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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 429 Documents
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Scientific Programme UPH, FK
Medicinus Vol 8, No 1 (2018): oktober 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i0.1300

Abstract

Scientific Programme of the Dies Natalis Faculty of Medicine Universitas Pelita Harapan XVII 2018
Randomized Trial Comparing Adjuvant Intravitreal Triamcinolone Acetonide 2mg and Bevacizumab 12,5mg for Diabetic Macular Edema maria Larasati; Arini Setiawati; Ari Djatikusumo
Medicinus Vol 7, No 2 (2018): February 2018 - May 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i2.1792

Abstract

ObjectivesTo evaluate the efficacy and safety of Intravitreal Triamcinolone Acetonide (IVTA) 2 mg and Bevacizumab (IVB) 12,5 mg for adjuvant therapy of Diabetic Macular Edema (DME)DesignThis was a prospective, randomized clinical trial. Each participants with DME was randomized to received single intravitreal injection of IVTA or IVB  and then being followed until fourth week after injection. The efficacy parameters were the improvement in Best Corrected Visual Acuity (BCVA) in logMAR and Standardized Central Macular Thickness (SCMT) by Optical Coherence Tomography. The safety parameters were the Intra Ocular Pressure (IOP) and Posterior Capsular cataract progression using LOCSIII criteria.ResultsTwenty five eyes of 20 participants were randomly assigned to receive IVTA 2 mg (n=12) and IVB (n=13). At 4 weeks, mean BCVA was better in IVTA group than in IVB group -0,39 logMAR (p<0,05). CMT reduction were significant in all visits of both groups. The SCMT showed 78,37%  at final follow-up for IVTA group. There were no statistic significant difference in the mean IOP and posterior capsular cataract changes among two groups. (p>0,05)ConclusionAdjuvant IVTA injections were more effective than IVB injections in patients with DME. However, it was associated with higher increment in IOP, despite not reaching statistical significance.
Comparison Of Progesterone-Induced Blocking Factor Serum Levels In Preterm Labor And Preterm Pregnancy Patrick Bayu; Johanes C Mose; Muhammad Alamsyah
Medicinus Vol 7, No 2 (2018): February 2018 - May 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i2.1793

Abstract

Preterm labor is a multifactorial phenomenon involving inflammatory processes that will affect the balance of Th1 to Th2 by increasing dominance of pro-inflammatory Th1 cytokines and also lead to functional progesterone withdrawal.Progesterone maintains pregnancy mainly by promoting myometrial quiescence and labor is initiated by progesterone withdrawal. Progesterone also has antiinflammatory properties and as an immunomodulator. While it has been postulated that the effect of progesterone on preterm birth is related to its anti-inflammatory properties, the spesific mechanism of action remains unclear.The biological effects of progesterone are mediated by a 34-kDa protein named the progesterone-induced blocking factor (PIBF). PIBF is synthesized by lymphocytes of healthy pregnant women in the presence of progesterone. PIBF inhibits arachidonic acid production, reduced NK cell activity, and modifies the cytokine balance.The objective of this study was to compare serum concentrations of PIBF of women with preterm labor with those women with normal pregnancy. A comparative analytical study with cross-sectional design was conducted. This study consisted of 16 women in each group. All the subjects met the inclusion criteria and were admitted to the Dr . Hasan Sadikin hospital and it’s district hospital. This study conducted from July until November 2013. Serum PIBF concentrations were measured by enzyme-linked immunosorbent assay ( ELISA) .Mean PIBF concentrations in serum of patients with preterm labor were significantly lower (391.4051 ± 1021.162 ng/mL ) than in those of normal pregnancy (174.2165 ± 1297.675 ng/mL) with p = 0.029 . It was concluded that the levels of serum PIBF preterm labor is lower than in normal pregnancy.
Epilepsi Dalam Kehamilan Fidelia Fidelia; Julita D L Nainggolan
Medicinus Vol 7, No 2 (2018): February 2018 - May 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i2.1796

