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INDONESIA
JURNAL KIMIA SAINS DAN APLIKASI
Published by Universitas Diponegoro
ISSN : 14108917     EISSN : 25979914     DOI : -
urnal Kimia Sains dan Aplikasi (p-ISSN: 1410-8917) and e-ISSN: 2597-9914) is published by Department of Chemistry, Diponegoro University. This journal is published four times per year and publishes research, review and short communication in field of Chemistry.
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Articles 7 Documents
Search results for , issue "Vol 28, No 6 (2025): Volume 28 Issue 6 Year 2025" : 7 Documents clear
Quantitative Structure-Activity Relationship of O-methyl Quercetin Analogs, Structure Modification, and Molecular Docking as Lung Anticancer EGFR-TK Inhibitor Sari, Bina Lohita; Setiani, Lusi Agus; Aulia, Shafana Zahra
Jurnal Kimia Sains dan Aplikasi Vol 28, No 6 (2025): Volume 28 Issue 6 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.6.316-326

Abstract

Cancer arises from the uncontrolled proliferation of cells. Lung cancer stands as one example among the diverse array of cancer types. The main cause of the development of lung cancer is the activation of epidermal growth factor receptor (EGFR)-tyrosine kinases (TK). O-methyl quercetin analogs, as one of the quercetin derivatives, can be potential drug candidates for treating lung cancer. In this study, we disclose our findings that O-methyl quercetin analogs and their modified forms, O-methylamino analogs, predicted EGFR-TK inhibitors as lung anticancer. The O-methylated quercetin analogs can be predicted using a Quantitative Structure-Activity Relationship (QSAR) model. The structures were optimized using the parameterized method 3 (PM3) and analyzed through multiple linear regression (MLR). A lower PRESS QSAR values are used for structural modification of O-methylamino as new compounds. Structures of O-methyl quercetin and O-methylamino analogs were docked to the EGFR-TK receptor using molecular docking. The best QSAR model of IC₅₀ predicted result is expressed as log IC50 = 23.059 + (7.397 × log P) + (0.273 × dipole moment) – (0.005 × heat of formation) – (0.733 × ELUMO) – (0.501 × EHOMO) with statistical parameters: R = 0.966; R2 = 0.933; Fcount/Ftable = 3.829853; and Q2 = 0.752226. The O-methyl quercetin analog QC14 (quercetin 5,3’,4’-trimethyl ether) and the modified derivative QC6_8 (3,5-dihydroxy-2-(3-hydroxy-4-((methylamino)methoxy)phenyl)-7-methoxy-4H-chromen-4-one) exhibited the lowest docking scores. Both compounds interact with the key residue Met769 of the EGFR-TK receptor, suggesting their potential as drugs for lung cancer.
Modification of a Carbon Paste Sensor with TiO₂ and ZnO Nanoparticles for the Cyclic Voltammetric Detection of Retinol Putra, Ananta Adita Eka; Setiarso, Pirim
Jurnal Kimia Sains dan Aplikasi Vol 28, No 6 (2025): Volume 28 Issue 6 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.6.327-335

Abstract

Retinol, a compound belonging to the retinoid group derived from vitamin A, is widely used in cosmetic formulations due to its proven efficacy in skin care. Analytical determination of retinol is commonly performed using conventional techniques such as HPLC and UV-Vis spectrophotometry. An alternative analytical method that offers potential yet remains underexplored is cyclic voltammetry. In this study, a cyclic voltammetry method for retinol analysis was developed using a modified carbon paste working electrode. The modification was done by adding ZnO and TiO2 nanoparticles to improve the electrode’s sensitivity. The sol-gel technique was employed to produce ZnO nanoparticles, which were then analyzed for their characteristics using several instruments, namely XRD, SEM, and FTIR. TiO2 nanoparticles were also subjected to characterization. The results of the study on ZnO nanoparticle synthesis demonstrated an average particle size measuring 30.5 nm. The optimum electrode composition was obtained at a ratio of 3:2:3:2 (Carbon: ZnO Nanoparticles: TiO2 Nanoparticles: Paraffin), producing an anodic peak current (IpA) of 4.58 × 10−3 A under optimum pH conditions at pH 7. As the generated peak current increases, the conductivity increases, as electron transfer for the reduction and oxidation processes becomes more facile. Applying this method to retinol analysis in brands X, Y, and Z facial serums yielded retinol contents of 0.00450 ppm, 0.00464 ppm, and 0.00427 ppm. The voltammetric method showed a LoD = 0.001029 ppm and LoQ = 0.003430 ppm, respectively. These results indicate that a ZnO and TiO2 modified carbon paste electrode is an effective tool for analyzing retinol by cyclic voltammetry.
Chitosan/Anthocyanin-Based Indicator Film with Carnauba Wax Addition for Monitoring Chicken Freshness Roichatuttamamah, Wirda; Mahatmanti, F. Widhi; Kusuma, Samuel Budi Wardhana; Rahayu, Endah Fitriani
Jurnal Kimia Sains dan Aplikasi Vol 28, No 6 (2025): Volume 28 Issue 6 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.6.283-291

