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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
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Articles 10 Documents
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Search results for , issue "Vol. 13 No. 3 (2024): June" : 10 Documents clear
Factors Associated with Low Back Pain in Pre-Clinical Students in the Faculty of Medicine at Pelita Harapan University: Original Research Samudra, Edeline; Kalumpiu, Jane Florida
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8881

Abstract

Background: Low back pain is one of the most common health problems globally, including in Indonesia, and can result in limitations on a person's activities. While low back pain is typically associated with adults and the elderly, its prevalence is also notably high among students, particularly medical students. Despite the various factors contributing to low back pain, there is limited data on its prevalence and associated factors in Indonesia.Methods: A cross-sectional study was conducted at the Faculty of Medicine, Pelita Harapan University, utilizing consecutive sampling. Data were collected using the Nordic Musculoskeletal Questionnaire, Pittsburgh Sleep Quality Index (PSQI), International Physical Activity Questionnaire (IPAQ), and Perceived Stress Scale (PSS).Results: Out of 179 students, 144 (80%) experienced low back pain, while 35 (20%) did not. Among students with low back pain, 1.4% had psychological history, 7.3% had history of spinal problems, 0.7% had family history, 15.3% were obese, 75% had poor sleep quality, 8.3% had high-risk physical activity, 6.9% had a high-risk position, and 7.6% had a high-risk stress level. While other factors showed no significant association with low back pain, sleep quality demonstrated a significant association with a p-value of 0.022 (OR 2.52, CI 1.18-5.43).Conclusion: There is a significant association between sleep quality and low back pain in pre-clinical medical students at UPH, while other factors did not exhibit significant correlations.
Deciphering Developmental Epileptic Encephalopathies (DEE): Unravelling the Key Signs Suryawijaya, Evlyne Erlyana; Lokito, Shania
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8882

Abstract

Background: Epilepsy, a chronic neurological disorder affecting over 50 million people worldwide, is marked by recurrent seizures and loss of consciousness. It is categorized based on EEG features, etiologies, and comorbidities. Developmental Encephalopathy (DE) involves developmental delays and early-onset seizures without causing developmental regression. In contrast, Epileptic Encephalopathy (EE) features severe epilepsy syndromes where frequent seizures result in developmental delays or regression.Methods: This review explores the clinical definitions, epidemiology, and diagnostic criteria for DE, EE, and DEEs. It covers their etiologies, clinical features, diagnostic methods, and treatment strategies, including genetic, structural, metabolic, and immune-related factors.Results: DE features developmental impairment with epilepsy, while EE involves severe epilepsy causing cognitive and behavioral dysfunction. DEEs are marked by early-onset severe epilepsy and EEG abnormalities that worsen developmental impairments. Essential diagnostic tools include EEG, neuroimaging, and genetic testing. Effective management requires personalized interventions to control seizures and address cognitive deficits.Conclusion: DEEs are a complex epilepsy subset with major developmental and cognitive challenges. Early diagnosis and targeted treatments are crucial for improving outcomes. Ongoing research into DEEs' genetic and pathophysiological mechanisms is key to enhancing understanding and management.
Characteristics of High-Risk Behaviours Related to Alcohol and Illicit Drug Use and their Associated Factors among Adolescents in Middle and High School Widjaja, Melanie; Latief, Abdul; Sekartini, Rini
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8883

