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JURNAL KIMIA SAINS DAN APLIKASI

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Published by Universitas Diponegoro

ISSN : 14108917 EISSN : 25979914 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering

urnal Kimia Sains dan Aplikasi (p-ISSN: 1410-8917) and e-ISSN: 2597-9914) is published by Department of Chemistry, Diponegoro University. This journal is published four times per year and publishes research, review and short communication in field of Chemistry.

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Articles 8 Documents

Search results for , issue "Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020" : 8 Documents clear

Molecular Docking and Chemical Analysis of Alcohol Compounds (C16-C20) Bound to InhA Receptors as Mycobactericidal Candidates Muhammad Iqbal Shihab; Gita Syahputra
Jurnal Kimia Sains dan Aplikasi Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Tuberculosis (TB) is an infectious disease caused by a bacterium called Mycobacterium tuberculosis. TB infection spreads through the air and is more likely when using inappropriate disinfectants in medical and laboratory equipment related to TB research. Appropriate disinfectants used for laboratory equipment can reduce the risk of TB disease transmission. Alcohol compound is a common disinfectant with broad-spectrum activity against microbes, viruses, and fungi. Molecular Docking can be applied to support virtual receptor-ligand screening in finding the right mycobactericidal agent as a disinfectant candidate from the alcohol group. Based on docking analysis, octadecanol (C18) has potential as a mycobactericidal agent with InhA as its specific receptor. Gibbs (ΔG) free energy obtained by octadecanol (C18) and InhA is -4.9 kcal/mol.

Electrocoating Polypyrrole on Gold-Wire Electrode as Potential Mediator Membrane Candidate for Anionic Surfactant Electrode Sensor Abdul Haris Watoni; Indra Noviandri; Muhammad Nurdin; La Ode Ahmad Nur Ramadhan
Jurnal Kimia Sains dan Aplikasi Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

The development of polypyrrole as a potential mediator membrane candidate for sodium dodecyl sulfate (SDS) sensor electrode has been investigated. The polypyrrole membrane was synthesized electrochemically from the pyrrole and coated at the surface of a 1.0 mm diameter of the gold-wire electrode. Electropolymerization of pyrrole and coating of the polypyrrole produced was performed by cyclic voltammetry technique in the electrochemical cell containing supporting electrolyte of 0.01 M NaClO4 with an optimum potential range of -0.9 V–1.0 V, the scanning rate of 100 mV/s, an electric current of 2 mA, and running of potential scanning of 10 cycles. By using the similar optimal parameters of cyclic voltammetry, electropolymerization of 0.01 M pyrrole solution containing 0.001 M SDS also produces a polypyrrole membrane coated at the gold-wire electrode surface. These coated electrodes have the potential response-ability toward DS- anions in the concentration range of 10-7 M–10-5 M with a limit of detection of 10-7 M and sensitivity of electrode of 9.9 mV/decade. This finding shows that the SDS solution’s role is as supporting electrolyte and also as a source of DS- dopant during the pyrrole electropolymerization processes. Dopants are trapped in the polymer membrane during the electrochemical formation of polypyrrole and role as ionophores for DS- anion in the analyte solution. A potential response to the electrode phenomena is excellent basic scientific information for further synthesis of conducting polymer and development of conducting polymer-coated wire electrode model, especially in the construction of ion-selective electrode (ISE) for the determination of anionic surfactants with those models.

Effect of methyl substituent on the solubility of 1,4-benzoquinone derivatives in n-octanol/water system Siti Mariyah Ulfa; Fath Dwisari; Ade Cintyia Sally; Mohammad Farid Rahman
Jurnal Kimia Sains dan Aplikasi Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

The solubility of the compound is a crucial task for new drug design. Quinone is a promising candidate to develop as a new drug. In this research, the synthesis of 1,4-benzoquinone derivatives, that is, 2-(5-bromoamyl)-3,5-dimethyl-1,4-benzoquinone (2a) and 2-(5-bromoamyl)-5-methyl-1,4-benzoquinone (2b) were carried out by decarboxylation and insertion reaction of alkyl bromides. The product 2a and 2b are purified using SiO2 gel column chromatography and analyzed by UV-Visible, FT-IR, and NMR. The yield of 2a is 13.75%, and 2b is 4.04%. The solubility of 2a and 2b, expressed by log P, is measured in the n-octanol/water (3:7 (v/v)) system by the shake flask method. The log P of 2a and 2b are 2.99 and 1.36, respectively. It is showed that the log P of 2a is higher compared to 2b. The presence of two methyl substituents on the quinone ring of 2a supports the increase of hydrophobicity of the compound in the n-octanol/water system.

