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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
  • Website
Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
Arjuna Subject : -
Articles 429 Documents
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Association Between Living With Parents And Not Living With Parents With Psychological Stress In Preclinical Medical Students In University Of Pelita Harapan Engelberta Pardamean; Andrew Theodorous Timothy
Medicinus Vol 7, No 3 (2018): June 2018 - September 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i3.2296

Abstract

Introduction: Stress is a response to stressor that came from the body (internal or external). According to several studies, medical student very evident to experience of stress, which compared to student from other major. In previous studies the level of stress among medical student was 45% – 72%. And lack data that connect stress with domisil in medical student, and one of the reasons for this research. Objective To find an association between domisil and psychological stress in medical students. Material and Methods This research is categorical comparative analytic, with cross sectional as the design study and needed 264 repondent that consis of preclinic medical student of Pelita Harapan University. Taken by questionnaire from GHQ – 12 for the data. Data will be analyzed using Chi – Square in SPSS version 23.Results: This result showed 43 (41%) students who experiencing psychologic stress and 62 students (59%) students who not experiencing psychologic stress in students who live with their parents. There’s also 104 (65.4%) students who experiencing psychologic stress and 55 (34.6%) students who not experiencing psychologic stress in students who don’t live with their parents. This research has a significant result with p-value <0.001 that support the hypothesis.Conclusions: There is an associaton between domisil and psychological stress in preclinic medical student at Pelita Harapan
Exclusive Breastfeeding And Acute Diarrhea In Children: A Cross-Sectional Study Lukman, Leni; Suryawan, I Wayan Bikin
Medicinus Vol 8, No 2 (2019): February : 2019
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i4.2383

Abstract

Introduction : Breastmilk is known to contain molecules such as oligosaccharides, sIgA and lactoferrin which hold vital importance in immune system. These molecules specifically functioned to protect the body from pathogens including those causing diarrhea. The objective of this study is to define the relationship between exclusive breastfeeding and acute diarrhea incidence frequency in children as primary outcome and age of first acute diarrhea occurrence in children as secondary outcome.Methods: This is an analytic observational cross-sectional study which included 35 children aged 6-24 months who were admitted to Kaswari Ward Wangaya General Hospital Denpasar between 01 June 2018 to 16 August 2018. Samples were obtained through consecutive sampling method and analyzed data were presented in both tables and narrative.Results: From 35 samples included in this study, 13 were exclusively breastfed (37,1%) and 22 were non-exclusively breastfed (62,9%). Sample characteristics including gender, number of siblings, nutritional status, residence, source of water, age of mother, parent’s occupation and education were comparable between two groups. Total samples who were exclusively breastfed and experience less diarrhea is 13 (p = 0,031; PR = 1,47 CI 95% 1,10-1,95). Total samples who were exclusively breastfed and first age of experiencing diarrhea over 12 months old is 11 (p = 0,002 ; PR = 3,10 CI 95% 1,47-6,27). Conclusion: There is statistically significant relationship between exclusive breastfeeding and acute diarrhea incidence frequency and age of first acute diarrhea occurrence in children aged 6-24 months in Kaswari Ward Wangaya General Hospital.
The Relationship Between Brain Tumor And Sleep Components (Psqi) In Siloam Hospitals Lippo Village 2015-2018 Uranus, Hans Christian; July, Julius
Medicinus Vol 8, No 2 (2019): February : 2019
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i4.2384

Abstract

Introduction: Brain tumor can cause symptoms such as headache and seizure which might reduce sleep quality. Currently, sleep quality in brain tumor patients aren’t getting much attention. This study’s purpose is to determine the effect of brain tumor to sleep quality and its components in patients.Methods: The design of this study is a retrospective cohort, and it is done in Siloam Hospitals Lippo Village and Paviliun Umum Rumah Sakit Siloam from January-April 2019 with sample population consisting of brain tumor patients from age 19 until 59 years old. The sample amount is 29 subjects. PSQI is used to assess sleep quality and components. Data analysis uses the SPSS version 24.0 software and statistical  analysis using chi2.Result: Brain tumor patients have worse sleep quality compared to the control, with 26 patients (89.7 %) having bad sleep quality. For the control, there are only 18 people (62.1%) who have bad sleep quality. The relationship between brain tumor and sleep quality have a p value of 0.032 and relative risk (RR) of 3,7. Brain tumor has a significant relationship with sleep latency (p value 0,015) and daytime dysfunction (p value 0,02)Conclusion: The relationship between brain tumor and sleep quality in brain tumor patients of Siloam Hospitals Lippo Village and Paviliun Umum Rumah Sakit Siloam, which was measured with the PSQI questionnaire is significant. Brain tumor also has a significant relation with sleep latency and daily dysfunction.
Short-Term Memory Comparison Of Students Of Faculty Of Medicine Pelita Harapan University Batch 2015 Between The Handwriting And Typing Method Widjaja, Caroline; Sumali, Stefanus Satria
Medicinus Vol 8, No 2 (2019): February : 2019
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i4.2385