Abstract

Background: Use of narcotics, psychotropic and addictive substances (NPA) in adolescents has become one of the major social problems we are facing in society and it gives a negative impact. This study was done to determine the characteristics and factors that influence high-risk behaviour of NPA use in adolescents in middle and high school, also introducing CRAFFT questionnaire as an early screening tool for alcohol an illicit drugs use.Methods: Quantitative study (validated questionnaire) was conducted among 514 subjects aged 12-18 years old. CRAFFT questionnaire was used to detect a high-risk behavior of alcohol and illicit drugs use and self-reported questionnaire used to determine the risk factors of NPA.Result: Most participants (19,6%) were involved in high-risk behaviour of alcohol and illicit drugs, with the majority was males (12,4%). This study showed smoking behaviour (23,8%), drinking alcohol (15,8%) and illicit drugs use (13,6%). The type of drugs being used were cannabis (52,7%), tramadol (15,2%), dextromethorphan (10,7%) and methamphetamine (6,3%). CRAFFT questionnaire has a good internal consistency with Cronbach’s α 0,73. Education level, authoritarian parenting style, unharmonious parents, peer pressure or threat, and extracurricular activities were factors that influenced high-risk behavior of alcohol and illicit drug useConclusions: Early detection, comprehensive treatment, and intervention of risk factors of NPA use are needed. CRAFFT can be use as one of the screening tools for detection of alcohol and illicit drugs use in adolescents.
Relationship Between Breast Milk Feeding and COVID-19 Incidence in Children Aged 0-2 Years at Siloam Hospital Kelapa Dua During The Pandemic Setiawan, Jovanicha P.; Rivami, Dwi Savitri
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8884

Abstract

Background: The COVID-19 pandemic has claimed more than 6 million lives worldwide, and children are not spared from its danger. Breast milk is known to protect babies from various kinds of infections. Until now there are few data regarding the relationship between breastfeeding and the incidence of COVID-19 in children aged 0-2 years in Indonesia. This study aims to further examine the relationship between breastfeeding and the incidence of COVID-19 in children aged 0-2 years. Siloam Hospitals Kelapa Dua (SHKD) was chosen as a location because it was one of the referral hospitals for treating COVID-19 for pediatric patients in Tangerang that can be accessed by the researcher.Methods: This study was conducted using a cross-sectional study method on a sample of children aged 0-2 years from the medical record database of Siloam Hospitals Kelapa Dua for the period 2020 to 2022.Result: Upon calculation, it was found that the p-value is 0,154 (p>0,05). From 61 sample, 37,7% of the samples were breastfed and 44,3% was COVID-19 positive.Conclusions: No significant relationship was found between breastfeeding and COVID-19 infection among children aged 0-2 years old in SHKD.
Anemia and Erythropoietin Use Among Hemodialysis Chronic Kidney Disease Patients at Rumah Sakit Umum Siloam Tjiang, Margaret Merlyn; Caroline, Elliscia; Siregar, Jeremia Immanuel
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8885

Abstract

Background: Chronic kidney disease (CKD) affects an estimated 8-16% of the population and is increasing in prevalence. Anemia, a common and significant complication of CKD, is primarily caused by reduced erythropoietin production, which is essential for red blood cell production. Erythropoietin, a kidney-produced hormone, stimulates bone marrow to produce red blood cells. This study examines trends in the use of erythropoiesis-stimulating agents (ESAs) and the management of anemia in dialysis CKD patients before and after the implementation of ESA reimbursemen.Methods: This cohort study was conducted at Rumah Sakit Umum Siloam, Tangerang, Indonesia, from February to July 2017. Patients who received blood transfusions or iron supplements during the study were excluded. Data collected included age, gender, dry weight, history of diabetes mellitus, hypertension, hemodialysis adequacy, and nutritional status. Statistical analysis with a 95% confidence interval (CI) was used to assess the association between hemoglobin levels (Hb) and erythropoietin use.Results: Sixty patients completed the study. The proportion of anemic patients (Hb <10 g/dL) increased from 22 (36.7%) to 28 (46.7%) after erythropoietin administration. A mean dose of 6000 IU/week (CI: 4679 to 7321 IU/week) was effective in achieving target hemoglobin levels, while a dose of 4131 IU/week (CI: 3479 to 4782 IU/week) was sufficient to maintain them. Additionally, a dosage of 103.31 IU/kg/week increased hemoglobin by 1 g/dL in anemic patients.Conclusions: Erythropoietin use should be optimized given the increasing prevalence of anemia. A dosage of 103.31 IU/kg/week is recommended to achieve target hemoglobin levels, while 4131 IU/week is suggested for maintaining hemoglobin within the target range. 
Prevalence and Risk Factors of Occupational Contact Dermatitis in Healthcare Workers Enggalhardjo, Muljani; Setiawan, Alan Dwi; Christianto, Putra Niko Laksamana Oceano
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8886

