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INDONESIA
Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
ISSN : 23386401     EISSN : 23387335     DOI : -
Core Subject : Health,
The Indonesian Journal of Obstetrics and Gynecology is an official publication of the Indonesian Society of Obstetrics and Gynekology. INAJOG is published quarterly.
Arjuna Subject : -
Articles 1,731 Documents
Compatibility between Menstrual Pictogram Assessment and Haemoglobin Assessment in Abnormal Uterine Bleeding: Uji Kesesuian Pemeriksaan Piktogram Menstruasi dengan Pemeriksaan Hemoglobin pada Pasien Perdarahan Uterus Abnormal Fitri Yulianti; Heriyadi Manan; Awan Nurtjahyo; Syarif Husin
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.475 KB) | DOI: 10.32771/inajog.v6i3.783

Abstract

Objective: To determine the amount of wasted blood and diagnosedAUB and determine amount of decrease in haemoglobinlevels by adjusting the examination of menstrual pictogramwith haemoglobin.Methods: Diagnostic test was conducted in the DepartmentObstetrics and Gynecology Dr. Mohammad Hoesin/Faculty ofMedicine Universitas Sriwijaya Palembang, start from January 2015through January 2017. Sample was obtained from 39 patients withabnormal uterine bleeding who meet the inclusion and exclusioncriteria. Frequency and distribution of data are described in tablesand cross analyze (cut-off point) to find cut points differencemenstrual pictogram and a decrease in haemoglobin levels usingROC curve. Accuracy is measured by the value of Kappa. Dataanalysis using SPSS version 21.Results: From 39 samples that obtained, majority characteristicsage > 35 years (59%), ideal BMI (59%) and multiparous(48.7%). From statistical analysis, there was significanceassociation between haemoglobin measurement toolsand menstrual pictogram (p = 0.063). Both measuring deviceshave compatibility in predicting the type of AUB (p = 0.047),with the degree of conformity is weak (Kappa = 0.232).Conclusion: Accuracy of menstrual pictogram examination andhaemoglobin has a weak degree of conformity, so menstrualpictogram examination can’t be used to determine a decrease inhaemoglobin levels. Menstrual pictogram menstruation only usedas an evaluation of therapeutic response.[Indones J Obstet Gynecol 2018; 6-3: 172-178]Keywords: abnormal uterine bleeding, haemoglobin, menstrual pictogram
Changes in Cortisol Levels before and after Supportive Psychotherapy in Patients with Comorbid Cervical Cancer Distress with Depression Type: Perubahan Kadar Kortisol sebelum dan sesudah Psikoterapi Suportif pada Pasien Kanker Serviks dengan Komorbiditas Distres Tipe Depresi Laila Nuranna; Kartiwa H Nuryanto; Andriansyah Andriansyah; Sylvia D Elvira; Bambang Sutrisna
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.702 KB) | DOI: 10.32771/inajog.v6i3.784

