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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Kedokteran Brawijaya Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kebidanan Dan Kesehatan Tradisional Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Universa Medicina AcTion: Aceh Nutrition Journal Jurnal Kesehatan Reproduksi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal of Medicine Journal of Maternal and Child Health JKM (Jurnal Kebidanan Malahayati) Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Jurnal Kebidanan Harapan Ibu Pekalongan Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Jurnal Abdidas Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Nusantara Science and Technology Proceedings Plexus Medical Journal Indonesian Basic and Experimental Health Sciences Folia Medica Indonesiana
Uki Retno Budihastuti
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Sebelas Maret, Surakarta/ Dr. Moewardi Hospital, Surakarta
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Mucin-1 expression in endometrium is higher in polycystic ovary syndrome than in normal women Budihastuti, Uki Retno; Sulistyowati, Sri; Melinawati, Eriana; Marbun, Yohan Pamuji
Universa Medicina Vol 39, No 2 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.805 KB) | DOI: 10.18051/UnivMed.2020.v39.74-80

Abstract

BackgroundThe polycystic ovary syndrome (PCOS) is caused by endocrine system dysfunction in women. MUCIN-1 (MUC-1) expression is found in endometrial tissues, which leads to implantation process dysfunction because of imbalance of trophoblast adhesion process. This study was conducted to compare endometrial MUC-1 expression between PCOS and normal women considering all existing external variables.MethodsThis cross-sectional study was conducted in General Hospital Dr. Moewardi Surakarta. Endometrial samples were obtained from 30 infertile PCOS women based on Rotterdam criteria, and 30 normal women. Life style and reproductive data such as age, menstrual problems, menstrual cycle, age at menarche, and BMI were collected. Subjects underwent endometrial biopsy in luteinizing hormone (LH) secretion phase LH + 5 days to LH + 10 days for immunohistochemistry (IHC) of MUC-1 expression. An independent-t and multiple linear regression test were used to analyze the data at significance level of p<0.05. ResultsMean MUC-1 expression in the PCOS endometrium (49.66 ± 47.79) was significantly higher than in normal women (7.66 ± 14.55) (p=0.03). Multivariate linear regression model of life style and reproductive variables with MUC-1 showed that PCOS (b=29.54; 95% CI 9.57-49.49; p=0.004) and BMI (b= 29.99; 95% CI 5.91-54.07; p=0.001) significantly increase MUC-1 expression. PCOS (Beta=0.37) was more important than BMI (Beta=0.30) in increasing the MUC-1 expression. ConclusionExpression of MUC-1 levels in the PCOS endometrium was higher than in normal women. This suggests that MUC-1 contributes to the unexplained reproductive failure in PCOS.
The role of genital tract infection inpreterm delivery: aretrospective study Satria, Yohanes Aditya Adhi; Budihastuti, Uki Retno; Susilawati, Tri Nugraha
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 3 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.648 KB) | DOI: 10.19106/JMedSci005103201904

Abstract

 Preterm delivery is associated with higher mortality and morbidity of neonates, also increasestheir risk of having growth and development impairment.This study aimed toidentify the role ofgenital tract infection in preterm delivery. A retrospective study was conducted on medical records of mothers who had preterm delivery in a tertiary hospital in Surakarta, Indonesia during 2017. The data collected were mothers’ age and their gestational age, the history of current pregnancy, the number of previous abortion(s), mothers’ body temperature, the extent of abnormal vaginal discharge, and laboratory findings (white blood cell count, platelet count, red blood cell count, hemoglobin count, hematocrit level, urinalysis and microbiology results). The statistical differences amongst categorical and numerical data were analyzed using the Chi-Square test and the Mann-Whitney test. Based on the patient’s history and the examination results, we suspected genital tract infections in22.52% (25/111)of subjects. All of them had abnormal vaginal discharge despite only one case had been confirmed as streptococcal infection. This study found that the majority of mothers with probable genital tract infection hadpreterm premature rupture of the membrane whilst preeclampsiawas more evident in those without genital tract infection. We conclude that genital tract infection during pregnancy is a significant contributor to the occurence of premature birth so that microbiological testing is needed to confirm the diagnosis.
The Differences of Folliculogenesis between Treated with Letrozole and Letrozole-Electroacupuncture in Women with Polycystic Ovary Syndrome Yulyanti, Yulyanti; Budihastuti, Uki Retno; Melinawati, Eriana; Sulistyowati, Sri; Nurwati, Ida
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.835 KB) | DOI: 10.26911/theijmed.2020.5.3.295