Abstract

Background: Occupational contact dermatitis (OCD) is prevalent among healthcare workers, especially during the COVID-19 pandemic. Symptoms include dryness, itchiness, and redness, with hands being the most affected. Risk factors include frequent hand washing, increased glove use, allergies, and lack of health and safety training. This review emphasizes the need for targeted prevention strategies and awareness programs.Methods: We conducted a systematic review using PubMed, focusing on studies involving healthcare workers and OCD. Keywords included "occupational contact dermatitis," "contact dermatitis," "healthcare workers," and "risk factors for OCD." Data were collected using a structured, interviewer-administered questionnaire, including the Nordic Occupational Skin Questionnaire (NOSQ-2002).Result: The review included 2,706 healthcare workers. Hand dermatitis was the most common, affecting 22% of participants. Key risk factors were a personal history of allergies, frequent hand washing, high glove usage, and insufficient health and safety training.Conclusions: This review identifies significant risk factors for OCD among healthcare workers, highlighting the need for interventions focused on reducing hand washing frequency, managing glove use, and improving health and safety training.
Sudden Onset of Diabetic Ketoacidosis in a Patient with Discordant HbA1C: A Unique Case of Fulminant Type 1 Diabetes Mellitus (FT1DM) in a Middle-aged Man Nadine, I Gusti Ayu; Siregar, Jeremia Immanuel; Prasetya, Yonesha Rahmania
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8887

Abstract

Introduction: Diabetic Ketoacidosis (DKA) is an acute complication of diabetes mellitus (DM) which present as the first manifestation in fulminant type 1 diabetes mellitus (FT1DM) without significant elevation of HbA1C. We present a unique case of a 52-years-old male with DKA without previous history of DM and HbA1c of 6.6.Case Illustration: A 52-years-old male was brought to hospital due to persistent vomiting. He experienced polyuria and unexplained weight loss but denied previous history of DM. He was diagnosed with DKA due to his blood glucose of 1107 mg/dL along with elevated blood ketone and metabolic acidosis. However, his HbA1c was a mere 6.6. His serum lipase was increased, consistent with pancreatic damage. He was then discharged with basal-bolus insulin.  Discussion: Although the symptoms of this patient was consistent with hyperglycemic crisis, the presentation of DKA is usually associated with elevated HbA1c, approximately 10.4 - 16.9%. This unusual HbA1c points to the diagnosis of FT1DM. It is caused by sudden beta-cell destruction triggered by viral infections, alongside genetic disposition, leading to sudden depletion of insulin occurred less than a week and presents with ketoacidosis. It is characterized by low HbA1c (< 8.7%) yet extremely high blood glucose (‰¥ 288 mg/dl) and elevated pancreatic enzymes (depicting pancreatic damage). A diagnosis of FT1DM can be ascertained in this patient as his presentations matches its characteristics.Conclusion: FT1DM is a sub-type of T1DM which can suddenly occur in patients and associated with discordant HbA1c. It is important to recognize and treat it accordingly to avoid fatal outcomes.
Uncommon Presentation of Perianal Condyloma Acuminata in a Young Male: A Case Report Christina, Natalia Maria; Prasetyo, Patricia Diana; Cendikiawan, Albert; Wijaya, Jeremiah Hilkiah
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8888