Abstract

Objective: To prove the success of supportive psychotherapy thatwas provided as a distress therapy on advanced cervical cancer.Knowing the prevalence of distress type of depression in patientwith epithelial cervical cancer, proving the benefits of psychotherapysupportive for distress can decreasing cortisol level in cervicalcancer patient, can assess distress thermometer score, HAM-D17score and scoring incident predictors of distress with depressiontype.Methods: There were 32 subjects from 71 advanced cervical cancerpatients had mild-moderate depression. Then randomizationblocking was performed to determine a subject who entered thetreatment group (n = 16) who got supportive psychotherapy orcontrol group who got common psychotherapy (n = 16). All ofparticipants assessed the distress level with cortisol value, distressthermometer score, and HAM-D17 score before and after they gotsupportive psychotherapy.Results: After the intervention of psychotherapy in the treatmentgroup decreased HAM-D17 score, the average decline 7.53 (SB 3.34).The mean decreasing in the control group was 3.98 (SB 2.85). Thereis a significant difference in mean reduction in HAM-D17 scores ontreatment and control groups with p = 0.003 (p <0.005). There wasdecreasing blood cortisol level in the treatment group amounted to39.43, while the control group there was a drop of 1.59. The reductionof cortisol level in the treatment group and the control has a pvalue0.302. After got supportive psychotherapy, found a decreasingthe average value of the thermometer distress in the treatmentgroup 3.02 and the control group 2.51, with a p value more than0.492.Conclusion: There were 45% of cervical cancer patients in the clinicexperiencing distress disorder with depressive type. The bloodcortisol level could be decreased by giving supportive psychotherapywith a mean decrease of 39.43 nmol/l. There was a significantreduction in the level of depression (HAM-D17 score) of 7.53 pointsand distress thermometer impairment by 3 points after givensupportive psychotherapy. Obtained scoring predictors for theoccurrence of distress type of depression in patients with advancedcervical cancer with a sensitivity of 46.15% and a specificity of89.47%.[Indones J Obstet Gynecol 2018; 6-3: 179-187]Keywords: cervical cancer, cortisol, distress, distress thermometer,HAM-D17 score
Human Papilloma Virus16 and 18 Infection and the Cervical Cytology Changes in Combined Hormonal Contraceptive Users: Infeksi Human Papilloma Virus Tipe 16 dan 18 dan Perubahan Sitologi Serviks pada Akseptor Kontrasepsi Hormonal Kombinasi Merdyana Darkuthni; Mardiah Tahir; Josephine L Tumedia
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.087 KB) | DOI: 10.32771/inajog.v6i3.785

Abstract

Objective: To evaluate the correlation between HPV-16 and 18infection and the cervical cytology changes among combinationhormonal contraceptives users. Methods: A cross-sectional study involved 40 women usingcombined hormonal contraceptive (oral or injection/DMPA contraceptive)and 40 women of non-hormonal contraceptive users wasconducted in Dr. Wahidin Sudirohusodo hospital, some affiliatedhospitals of Department of Obstetrics and Gynecology Faculty ofMedicine, Universitas Hasanuddin and a private clinic in Makassarfrom November 2015 and April 2016. HPV 16 and 18 genotypingin cervix using PCR method and cervical cytology changes usingliquid-based cytology (LBC) method were performed. HPV infectionand cervical cytology changes were analysis based on Fisher’s testand chi-square test. Results: A significant difference found only in parity (p<0.05)between users and control of baseline characteristics. Neither usersnor control were significantly associated with HPV-16 and 18infection and changes in cervical cytology. Conclusion: Combined hormonal contraceptives are not correlatedwith HPV-16 and 18 infection and changes in cervical cytology. Keywords: cervix, combined hormonal contraceptive, human papillomavirus
Vaginal Delivery in Placental Abruption: Persalinan Pervaginam pada Solusi Plasenta JM Seno Adjie; M Farid Ghazali; Denny Khusen
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.502 KB) | DOI: 10.32771/inajog.v6i3.786

Abstract

Objective: To describe the case of vaginal delivery in placental abruption. Methods: A case report Results: In the case of placental abruption, we could perform vaginal delivery. Conclusion: The treatment of placental abruption can be vaginally or by cesarean section depending on the severity of disease, gestational age, and state of the mother and fetus. Keywords: IUFD, placental abruption, vaginal delivery
Endoglin Expression (CD105) in Ephithelial Ovarian Cancer: Ekspresi Endoglin (cd105) Pada kanker Ovarium Tipe Epitelial Rizkinov Jumsa; John Rambulangi; Sharvianty Arifuddin; Upik Miskad
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 2 April 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.694 KB) | DOI: 10.32771/inajog.v6i2.801

