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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 429 Documents
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Reversible Bilateral Basal Ganglia and Brainstem Lesions in Neuropsychiatric Systemic Lupus Erythematosus: A Case Report Rocksy Fransisca V. Situmeang; Reza Stevano; Ekawaty Yasinta Yohana Larope; Ratna Sutanto
Medicinus Vol 9, No 3 (2021): October 2021-January 2022
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v9i3.5390

Abstract

The pathophysiology behind neuropsychiatric SLE (NPSLE) remains poorly understood and its clinical and radiological manifestations are highly varied. In this report, we present a complex case of an adolescent female patient with a three-week history of systemic symptoms (fever, nausea, vomiting, weight loss, polyarticular joint pain), progressive motor weakness, tremor, and altered mental status. Physical examination was significant for oromandibular and cervical dystonia rigidity, and general weakness with imposed right-sided hemiparesis. A head MRI demonstrated bilateral hyperintense lesions of the basal ganglia and brainstem, without restricted diffusion. The patient was diagnosed with NPSLE, lupus nephritis, electrolyte imbalance, severe hypoalbuminemia, lupus cardiomyopathy, autoimmune hemolytic anemia, pulmonary tuberculosis, and sepsis. The patient was given treatment in the ICU with pulse dose corticosteroids, intravenous antibiotics, intravenous immunoglobulins (IVIg), and supportive treatment with correction of hematologic and electrolyte abnormalities. Her condition improved rapidly. Full alertness was regained, and symptoms of oromandibular dystonia, tremor, and weakness diminished significantly. A follow-up MRI three weeks later revealed the complete disappearance of lesions, which we attribute to the resolution of the inflammatory process in the brain.
Failure Factors & Prediction Model of Indonesian Medical Doctor Proficiency & Competency Test (UKMPPD) within COVID-19 Pandemic Jonathan Salim; Jannatin Nisa Arnindita; Sutiono Tandy; Jacobus Jeno Wibisono; Maria Georgina Wibisono
Medicinus Vol 10, No 1 (2022): February 2022 - May 2022
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i1.5337

Abstract

Background: Coronavirus Disease 2019 drastically modulate the healthcare world. The pandemic's immense transmission and lethality rate enforce the Indonesian Medical Doctor Proficiency & Competency Test to discard practical measures and rely only on a written exam. These with pandemic social and physical restrictions impede prospective doctors’ learning opportunities leading to easier failure. Henceforth, the present study has high urgency to identify and manage failure factors, especially during the pandemic. Methods: The cross-sectional study examines 75 clinical medical students through purposive analysis with an online questionnaire in August 2021. Data are analyzed with Chi-Square, Mann-Whitney, and binary logistics. Result: Respondents have an average age of 24.15 (1.322) years old, majorly female (82.7%), and pass as first takers (86.7%) with 1.27 (0.949) off-campus tutelage. The significant factors for the test failure are depression and economic status. The study developed a failure prediction model with the area under the curve 0.845, cut-off 366.5, 80.0% sensitivity, and 84.6% specificity. Conclusion: Intrinsic, extrinsic, and academic factors have significant roles in the failure outcome. For this reason, preparation is crucial not only among individuals but also in institutions. The study also provides feedback about the importance of mental health and economic status for Indonesian medical students.
The Correlation Of Insomnia And Anxiety In Students Of The Faculty Of Medicine, University Of Pelita Harapan Kinley Dhinata; Nicolaski Lumbuun
Medicinus Vol 10, No 1 (2022): February 2022 - May 2022
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i1.5338

Abstract

Background and Aim: Insomnia and anxiety are common disorders with a high prevalence rate, especially in medical students. Moreover, many confounding factors play a role in influencing anxiety. Most studies do not include or measure other confounding factors of anxiety in the analysis. This requires research that examines insomnia and anxiety assessing the contribution of the factors influencing anxiety.Methods: A cross-sectional study methodology with linear regression analysis on a sample of students from the Faculty of Medicine, University of Pelita Harapan using the DASS-21 questionnaire to assess anxiety and ISI to assess insomnia.Results: Prevalence rates of insomnia was 34.29% and anxiety 32.38% in Pelita Harapan University medical student. From the results of the bivariate linear regression, a weak relationship between insomnia and anxiety (r = 0.322; p = 0.000) is seen. In multivariate results, there were confounding stress variables (r = 0.565; p = 0.000) and trauma (r = 0.250; p = 0.005) which contributed greatly to anxiety (In order of largest).Conclusion: There is a weak correlation and anxiety. Moreover, the high prevalence rate of anxiety in medical students may be contributed heavily not only by insomnia but also by stress and childhood trauma.
The Relationship Between Breastfeeding Pattern and the Risk of Postpartum Depression of Mothers in Tangerang Angeline Tancherla; Melanie Widjaja
Medicinus Vol 10, No 1 (2022): February 2022 - May 2022
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i1.5341

