Nur Laili Quinita M. J. Noronha Rahardjo, Setyo Sri Rahayu, Baiq Zulvita Rahayu, Putu Sri Rahmadani, Latifah Nur Rakano Kautsar Dwiyana Rantasari, Affi Angelia Ratih Sakti Prastiwi Ratih Sakti Prastiwi, Ratih Sakti Ratnasari, Affi Angelia Reso, Mulya Cunda Ratu Reso, Mulya Cunda Ratu Retno, Yulia Lanti Ria, Matilda Bupu Riawati, Meida Siwi Risang Bhaskoro Rita Adriani Benya Adriani Rita Cempaka Rizkiani, Inne Rofi’atul Hanifah Saputra, Ricky Bernadi Sari, Arum Dessy Rahma Sari, Lutfiana Puspita Sari, Prafista Wulan Satria, Yohanes Aditya Adhi Selvia Febrianti Septiana, Yesika Cahya Simarmata, Imelda Dearni Simarmata, Imelda Dearni Siti Maesaroh Siti Munawaroh Siti Nur Hidayati Soetrisno Soetrisno Soetrisno Soetrisno Sri Lestariningsih Sri Sulistyowati Sri Sulistyowati Sri Widarti, Sri Suci Arsita Sari Sulistyoningrum, Indah SUMIYATI SUMIYATI Suparno, Amalia Ulfah Supriyadi Hari Respati Supriyadi Hari Respati Tanti Arianti Teguh Prakosa Teguh Prakosa, Teguh Teha, Zadia Dara Cynintya Tri Nugraha Susilawati Verasita, Prissy Vitri Widyaningsih Wardana, Aisyah Puspa Wardhani, Anindyah Tri Lhaksmi Kusuma Wasyanto, Trisulo Wesliaprilius, Todung Antony Wijayanti, Agung Sari Wisnu Prabowo WISNU PRABOWO Wulandari, Rizqi Amalia Wulandari, Umianita Risca yulia lanti retno dewi Yulyanti, Yulyanti

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