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder that most often causes infertility. It occurs due to the failure of folliculogenesis, thus causing non-ovulation. Letrozole is a 3rd generation drug of non-ste­roidal aromatase inhibitors, which can increase ovulation rates. Electroacupuncture is the insert­ion and manipu­lation of needles into acupunc­ture points (acu­points) that are selected speci­fically based on the meridian system and con­nected to the electrode stimulator. This study aimed to determine the differences of the effects of letrozole and letrozoleelectroacupuncture (letrozole-EA) on the improve­ment of folliculo­genesis in women with PCOS.Subjects and Method: This was an analytic observational study with a case-control design. This study was conducted at the Gynecology Polyclinic and Sekar Clinic, Dr. Moewardi Hos­pital, Surakarta. A sample of 30 infertile women aged 20-45 years was selected by fixed disease sampling. The criteria of the PCOS were deter­mined based on Rotterdam criteria. The depen­dent variable was the diameter of the follicle. The independent vari­ables were the administration of letrozole and letrozole-EA. Transvaginal ultra­sound of Voluson P6 was used to measure the folliculo­genesis. The data were analyzed by independent t-test.Results: On the second day after treatment, the diameter of the follicles in the letrozole-EA group (mean= 6.92; SD= 1.60) was bigger than the letrozole group (mean=5.66; SD=1.11), and it was statistically significant (p=0.004).Conclusion: Combination of letrozole and letrozole-EA therapy is more effective in increasing follicular diameter development than letrozole therapy only.Keywords: polycystic ovary syndrome, folli­culogenesis, Letrozole, electro-acupunctureCorrespondence: Yulyanti. Department of Obstetrics and Gyneco­logy, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Cen­tral Java, Indonesia. Email: dr.yulyanti­@gmail­.­com. Seluler: +6285264806570.Indonesian Journal of Medicine (2020), 05(03): 214-223https://doi.org/10.26911/theijmed.2020.05.03.06
The Difference of Endometrial Vascular Endothelial Growth Factor (VEGF) Expression between Polycystic Ovarian Syndrome (PCOS) and Normal Women Saputra, Ricky Bernadi; Budihastuti, Uki Retno; Sulistyowati, Sri; Melinawati, Eriana; Respati, Supriyadi Hari
Indonesian Journal of Medicine Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (32.015 KB) | DOI: 10.26911/theijmed.2020.5.3.296