Abstract

Background and Aim: Postpartum depression (PPD) has a negative impact on mothers and children, such as breastfeeding (BF) disturbance. However, the relationship between BF pattern and PPD is still unclear due to contrasting results, and no related study has been done in Indonesia. Therefore this study is conducted to evaluate the relationship between BF pattern and the risk of PPD in mothers in Tangerang. Method: This is an analytic observational study with a cross-sectional design.  The samples of this study are 58 mothers that fulfill the inclusion criteria. Samples are chosen by the purposive sampling method. Data collection is conducted from January to April 2020. The results were analyzed using the SPSS program version 22.0 with the Chi-Square method. Results: There were 37 samples (63.8%) without PPD risk and 21 samples (36.8%) with PPD risk. Among 37 samples without PPD risk, 70.3% had exclusive BF and 29,7% had non-exclusive BF. Among 21 samples with PPD risk, 14.3% had exclusive BF and 85,7% had non-exclusive BF. The chi-Square analysis result showed that there is a significant association between BF pattern and PPD risk ( p=0.0001), with an OR of 0.071 (95% CI: 0.17-0.289).Conclusion: Breastfeeding pattern has a significant association with PPD risk. Exclusive BF has a protective effect on the risk of PPD at one month postpartum.
The Relationship Between High Emotional Intelligence and Stress in Medical Students of Medicine, Pelita Harapan University During the Covid-19 Pandemic Neneng Suryadinata; Sabrina Amadea; Fred Rich Conney
Medicinus Vol 10, No 2 (2022): June 2022 - September 2022
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.5678

Abstract

Background: The World Health Organization (WHO) has declared Coronavirus Disease 2019 (COVID-19) a global pandemic. This also has an impact on student's lives. Most of the students have been in a stressful condition due to changes in the online teaching and learning process as an adaptation to COVID-19. Although it has been reported that emotional intelligence can reduce stress, there are still a few studies that study about relationship between the two during COVID-19 pandemic, especially among medical students.Methods: A cross sectional using comparative numerical analysis was conducted with 305 medical students. Data were collected by an online survey using Emotional Intelligence Appraisal (EIA) questionnaire, and Medical Student Stressor Questionnaire (MSSQ). Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) version 25.Results: The EIA questionnaire showed that there were 1.3% low EI groups, 38.7% normal EI groups, and 60.0% high EI groups. The MSSQ questionnaire showed that there was 24% mild stress, 49% moderate stress, 26% severe stress, and 1% very severe stress. A normal data distribution was obtained through the Kolmogorov-Smirnov test, so that the T test could be used with a 95% confidence degree (p value <0.05). T-test analysis in the high EI group with an average stress (1.76±0.64) and the normal EI group with an average stress (1.40±0.75) showed a significant difference with p value = 0.008. Conclusion: In accordance with the hypothesis in this study, during the COVID-19 pandemic, there is a significant relationship between high emotional intelligence and stress in UPH Medical Faculty students.
A Comparative Efficacy of Atezolizumab plus Bevacizumab Versus Sorafenib in Advanced Hepatocellular Carcinoma: A Review Kristin Talia Marbun; Juandy Jo
Medicinus Vol 10, No 2 (2022): June 2022 - September 2022
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.5679

Abstract

Hepatocellular carcinoma (HCC) ranks sixth as the most common cancer and fourth as the most common cause of cancer-related death globally. The standard treatment for advanced HCC is by prescribing sorafenib, a tyrosine kinase inhibitor. Despite its moderate efficacy and concerning side effects, there is no better alternative to sorafenib to treat HCC. However, a new combination of atezolizumab (an inhibitor of PD-L1) and bevacizumab (an inhibitor of vascular endothelial growth factor), has shown a potential to surpass the efficacy of sorafenib. This review was written to provide an insight into pharmacodynamics of sorafenib and atezolizumab plus bevacizumab, effectiveness of sorafenib and the one of atezolizumab plus bevacizumab, utilization of atezolizumab plus bevacizumab in the clinical practice, as well as to argue that this combination can replace sorafenib as the standard palliative treatment for HCC.
Clinical Factors Related To Histopathologic Grade in Meningioma Erna Kristiani; Michelle Agelica; Sally Suharyani; Kevin Dharmawan
Medicinus Vol 10, No 2 (2022): June 2022 - September 2022
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.5675