Validation of High-Performance Liquid Chromatography Method for Determination of Vitamin B1 in Powder Milk Supriyono Supriyono; Mudhiah Fitrillah; Arie Pratama Putra
Jurnal Kimia Sains dan Aplikasi Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Vitamin B1 plays an important role in the co-enzymatic reactions for energy-rich compounds called ATP (Adenosine Tri Phosphate). Therefore, it should be added to various food products, for example, milk powder. One method that can be used to determine vitamin B1 is SNI number 3751: 2009, but the method is intended for wheat flour. If the method is to be used for the analysis from other samples, such as milk powder, optimization, and validation, are needed. This experiment was carried out using HPLC, C18 column, and UV detector with a wavelength of 254 nm. The mobile phase used is methanol: acetic acid: bi-distilled water = 32:1:67 (v/v/v), flow rate = 1 mL/minute, isocratic, and reverse phased technique. Method validation parameters include tests of system suitability, linearity, the limit of detection, the limit of quantitation, precision (repeatability), and accuracy. The results showed that the system suitability test was obtained relative standard deviations (% RSD) for retention time and peak area, tailing factor, resolution, separation factor was 0.297%, 1.476%, 1.113, 6.693, and 4.406 respectively. The validation test gets a correlation coefficient (R) of 0.9996, the limit of detection and limit of quantitation were 0.0122 mg/100 mL and 0.0244 mg/100 mL, respectively. The precision test obtained Horwitz's ratio of 0.27%. Accuracy test using CRM obtained % recovery of 93.79-97.77%. All these results meet the requirements of method validation, so it can be concluded that the method of SNI number 3751: 2009 is valid for the determination of vitamin B1 in milk powder and can be used for routine analysis procedure.

Production of Micro Crystalline Cellulose from Tapioca Solid Waste: Effect of Acid Concentration on its Physico-chemical Properties Ansharullah Ansharullah; Nur Muhammad Abdillah Saenuddin; RH Fitri Faradilla; Asranuddin Asranudin; Asniar Asniar; Muhammad Nurdin
Jurnal Kimia Sains dan Aplikasi Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

This study was aimed to examine the production of microcrystalline cellulose (MCC) from tapioca solid waste (TSW), using HCl hydrolysis with various concentrations, i.e., 2 N, 2.5 N, 3 N, and 3.5 N. MCC was produced by delignifying the TSW with NaOH 20%, and bleaching with NaOCl 3.5% to produce α-cellulose, and subsequently hydrolyzing α-cellulose with three different HCl concentrations to produce MCC. The physicochemical properties of MCC were then analyzed, including Scanning Electron Micrograph (SEM), X-ray diffraction (XRD), and FTIR spectra. The results showed that hydrolysis with 2.0 N HCl resulted in a higher yield of 61.28%, α-cellulose content of 56.33%, moisture 6.25%, pH of 6.54; ash 0.23%, and water solubility 0.34%. SEM analysis showed the morphology and size of the MCC produced were like those of a commercial MCC (Avicel PH101), while the XRD analysis showed the higher concentration of HCl gave rise to an increased crystalline index. FT-IR spectrum analysis indicated that TSW, MCC produced, and commercial MCC had similar functional groups.