Abstract

Background: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder in women cha­rac­terized by increased levels of androgens, ovu­la­tory dysfunction, and Polycystic Ovarian Mor­p­ho­logy (PCOM), as well as a combination of clas­sic clinical features. Women with PCOS expe­ri­ence changes in the endometrium and endo­met­rial receptivity markers such as VEGF (Vascular En­dothelial Growth Factor). VEGF increases the per­meability and dilation of endometrial blood vessels which play an important role in imp­lan­ta­tion. This study aimed to analyze the difference of VEGF expression between women with PCOS and nor­mal women.Subjects and Method: This study was a case-con­trol study design conducted at the polyclinic of the Department of Obstetrics and Gynecology, Dr. Moewardi Hospital, Surakarta, Central Java, in July 2020. There were 30 infertile women with PCOS (diagnosis based on Rotterdam criteria, con­sensus 2003) and 30 women without PCOS as the sample of this study. The dependent variable was VEGF expression. The independent variables were age, BMI, family history with PCOS, menar­che, occu­pa­tion, and education. VEGF expression was ob­tained from an endometrial biopsy on days 19-24 of periods. The differences in VEGF exp­res­sion (in %) were analyzed by the Mann-Whitney test. VEGF determinants were analyzed by a mul­ti­ple linear regression.Results: The mean of VEGF expression in wo­men with PCOS (Mean=64.33; SD=44.43) was high­er than in women without PCOS (Mean­= 7.90; SD=8.73) and the result was statistically sig­ni­ficant (p<0.001). PCOS (b=42.09; 95%­CI­=­64.­2­6 to -19.93; p<0.001) and obese (b=38.63; 95%­CI=-63.44 to -13.82; p=0.003) increased VEGF expression.Conclusion: VEGF expression in the endo­met­rium of women with PCOS is higher than normal wo­men.Keywords: VEGF, endometrium, Polycystic Ova­rian SyndromeCorrespondence: Ricky Bernadi Saputra. Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebe­las Maret/ Dr. Moewardi Hospital, Sura­karta, Indo­nesia. Telp: 081221161933 Email: ricky­sa­put­radr@gmail.comIndonesian Journal of Medicine (2020), 05(03): 230-239https://doi.org/10.26911/theijmed.2020.05.03.08
The Effectiveness of Letrozole Adjuvant Therapy - Electro Acupuncture in Reducing the Number of Follicles and Body Weight and Increasing Endometrial Thickness in Women with Polycystic Ovary Syndrome Wesliaprilius, Todung Antony; Budihastuti, Uki Retno; Melinawati, Eriana; Sulistyowati, Sri; Nurwati, Ida; Hadi, Cahyono
Journal of Maternal and Child Health Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (36.052 KB)

Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Acupuncture can improve menstrual cycle recovery and decrease body mass index (BMI) in women with PCOS. The effect of acupuncture can be enhanced by giving letrozol. Researchers are interested in knowing the comparison between letrozol therapy with letrozol + electroacupuncture on body weight, follicle count, and endometrial thickness in women with polycystic ovary syn
The Effectiveness of Letrozole-Electroacupuncture Adjuvant Therapy in Reducing Resistance and Pulsatility Indices in Women with Polycystic Ovarian Syndrome Octavia, Dhamayanti Eka; Budihastuti, Uki Retno; Melinawati, Eriana; Anggraini, Nutria Widya Purna; Yuliantara, Eric Edwin; Nurwati, Ida; Hadi, Cahyono
Journal of Maternal and Child Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (35.881 KB)

Abstract

Background: Polycystic Ovarian Syndrome (PC
The Effectiveness of Edutainment toward Pregnancy Care on Knowledge, Attitude, and Action in Pregnant Women Firdausia, Shalsabilla Tiara; Budihastuti, Uki Retno; Dewi, Yulia Lanti Retno
Journal of Maternal and Child Health Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Playing or studying in a plea
Improved Understanding of IUD and Implant Family Planning Acceptors in Family Planning Services at Solo Peduli Clinic Budihastuti, Uki Retno; Laqif, Abdurahman; Melinawati, Eriana; Prakosa, Teguh; Udiyanto, Hermawan; Priyanto, Heru; Darto, Darto; Ratnasari, Affi Angelia; Anggraeni, Asih; Prisasanti, Dympna Prameilita
Journal of Maternal and Child Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (36.944 KB)

Abstract

Background: Family planning acceptor's understanding of intra uterine device (IUD) and implant contracep
The Effects of Age, Endometriosis, Polycystic Ovarium Syndrome, and Obesity on the Success of Embryo Transfer on In Vitro Fertilization Hafiizha, Atthahira Amalia; Budihastuti, Uki Retno; Murti, Bhisma
Journal of Maternal and Child Health Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (34.063 KB)

Abstract

Background: One of the important stages in in vitro fertilization (IVF) success is the embryo transfer (ET). Many studies are examining the effect of maternal factors on in vitro fertiliza
Partial molar pregnancy with live fetus in first trimester: what should we do next Eric Edwin; Uki Retno Budihastuti; Cut Sheira Elnita
Jurnal Kedokteran Syiah Kuala Vol 20, No 2 (2020): Volume 20 Nomor 2 Agustus 2020
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v20i2.18505