Abstract

Introduction : A lot of research has been done to determine if handwriting or typing note influenced short-term memory, however, the results obtained are still controversial. Therefore this study is structured to see the effect of note taking methods by handwriting and typing on short-term memory.Aim : The aims of this study were to increase the performance of students in Faculty of Medicine Pelita Harapan University as well as providing the right and effective method of taking notes.Method : Experimental study design was chosen in this study. Study population is students of faculty of medicine Pelita Harapan University batch 2015. 40 samples will be divide randomly into two, one group will take a note by handwriting and another by typing. Each group is required to watch a video about 15 minutes long.  The results were analyzed statistically using T-test.Result : The average of  new information that can be remembered by group that take a note by handwriting significantly (p<0,05) higher than group than take a note by typing with a p-value of 0,009.Conclusion : Take a note by handwriting allows people to remember more new information than typing.
Magnesium Sulphate For Tetanus, review of two cases Susanto, Tirta Darmawan
Medicinus Vol 8, No 2 (2019): February : 2019
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i4.2386

Abstract

Introduction: Tetanus is critically ill disease with long term hospitalization period. It need to be carefully monitored, usually in intensive care unit and involves critical care physicians. Benzodiazepine is preferred by World Health Organization (WHO) for muscle spasm control in tetanus, but it will be less costly if magnesium sulphate can be used alone to control spasm and autonomic dysfunction in tetanus. We report a series of 2 tetanus cases that were treated using magnesium sulphate to provide a brief clinical description about the use of magnesium sulphate in tetanus. We also give a brief review on epidemiology, pathophysiology, clinical findings, diagnosis, and treatment of tetanus to provide implications for intensive care physicians. Methods : Case series reportResults : Two patients with tetanus was given magnesium sulphate infusion to control muscle spasm and autonomic dysfunction with good results as expected. Both of them were survive and discharged home in healthy condition.Conclusions :Magnesium sulphate can also be used to control muscle spasm and autonomic dysfunction although WHO recommend benzodiazepines for controlling muscle spasm. Intensive care physicians should have enough knowledge about tetanus and how it should be managed adequately to ensure survival from tetanus.
Treatment with High Dose Rifampicin in Tuberculous Meningitis: A Case Report Ketaren, Retno J; Goenawan, Vonny; Simca, Jennifer
Medicinus Vol 8, No 2 (2019): February : 2019
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i4.2387

Abstract

Introduction : Tuberculous meningitis continues to be associated with considerable mortality and morbidity.A randomized comparison of higher-dose intravenous rifampicin (approximately 13 mg/kg per day) versus a standard oral dose in adults with tuberculous meningitis showed that mortality among patients who received higher intravenous dose was 50% lower than those who received the standard dose.1 While there are other contradictory results regarding the use of high-dose rifampicin in patients with tuberculous meningitis.Method  : We hereby report a case of a 20-year-old female patient presented with a history of fever, palpable neck lymph nodes and headache since 1 month before admission. Neurological examination revealed nuchal rigidity without other neurological deficits. Head MRI  with contrast showed meningitis with tuberculoma in the right parietal lobe +/- 0.4 cm and neck ultrasonography showed multiple lymphadenopathy with 1 cm in diameter. Cerebrospinal fluid examination revealed tuberculous meningitis. The patient had been treated with rifampicin 450 mg, other tuberculosis regiments, levofloxacin, and dexamethasone. After one week of treatment, the patient developed generalized seizure and deterioration of consciousness. Imaging re-evaluation showed multiple acute infarction in the cortical and subcortical left frontal lobe, bilateral insula, bilateral temporal lobe, right parietal lobe to the corpus callosum, more prominent leptomeningeal contrast, and communicating hydrocephalus. Ventriculoperitoneal shunt was done. The patient was then treated with a higher dose of Rifampicin (15 mg/kg ~ 900 mg) and showed improvement after 2 weeks of treatment without any abnormal laboratory findings.Conclusion   : The usage of high dose rifampicin is still controversial. From this case we can conclude that by giving high dose rifampicin, the patient has a better outcome without any significant side effects. Thus, we support the hypothesis of using high-dose rifampicin in  patients with tuberculous meningitis that does not respond to the standard treatment.
Pilot Study for Azoxymethane-induced Colon Cancer in Male Wistar Rats Taufik, Riska; Pandianta, Abidin; Kusuma, Rinaldy; Winoto, Imelda L.; Suriapranata, Ivet; Mathew, George
Medicinus Vol 8, No 3 (2019): June 2019
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i5.2469