Abstract

Abstract Objective: Endoglin ( CD105 ) is one of the factors that play a role in vascular development , angiogenesis and vascular homeostasis. The aim of this research is to address the endoglin expression (CD105) in primary tumor and metastasis tumor (omentum) and their relation with clinicopathological factor: stadium, differentiation level, and histological epithelial ovarian cancer. Method: The research was performed at Public Service Hall of Dr. Wahidin Sudirohusodo Hospital and educational networking hospital of Obstetrics and Gynecology Departement of Medical Faculty Hasanuddin University Makassar. The research design is cross sectional with 55 samples consisting of 55 samples of primary tumor and 55 matastasis tumor. Imunohistochemistry examination was performed to all samples. Result:The results show a significant relation between endoglin (CD105) at omentum metastasis tumor and stadium and cell differentiation level of epithelial ovarian cancer. There is no significant relation between endoglin (CD105) expression at primary tumor of ovarian cancer and stadium and differentiation and type of histopathological cell. In addition, there is no significant relation between endoglin expression (CD105) at omentum metastasis tumor and type of histophatological cell of ovarian cancer. There is a significant correlation (strong category) between endoglin expression at omentum metastasis tumor and endoglin expression at primary tumor of epithelial ovarian cancer. Conclusion: Endoglin expression in ovarian cancer metastatic tumor to omentum is correlated to clinical stage and differentiation level of ovarian cancer. And endoglin is one of the pro angiogenic and pro metastasis factors. Keywords:epithelial ovarian cancer, endoglin expression, CD105, immunohistochemistry
Concordance of Human Papillomavirus Type 16 and 18 in Cervical and Oral Specimen of Cervical Cancer Patients: Perbandingan Tingkat Kesesuaian Hasil Identifikasi Human Papilomavirus Tipe 16 dan 18 antara Spesimen Serviks dan Oral pada Penderita Kanker Serviks Willy Akbar; Syahrul Rauf; Deviana S. Riu; St. Maisuri T. Chalid
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (61.295 KB) | DOI: 10.32771/inajog.v7i1.817

Abstract

Abstract Objective : To determine the conformity of HPV type 16 and 18 in cervical and oral/buccal specimens from cervical cancer patients. Methods :A cross-sectional study was conducted in March - September 2016 at several hospitals in Makassar. HPV 16 and 18 genotyping in cervical and oral fluid of 77 patients with cervical cancer performed with PCR method. Results : The prevalence of HPV type 18 infection both in the cervical and the oral fluid was higher than HPV type 16 [9(47.4%) vs 5(26.3%)]. The aggreement of HPV type 18 infection (r=0.328;p=0.000) in the cervical-oral sites was higher than HPV type 16 (r=0.194;p=0.042). Conclusion : HPV type 16 and 18 could infect both cervix and oral cavity although type-specific concordance is low. Keywords :Human papillomavirus,servix, oral cavity Abstrak Tujuan: Mengetahui tingkat kesesuaian hasil pemeriksaan HPV tipe 16 dan 18 antara spesimen serviks dan oral/buccal pada penderita kanker serviks. Metode: Penelitian cross sectional ini dilakukan pada Maret – September 2016 pada beberapa rumah sakit di Makassar. Pemeriksaan HPV 16 dan 18 pada cairan serviks dan oral dari 77 orang penderita kanker serviks menggunakan teknik PCR. Hasil: Prevalensi infeksi bersama pada serviks dan oral HPV tipe 18 lebih tinggi dibandingkan HPV tipe 16 [9(47,4%) vs 5(26,3%)]. Tingkat kesesuaian antara HPV tipe 18 (r=0,328;p=0,000) pada serviks dan oral lebih tinggi dibandingkan tipe 16 (r=0,194;p=0,042). Kesimpulan: HPV tipe 16 dan 18 dapat menginfeksi serviks dan oral meskipun tingkat kesesuaian kedua tipe ini lemah. Kata kunci : Human papillomavirus, serviks, kavum oral
Socio-Demographic and Nutritional Determinants of Birth Weight in Coastal Areas: Determinan Sosio-demografikdan Gizi yang Berhubungan dengan Berat Badan Lahir Bayi di Daerah Pesisir Juminten Saimin; Amalia N Azizah; Satrio Wicaksono
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (63.897 KB) | DOI: 10.32771/inajog.v7i1.818