Abstract

Indicator films can be applied to food packaging to monitor the quality of food products. However, chitosan/anthocyanin films tend to have low hydrophobicity, which may compromise their performance as indicators and lead to dye migration. One approach to address this issue is by incorporating additional materials such as carnauba wax. This study investigates the effect of carnauba wax addition on the mechanical properties and water contact angle of chitosan/anthocyanin-based indicator films, as well as evaluates the performance of the resulting films in monitoring the freshness of chicken meat. Indicator films were prepared by adding carnauba wax at concentrations of 6, 9, 12, and 15% (w/w of chitosan). The results showed that the addition of carnauba wax improved the mechanical properties of the films, although the improvement was not statistically significant. The best mechanical performance was observed with the 15% wax formulation. Additionally, the water contact angle increased with higher concentrations of carnauba wax, with the highest value (71.630°) observed for the CS/ABT/CW15% film. The indicator films were applied to chicken packaging and evaluated based on color changes during storage as a measure of freshness. After 30 hours, the film color changed from dark brown to green. The color change pattern during storage was similar for films with and without carnauba wax, indicating that the addition of carnauba wax does not affect the film’s ability to monitor chicken freshness.
Potential Antioxidant Activity of the Unused Part of Tamarillo (Solanum betaceum Cav.) Choirunnisa, Atina Rizkiya; Regiana, Zhafira Amalia; Insanu, Muhamad; Hartati, Rika; Pramastya, Hegar; Rizaldy, Defri; Fidrianny, Irda
Jurnal Kimia Sains dan Aplikasi Vol 28, No 6 (2025): Volume 28 Issue 6 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.6.336-344

Abstract

Tamarillo (Solanum betaceum Cav.) is a member of the Solanaceae family that contains phenolic and flavonoid compounds. The fruit of the tamarillo is commonly consumed. However, other parts that are rarely used also have many potential benefits, including antioxidant activity. This study aims to evaluate antioxidant activity of used part (flesh) and unused part (leaves and peel) extracts of tamarillo through ascorbic acid equivalent antioxidant capacity (AEAC), phenolic and flavonoids content, correlation the phenolic and flavonoid content on antioxidant activity, correlation the DPPH and CUPRAC methods and the levels of flavonoid compound in selected extract. Three organs (flesh, leaves, peel) were extracted using polarity solvents (n-hexane, ethyl acetate, ethanol). Antioxidant activity was conducted using DPPH and CUPRAC assays, and total phenolic acid and flavonoid acid were also investigated. The result showed that the highest antioxidant activity of tamarillo extracts using DPPH and CUPRAC methods was given by ethanol leaves, 94.917 ± 3.920 and 110.182 ± 7.987 mg AEAC/g sample. The highest TPC in the ethanol leaves extract 10.416 g GAE/100 g, while the highest TFC in the n-hexane leaves extract 8.367 g QE/100 g. Phenolic and flavonoid compounds were identified as significant contributors to the antioxidant activity, with both assessment methods showing a strong linear correlation. In conclusion, Tamarillo leaves had the potential to be a natural antioxidant source, with a rutin content of 0.088%, according to HPLC analysis.
Synthesis and Characterization of Aluminated Santa Barbara Amorphous-15 via Ultrasonic-Enhanced Hydrothermal Method: Effects of Sonication, Solvent Acidity, and Si/Al Ratio Putri, Dini Hariyanto; Subagyono, RR Dirgarini Julia Nurlianti; Allo, Veliyana Londong; Manawan, Maykel
Jurnal Kimia Sains dan Aplikasi Vol 28, No 6 (2025): Volume 28 Issue 6 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.6.292-298

