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Pharmacology and Clinical Pharmacy Research
Published by Universitas Padjadjaran
ISSN : 25277332     EISSN : 26140020     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmacology and Clinical Pharmacy Research (PCPR) is an international, peer-reviewed journal, publishing original research, review, case reports, and commentaries on all aspects of pharmacology and clinical pharmacy. The journal aims to contribute to the scientific committee by publishing the high quality articles. It is published 3 times a year to provide a forum for pharmacologists, pharmacists, and other healthcare professionals to share best practice, encouraging networking, and a more collaborative approach in pharmacology and clinical pharmacy.
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Articles 5 Documents
 1 
Search results for , issue "Vol 4, No 3" : 5 Documents clear
Adverse Drug Reactions in Hospitalized-Geriatric Patients with Hypertension Andi I. Julianti; Lia Amalia; Sri Hartini
Pharmacology and Clinical Pharmacy Research Vol 4, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.573 KB) | DOI: 10.15416/pcpr.v4i3.24923

Abstract

Adverse drug reactions (ADRs) occur often in geriatric patients due to various factors which include a decrease in the physiological function and organs, nutritional deficiencies, multipathology, and polypharmacy. This study aimed to identify and analyse ADRs of hospitalized-geriatric patients with hypertension. We conducted a cross-sectional retrospective study (August 2012 to January 2013). Probability determination was calculated by the Naranjo scale. The subjects on this study were hospitalized-geriatric patients (n=86, 46.51% male, and 53.48% female). Thirty-one patients (11 men and 20 women) participated in this study by completing questionnaires to calculate ADRs probability using the Naranjo scale. The probability results were 7 probable, 8 possible, and 16 doubtful. Moreover, we observed that there were drug-related problems (DRP) during therapy, e.g., appropriate dose (59.37%), and inappropriate dose 34.37%. It can be concluded that in hospitalized-geriatric patients with hypertension, some problems related to ADRs remain existed.
Efficiency Fast-Moving Drug Plan with Reorder Point Intervention at a Private Hospital in Bandung Aisha K. Nur; Angga P. Kautsar; Indah L. Hilmi; Rizky Abdulah
Pharmacology and Clinical Pharmacy Research Vol 4, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.422 KB) | DOI: 10.15416/pcpr.v4i3.24924

Abstract

Drug supplies are the major portion of the hospital expenses. The rising of drugs cost directly affect the total expenses of the hospital. Thus, their procurement, especially for fast-moving drugs, should be managed effectively. This study aimed to examine the efficiency of fast-moving drug plan after reorder point (ROP) intervention at a private hospital in Bandung. We conducted a pre-experimental study and used turn-over ratio (TOR) as a parameter. Data were taken from the stock of antibiotics in May-June of 2013 and May-June 2014. Cost components were collected; included the amount of stock, the cost of goods sold, and daily drug use. We did pre-test and post-test analysis to check the efficiency of intervention. The results showed that ROP intervention increased the efficiency of fast-moving drug plan. The comparison of pre- and post- intervention resulted a lower inventory value and a greater TOR value. We concluded that the increase in efficiency will eventually require a smaller budget of drug expenses.
In Vitro Effectiveness of Neem Oil (Azadirachta Indica A. Juss) Shampoo as Anti Head Lice (Pediculus humanus capitis) Norisca A. Putriana; Azizul Hakim; Patihul Husni; Taofik Rusdiana
Pharmacology and Clinical Pharmacy Research Vol 4, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v4i3.25780