Abstract

Abstract Objective : To identify socio-demographic and nutritional determinant associated with birth weight in coastal areas. Method : A cross sectional study using simple random sampling method. Data of labour in coastal areas of Kendari City was analyzed. Total of 215 women who aterm delivery in Community Health Centre of Mata, Nambo and Abeli on January to December 2016 were included in this study. Birth weight was examined in association with independent variable as maternal age, education, occupation, husband’s job, parity, antenatal care, iron tablets consumption and upper arm circumference. Results : Most participants were aged 20-25 years old, primary education, as housewife, multiparity and husband work as self-employed. There was 8.9% low birth weight in coastal areas. Maternal age, education and ANC visits were significantly associated with birth weight (p < 0.05). Consumption of iron tablets and upper arm circumference were significantly associated with birth weight (p < 0.05). Conclusion :Maternal age, education and ANC visits were socio-demographic determinant that associated with birth weight. Iron tablets consumption and upper arm circumference were nutritional determinant that significantly associated with birth weight. Keywords : age, antenatal care, birth weight, education, iron tablets, upper arm circumference Abstrak Tujuan :Mengidentifikasi determinan sosio-demografik dan gizi yang berhubungan dengan berat badan lahir bayi di daerah pesisir. Metode :Penelitian potong lintangdengan pengambilan sampel secara simple random sampling. Dilakukan analisis terhadap 215 ibu hamil yang melahirkan bayi cukup bulan di wilayah kerja Puskesmas Mata, Nambo dan Abelipada bulan Januari sampai Desember 2016. Varia beli independen berupa usia ibu, tingkat pendidikan, pekerjaan, pekerjaan suami, paritas, antenatal care, konsumsi tablet besi dan ukuran lingkar lengan atas. Hasil :Responden terbanyak berusia 20-25tahun, berpendidikan rendah, bekerja sebagai ibu rumah tangga, multiparitas dan pekerjaan suami wiraswasta. Terdapat8,9% bayi BBLR. Terdapat hubungan yang bermakna antara usia ibu, tingkat pendidikan dan ANC dengan BBL (p < 0.05). Terdapat hubungan yang bermakna antara konsumsi tablet besi dan ukuran LILA dengan BBL (p < 0.05). Kesimpulan :Determinan sosio-demografik yang berhubungan dengan BBL adalah usia, tingkat pendidikan, dan ANC. Sedangkan determinan gizi yang berhubungan dengan BBL adalah konsumsi tablet besi dan ukuran LILA. Kata kunci: ANC, BBL, LILA, pendidikan, tablet besi, usia
Differences in Serum Lipid Profile Value in Pregnancy and Postpartum on Severe Preeclampsia: Perbandingan Kadar Profil Lipid Serum pada Preeklampsia Berat dalam Kehamilan dan Postpartum I Putu F I White; John J E Wantania; Maya E Mewengkang
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (69.793 KB) | DOI: 10.32771/inajog.v7i1.820

