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All Journal JURNAL GIZI INDONESIA Nutriology: Jurnal Pangan, Gizi, Kesehatan Bali Dermatology Venereology and Aesthetic Journal
Karina Anindita
Institut Teknologi Sepuluh Nopember (ITS)
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Dermatomyositis with multiple organ involvement: a case report and literature review Putri, Wayan Julita Krisnanti; Wardiana, Maya; Anindita, Karina; Putri, Adisti Prafica; Kumaladewi, Baiq Ratna; Santosa, Hilda
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 2 (December 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/4x0xd735

Abstract

Background: Dermatomyositis (DM) is a chronic autoimmune disorder characterized by muscle and skin inflammation, a part of the idiopathic inflammatory myositis (IIM). Even though the disease is idiopathic, there are multifactorial factors related to dermatomyositis. This care report aimed to describe a DM case in a male patient to increase the knowledge and management of DM patients. Case description: A 44-year-old Filipino male was referred to the emergency department (ED) of Siloam Hospital Mataram complaining of muscle pain and weakness with skin rashes 3 weeks before admission. Before the skin rash started, he had enlarged femoral lymph nodes in both thighs. The patient was afebrile with normal vital signs and was prescribed ibuprofen and amoxicillin. After that, he experienced skin rashes around his neck and the back of his ears with minimal pruritus.  The symptoms worsened, making him unable to open his mouth and hard to breathe. In the ED, he also threw up dark-colored blood twice. Supporting examination showed elevated transaminase, increased LDH, and creatinine kinase. Biopsy results showed a histologic pattern of dermatomyositis. During hospitalization, he received a high-dose systemic steroid, antibiotic, and symptomatic treatment. He was discharged with a good outcome and planned to continue medical treatment in his country. Conclusion: Dermatomyositis is an idiopathic autoimmune disease involving skin and internal organs. It is a multifactorial disease yet with unclear etiopathogenesis. Specific treatment guidelines for DM are not yet established, but initial systemic corticosteroid and additional steroid-sparring agents may exhibit good outcomes.
Analisis Klaster Dampak Kesehatan Akibat Pandemi Covid 19 Metode K-Means dan C4.5 Anindita, Karina; Wirakusuma, Anak Agung Ngurah Bagus Adhitya; Pamudji, Kristopher May; Budi, Dini Wurnaning; Yudha Putra, I Komang Reka
Nutriology : Jurnal Pangan, Gizi, Kesehatan Vol. 6 No. 2 (2025): Oktober 2025
Publisher : Program Studi Gizi, Universitas Bumigora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/nutriology.v6i2.5659

Abstract

The COVID-19 pandemic has had a broad impact on the health system and the socio-economic conditions of communities, including in the Province of West Nusa Tenggara. Inequalities in healthcare access, the prevalence of comorbid diseases, and economic disparities have resulted in varying levels of risk across regions. This study aims to analyze clusters of health impacts resulting from the COVID-19 pandemic in West Nusa Tenggara. The research employed the K-Means and C4.5 Decision Tree methods with a CRISP-DM approach. Secondary data were obtained from the West Nusa Tenggara Provincial General Hospital, the West Nusa Tenggara Health Profile, Statistics Indonesia (BPS) 2022–2023, the 2021 Basic Health Research (Riskesdas), and the World Health Organization (WHO). The variables included COVID-19 cases per 100,000 population, vaccination rates, healthcare facility ratios, prevalence of hypertension and diabetes, and poverty rates. The K-Means results identified three risk clusters: high (Mataram, West Lombok), moderate (Central Lombok, East Lombok), and low (Sumbawa, Dompu, Bima). The C4.5 model achieved an accuracy of 80.67%, with age and comorbidities emerging as dominant factors. These findings highlight the potential of data mining analysis as a foundation for post-pandemic mitigation policies and strengthening regional health system resilience.
The Effect of Red Dragon Fruit (hylocereus polyrhizus) Juice on Leptin Levels in Sprague Dawley Rats Using an Overweight Model Solehah, Novia Zuriatun; Herviana, Herviana; Anggriany, Nissa; Anindita, Karina
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) 2026: Just Accepted Manuscript and Article In Press 2026
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.0.0.%p

Abstract

Background: Obesity is strongly linked to elevate leptin levels and oxidative stress, both of which contribute to the development of various metabolic disorders. Leptin, a hormone that regulates metabolism and appetite, becomes less effective in obese individuals due to leptin resistance, thereby exacerbating metabolic dysfunction.Objective: This study aims to evaluate the effect of red dragon fruit (hylocereus polyrhizus) juice on leptin levels in Sparague Dawley rats using an overweight model.Method: This experimental study used a pre-post test control group design and involved six groups of rats (n=6 per group), including a normal group, a negative control group, a positive control group (orlistat), and three treatment groups receiving different doses of red dragon fruit juice (3.5 g, 7 g, and 10.5 g per 200 g body weight). The intervention was carried out for 14 days following a 14- day induction of obesity using a high-fat and high-carbohydrate diet. Leptin levels were measured before and after the intervention.  Results: The results showed that administration of red dragon fruit juice significantly reduced leptin levels (p<0,001) in all treatment groups. The greatest reduction was observed in the group receiving the 10.5 g dose, with an average decrease of 75.03%, which was nearly equivalent to the orlistat group that reduced leptin levels by 79.93%.Conclusion: Red dragon fruit juice has the potential to serve as a non-pharmacological agent in reducing leptin levels and oxidative stress under obesity conditions, with an effectiveness approaching that of orlistat.
Co-Authors Alius Cahyadi Anggriany, Nissa Budi, Dini Wurnaning Herviana, Herviana Kumaladewi, Baiq Ratna Maria R. Iryaningrum Novia Zuriatun Solehah Pamudji, Kristopher May Putri, Adisti Prafica Putri, Wayan Julita Krisnanti Santosa, Hilda Wardiana, Maya Wirakusuma, Anak Agung Ngurah Bagus Adhitya Yudha Putra, I Komang Reka