Abstract

Background: Perianal warts, also known as anogenital warts or condyloma acuminata, represent a significant health concern in the young male population. Here, we present a unique case of a large perianal wart in a 26-year-old male patient.Case Description: The patient came to the surgical clinic with complaints of an anal lump for 7 months ago. The lump first appeared in February 2019 as big as a green bean, it increased in size, bled easily and painful to be touched. The patient had a history of anal intercourse 1 month before the lump appeared. The lump size was about 8 x 5 cm and resembled “cauliflower”. Diagnosis of suspected anal papilloma was made.  In July 2019, an incisional biopsy was performed, and the result showed papilloma squamosa with condyloma acuminata as a differential diagnosis. In September 2019, perianal soft tissue tumor excision with advancement flap was performed and the result showed condyloma acuminata. Discussions: The case highlights the importance of careful evaluation and diagnosis in such clinical scenarios, as the initial diagnosis of anal papilloma was later refined to condyloma acuminata based on the biopsy and surgical findings. Early detection and appropriate management are crucial in cases like this to ensure the best possible patient outcomes.
Age, Onset, and Tumor Size Differences in Newly Diagnosed Breast Cancer Patients Before and During the SARS-CoV-2 Pandemic at Siloam Hospital Lippo Village (April 2019 - December 2020) Halim, Freda Susana
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8889

Abstract

Background: The current pandemic condition has caused delays in cancer treatment therefore surveillance should be increased.Methods: By total sampling, this retrospective cross-sectional study enrolled 108 samples, who were newly diagnosed breast cancer patients at the outpatient department of Siloam Hospital Lippo Village (April 2019 - December 2020). Data obtained from medical records and interviews from December 2020 - February 2021.Result: From the total of 108 samples which consisted of 54 samples before the pandemic (April 2019 - February 2020) and 54 samples during the pandemic (March 2020 - December 2020), accompanied by an increasing trend. The age during pandemic was younger than before pandemic (51,167 years old ± 11,255 vs 47,537 years old ± 9,824, p value=0,038), the tumor size during pandemic was bigger than before pandemic (3,403 cm ± 3,024 vs 4,262cm ± 4,212, p value=0,046) but the onset of patient during pandemic was not longer than before pandemic (281,69 days ± 401,387 vs 178,09 days ± 292,563, p value=0,036).Conclusions: Newly diagnosed patients have younger age and larger tumor size during pandemic when we compare to before pandemic period, but no difference in onset term. Surveillance to society is needed to ensure older people with smaller tumor size to seek medical attention.
Intracranial Solitary Fibrous Tumor in a 25-Year-Old Woman Prasetyo, Patricia Diana; Marisca, Stephanie; Wahjoepramono, Eka J.
Medicinus Vol. 13 No. 3 (2024): June
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i3.8890

Abstract

Introduction: Intracranial solitary fibrous tumors (ISFTs) are extremely rare spindle cell tumors originating from dendritic mesenchymal cells expressing CD34 antigens that are usually benign, although malignant transformation had been reported. The knowledge of natural course and prognostic factors of ISFTs is still limited and the tumor is easily misdiagnosed.Case Presentation: An intra-cranial extra-axial tumor tissue resection from a 25-year-old woman was evaluated in the Surgical Pathology Laboratory. Histologic findings (cellular spindle cell tumor with ”˜patternless’ pattern, staghorn blood vessels and <5 mitoses per 10 hpf) and immunophenotype (positive for CD34, weakly and focally positive for STAT6) suggested a diagnosis of intracranial solitary fibrous tumor WHO Grade II.Discussion: ISFTs have very low incidence in the CNS and are difficult to distinguish radiologically from meningiomas, thus post operative pathological examination and immunohistochemistry markers evaluations are the mainstay for diagnosis. ISFT is associated with NAB2-STAT6 gene fusion and may exhibits a wide spectrum of histological features. STAT6 immunohistochemistry is considered as one of the most sensitive diagnostic methods, while the evaluation of CD34 expression can be used as alternative diagnostic method despite having lower sensitivity.

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