Abstract

Abstract Objective:Uncovering the connection of serum lipid profile (total cholesterol, triglyceride, HDL, LDL, VLDL) with preeclampsia in pregnancy and postpartum, and its outcome. Method:This is a cross-sectional comparative analytic study Result:From 28 preeclampsia subject were found, mean value of systole 165.36 mmHg and 105.71 diastole. Serum lipid profile in pregnancy and postpartum has a significant differences and correlated with preeclampsia, total cholesterol 234.5 mg/dl and 192.71 mg/dl, p=0.000; medium positive in pregnancy with systole r=0.461; p=0.013, weak positive with diastole r=0.380; p=0.046; postpartum with systole medium positive r=0.615; p=0.001, and weak positive with diastole r=0.317; p=0.100. LDL 140.5 mg/dl and 102.5 mg/dl, p=0.000; pregnancy and systole r=0.446; p=0,017; and postpartum were medium positive r=0.546; p=0.003. HDL 51.5 mg/dl and 43.5 mg/dl, p=0.003; not correlated with BP. Triglyceride 268.89 mg/dl and 208.96 mg/dl, p=0.000; pregnancy r=0.516; p=0.005; postpartum r= 0.515; p=0.005 has medium correlation with systole. VLDL 53.78 mg/dl and 41.79, p=0.000; pregnancy r=0.461; p=0.013 systole medium positive; r=0.380; p=0.046 diastole weak positive; postpartum r=0,615; p=0,001 systole strong positive. Conclusion:All parameter of serum lipid profile in pregnancy and postpartum has significant differences and related with severe preeclampsia. Total cholesterol, LDL, triglyceride, and VLDL correlated with BP in severe preeclampsia. Key word:endothelial dysfunction, lipid profile, preeclampsia. Abstrak Tujuan: Untuk mengetahui hubungan profil lipid serum (kolesterol total, trigliserida, HDL, LDL, VLDL) dengan preeklampsia dan luarannya dalam kehamilan dan postpartum. Metode: Penelitian ini merupakan studi potong lintang analitik komparatif Hasil: Dari 28 subjek dengan preeklamsia, ditemukan rerata systole 165,36 mmHg dan 105,71 diastole. Profil lipid serum dalam kehamilan dan postpartum ditemukan berbeda bermakna dan berhubungan dengan preeklampsia berat, kolesterol total 234,5 mg/dl dan 192,71 mg/dl, p=0,000; kehamilan dengan sistole positif sedang r=0,461; p=0,013, diastole positif lemah r=0,380; p=0,046; postpartum dengan sistole positif sedang r=0,615; p=0,001, dan diastole postitif lemah r=0,317; p=0,100. LDL 140,5 mg/dl dan 102,5 mg/dl, p=0,000; dalam kehamilan dengan sistole r=0,446; p=0,017; dan postpartum positif sedang r=0,546; p=0,003. HDL 51,5 mg/dl dan 43,5 mg/dl, p=0,003; tidak berkorelasi dengan TD. Trigliserida 268,89 mg/dl dan 208,96 mg/dl, p=0,000; kehamilan r=0,516; p=0,005; postpartum r= 0,515; p = 0,005 korelasi positif sedang dengan sistole. VLDL 53,78 mg/dl dan 41,79, p=0,000; kehamilan r=0,461; p=0,013 positif sedang dengan sistole; r=0,380; p=0,046 positif lemah dengan diastole; postpartum r=0,615; p=0,001 positif kuat dengan sistole. Kesimpulan: Seluruh parameter profil lipid serum kehamilan dan postpartum ditemukan memiliki perbedaan bermakna dan berhubungan dengan preeklampsia berat. Kolesterol total, LDL, trigliserida, dan VLDL ditemukan berhubungan dengan TD pada PEB. Kata kunci: disfungsi endothel, lipid, preeklampsia.
Comparison between Leukocyte Esterase Activity (LEA) and Histopathology Examination in Identifying Chorioamnionitis Cases: Uji Diagnostik Leukocyte Esterase Activity (LEA) terhadap Histopatologi pada Kasus korioamnionitis Putri H Novianesari; Nuswil Bernolian; Henni Maulani; Afifa Ramadanti; Theodorus Theodorus
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (72.754 KB) | DOI: 10.32771/inajog.v7i1.823