Abstract

Head lice (Pediculus humanus capitis), a parasite causing hair problem,  often occurs in society.The study aimed to evaluate in vitroeffectiveness of shampoo formulation containing neem oil as an anti head lice. An experimental method was used to examine the formulation of shampoo, irritation test, testing the effectiveness of shampoo against head lice (Pediculicidal activity), and testing the effectiveness of shampoo against nits (Ovicidal activity). The effectiveness test employed an in vitromethod where neem oil shampoo were tested directly towards head lices and nits isolated from humans, then the mortality was observed. To recognize the safety of the shampoo, skin and eye irritation tests were carried out by applying 0.5 ml on the skin and dripping 0.1 ml shampoo into New Zealand white rabbit’s eyes.Data were analyzed using Kruskal Wallis and Mann Whitney. The study results showed that the primary irritation index for 5%, 10%, 15%, and 20% neem oil shampoo were 0; 0111; 0.222; and 0.222, respectively. All of the shampoos were very mild irritation response category. Eye irritation tests showed that only the 20% neem oil shampoo gave a mild irritation response with degree of corneal opacity ≥ 1 and recovered after 7 days of observation. The 5%, 10%, 15%, and 20% neem oil shampoo were effective as an anti head lice. The 15% and 20% neem oil shampoo had anti head lice effectiveness activity as same as 1% permethrin lotion. In conclusion, the 15% neem oil shampoo was chosen as the best shampoo, its high anti head lice effect and light irritation response. Keywords: Head lice, neem oil (Azadirachta indica A. Juss), shampoo
Perinatal Propylthiouracil-Induced Hypothyroidism Impaired Motor Coordination in Adult Female Offspring Miski A. Khairinisa; Yusuke Takatsuru; Izuki Amano; Michifumi Kokubo; Asahi Haijima; Wataru Miyazaki; Noriyuki Koibuchi
Pharmacology and Clinical Pharmacy Research Vol 4, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v4i3.25264

Abstract

Thyroid hormone (TH) play crucial roles in the growth and development of brain. Efficiency of TH during the perinatal period results in severe mental and physical retardation, known as cretinism in humans. Animal models have largely focused on mild and severe hypothyroidism associated with deficits in body weight, developmental delays, and cognitive deficits. Although various behavioral analyses have been reported, the effect of perinatal hypothyroidism in adult female mice has not been clarified. The aim of this study was to examine whether propylthiouracil (PTU)-induced hypothyroidism could impair motor coordination in female offspring. We used C57BL/6j mice and divided them into three groups based on the dose of PTU which was applied during perinatal period (embryonic day-14 to postnatal day-14); control, 5 ppm, and 50 ppm groups. We observed motor coordination function and additional nociceptive test in female offspring. We found that motor coordination and nociceptive threshold were affected in 50 ppm groups. We concluded that the moderate hypothyroidism could impair motor coordination in adult offspring.
Natural Antidiabetic of Tunjuk Langit (Helminthostachys zeylanica) Rhizome Extracts Fania E. Ridhasya; Hilwan Y. Teruna; Rudi Hendra; Muhammad Almurdani
Pharmacology and Clinical Pharmacy Research Vol 4, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.924 KB) | DOI: 10.15416/pcpr.v4i3.24897

Abstract

The use of medicinal plants in treating diabetes mellitus is increasing in Indonesia. Plenty of plants from different regions may have anti-diabetic effect, including Helminthostachys zeylanica. This plant is commonly used as a traditional medicine to treat inflammation, cough, dysentery, and malaria in Talang Mamak tribe, Indragiri Hulu, Riau, however in China it is used to treat diabetic. Thus, we examined whether the extract of H. zeylanica originated from Riau have potential antidiabetic activity. We assessed the α-glucosidase inhibitory activity of the extract of H. zeylanica rhizome. The results showed the antidiabetic values of n-hexane, dichloromethane (DCM), ethyl acetate (EtOAc), methanol (MetOH), and ethanol (EtOH) extracts were 380.88 ± 0.09; 190.76 ± 0.22; 61.18 ± 0.59; 47.86 ± 0.06; and 60.78± 0.02, respectively. Acarbose were used as standard with antioxidant values of 19.73± 0.07. It can be concluded that the methanol extract is potential to be proposed as antidiabetic.

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