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INDONESIA
JURNAL GIZI INDONESIA
Published by Universitas Diponegoro
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Health Professions
Arjuna Subject : -
Articles 2 Documents
 1 
Search results for , issue "2026: Just Accepted Manuscript and Article In Press 2026" : 2 Documents clear
The Effect of Red Dragon Fruit (hylocereus polyrhizus) Juice on Leptin Levels in Sprague Dawley Rats Using an Overweight Model Solehah, Novia Zuriatun; Herviana, Herviana; Anggriany, Nissa; Anindita, Karina
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) 2026: Just Accepted Manuscript and Article In Press 2026
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.0.0.%p

Abstract

Background: Obesity is strongly linked to elevate leptin levels and oxidative stress, both of which contribute to the development of various metabolic disorders. Leptin, a hormone that regulates metabolism and appetite, becomes less effective in obese individuals due to leptin resistance, thereby exacerbating metabolic dysfunction.Objective: This study aims to evaluate the effect of red dragon fruit (hylocereus polyrhizus) juice on leptin levels in Sparague Dawley rats using an overweight model.Method: This experimental study used a pre-post test control group design and involved six groups of rats (n=6 per group), including a normal group, a negative control group, a positive control group (orlistat), and three treatment groups receiving different doses of red dragon fruit juice (3.5 g, 7 g, and 10.5 g per 200 g body weight). The intervention was carried out for 14 days following a 14- day induction of obesity using a high-fat and high-carbohydrate diet. Leptin levels were measured before and after the intervention.  Results: The results showed that administration of red dragon fruit juice significantly reduced leptin levels (p<0,001) in all treatment groups. The greatest reduction was observed in the group receiving the 10.5 g dose, with an average decrease of 75.03%, which was nearly equivalent to the orlistat group that reduced leptin levels by 79.93%.Conclusion: Red dragon fruit juice has the potential to serve as a non-pharmacological agent in reducing leptin levels and oxidative stress under obesity conditions, with an effectiveness approaching that of orlistat.
Relationship between skeletal muscle mass index and length of stay in stroke patient Murbawani, Etisa Adi; Wahyu Subagio, Hertanto; Tugasworo Pramukarso, Dodik; Fatimah Muis, Siti; Pudjonarko, Dwi; Probosari, Enny; Candra, Aryu; Ardiaria, Martha
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) 2026: Just Accepted Manuscript and Article In Press 2026
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.0.0.%p

Abstract

Background: Sarcopenia is a syndrome characterized by progressive condition and generalized loss of skeletal muscle mass and strength. It is associated with poor prognosis and increased length of stay in stroke patients. Skeletal Muscle Mass Index (SMI) is an important parameter for assessing skeletal muscle mass and the clinical outcomes of stroke patients.Objective: to examine the relationship between SMI and length of stay in stroke patient.Materials and Methods: Cross-sectional observational analytical research was conducted at Dr. Kariadi Semarang Hospital from June 2024 to March 2025 in hospitalized stroke patients aged >18 years. Body composition, including skeletal muscle mass, is measured using BIA. Data were analyzed by Independent t-test, Pearson Correlation and Double Linear Regression.Results: The average length of stay among the 78 individuals (43 males and 35 females) was 11 days. The SMI levels were normal, indicating no sarcopenia.Conclusion: Skeletal Muscle Mass Index (SMI) was significantly related (p<0.05) with length of stay in stroke patients; the higher the SMI score, the shorter the duration of hospital stay. 

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