Abstract

Objective: To compare sensitivity and specificity of LEA to histopathology examination in diagnosing chorioamnionitis. Methods: We compared diagnostic tests in dr. Mohammad Hoesin hospital, Palembang, from September 2015 to April 2016. Ninety-one pregnant women were included. LEA and histopathology examination were carried out with neonatal sepsis as main outcome. Data were analysed by SPSS version 21.0 and Med-calc statistic. Results: Chorioamnionitis was detected in 54 (77.1%) patients with gestational period ≥37 weeks and in 16 (22.9%) patients with gestational period <37 weeks. Duration of membrane rupture was significantly associated with chorioamnionitis (p = 0.001 and p = 0.011). Neonatal sepsis was also significantly associated with chorioamnionitis in both groups (p = 0.014 and p = 0.036). LEA value with cut-off point >0.5 was able to significantly predict chorioamnionitis with 98.6% sensitivity and 95.2% specificity, providing better accuracy in diagnosing chorioamnionitis in preterm pregnancy group. Conclusion: LEA had a very good predictive value for chorioamnionitis with better accuracy in diagnosing chorioamnionitis in preterm pregnancy. Keywords: Chorioamnionitis, Histopathology, Leukocyte esterase activity, Neonatal sepsis, Salafia criteria Tujuan: Membandingkan sensitifitas dan spesifisitas diagnosis korioamnionitis antara pemeriksaan Leukocyte esterase activity (LEA) terhadap histopatologi. Metode: Penelitian uji diagnostik dilakukan di RSUP dr. Mohammad Hoesin Palembang selama periode September 2015 – April 2016, 91 wanita hamil yang memenuhi kriteria inklusi selanjutnya dilakukan pemeriksaan LEA, Histopatologi dan luaran sepsis neonatorum. Data kemudian dianalisis dengan menggunakan software SPSS versi 21.0 dan Med-calc statistic. Hasil: Korioamnionitis terdeteksi pada 54 (77,1%) pasien dengan usia gestasi ≥37 minggu dan 16 (22,9%) pada usia gestasi <37 minggu. Durasi lamanya pecah ketuban akan berpengaruh secara signifikan terhadap kejadian korioamnionitis (p = 0,001 dan p = 0,011), Sepsis neonatorum juga secara signifikan berhubungan dengan kejadian korioamnionitis pada kedua kelompok (p = 0,014 dan p = 0,036). Kadar LEA dengan cut off point >0,5 secara signifikan mampu memprediksi kejadian korioamnionitis dengan sensitivitas 98,6%, spesifisitas 95,2% dan nilai akurasi yang lebih baik ditemukan dalam penegakan diagnosis korioamnionitis pada kelompok kehamilan preterm. Kesimpulan: Pemeriksaan LEA memiliki kekuatan prediksi yang sangat baik terhadap kejadian korioamnionitis dengan akurasi yang lebih baik dalam mendiagnosis korioamnionitis pada kehamilan preterm. Kata kunci: Korioamnionitis, Histopatologi, Leukocyte Esterase Activity,Sepsis Neonatorum, Kriteria Salafia
The Associated of Serum Inhibin A Levels in Severe Preeclampsia: Hubungan Kadar Inhibin A Serum pada Preeklamsia Berat Anatasia M Lumentut; Junneke J Kaeng; Eddy Suparman
Indonesian Journal of Obstetrics and Gynecology Volume 7, No. 1 January 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (71.763 KB) | DOI: 10.32771/inajog.v7i1.824

Abstract

Objective: to prove the associated of serum Inhibin A levels in severe preeclampsia. Method: this study was an observational analytic research with cross-sectional design. The subject of this study consists of 23 samples of normotensive pregnancy and 23 of samples severe preeclampsia who meet the inclusion and exclusion criteria.This study was conducted and evaluated fromSeptember 2016 until December 2016 at Department of Obstetrics and Gynecology Faculty of Medicine University of Sam Ratulangi Prof. Dr. R. D. Kandou Hospital Manado and satellite hospitals. Samples were analyzed using ELISA method at Prodia laboratory. Data were analyzed with SPSS version 20.0 Result: Mean serum Inhibin A levels in normotensive pregnancy is 477,22pg/ml while mean in severe preeclampsiais 2712,39 pg/ml with p value = 0,000. Conclusion: Levels of serum Inhibin A in severe preeclampsia significantly higher compared to normotensive pregnancy. Keywords: inhibin A, normotensi, severe preeclampsia Tujuan: untuk membuktikan hubungan kadar inhibin A serum pada preeclamsia berat. Metode: penelitian ini merupakan studi analitik observasional dalam bentuk desain potong lintang. Dilakukan pemeriksaan kadar Inhibin A serum pada 46 sampel ibu hamil yang memenuhi kriteria inklusi dan eksklusi, terdiri atas 23 kelompok preeclamsia berat dan 23 kelompok kehamilan normotesi. Penelitian dilaksanakan dan dievaluasi sejak bulan September 2016 sampai Desember 2016 di Bagian Obstetri dan Ginekologi Fakultas Kedokteran Universitas Sam Ratulangi / RSU Prof. dr. R. D. Kandou Manado dan rumah sakit jejaring. Analisis sampel dilakukan di Laboratorium Prodia Jakartamenggunakan metode ELISA. Data dianalisis denganSPSS versi 20.0. Hasil: rerata kadar Inhibin A serum pada kelompok kehamilan normotesi yaitu 477,22 pg/mlsedangkan rerata pada kelompok preeklamsia berat yaitu 271,.39 pg/ml dengan nilai p=,.000. Kesimpulan: kadar Inhibin A serum pada preeclampsia berat lebih tinggi secara bermakna dibandingkan dengan kehamilan normotensi. Kata kunci: inhibin A, normotensi, preeclamsia berat

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