Abstract

Background: Meningiomas are the most common intracranial tumor of central nervous system tumors. Although the prevalence is lower, the WHO grade II and III meningiomas are more aggressive, with higher mitosis rates, are more likely to recur after surgery, and have lower survival rates. The ability to differentiate between WHO I and WHO II/ III meningiomas before surgery can contribute to a significant clinical benefit in helping the neurosurgeon doing the best management planning.Methods: This is a retrospective cross-sectional study of meningioma patients in Siloam Hospital Lippo Village between 2014 – 2018. The sample will be recruited using consecutive sampling. The relationship between analyzed variables and meningioma grades will be investigated using a chi-square test if the data was eligible; otherwise, the Fisher-exact test will be performed.Result: Ninety eight (69%) patients diagnosed as low grade meningioma, and 44 (31%) as high grade meningioma. Tumor location, size, edema, necrosis, age, and gender had significant results with p £0.05. Multivariate results also show that all six variables have a significant relationship with each other.Conclusions: Tumor location, size, edema, necrosis, age, and gender have a significant relationship to histopathological meningioma grade in patients at Siloam Hospital Lippo Village in 2014-2018.
A Case of Neuropsychiatric Systemic Lupus Erythematosus As A Sequela of Kikuchi’s Disease Theo Audi Yanto; Nathania Raphaeli Mulia; Abraham Fatah
Medicinus Vol 10, No 2 (2022): June 2022 - September 2022
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.5680

Abstract

The aetiology of Kikuchi’s Disease (KD), a benign condition associated with multiple lymph node enlargements, remains unknown but several reported cases associate it with systemic lupus erythematosus (SLE). A 34-year-old Indonesian woman presented with multiple painless lymph node enlargements around the neck with three weeks of fever, myalgia, arthralgia, night sweats, and weight loss. Laboratory examination showed pancytopenia and elevated ESR. HIV and tuberculin skin testing were negative. Lymph node biopsy confirmed the diagnosis of KD. One week later, despite improvement in lymphadenopathy, she developed fever. Her ANA, anti-Smith antibodies, and anti-Ribosomal-P protein antibodies were positive. She was diagnosed with SLE and managed as an inpatient with high dose methylprednisolone. One week later, the patient developed psychotic symptoms and fever. The results of Laboratory examinations with lumbar puncture were unremarkable. She was diagnosed with neuropsychiatric SLE (NPSLE) and managed with methylprednisolone, paracetamol, folic acid, alprazolam, and amitriptyline. One month later, the patient returned with three days of fever and dyspnea. Despite improvement in neuropsychiatric symptoms, pneumonia and tonsillopharyngitis were diagnosed based on physical examination and chest X-rays. Her condition deteriorated into septic shock. She suffered cardiac arrest and was pronounced dead, despite attempted resuscitation.While KD is a benign condition, diagnosis is challenging due to its rarity and similarity to other lymphadenopathy diseases. Its association with SLE and NPSLE carries poor prognosis with higher mortality rate from the disease progression and adverse medication effects. Thus, early intervention and prevention of complications are crucial in managing patientswith KD.
The Calamity Among Medical Students: Sleep Deprivation and Dry Eye Disease Anastasia Johanna Salim; Jonathan Salim; Josiah Irma
Medicinus Vol 10, No 2 (2022): June 2022 - September 2022
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.5676

Abstract

Background: Medical students’ burden upon academic and professional duties often blinded them from attending to themselves. Piling works and nightshifts interfere ferociously with their self-care behavior, including adequate sleep. The matter not only disrupts concentration and consciousness but also tolls the eye by reducing tear secretion. Hence, the present study urgently assesses sleep quality and dry eye disease (DED) among medical students.Methods: The cross-sectional study observed 172 eyes among medical students in Indonesia. We assessed sleep quality and dry eye disease through Pittsburgh Sleep Quality Index and Schirmer test. Independent statistician analyzed the data with chi-square.Result: From the eligible samples, there is a dominancy of females (55.8%) with poor sleep quality (55.2%). There is no significant difference in DED or sleep quality across gender though they lean toward females. Contrarily, poor sleepers significantly correspond to 2.96 times more risk of DED than an adequate sleeper.Conclusions: Medical students’ well-being is crucial. Aside from the academic burden, institutions and individuals shall strongly emphasize better sleep habits and eye care.
Case Report : Management Penetrating Brain Injury Across Middle Third of Superior Sagittal Sinus Achmad Chumaidi; Julius July
Medicinus Vol 10, No 2 (2022): June 2022 - September 2022
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.5681

Abstract

Background: Penetrating cranial injuries are rarely reported on thick parietal bone. Goal of its management include removal of the foreign object while minimizing furher damage to the brain and associated neurovascular structures, also prevent further complications.Case Description: We report a case of a 22-year-old male presented with machete stucked in his head following an accidentally fell down of the weapon from a coconut tree. The cranial location affected were midparietal. He was disoriented on admission, with neither neurological focal signs nor seizure. Computed tomography (CT) revealed that the object penetrate middle superior sagittal sinus. After emergency craniotomy to remove the objects, debridement, dural sinus repair were performed. Recovery was complete without sequelae.Conclusion: Laceration of the middle thirds of the superior sagittal sinus require special handling and care during surgery. Operative approach and treatment strategies are among the most important considerations to achieve the best patient outcomes

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