Abstract

Introduction : The use of animal models could significantly further the elucidation of Colorectal Cancer (CRC) molecular pathogenesis and help in the discovery of preventive and therapeutic agents for the disease. Dimethylhydrazine (DMH) is a widely used chemical agent for Carcinogen induced CRC model. As agent, DMH is however becoming less readily available; hence in this Pilot Study we use Azoxymethane (AOM), a DMH metabolite as an alternative agent to induce CRC in male Wistar rats. Methods: Forty two male Wistar rats at six weeks of age were randomly assigned into negative control groups and groups receiving two AOM injections subcutaneously (SC) within one week interval at 15 mg/kg body weight (BW) and 20 mg/kg BW respectively. Rats were sacrificed 8, 16 and 24 weeks post- AOM administration. Aberrant crypt foci (ACF) were analyzed. Tumor foci were characterized by gross examination and histopathological characteristics. Results: All rats in the AOM groups developed tumors in the colonic mucosa. Formation of ACF was detected starting from 8 weeks post-AOM injection. The highest number of ACF with multiple crypts was observed at 16 weeks post-AOM administration. The total number of ACF did not vary between the two AOM doses. Mild, moderate and severe dysplastic cells were observed in colonic mucosa starting 8 weeks post-AOM injection. There was no statistically significant difference between number of severe dysplastic cells between the two AOM doses. Conclusion: Administration of AOM 15 mg/kg BW SC is able to induce CRC in male Wistar rats. Higher dose is not necessary since it does not result in higher tumor incidence. This cancer model may be utilized to study chemopreventive effect of various agents in the future.
Case Report : Generalized Myasthenia Gravis Widjaja, Devita; Puspitasari, Vivien
Medicinus Vol 8, No 3 (2019): June 2019
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i5.2497

Abstract

Generalized myasthenia gravis is a rare case of autoimmune wherein the antibodies destroy the post-sinaptic acetylcholine receptors at skeletal muscle’s neuromuscular junctions. The clinical presentation is specific distributin of motoric deficit without sensoric deficit which diminished with rest and worsens with excessive use. We report a case of a woman 52 yo with symptoms of ptosis, diplopia and dificulty of swallowing. Repetitive nerve stimulation showed >10% decrement and prostigmin test was positive. The patient was treated and showed clinical improvement.
Risk Factors of Cervical Cancer in Outpatient and Inpatient at Obstetric and Gynecology RSUP Dr. Mohammad Hoesin Palembang Trifitriana, Monica; Sanif, Rizal; Husin, Syarif; Mulawarman, Rido
Medicinus Vol 8, No 3 (2019): June 2019
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i5.2470

Abstract

 Introduction: Cervical cancer is a malignant tumor originating from primary squamous epithelial cells and it is one of the several types of cancers that affects more to women. Methods: This research uses descriptive analytic with case- control. The sample was 52 patients who divided into 26 patients with cervical cancer and 26 patients with non - cervical cancer were outpatient and inpatient at Department of Obstetrics and Gynecology Hospital Dr. Mohammad Hoesin Palembang during the period September 2016 -November 2016. This study uses primary data in the form of interviews. Data was analyzed by univariate and presented in a frequency distribution table. Furthermore, using bivariate analysis to determine the relationship and OR. Result: From 8 risk factors studied, there is sygnificancy correlation between pathological vaginal discharge (p= 0,0005 OR= ∞), parity (p= 0,0005 OR= 22,7), age (p= 0,0005 OR= 19,2), oral contraception usage for a long time (p= 0,0005, OR= 12,4), age of the first intercourse (p= 0,006, OR= 6,1 ), and the husband’s occupation (p= 0,05 OR= 3,6) with the incidence of cervical cancer. While, there are two risk factors that don’t have a sygnificancy correlation between smoking (p= 1,0) and changing sexual partners (p= 1,0) with the incidence of cervical cancer. Conclusion: The results of this research identified  risk factors that significantly related to cervical cancer incidence was the age, the age of first sexual intercourse, parity, long-term oral contraceptive use, a history of vaginal discharge, and the husband's occupation.
Epidemiology of Traumatic Brain Injury in Neurosurgery Department of Tertiary Referral Hospital at North Sumatera, Indonesia Tandean, Steven; Japardi, Jeffrey; Kollins, Fini; Loe, Michael Lumintang
Medicinus Vol 8, No 3 (2019): June 2019
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i5.2471

Abstract

Introduction : Traumatic brain injury (TBI) is the most common problem that caused morbidity and mortality in the world. Epidemiology information of TBI is very important in understanding the causes and the risk factors of TBI, so that effective programs can be designed to prevent injury. This study purposed to provide overview of TBI pattern in tertiary referral hospital at North Sumatera with focus on epidemiological data of TBI pattern. Methods : The design of this study is a retrospective, and it is done in general hospital H. Adam Malik from June-December 2018 with sample from all patient with traumatic brain injury that admited in hospital. All medical records with diagnosis traumatic brain injury will be assessed for several variables as age, gender, etiology, severity, length of stay and outcome. Results : During the period of study, 118 patients with traumatic brain injury were admitted in neurosurgery ward. The highest TBI cases was occurs in male patients with range age between 18-35 years old, and caused by traffic accident. Most patients admitted to Emergency department with GCS 13-15 and epidural hematoma was the most common lesion found in head CT scan. Length of stay in this research mostly between 1-5 days,  and  the mortality rate is about 16.9%, which is dominated by severe head injury. Conclusions : Head injury mostly found in male with productive age, and traffic accident be the most common caused. Severe head injury still have quite high mortality rate.

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