Abstract

Epilepsi merupakan salah satu kondisi neurologis yang paling sering ditemukan pada ibu hamil, dengan prevalensi 0,5-1%. Telah dilaporkan bahwa sebanyak 12 dari 14 kasus kematian ibu yang terjadi sejak tahun 2009 hingga 2012, diklasifikasikan sebagai sudden unexpected death in epilepsy atau SUDEP dengan kondisi kejang yang tidak terkontrol dengan baik yang merupakan faktor penyebab utama. Perubahan fisiologis selama kehamilan dapat berpengaruh terhadap farmakokinetik dari obat antiepileptik sehingga dapat menimbulkan bangkitan kejang pada wanita dengan epilepsi yang sedang hamil. Angka kejadian fetal loss akibat pengaruh epilepsi atau obat antiepileptik cenderung rendah. Pengaruh obat antiepileptik terhadap kehamilan dapat berakibat pada malformasi kongenital mayor, perkembangan neurokognitif yang terganggu, risiko obstetrik, dan komplikasi perinatal.
Pseudokista Pankreas pada Pasien Pediatrik yang Diterapi dengan Drainase Eksternal Freda S Halim
Medicinus Vol 7, No 2 (2018): February 2018 - May 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i2.1839

Abstract

Background : Pseudocyst of pancreas in pediatric patient is a rare case. Therapy usually conservative, while we wait the wall of the pseudocyst become thick and mature, then followed by internal drainage of jejunum and the pseudocyst. The controversy arise in this case where the external drainage is performed due to feeding trouble with significant decrease of the patient’s body weight after trauma. The purpose of this case report is to give insight that external drainage is possible and should be considered in pediatric patient with pseudocyst of pancreas,  primarily  where the exploratory by laparoscopy is possible and feeding problem becomes the main problem.Case : A 4 year old boy come to ER with chief complain pain at the gastric region after blunt abdominal trauma 12 hours before admission. Primary survey was normal with stabile hemodynamic. At first admission, the physician found abdominal distention with tenderness and rebound tenderness without muscular rigidity. In bed-site abdominal USG free fluid was found without abnormality at the solid nor hollow organs.  Abdominal CT showed no active bleeding nor abnormality. After 1 week of inpatient care, feeding (even fluid by oral feeding)becomes a constant problem and abdominal distention is increasing.Therapy : Exploratory by laparoscopic of the abdomen cannot be conducted due to inadequate instruments, then exploratory laparotomy was chosen. Pseudocyst of pancreas was found, 5x4 cm in size with hematoma at the tail of pancreas. External drainage was performed. After the operation the patient dramatically improved, he could tolerate both fluid and solid diet. The patient discharged 4 days after the operation. 3 months after the 1st operation, the patient come with good condition and minimal fluid come from the drain, so the drain was pulled out. Internal drainage was not needed in this case.Conclusion : External drainage could be considered in pediatric patient with pseudocyst of the pancreas if the feeding problem becomes prominent and the laparoscopic instrument is available.
Trigeminal Neuralgia Etiologi, Patofisiologi, dan Tatalaksana Pricilla Y Gunawan; Annisa Dina
Medicinus Vol 7, No 2 (2018): February 2018 - May 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i2.1840

Abstract

Neuralgia trigeminal is unilateral, chronic and recurring facial pain syndromes, in which pain is distributed following trigeminal nerve branches and is commonly found in healthcare practice. The prevalence of trigeminal neuralgia is 4,3 / 100.000 case worldwide. As a facial pain syndrome, trigeminal neuralgia is well-known for reducing quality of life of its sufferers, hence the etiology, pathophysiology, and the management of trigeminal neuralgia are important to be recognized in daily clinical practice.
Functional Outcome on Surgical Treatment For Lower Extrimity Tuberculosis Arthritis At Cipto Mangunkusumo Hospital Jakarta Mirna Phandu; Ismail HD
Medicinus Vol 7, No 3 (2018): June 2018 - September 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i3.2291

Abstract

Introduction: Osteoarticular tuberculosis more frequently occur on weight bearing joints.1,8 On late stage tuberculosis osteoarthritis choices of surgical treatment involved synovectomy, osteotomy, arthrodesis, and arthroplasy11 Results on functional outcome after surgery would be useful to decide appropriate treatments and prognosis.Method: This descriptive analytic study involved all lower extremity tuberculosis osteoarthritis that underwent surgical procedure at Cipto Mangunkusumo hospital in 5 years periods from 2008 to 2012. Follow up performed for minimal 6 months after surgery. Patients were evaluated using Lower Extremity Functional Score (LFES) and functional score according the joints involved, including Harris Hip Score (HHS), Knee Society Score (KSS), and Foot & Ankle Disability Index (FADI). Results: Study only involved late stage cases with average age at surgery was 30.04 (SD 16,67) years old. Average follow-up 33.68 months (SD 18.67). There are significant difference (p<0.001) of the LFES between preoperative (27.41), 6 months after surgery (42.19) and on last follow up (63.04). There were also difference (p<0.001) on Functional Score (HHS, KSS and FADI) preoperative (27.48), 6 months after surgery (60.11) and on last follow up (82.56). There is positive correlation between time of follow up and LEFS on last follow up. On last follow up, there is also significant difference of LEFS between groups that had arthrodesis and arthroplasty (p 0.045.)Conclusions: Results of surgical treatment gave significant improvement on functional outcome of the joint involved.  The result however is correlated to the type of joints involved, type of surgery performed and the time after surgery.
Intradialytic Hypertension in End Stage Renal Disease patient : Prevalence and clinical characteristic Margaret Merlyn; Akhil Deepak Vatvani
Medicinus Vol 7, No 3 (2018): June 2018 - September 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i3.2293