Abstract

Abstract. The incidence of a normal live fetus with a partial mole is extremely rare, and it varies between 5 per 100000 and 1 per 10000 of the pregnancies. A partial molar pregnancy is a variation of a molar pregnancy in which an embryo either develops incompletely or with multiple structural anomalies.A 27-year-old Primigravide at 13 weeks of gestation got admitted with spotting per vaginam, excessive nausea and vomiting, and her ultrasound revealed a hydropic placenta with multiple cysts with a live fetus. Regarding these findings, the patient continued her pregnancy under close observation, and advanced sonographic evaluations were done to rule out other differentials. Ultrasonography found mosaicism in the partial mole (mostly diploid, a small part is triploid). In this condition, the prognosis condition for the fetus to be born safely is still probable. Ethics committee meetings are held with the consideration of the fetus's condition, whether monitoring is carried out regularly, and terminating the pregnancy in case of fetal emergency.The optimal management of hydatidiform mole with the coexistent live fetus is currently uncertain. Antenatal consultation should include a detailed discussion of maternal and fetal risks. It is also necessary to have close follow-up and evaluation of the patient's condition during the antenatal and postnatal period. Keywords: first trimester, live fetus , management, partial molar pregnancy
Co-Authors -, Kartika ., Darto Abdurahman Laqif Abdurahman Laqif Abdurahman Laqif Abida Zuhra Jatiningtyas Adhimukti, Fahmi Agustina, Devita Alfi Marita Tristiarti Alfi Marita Tristiarti Alfi Marita Tristiarti Ali Djamhuri Alifa, Rosita Ambar Mudigdo Amir, Nikmah Ayu Ramadhani Angelia Ratnasari, Affi Anggraeni, Asih Anik Lestari Anik Lestari Annang Giri Moelyo Argyo Demartoto, Argyo Arianty, Meike Arifiana, Ratna Arifin, Ayu Kusuma Puspasari Aris Sudiyanto Armadhani, Riska Asih Anggraeni Astuti, Susiana Yuni Bachnas, Muhammad Adrianes Bachtiar, Harrys Bambang Purwanto Besar, Dwi Sakti Berlian Bhisma Murti Brahmana, Ivanna Beru Brian Wasita Cahyono Hadi Chintya, Shally Ayu Cut Sheira Elnita Damalita, Annisa Fitriana Damayanti, Siti Darto Darto Darto Darto - Darto Darto Debree Septiawan Dewanto Suryoningrat Dewi, Rizqa Kartika Dewi, Yulia Lanti Ratna Dewi, Yulia Lanti Ratna Dian Asih Ning Utami Dian Kusumawardani Dian Kusumawardani Dian Rahmawati Diani Octaviyanti Handajani Didik Gunawan Tamtomo Didik Tamtomo, Didik Dwi Apriyanti Eka Tri Wulandari, Eka Tri Endang Sutisna Endang Sutisna Sulaeman Eriana Melinawati Eric Edwin Yuliantara Erin Rizkiana Ermawati, Dwi Hesti Ertiana, Dwi Eti Poncorini Pamungkasari Fahsan, Fatmiyanti Farras Wahdan, Arib Fatmawati, Zeny Fauzia, Raina Lola Fazrina, Gina Firdausia, Shalsabilla Tiara Fitria Wulandari Frafitasari, Dika Yanuar Habibatullah, Afifa