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Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
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Articles 5 Documents
 1 
Search results for , issue "Vol 3, No 3" : 5 Documents clear
Should Cannabis as Medicine be Specifically Regulated? Gunawan Widjaja
Pharmacology and Clinical Pharmacy Research Vol 3, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (326.481 KB) | DOI: 10.15416/pcpr.v3i3.19979

Abstract

In 2017, a patient case in Sangau, West Kalimantan, involving a women with syringomyelia has drawn public attention. The case ended with the arrest of her husband who cultivated Cannabis to treat her disease. Currently, Indonesian regulation classifies Cannabis as the first group of narcotics which are prohibited to be used as medicine. This research aimed to ellaborate whether Cannabis as medicine should be specifically regulated. Data source was national and international regulation on narcotics and scientific evidence regarding medical benefit of Cannabis The data was obtained from literature search with following keywords; regulation of Cannabis, medical use of Cannabis, Cannabis medicine. Analysis was conducted using qualitative approach. The results of this study showed that Indonesian regulation regarding Cannabis is associated with International Convention on narcotics. Evidence-based data on Cannabis application in medical treatment have been extensively studied. Given beneficial effect of Cannabis to treat many diseases, several countries have already regulated the use of Cannabis for medical purpose. In conclusion, it is worth to consider a specific regulation for medical Cannabis in Indonesia, given its beneficial utilization to treat certain diseases.Key words: Regulation, Cannabis, medical Cannabis, syringomelia
In Vitro Inhibition of α-Amylase and α-Glucosidase by Different Parts of Amla Plant (Phyllanthus emblica L) Novi I. Fauzi; Maria Ulfah; Syarif Hamdani; Saeful Hidayat
Pharmacology and Clinical Pharmacy Research Vol 3, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (469.883 KB) | DOI: 10.15416/pcpr.v3i3.19980

Abstract

Amla plant (Phyllanthus emblica L) has been empirically used to treat diabetes. The aim of this study was to determine the most potential part of amla plant that can be used as α-glucosidase and α-amylase inhibitors. The fruit was subjected to cold extraction method, while the stem underwent soxhlet extraction process. Ethanol was used as solvent for both extracts. In-vitro inhibiton against α-glucosidase and α-amylase enzyme was measured by calculating IC50 of water fractions of stem and fruits. Fruit fraction exhibited the highest percentage of inhibitory activity on α-amylase (IC50=5.68% w/v), while the strongest inhibition against α-glucosidase was shown by leaves fraction (IC50=0.87% w/v). In conclusion, the stem of P. emblica L was potential inhibitor of α-amylase , while the leaves was potential α-glucosidase inhibitor.Keywords: Phyllanthus emblica, α-glucosidase inhibitor, α-amylase inhibitor, fruit, leaves
Formulation and Evaluation of Anti-Acne Lotion Containing Red Ginger (Zingiber officinalle Roscoe) Essential Oil Dwi Indriati; Ike Y. Wiendarlina; Annisa S. Carolina
Pharmacology and Clinical Pharmacy Research Vol 3, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.19 KB) | DOI: 10.15416/pcpr.v3i3.19841

Abstract

Red ginger (Zingiber officinalle Roscoe) has been empirically used as antibacterial agent. This study was aimed to formulate anti-acne lotion containing red ginger essential oil and to evaluate its antibacterial activity against Propionibacterium acnes and Staphylococcus epidermidis. Extraction and distillation of 10 kg of red gingers were performed to obtain its essential oils. The lotions were prepared using oil in water (o/w) base with various concentration of red ginger essential oils, i.e., 2.5%, 5%, and 7.5%. The lotion was assayed to determine organoleptic, homogeneity, pH, viscosity, and irritation-inducing level. Antibacterial activity test was conducted using disk-difussion method. Results indicated that the 7.5% concentration exerted the strongest activity in inhibiting P. acnes (inhibition zone 12.4 mm) and S. epidermidis (inhibition zone 29 mm). In conclusion, anti-acne lotion containing 7.5% of red ginger essential oil was effective to control acne inducing bacteria and fulfilled the required standards.Keywords: Red ginger, essential oil, anti-acne, Propionibacterium acnes, Staphylococcus epidermidis
Prescription Pattern and Costs of Angiotensin II Receptor Blockers in Hypertensive Outpatients Nurmainah Nurmainah; Nur Anisyah
Pharmacology and Clinical Pharmacy Research Vol 3, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.191 KB) | DOI: 10.15416/pcpr.v3i3.19864

Abstract

Angiotensin II receptor blockers (ARBs) have been widely prescribed for primary hypertension. Nevertheless, the cost of ARBs are relatively expensive. The objective of this study was to describe prescribing pattern and the cost of ARBs in hypertensive outpatients. This study used descriptive observational method based on cross-sectional study. Data source was hypertensive outpatients medical records and prescriptions at Pemangkat General Hospital, West Kalimantan, Indonesia, during 2014-2015. The most frequently prescribed anti-hypertensive medication in 1,506 patients were ARBs. There was an increasing trend in the use of ARBs during 2014-2015 (31-38%). The most frequently prescribed ARBs were 8 mg and 18 mg of candesartan, and 80 mg of valsartan. ACE inhibitors were the least prescribed anti-hypertensive drugs (4-8%). The largest portion of anti-hypertensive drugs expenditure was spent on ARBs, both in 2014 and 2015, respectively accounted for IDR 50,493,876.00 (67%) and IDR 58,903,112.00 (79% ). In conclusion, the prescribing of ARBs increased during study period and it represented the largest contributor on total expenditures of anti-hypertensive drugs.Keywords: Angiotensin II receptor blockers, cost, hypertensive patients
Comparison of Anti-Inflammatory Activity between Fermented and Dried Breadfruit Leaves Extract Hesti Riasari; Sani N. Fitriansyah; Oktamuman Putra
Pharmacology and Clinical Pharmacy Research Vol 3, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.616 KB) | DOI: 10.15416/pcpr.v3i3.19973

Abstract

Breadfruit leaves (Artocarpus altilis) have been empirically used to treat inflammation. Biosynthesis process such as fermentation can possibly changes the composition of secondary metabolites in breadfruit leaves. The aim of this study was to compare the anti-inflammatory activity between fermented and natural-dried breadfruit leaves extract. Fermented and dried breadfruit leaves were extracted with soxhlet device using methanol solvent. The anti-inflammatory activity of both extracts were evaluated using carrageenan (1% w/v) foot edema model of inflammation in male Wistar rats. The edema was measured with plethysmometer every 1 hour for 6 hours. The results showed that both extracts exhibited anti-inflammatory activity. 50 mg and 100 mg fermented leaves extracts exhibited 37.17% and 71.82% inhibition, while the same concentrations of dried extract exhibited 39.50% and 57.72%, inhibiton respectively. In conclusion, the best anti-inflammatory activity was shown by fermented breadfruit leaves extract.Keywords: Artocarpus altilis, anti-inflammatory, breadfruit, fermentation

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