Abstract

Aluminated Santa Barbara Amorphous-15 (Al-SBA-15) materials were successfully synthesized using an ultrasonic-enhanced hydrothermal method. The synthesis was conducted by varying the mole ratio of Si precursor and Al precursor (10 and 20), sonication time (3 and 5 hours), and solvent type (2 M hydrochloric acid (HCl) and distilled water). The resulting materials were characterized using N2 sorption analyzer, Fourier Transform Infrared Spectroscopy (FTIR), Small-Angle X-ray Diffraction (SAXRD), Scanning Electron Microscopy (SEM), and Ammonia-Temperature Programmed Desorption (NH3-TPD). FTIR spectra confirmed the presence of siloxane, silanol, and hydroxyl functional groups in all Al-SBA-15 samples. SAXRD analysis showed three characteristic peaks of SBA-15, indicating a two-dimensional hexagonal structure (p6mm). Increasing the sonication time enhanced the surface area from 718 to 767 m2/g, while reducing the pore diameter from 5.96 to 4.81 nm and the pore volume from 1.07 to 0.92 cm3/g. Raising the Si:Al molar ratio slightly increased the surface area (718 to 722 m2/g) and decreased the pore diameter and volume. Additionally, using distilled water instead of 2 M HCl as the solvent raised the surface area from 722 to 785 m2/g, while decreasing the pore diameter from 5.61 to 5.05 nm and slightly lowering the pore volume. The acidity of the Al-SBA-15 material varied according to the sonication time and the amount of Al precursor used, suggesting the potential of regulating the acidic properties through optimization of the synthesis parameters.
Physicochemical Characteristics of PVDF/ZSM-5 Composite Membrane for Potential Applications in Vanadium Redox Battery Alifia, Zaskia; Haryanto, Michael Julian; Fitriyani, Devi Ayu; Riapanitra, Anung
Jurnal Kimia Sains dan Aplikasi Vol 28, No 6 (2025): Volume 28 Issue 6 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.6.299-306

Abstract

Composite membranes were synthesized using poly-(vinylidene fluoride) (PVDF) and zeolite (ZSM-5) to improve the performance of PVDF as a battery separator. The PVDF-ZSM-5 membranes, prepared with varying concentrations of ZSM-5, underwent characterizations of X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). These analyses revealed a notable increase in β-phase formation in PVDF, greater porosity, and improved surface morphology due to the incorporation of ZSM-5. Evaluations of their physicochemical properties showed that these membranes resulted in electrical conductivity up to 96.4 mS/cm, enhanced contact area, porosity reaching 78.61%, and flux value up to 5.4 ×10⁻2 L m⁻2 h⁻2. Adjustments in ZSM-5 concentrations proved instrumental in fine-tuning these performance metrics. These findings highlight the potential of PVDF-ZSM-5 membranes as a cost-effective membrane separator for redox battery systems. This research lays the groundwork for future advancements and broader commercial applications in energy storage technology.
Synthesis and Characterization of Nickel(II) Imprinted Polymers as a Selective Adsorbent for Nickel(II) Ions Kartika, Siska Ela; Hariyanto, Putri Septiani; Madjid, Armeida D. R.; Siboro, Sonita Afrita Purba; Sujarwadi, Roni
Jurnal Kimia Sains dan Aplikasi Vol 28, No 6 (2025): Volume 28 Issue 6 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.6.307-315

Abstract

The rapid expansion of nickel mining in Indonesia, driven by the growing demand for electric vehicle batteries, has raised concerns about the environmental and health impacts of nickel pollution. This study presents the synthesis and characterization of a highly selective adsorbent, Nickel(II) Imprinted Polymer (Ni(II)-IPs), for the monitoring and removal of Ni(II) ions. Ni(II)-IPs were synthesized using precipitation polymerization by imprinting the Ni(II)-8-hydroxyquinoline complex into a polymer matrix through the polymerization of methacrylic acid and ethylene glycol dimethacrylate. Successful imprinting and subsequent leaching of Ni(II) ions using HNO3 were confirmed by FTIR, SEM, and EDX characterization. Adsorption studies revealed that Ni(II)-IPs exhibit a high adsorption capacity of 70.26 mg/g at pH 7 within a short contact time of 15 minutes. Moreover, Ni(II)-IPs demonstrated excellent selectivity towards Ni(II) ions in the presence of competing ions, with relative selectivity coefficients of 1.20, 1.24, and 1.31 for Ni(II)/Cu(II), Ni(II)/Co(II), and Ni(II)/Pb(II), respectively. These findings highlight the potential of Ni(II)-IPs as an efficient and selective adsorbent for monitoring and removing Ni(II) ions from complex aqueous matrices, thereby addressing growing concerns about nickel pollution in Indonesia and beyond.

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