Intifadha Hadi, Cahyono Hadianti, Ayunita Dwi Hafi Nurinasari Hafiizha, Attahira Amalia Hafiizha, Atthahira Amalia Handriani, Winei Haniah, Alfi Zamilul Hanifah, Rofi'atul Hanifah, Rofi’atul Harsono Salimo Harsono Salimo Hastuti, Tri Ari Hermawan Udiyanto Heru Priyanto Heru Priyanto Hidayah, Fristyaningrum Ida Nurwati Ilmiyah, Desy Eka Indradewa, Rhian Jannah, Ahadyah Miftahul Jannah, Ahadyah Miftahul Jatiningtyas, Abida Zuhra Jayanti, Saktryana Endang Ragil Juhrotun Nisa, Juhrotun Ksatriya, Yudhistya Ngudi Insan Kunaryanti, Kunaryanti Kunaryanti, Kunaryanti Kusnandar Kusnandar Laqif, Abdurahman Laqif, Abdurrahman Lunardhi Susanto Lutfiana Puspita Sari Maghfiroh, Ainul Mahendra Wijaya Mahendra Wijaya Marbun, Yohan Pamuji Marliana, Wiwit Martaningrum, Herlina Ika Metanolia Sukmawati Mufidah, Amatullah Muhammad Adrianes Bachnas MULYOTO PANGESTU Mulyoto Pangestu Murdikawati, Dayang Fitri Murdikawati, Dayang Fitri Mushthafa, Mufti Mutiara, Bunga Ngudi Insan Ksyatria, Yudhistira Ningrum, Sintia Ayu Ningsih, Hepti Widia Nugrahani, Rosi Rizqi Nurul Qomariah Nurul Wahidah Nutria Widya Purna Anggraini Nuur, Aliffudin Octavia, Dhamayanti Eka Ode, Diana Oktaviani, Anisa Sevi Pamungakasari, Eti Poncorini Pawito -, Pawito Pertiwi, Mumpuni Intan Poncorini, Eti Prasetya, Hanung Prastyoningsih, Aris Prisasanti, Dympna Prameilita Puspita, Ita Fijanah Putriarsih, Ryanawati Qadrijati, Isna Qomariah, Nur Laili Quinita M. J. Noronha Rahardjo, Setyo Sri Rahayu, Baiq Zulvita Rahayu, Putu Sri Rahmadani, Latifah Nur Rakano Kautsar Dwiyana Rantasari, Affi Angelia Ratih Sakti Prastiwi Ratih Sakti Prastiwi, Ratih Sakti Ratna Dewi Permatasari Ratnasari, Affi Angelia Regita, Immanuela Maria Reso, Mulya Cunda Ratu Reso, Mulya Cunda Ratu Retno, Yulia Lanti Ria, Matilda Bupu Riawati, Meida Siwi Risang Bhaskoro Rita Adriani Benya Adriani Rita Cempaka Rizkiani, Inne Rofi’atul Hanifah Saputra, Ricky Bernadi Sari, Arum Dessy Rahma Sari, Lutfiana Puspita Sari, Prafista Wulan Satria, Yohanes Aditya Adhi Selvia Febrianti Septiana, Yesika Cahya Simarmata, Imelda Dearni Simarmata, Imelda Dearni SITI KHOLIFAH Siti Maesaroh Siti Munawaroh Siti Nur Hidayati Soetrisno Soetrisno Soetrisno Soetrisno Sri Lestariningsih Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Sri Sulistyowati Sri Widarti, Sri Sringatin, Sringatin Suci Arsita Sari Sulistyoningrum, Indah SUMIYATI SUMIYATI Sunarta, Elfania Arumma Suparno, Amalia Ulfah Supriyadi Hari Respati Supriyadi Hari Respati Supriyadi Hari Respati Tanti Arianti Teguh Prakosa, Teguh Teha, Zadia Dara Cynintya Tri Nugraha Susilawati Verasita, Prissy Vitri Widyaningsih Wardana, Aisyah Puspa Wardhani, Anindyah Tri Lhaksmi Kusuma Wasyanto, Trisulo Wesliaprilius, Todung Antony Wijayanti, Agung Sari WISNU PRABOWO Wisnu Prabowo Wulandari, Rizqi Amalia Wulandari, Umianita Risca yulia lanti retno dewi Yulyanti, Yulyanti