Abstract

Introduction : Intradialytic hypertension (IDH) is common and it increases the incidence of cardiovascular morbidity and mortality, however this is often ignored. The aim of this study is to identify the prevalence of IDH and compare the clinical characteristics of patients with and without IDH.Methods : A cross sectional study was carried out in 3 hemodialysis clinics in Jakarta, Indonesia. We compared several clinical characteristics inpatients with IDH and control group without IDH. Nutritional status was also assessed using Subjective Global Assessment (SGA). IDH was defined as >10 mmHg increase in systolic blood pressure (BP) in at least four of six prior consecutive hemodialysis sessions. Student’s T-test or Mann-Whitney test was used to compare the quantitative variables. Chi-Square or Fischer exact test was used to compare categorical variables.Results : A total of 114 patients was included in this study. There were 86 (62.3%) male patients. IDH was present in 47 (34.1%) patients. The mean age in IDH and control group were 53.4 (±13.2) and 52.8 (±12.4) years respectively (p: 0.800). The mean BMI of IDH and control group were 21.8 (±3.7) and 24.0 (±4.4) kg/m2 respectively (p: 0.031). The mean MAP during dialysis of IDH and control group were 108 (±13.1) and 98.6 (±23.2)mmHg respectively (p: 0.011). The median creatinine levels of IDH and control group were 8.1 (3.02-22.20)mg/dl and 10.8 (2.89-22.0)mg/dl respectively (p: 0.008). Interestingly, moderate to severe malnutrition status had significant association with IDH (OR: 2.31, p: 0.031). Patients who undergo dialysis thrice a week was associated with IDH rather than patients who undergo dialysis twice a week (OR: 2.27, p: 0.035).Conclusion : The prevalence of IDH is higher than previously reported in other countries. The clinical characteristic of patients with IDH is lower BMI, higher MAP and lower creatinine levels than in patient without IDH. Moderate to severe malnutrition and frequency of dialysis per week had significant association with IDH.
Perforation Of Descending Colon Caused By Tumor Infiltration : A Case Report Andry Irawan; Adeline Adeline; Martinus H. N. P Linggo
Medicinus Vol 7, No 3 (2018): June 2018 - September 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i3.2294

Abstract

Introduction: Colorectal cancer is one of the most common cancer found in the gastrointestinal tract. This tumor is less commonly found on the descending part of colon and about 15 - 30 % can progress to obstruct the passage of the colon and invade other organs and may cause perforation which may show sign of peritonitis. The majority of perforation cases occur in patients with acute obstruction, only in a rare setting of colonic cancer cases due to penetration of the tumor mass through the intestinal wall. Clinical Presentation: A 34-year-old male came with pain on his whole abdomen area for 1 day and keeps on getting worse. On clinical examination There were sign and symptoms of peritonitis and during emergency laparotomy, we found perforation on descending colon caused by tumor infiltration and performed Left Hemicolectomy and Stoma at emergency settings.Conclusion: Perforation of descending colon caused by tumor infiltration is a rare case, Left hemicolectomy and stoma shows good results in emergency settings.
Use of Fluconazole in Pulmonary Mycosis : A Case Report Trowce Lista Nalle
Medicinus Vol 7, No 3 (2018): June 2018 - September 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i3.2295

Abstract

The diagnostic criteria for pulmonary mycosis are long-term use of invasive medical devices, long-term use of broad-spectrum antibiotics and corticosteroids, lung infiltrate images with unfavorable fever after adequate antibiotic treatment, an increase in eosinophil count. Should be considered during patients undergoing hospitalization, from the beginning the antifungal that fluconazole can be used. Fluconazole is recommended for candida infections by the FDA because it is safe, fewer side effects and better tolerated than other antifungal classes.

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