Polymerization Domain Translated from 0.9 kb Gene Fragment of DNA Polymerase I from a Thermo-Halophilic PLS A Strain Teuku Mohamad Iqbalsyah; Muhammad A Velayati; Hira Helwati; Febriani Febriani
Jurnal Kimia Sains dan Aplikasi Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

The search for novel DNA Polymerases I, with higher fidelity and better polymerization rate, is essential to improve the Polymerase Chain Reaction method. A thermo-halophilic bacterium has been isolated from an undersea hot spring, dubbed Pria Laot Sabang (PLS) A strain. The 0.9 kb DNA Polymerase I gene fragments from the isolate were amplified, sequenced, and identified. The fragments were part of the polymerization domain of the enzyme. Homological analysis of the gene sequence showed that the PLS A strain was closely related to Bacillus caldolyticusstrain XM. However, Swissprot structural analysis reveals that PLS A strain had high homology to Geobacillus stearathermophilus. Full sequence analysis is still needed to identify the species and evaluate the intact enzyme structure.

Stability Improvement of Humic Acid as Sorbent through Magnetite and Chitin Modification Bambang Rusdiarso; Rahmat Basuki
Jurnal Kimia Sains dan Aplikasi Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Stability improvement of humic acid (HA) through modification of HA by chitin (HA-chitin) followed by a coating of HA-chitin on magnetite has been successfully performed. The coated magnetite (magnetite/HA-chitin) was conducted by the co-precipitation method, and the synthesized magnetite/HA-chitin was characterized by FT-IR, XRD, SEM-EDX, and VSM. The successful coated-magnetite by HA-chitin was proved by the appearance of a new band at 1627 cm-1 (FT-IR), the formation of a crystalline phase with characteristic 2θ of magnetite: 30.259° [220]; 35.64° [311]; 42.590° [400]; 57.280° [511]; and 62.896° [440] (XRD), an increasing of carbon content in magnetite/HA-chitin (SEM-EDX), and the ease of magnetite/HA-chitin being attracted to external magnetic fields with magnetic saturation strength 29.3 emu/g (VSM). Stability tests at pH 2.0 - 10.0 prove that magnetite/HA-chitin remains stable as a solid sorbent on average above 80%. Its application to Hg (II) sorption occurred optimum at pH 7.0, where 75.89% Hg (II) is sorbed on 0.1 g of sorbent and agreed well to the pseudo-second-order kinetics model of Ho.

Utilization of Jengkol Peel (Pithecellobium jiringa (Jack) Prain) as Lead (II) Ions Bio-sorbent with Column Method Gatut Ari Wardani; Lia Nuramalia; Winda Trisna Wulandari; Estin Nofiyanti
Jurnal Kimia Sains dan Aplikasi Vol 23, No 5 (2020): Volume 23 Issue 5 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Problems arising from laboratory waste include the content of lead metal ions in it, which can affect health. While on the other hand, Jengkol peel is a market waste and has no economic value. Jengkol peel contains hydroxyl groups and carboxylates to bind heavy metals such as lead (II) ions. So, this study aims to determine the effect of variations in flow rate, adsorbent height, and solution acidity and determine the ability of Jengkol peel in adsorbing lead (II) ions in the laboratory liquid by the column method. Organic groups that include active sides can be removed using 1N sodium hydroxide to increase the adsorption ability. Sodium hydroxide functions to dissolve lignin in lignocellulose compounds so that carboxylic groups are formed in cellulose, which has a role in binding metal ions. The determination of functional groups was carried out by Fourier-transform Infrared Spectroscopy. The identification of the adsorbent morphology was carried out by Scanning Electron Microscope. The adsorption of lead (II) ions by Jengkol peel was determined by calculating the difference between the lead (II) ions in the solution after and before passing through the column. The amount of lead metal remaining in solution was determined using Atomic Absorption Spectroscopy. Sodium hydroxide solution with a concentration of 1N can separate lignin from cellulose contained in lignocellulose to enhance the bio-sorbent ability of the Jengkol peel in binding metal ions. The smaller the flow rate in the column, the higher the amount of lead (II) ions adsorbed in the bio-sorbent. The acidity of the solution has the best adsorption at pH 5. The metal ions from the simulation sample can reduce the number of lead (II) metal ions adsorbed by 11%.

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Adi Darmawan

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Home Page

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Contact Name Adi Darmawan

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Contact Name
Adi Darmawan

Contact Email
adidarmawan@live.undip.ac.id

Phone
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Journal Mail Official
jksa@live.undip.ac.id

Editorial Address
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Location
Kota semarang,

Jawa tengah

INDONESIA